Abstract
There has been much discussion in this meeting regarding the involvement of hydroxyl radicals (OH), oxidizing lipids, and metal ions in oxidative damage in living tissue and in food systems. However, the causal relationships linking these three species to each other and to specific damage in cells have not yet been clarified. Indeed, the literature is replete with contradictory claims regarding their activity and effects.
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D. С. Borg and K. M. Schaich, Cytotoxicity from coupled redox cycling of autoxidizing xenobiotics and metals, Isr. J. Chem. 24:38 (1984).
S. Goldstein and G. Czapski, The role and mechanism of metal ions and their complexes in enhancing damage in biological systems or in protecting these systems from the toxicity of O2, J. Free Rad. Biol. Med. 2:3 (1986).
K. M. Schaich and D. C. Borg, Fenton reactions in lipid phases, Lipids 23:in press (1988).
D. С Borg, K. M. Schaich, and A. Forman, Autoxidative cytotoxicity: Is there metal-independent formation of hydroxyl radicals? Are there “crypto-hydroxyl” radicals?, in: “Oxygen Radicals in Chemistry and Biology,” W. Bors, M. Saran, and D. Tait, eds., Walter de Gruyter, Berlin (1984).
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© 1988 Plenum Press, New York
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Schaich, K.M., Borg, D.C. (1988). Fenton Reactions in Lipid Phases: Iron Solubility, Oh Production, and Initiation of Lipid Oxidation. In: Simic, M.G., Taylor, K.A., Ward, J.F., von Sonntag, C. (eds) Oxygen Radicals in Biology and Medicine. Basic Life Sciences, vol 49. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5568-7_22
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DOI: https://doi.org/10.1007/978-1-4684-5568-7_22
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