Abstract
A family of membrane-associated G-proteins are essential for receptor-effector coupling (Gilman, 1987; Neer and Clapham, 1988; Ross, 1989). G-proteins are composed of three subunits termed α,βPand γ. The α-subunit contains a binding site for guanine nucleotides and possesses the GTPase activity. It is believed that the GTP-bound α-subunit is an active form for the effector system and the functional life time is determined by the GTPase activity. Molecular cloning of G-protein α-subunit (Gα) has revealed the existence of nine or more Gα genes and a high degree of amino acid sequence homology. However, it is not clear whether each Gα transduces a distinct signal or not.
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© 1991 Plenum Press, New York
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Nukada, T. (1991). Expression of G-Protein α-Subunit cDNA. In: Kito, S., Segawa, T., Olsen, R.W. (eds) Neuroreceptor Mechanisms in Brain. Advances in Experimental Medicine and Biology, vol 287. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5907-4_12
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DOI: https://doi.org/10.1007/978-1-4684-5907-4_12
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