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The Biological Functions of Amine Oxidases and their Reaction Products: An Overview

  • Chapter
Progress in Polyamine Research

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 250))

Abstract

Amine oxidases (AO) are enzymes widely distributed among all living organisms.1 Their widespread occurrence accounts for an undoubtedly relevant biological function in biogenic amine metabolism. AOs represent a class of enzymes heterogenous in structure, catalytic mechanism and mode of substrate oxidation. Mono-, di- and polyamines, as well as several N-acyl amines, are oxidatively deaminated by AOs in a reaction consuming O2 and H2O and producing the corresponding aldehyde, the removed amine moiety and H2O2 in stoichiometric amounts according to the following equations:

$${\text{R - C}}{{\text{H}}_{\text{2}}}{\text{ - N}}{{\text{H}}_{\text{2}}}{\text{ + }}{{\text{O}}_{\text{2}}}{\text{ + }}{{\text{H}}_{\text{2}}}{\text{O }} \to {\text{R - CHO + N}}{{\text{H}}_{\text{3}}}{\text{ + }}{{\text{H}}_{\text{2}}}{{\text{O}}_{\text{2}}}$$

cleavage at a primary amino group (terminal oxidation reaction).

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Authors and Affiliations

  1. Department of Biochemical Sciences and CNR Centre for Molecular Biology, University “La Sapienza”, Rome, Italy

    B. Mondovì, P. Riccio & E. Agostinelli

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  1. B. Mondovì
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  2. P. Riccio
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  3. E. Agostinelli
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  1. Institute of Biochemistry of Macromolecules, University of Naples, Naples, Italy

    Vincenzo Zappia

  2. The Milton S. Hershey Medical Center, The Pennsylvania State University, Hershey, Pennsylvania, USA

    Anthony E. Pegg

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Mondovì, B., Riccio, P., Agostinelli, E. (1988). The Biological Functions of Amine Oxidases and their Reaction Products: An Overview. In: Zappia, V., Pegg, A.E. (eds) Progress in Polyamine Research. Advances in Experimental Medicine and Biology, vol 250. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5637-0_14

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