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Amygdala Versus Local Anesthetic Kindling: Differential Anatomy, Pharmacology, and Clinical Implications

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Kindling 4

Part of the book series: Advances in Behavioral Biology ((ABBI,volume 37))

Abstract

Electrical kindling, first described by Goddard and associates (14), was elicited by repeated intermittent electrical stimulation of a variety of brain areas culminating in the production of major motor seizures to a previously subconvulsant stimulation. This process is accompanied by growth and spread of afterdischarges and a succession of behavioral seizure stages progressing to the onset of major motor seizures (14,38). With sufficient repetition of the kindled seizures, a stage of spontaneity occurs in which exogenous electrophysiological stimulation is no longer required in order for the animal to experience a seizure (20–22,43).

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Authors and Affiliations

  1. Biological Psychiatry Branch, NIMH, Bldg. 10, Room 3N212 9000 Rockville Pike, Bethesda, Maryland, 20892, USA

    Robert M. Post, Susan R. B. Weiss, Mike Clark, Takashi Nakajima & Agu Pert

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  1. Robert M. Post
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  2. Susan R. B. Weiss
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  4. Takashi Nakajima
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  1. Neurosciences and Neurology, University of British Columbia, Vancouver, British Columbia, Canada

    Juhn A. Wada

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© 1990 Plenum Press, New York

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Post, R.M., Weiss, S.R.B., Clark, M., Nakajima, T., Pert, A. (1990). Amygdala Versus Local Anesthetic Kindling: Differential Anatomy, Pharmacology, and Clinical Implications. In: Wada, J.A. (eds) Kindling 4. Advances in Behavioral Biology, vol 37. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5796-4_26

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  • DOI: https://doi.org/10.1007/978-1-4684-5796-4_26

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5798-8

  • Online ISBN: 978-1-4684-5796-4

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