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Biocompatibility — A System Approach

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 260))

Abstract

The use of more than 2 billion biomaterial devices per year in therapeutic medicine elucidates the magnitude of one of the biggest problems today’s medicine is dealing with. Clinical application of biomaterials has by far exceeded in both quality and quantity our knowledge about the interaction between the biomaterial and the human organism (1).

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References

  1. Klinkmann, H.: The role of biomaterials in the application of artificial organs. In: Paul, J.P., Gaylor, J.D.S., Courtney, J.M., Gilchrist, T. (eds.), Biomaterial in Artificial Organs, p. 1, Macmillan, London (1984) .

    Google Scholar 

  2. Szycher, M.: Thrombosis, hemostasis, and thrombolysis at prosthetic interfaces. In: Szycher, M. (ed.), Biocompatible Polymers, Metals, and Composits, p. 1, Technomic Publ. Co., Lancaster, Pennsylvania (1983).

    Google Scholar 

  3. Klinkmann, H., Falkenhagen, D., Courtney, J.M.: Clinical relevance of biocompatibility. “The material cannot be divorced from the device”. In: Nefrologia, Vol.VII. Suplemento 3: 13 (1987).

    Google Scholar 

  4. Bjornson, J.: Thrombus formation in the artificial kidney. Scand. J. Urol. Nephrol. 12:251 (1978).

    Article  PubMed  CAS  Google Scholar 

  5. Wilson, R.D., Lelah, M.D. , Cooper, S.L.: Blood-material interactions: Assessment of in-vitro and in-vivo test methods. In: Williams, D.F. (ed.), Techniques of Biocompatibility Testing, Vol.II: p. 151 (1986).

    Google Scholar 

  6. Klinkmann, H., Wolf, H., Schmitt, E.: Definition of biocompatibility. Contrib. Nephrol. 37:70 (1984).

    PubMed  CAS  Google Scholar 

  7. Craddock, P.R., Fehr, J., Dalmasso, A.P., Brigham, K.L., Jacob, H.S.: Hemodialysis leukopenia. Pulmonary vascular leucostasis resulting from complement activation by dialyzer cellophane membranes. J. Clin. Invest. 59:879 (1977).

    Article  PubMed  CAS  Google Scholar 

  8. Ivanovich, P., Chenoweth, D.E., Schmidt, R., Klinkmann, H., Boxer, L.A., Jacob, H.S., Hammerschmidt, D.E.: Symptoms and activation of granulocytes and complement with two dialysis membranes. Kidney Int. 24:758 (1983).

    Article  PubMed  CAS  Google Scholar 

  9. Chenoweth, D.E.: Biocompatibility of hemodialysis membranes. Evaluation with C3a anaphylatoxin radioimmunoassays. Am. Soc. Artif. Intern. Organs J. 7:44 (1984).

    CAS  Google Scholar 

  10. Hakim, R.M., Fearon, D.T., Lazarus, J.M.: Biocompatibility of dialysis membranes: effects of chronic complement activation. Kidney Int. 26:194 (1984).

    Article  PubMed  CAS  Google Scholar 

  11. Wegmüller, E., Montandon, A., Nydegger, U., Desceudres, D.: Biocompatibility of different hemodialysis membranes: activation of complement and leukopenia. Int. J. Artif. Organs 9:85 (1986).

    PubMed  Google Scholar 

  12. Chenoweth, D.E., Cheung, A.L., Ward, D.M., Henderson, L.W.: Anaphylatoxin formation during hemodialysis: effects of two different dialyzer membranes. Kidney Int. 24:764 (1983) .

    Article  PubMed  CAS  Google Scholar 

  13. Bingel, M., Lonnemann, G. , Shaldon, S., Koch, K.M., Dinarello, C.A.: Human interleukin-1 production during hemodialysis. Nephron 43:161 (1986).

    Article  PubMed  CAS  Google Scholar 

  14. Cooper, N.R.: The complement system. In: Fundenberg, H.W., Sites, D.P., Caldwell, J.L., Wells, J.V., (eds.), Basic and Clinical Immunology, Chapter 6, Lange Medical Publications, Los Altos, CA (1976).

    Google Scholar 

  15. Rudy, S., Gigli, L., Austen, K.F.: The complement system of man. New Engl. J. Med. 287:489, 545, 592, 642 (1972) .

    Article  Google Scholar 

  16. Henderson, L.W., Cheung, A.K., Chenoweth, D.E.: Choosing a membrane. Am. J. Kidney Pis. 3:5 (1983).

    CAS  Google Scholar 

  17. Hoenich, N.A. , Johnston, S.R.D., Woffindin, C., Kerr, D.N.S.: Hemodialyzers leucopenia: the role of membrane type and re-use. Contr. Nephrol. 37:120 (1984).

    CAS  Google Scholar 

  18. Falkenhagen, D., Bosch, T., Brown, G.S., Schmidt, R., Holtz, M., Bauermeister, U., Gurland, H., Klinkmann, H.: A clinical study on different cellulosic dialysis membranes. Nephrol. Dial. Transplant. 2:537 (1985).

    Google Scholar 

  19. Bosch, T., Schmidt, B., Samtleben, W., Gurland, H.J.: Biocompatibility and clinical performance of a new modified cellulose membranes. Clin. Nephrol. 26 (Suppl. 1):S22 (1986).

    Google Scholar 

  20. Klinkmann, H.: Clinical Relevance of Biocompatibility in Hemodialysis. “Verhandelingen van de Koningklijke Academie voor Geneeskunde van Belgie”, XLIX 1:59 (1987).

    Google Scholar 

  21. Aljama, P., Bird, D.A.E., Ward, M.K., Feest, T.G., Walker, W., Tanboga, H.: Hemodialysis-induced leucopenia and activation of complement. Effects of different membranes. Proc. Eur. Dial. Transplant. Assoc. 15:144 (1978).

    PubMed  CAS  Google Scholar 

  22. Jacob, A.J., Gavellas, G. , Zarco, R., Perez, G., Bourgoignie, J.J.: Leucopenia, hypoxia and complement function with different hemodialysis membranes. Kidney Int. 18:505 (1980).

    Article  PubMed  CAS  Google Scholar 

  23. Jorstadt, S., Smeby, L.C., Balstad, T., Wideroe, T.-E.: Generation and removal of anaphylatoxins during hemofiltration with five different membranes. Blood Purif. 6:325 (1988).

    Article  Google Scholar 

  24. Shaldon, S., Deschodt, G., Branger, B., Granolleras, G. , Baldamus, C.A., Koch, K.M., Lysaght, M. J. , Dinarello, C.A.: Hemodialysis hypotension: The interleukin hypothesis restated. Proc. Eur. Dial. Transplant. Ass. 22:229 (1985).

    Google Scholar 

  25. Lonnemann, G., Koch, K.M., Shaldon, S., Dinarello, CA.: Plasma interleukin-1 activity in humans undergoing hemodialysis with regenerated cellulosic membranes. Lymphokine Res. 6:63 (1987).

    PubMed  CAS  Google Scholar 

  26. Dinarello, C.A.: Interleukin-1 — Its multiple biological effects and its association with hemodialysis. Blood Purif. 6:164 (1988).

    Article  PubMed  CAS  Google Scholar 

  27. Vanherweghem, J.L., Drukker, W., Schwarz, A.: Clinical significance of blood-device interaction in hemodialysis. A review. Int. J. Artif. Organs. 10:219 (1987).

    PubMed  CAS  Google Scholar 

  28. Gejyo, R., Yamada, T., Oami, S., Nakagawa, Y., Kunimoto, T.,Kataoka, H., Sizuki, M., Hirasawa, Y., Shirahama, T., Cohen, A.S., Schmid, K.: A new form of amyloid protein associated with hemodialysis was identified as β2-microglobulin. Biochem. Biophys. Res. Commun. 129:701 (1985).

    Article  PubMed  CAS  Google Scholar 

  29. Ritz, E., Bommer, J.: Beta-2-microglobulin-derived amyloid — problems and perspectives. Blood Purif. 6:61 (1988) .

    Article  PubMed  CAS  Google Scholar 

  30. Floege, J., Granolleras, C., Koch, K.M., Shaldon, S.: Which membrane? Should beta-2-microglobulin decide on the choice of today’s hemodialysis membrane? Nephron 50:177 (1988).

    Article  PubMed  CAS  Google Scholar 

  31. Schmidt, H.: Staphylococcus saprophyticus als Erreger von Harnwegsinfektionen. B-Promotion, Rostock (1988).

    Google Scholar 

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© 1989 Plenum Press, New York

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Klinkmann, H., Falkenhagen, D. (1989). Biocompatibility — A System Approach. In: Hörl, W.H., Schollmeyer, P.J. (eds) New Perspectives in Hemodialysis, Peritoneal Dialysis, Arteriovenous Hemofiltration, and Plasmapheresis. Advances in Experimental Medicine and Biology, vol 260. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5718-6_5

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  • DOI: https://doi.org/10.1007/978-1-4684-5718-6_5

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5720-9

  • Online ISBN: 978-1-4684-5718-6

  • eBook Packages: Springer Book Archive

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