Abstract
The gut is one of the main targets of acute GVHR in man and the pathogenesis of the injury is poorly understood. Using various experimental models in mice we tried (1) to shed some light on the occurrence, nature and mechanism of lesions. Our observations led us to the conclusion that the basic situation responsible for intestinal tissue damage is the stimulation of the foreign “donor” T lymphocytes. T lymphocytes activated to proliferate under alloantigenic influence in Peyer’s patches, reach the gut wall through the thoracic duct (2) and are further stimulated by contact with antigen. Release of T cell factors are probably mainly responsible for the acceleration of the epithelial renewal which is the most sensitive index of the epithelial damage.
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References
Guy-Grand, D. and Vassalli, P., J. Clin. Invest, 77, 1584, 1986.
Guy-Grand, D., Griscelli, C and Vassalli, P., J. Exp. Med. 148, 1661, 1978.
Guy-Grand, D., Dy, M., Luffau, G. and Vassalli, P., J. Exp. Med. 160, 12, 1984.
Korngold, R. and Sprent, J., J. Exp. Med. 155, 872, 1982.
Piguet, P.-F., J. Immunol. 135, 1637, 1985.
Sprent, J., Schaefer, M., Lo, D. and Korngold, R., J. Exp. Med. 163, 998, 1986.
Elson, CO., Reilly, R.W. and Rosenberg, E.H., Gastroenterology 72, 886, 1977.
Mcintosh, A., Mowat, A. and Ferguson, A., Transplantation 32, 238, 1981.
Mayrhofer, G., Pugh, C.W. and Barclay, A.N., Eur. J. Immunol. 13, 112, 1984.
Barclay, A.N. and Mason, D.W., J. Exp. Med. 156, 1665, 1982.
Cerf-Bensussan, N., Quaroni, A., Kurnick, J.T. and Bhan, A.K., J. Immunol. 132, 2244, 1984.
Kindler, V., Thorens, C., de Kossodo, S., Allet, C., Eliason, J.F., Thatcher, D., Farber, N. and Vassalli, P., Proc. Natl. Acad. Sci. 83, 1001, 1986.
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© 1987 Plenum Press, New York
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Guy-Grand, D., Vassalli, P. (1987). Gut Injury in Mouse Graft-Versus-Host Reaction (GVHR). In: Mestecky, J., McGhee, J.R., Bienenstock, J., Ogra, P.L. (eds) Recent Advances in Mucosal Immunology. Advances in Experimental Medicine and Biology, vol 216 A. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5344-7_78
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DOI: https://doi.org/10.1007/978-1-4684-5344-7_78
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