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Energy and Macronutrient Intake Regulation: Independent or Interrelated Mechanisms?

  • Chapter
Fuel Homeostasis and the Nervous System

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 291))

Abstract

The initiation and termination of feeding are complex processes involving many signals and their integration in the central nervous system. Fluxes of metabolic fuels should logically be determinants of both the initiation and termination of feeding to meet energy needs of the organism, but the relationships of these fluxes to the regulatory centres in the central nervous system are presently undefined. Furthermore, it has become clear that the ingestion, digestion and metabolism of carbohydrate, fat and proteins provides a wide array of signals to the central nervous system and that these signals influence not only the quantity of food consumed but also the composition of the chosen foods. The purpose of this presentation is to highlight these influences and their role in food intake regulation and to provide examples of linkages between body fuel composition, central nervous system neurotransmitters and feeding behaviour.

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References

  • Anderson, G. H., 1979, Control of protein and energy intake: Role of plasma amino acids and brain neurotransmitters. Can. J. Physiol. Pharmacol., 57:1043.

    Article  PubMed  CAS  Google Scholar 

  • Anderson, G. H., 1988, Metabolic regulation of food intake, in: Modern Nutrition in Health and Disease, 7th ed., M. E. Shils and V. R. Young, eds., Lea and Febiger, Philadelphia, Penn.

    Google Scholar 

  • Anderson, G. H., and Johnston, J. L., 1983, Nutrient control of brain neurotransmitter synthesis and function. Can. J. Phvsiol. Pharmacol.. 61:271.

    Article  CAS  Google Scholar 

  • Anderson, G. H., Leprohon, C., Chambers, J. H., and Coscina, D. V., 1979, Intact regulation of protein intake during the development of hypothalamic or genetic obesity in rats. Phvsiol. Behav., 22:777.

    Article  Google Scholar 

  • Anderson, G. H., Li, E. T. S., and Glanville, N.T., 1984, Brain mechanisms and the quantitative and qualitative aspects of food intake. Brain Res. Bull., 12:167.

    Article  PubMed  CAS  Google Scholar 

  • Anil, M. H., and Forbes, J. M., 1987, Neural control and neurosensory functions of the liver. Proc. Nutr. Soc. , 46:125.

    Article  PubMed  CAS  Google Scholar 

  • Ashley, D. V. M., Coscina, D. V., and Anderson, G. H., 1979, Selective decrease in protein intake following drug induced brain serotonin depletion. Life Sci., 24:973.

    Article  PubMed  CAS  Google Scholar 

  • Collier, G., Leshner, A. I., and Squibb, R. L., 1969, Dietary self-selection in active and non-active rats. Physiol. Behav., 4:79.

    Article  Google Scholar 

  • Campfield, L. A., Brandon, P., and Smith, F. J., 1985, On-line continuous measurement of blood glucose and meal pattern in free feeding rats: the role of glucose in meal initiation. Brain Res. Bull., 14:605.

    Article  PubMed  CAS  Google Scholar 

  • Carlisle, H. J., and Stellar, E., 1969, Caloric regulation and food preference in normal, hyperphagic and aphagic rats. J. Comp. Phvsiol. Psvch.. 69:107.

    Article  CAS  Google Scholar 

  • Dyer, J. R., Greenwood, C. E., and McBurney, M. I., 1988, The effects of diet and duration of diabetes on hypermethionemia in streptozotocin-diabetic rats. Can. J. Physiol. Pharmacol., 66:95.

    Article  PubMed  CAS  Google Scholar 

  • Durin, J. G. V. A., 1961, Appetite and the relationship between expenditure and intake of calories in man. J. Physiol., 156:294.

    Google Scholar 

  • Fernstrom, J. D., 1987, Food-induced changes in brain serotonin synthesis: is there a relationship to appetite for specific macronutrients Appetite, 8:163.

    Article  PubMed  CAS  Google Scholar 

  • Fernstrom, J. D., and Wurtman, R. J., 1971a, Brain serotonin content: physiological dependence on plasma tryptophan levels. Science, 173:183.

    Article  Google Scholar 

  • Fernstrom, J. D., and Wurtman, R. J., 1971b, Brain serotonin content: increase following the ingestion of carbohydrate diet. Science, 174:1023.

    Article  PubMed  CAS  Google Scholar 

  • Friedman, M. I., Tordoff, M. G., and Ramirez, I., 1986, Integrated metabolic control of food intake. Brain Res. Bull., 17:855.

    Article  PubMed  CAS  Google Scholar 

  • Glanville, N. T., and Anderson, G. H., 1984a, Altered methionine metabolism in streptozotocin diabetic rats. Diabetolocria, 27:468.

    Article  CAS  Google Scholar 

  • Glanville, N. T., and Anderson, G. H., 1984b, Dietary tyrosine supplementation enhances weight gain in streptozotocin-diabetic rats. Can. J. Physiol. Pharmacol., 62:781.

    Article  PubMed  CAS  Google Scholar 

  • Glanville, N. T., and Anderson, G. H., 1985, The effect of insulin deficiency, dietary protein intake and plasma amino acid concentrations on brain amino acid levels in rats. Can. J. Physiol. Pharmacol., 63:487.

    Article  PubMed  CAS  Google Scholar 

  • Glick, Z., and Mayer, J., 1968, Hyperphagia caused by cerebral ventricular infusion of phlorizin. Nature London, 219:1374.

    Article  PubMed  CAS  Google Scholar 

  • Hrboticky, N., Leiter, L. A., and Anderson, G. H., 1985, Effects of L-tryptophan on short term food intake in lean men. Nutr. Res., 5:595.

    Article  CAS  Google Scholar 

  • Jeanningros, R., 1982, Vagal unitary responses to intestinal amino acid infusions in the anesthetized cat: a putative signal for protein induced satiety. Physiol. Behav., 28:9.

    Article  PubMed  CAS  Google Scholar 

  • Johnson, D. S., Li, E. T. S., Coscina, D. V., and Anderson, G. H., 1979, Different diurnal rhythms of protein and nonprotein energy intake by rats. Physiol. Behav., 21:777.

    Article  Google Scholar 

  • Lat, J., 1967, Self-selection of dietary components, in: Handbook of Physiology, Vol. 1, Section 6, American Physiological Society, Washington, D.C.

    Google Scholar 

  • Le Magnen, J., 1983, Body energy balance and food intake: a neuroendocrine regulatory mechanism. Physiol. Rev., 63:314.

    PubMed  Google Scholar 

  • Le Magnen, J., and Devos, M., 1970, Metabolic correlates of the meal onset in the free food intake of rats. Physiol. Behav.. 5:805.

    Article  PubMed  Google Scholar 

  • Leibowitz, S. F., and Shor-Posner, G., 1986, Brain serotonin and eating behavior. Appetite. 7 (Suppl):l.

    Article  Google Scholar 

  • Li, E. T. S., and Anderson, G. H., 1982, Meal composition influences subsequent food selection in the rat. Physiol. Behav.. 29:779.

    Article  PubMed  CAS  Google Scholar 

  • Louis-Sylvestre, J., and Le Magnen, J., 1980, A fall in blood glucose level precedes meal onset in free feeding rats. Neurosci. Biobehav. Rev., 4 (Suppl. 1):13.

    Article  PubMed  Google Scholar 

  • Luo, S., and Li, E. T. S., 1990, Food intake and selection pattern of rats treated with dexfenfluramine, fluoxetine and RU 24969. Brain Res. Bull., 24:729.

    Article  PubMed  CAS  Google Scholar 

  • Luo, S., Ransom, T., and Li, E. T. S., 1990, Selective increase in carbohydrate intake by rats treated with B-hydroxy-2-(Di-N-propylamino)-tetraline or buspirone. Life Sci, 46:1643.

    Article  PubMed  CAS  Google Scholar 

  • Mayer, J., 1953, Glucostatic mechanism in regulation of food intake. N. Engl. J. Med.. 249:13.

    Article  PubMed  CAS  Google Scholar 

  • Mayer, J., 1980, Physiology of hunger and satiety: regulation of food intake, in: Modern Nutrition in Health and Disease R. S. Godhard and M. E. Shills. eds., Lea and Febiger, Philadelphia.

    Google Scholar 

  • Masiello, P., Balestreri, E., Bacciola, D., and Bergamini, E., 1987, Influence of experimental diabetes on brain levels of monoamine neurotransmitters and their precursor amino acids during tryptophan loading. Acta. Diabetol. lat., 24:43.

    Article  PubMed  CAS  Google Scholar 

  • Mellinkoff, S. M., Franklin, M., Boyle, D., and Geipell, M., 1956, Relationship between serum amino acid concentration and fluctuation in appetite. J. Appl. Physiol., 8:535.

    PubMed  CAS  Google Scholar 

  • Morley, J. E., and Levine, A. S., 1983, The central control of appetite. Lancet, 1:398.

    Article  PubMed  CAS  Google Scholar 

  • Morris, P., Li, E. T. S., MacMillan, M., and Anderson, G. H., 1986, Effect of tryptophan on food intake and selection in rats. Physiol. Behav.

    Google Scholar 

  • Muller, E. E., Paneri, A., Cocchi, D., Frohman, L. A., and Mantegazza, P., 1973. Central glucoprivation: some physiological effects induced by the intraventricular administration of 2-deoxy-D-glucose. Experientia, 29:874.

    Article  PubMed  CAS  Google Scholar 

  • Musten, B., Peace, D., and Anderson, G. H., 1974, Food intake regulation in the weanling rat: self-selection of protein and energy. J. Nutr., 104:563.

    PubMed  CAS  Google Scholar 

  • Oomura, Y., 1976, Significance of glucose, insulin and free fatty acids in the hypothalamic feeding and satiety neurons, in: “Hunger: Basic Mechanism and Clinical Implications”, D. Novin, W. Wyrwicka, G. Bray, eds., Raven Press, New York.

    Google Scholar 

  • Osborne, T. B., and Mendel, L. B., 1918, The choice between adequate and inadequate diets, as made by rats, J. Biol. Chem., 35:19.

    CAS  Google Scholar 

  • Pardridge, W. M., 1984, Transport of nutrients and hormones through the blood brain barrier, Federation Proc., 43:201.

    CAS  Google Scholar 

  • Pardridge, W. M., and Oldendorf, W. H., 1975, Kenetic analysis of blood-brain barrier transport of amino acids, Biochim. Biophvs. Acta.. 401:128.

    Article  CAS  Google Scholar 

  • Pardridge, W. M., and Oldendorf, W. H., 1977, Transport of metabolic substrates through the blood-brain barrier, J. Neurochem., 28:5.

    Article  PubMed  CAS  Google Scholar 

  • Parkinson, W., and Weingarten, H. P., 1989, A dissociative analysis of the ventromedial hypothalamic obesity syndrome. Am. J. Physiol.. in press.

    Google Scholar 

  • Reuterving, C.-O., and Hagg, E., 1987, Circadian eating and drinking habits in alloxan diabetic rats, Diabetes and Metabolisme (Paris), 13:99.

    CAS  Google Scholar 

  • Rezek, M., Havlicek, V, and Novin, D., 1975, Satiety and hunger induced by small and large duodenal loads of isotonic glucose, Am. J. Physiol., 299:545.

    Google Scholar 

  • Richter, C. P., Holt, L. E., and Barelare, B., 1938, Nutritional requirements for normal growth and reproduction in rats studied by the self-selection method, Am. J. Physiol., 122:734.

    CAS  Google Scholar 

  • Rogers, Q. R., and Leung, P. M. B., 1973, The influence of amino acids on the neuroregulation of food intake, Fed. Proc., 32:1709.

    PubMed  CAS  Google Scholar 

  • Schmitt, M., 1973, Circadian rhythmicity in responses of cells in the lateral hypothalamus, Am. J. Physiol., 225:1096.

    PubMed  CAS  Google Scholar 

  • Sellers, E. A., You, R. W., and Moffat, N. W., 1954, Regulation of food consumption by calorie value of the ration in rats exposed to cold. Am. J. Physiol.. 177:367.

    PubMed  CAS  Google Scholar 

  • Shimazu, T., 1981, Central nervous system regulation of liver and adipose tissue metabolism. Diabetolocria, 20 (Suppl) : 343 .

    Article  CAS  Google Scholar 

  • Shimomura, Y., Takahashi, M., Shimizu, H., Sato, N., Uehara, Y., Negishi, M., Inukai, T., Kobayashi, I., and Kobayashi, S., 1990, Abnormal feeding behavior and insulin replacement in STZ-induced diabetic rats, Physiol. Behav., 47:731.

    Article  PubMed  CAS  Google Scholar 

  • Smith, G. P., and Gibbs, J., 1981, Brain-gut peptides and the control of food intake, in: “Neurosecretion and Brain Peptides” J. B. Martin, S. Reichlin and K. L. Bick, eds., Raven Press, New York.

    Google Scholar 

  • Sokoloff, L., FitzGerald, G. G., and Kaufman, E. E., 1977, Cerebral nutrition and energy metabolism, in: “Nutrition and the Brain, Vol. 1”, R. W. Wurtman, J. J. Wurtman, eds., Raven Press, New York.

    Google Scholar 

  • Stricker, E. M., Rowland, N., and Sailer, C. F., 1977, Homeostasis during hypoglycemia: central control of adrenal secretion and peripheral control of feeding. Science, 196:79.

    Article  PubMed  CAS  Google Scholar 

  • Teff, K., and Young, S. M., 1988, Effects of carbohydrate and protein administration on rat tryptophan and 5-hydroxytryptamine: differential effects on the brain, intestine, pineal, and pancreas. Can. J. Physiol. Pharmacol., 66:683.

    Article  PubMed  CAS  Google Scholar 

  • Wayner, M. J., Ono, T., DeYoung, A., and Barone, F. C., 1975, Effects of essential amino acids on central neurons. Pharmac. Biochem. Behav., 3(Suppl.1):85.

    CAS  Google Scholar 

  • Weingarten, H. P., Chang, P. K., and McDonald, T. J., 1985, Comparison of the metabolic and behavioral disturbances following paraventricular-and ventromedial-hypothalamic lesions. Br. Res. Bull., 14:551.

    Article  CAS  Google Scholar 

  • Woodger, T. L., Sirek, A., and Anderson, G. H., 1979, Diabetes, dietary tryptophan, and protein intake regulation in weanling rats. Am.J. Physiol., 236:R307.

    PubMed  CAS  Google Scholar 

  • Wurtman, J. J., Moses, P. L., and Wurtman, R. J., 1983, Prior carbohydrate consumption affects the amount of carbohydrate that rats choose to eat. J. Nutr., 113:70.

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Nutritional Sciences Faculty of Medicine, University of Toronto, Toronto, Canada

    G. Harvey Anderson & Richard M. Black

Authors
  1. G. Harvey Anderson
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  2. Richard M. Black
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Editors and Affiliations

  1. University of Toronto, Toronto, Ontario, Canada

    Mladen Vranic

  2. Karolinska Hospital, Stockholm, Sweden

    Suad Efendic

  3. Banting and Best Diabetes Centre, University of Toronto, Toronto, Ontario, Canada

    Charles H. Hollenberg

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© 1991 Plenum Press, New York

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Anderson, G.H., Black, R.M. (1991). Energy and Macronutrient Intake Regulation: Independent or Interrelated Mechanisms?. In: Vranic, M., Efendic, S., Hollenberg, C.H. (eds) Fuel Homeostasis and the Nervous System. Advances in Experimental Medicine and Biology, vol 291. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5931-9_7

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  • DOI: https://doi.org/10.1007/978-1-4684-5931-9_7

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5933-3

  • Online ISBN: 978-1-4684-5931-9

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