Skip to main content
SpringerLink
Log in

DNA Repair and Replication in Xeroderma Pigmentosum and Related Disorders

  • Chapter
Antimutagenesis and Anticarcinogenesis Mechanisms

Part of the book series: Basic Life Sciences ((BLSC,volume 39))

  • 565 Accesses

Abstract

Xeroderma pigmentosum (XP), ataxia telangiectasia (AT), and Cockayne syndrome (CS) are human diseases t hat exhibit increased sensitivity to environmental carcinogens [e.g., ultraviolet (UV) light, ionizing radiations, chemicals] because of genetic defects in the patient’s capacity to repair and replicate damaged DNA accurately. The major defect in XP is a failure to repair UV damage to DNA; in AT, the failure is in repair or replication of double-strand breaks in DNA; in CS, the failure is in recovery of DNA replication after UV irradiation. Cancer is a major clinical feature of XP and AT, but not of CS. Each disease is complex, with multiple groups defined by complementation in cell-cell hybridization. Overlap is reported between some XP and CS groups. UV-sensitive hamster cell mutants are also known: most of these complement XP groups, and a human gene on chromosome 19 can correct the defects in hamster mutants, but not XP. XP group C is distinct from the other groups in exhibiting a strongly clustered mode of repair, as if only certain regions of the genome can be mended. This mode mainly occurs in confluent group C cells under conditions that permit much greater survival than in exponential growth, and therefore represents a more efficient mode of repair. These diseases all represent important examples of perturbation in the way carcinogen damage in DNA is metabolized, and further research aimed at identifying the kinds of molecular changes involved in the malignancy will be important.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Adams, J.M., S. Gerondakis, E. Webb, L.M. Corcoran, and S. Cory (1983) Cellular myc oncogene is altered by chromosome translocation to an immunoglobulin locus in murine plasmacytomas and is rearranged similarly in human Burkitt lymphomas. Proc. Natl. Acad. Sei., USA 80:1982.

    Article  CAS  Google Scholar 

  2. Ames, B.N. (1983) Dietary carcinogens and anticarcinogens. Science 221:1256.

    Article  CAS  Google Scholar 

  3. Andrews, A.D., S.F. Barrett, and J.H. Robbins (1978) Xeroderma pigmentosum neurological abnormalities correlate with colony-forming ability after ultraviolet radiation. Proc. Natl. Acad. Sei., USA 75:1984.

    Article  CAS  Google Scholar 

  4. Andrews, A.D., and C. Borek (1982) UVB light-induced vitro transformation of skin fibroblasts from xeroderma pigmentosum and Bloom’s syndrome patients (abstract). J. Invest. Dermatol. 78:355.

    Google Scholar 

  5. Bootsma, D., M.P. Mulder, F. Pot, and J.A. Cohen (1970) Different inherited levels of DNA repair replication in xeroderma pigmentosum cell strains after exposure to ultraviolet irradiation. Mutat. Res. 9:507.

    Article  CAS  Google Scholar 

  6. Borek, C. (1980) X-ray-induced vitro neoplastic transformation of human diploid cells. Nature 283:776.

    Article  CAS  Google Scholar 

  7. Borek, C., and J.E. Cleaver (1981) Protease inhibitors neither damage DNA nor interfere with DNA repair or replication in human cells. Mutat. Res. 82:373.

    Article  CAS  Google Scholar 

  8. Chan, G.L., and J.B. Little (1979) Resistance of plateau-phase human normal and xeroderma pigmentosum fibroblasts to the cytotoxic effect of ultraviolet light. Mutat. Res. 63:401.

    Article  CAS  Google Scholar 

  9. Cheng, W.-S., R.E. Tarone, A.D. Andrews, J.S. Whang-Peng, and J.H. Robbins (1978) Ultraviolet light-induced sister chromatid exchanges in xeroderma pigmentosum and in Cockayne’s syndrome lymphocyte cell lines. Cancer Res. 38:1601.

    CAS  Google Scholar 

  10. Cleaver, J.E. (1968) Defective repair replication of DNA in xeroderma pigmentosum. Nature 218:652.

    Article  CAS  Google Scholar 

  11. Cleaver, J.E. (1969) Xeroderma pigmentosum: A human disease in which an initial stage of DNA repair is defective. Proc. Natl. Acad. Sei., USA 63:428.

    Article  CAS  Google Scholar 

  12. Cleaver, J.E. (1983) Workshop summary: DNA repair in normal and re- pair-defective human cells. In Cellular Responses to DNA Damage, E.C. Friedberg and B.A. Bridges, eds. Alan R. Liss, Inc., New York, p. 327.

    Google Scholar 

  13. Cleaver, J.E. (1983) Xeroderma pigmentosum. In Metabolic Basis of Inherited Disease, 5 th ed., J.B. Stanbury, J.B. Wyngaarden, D.S. Fredrickson, J.L. Goldstein, and M.S. Brown, eds. McGraw-Hill, New York, p. 1227.

    Google Scholar 

  14. Cleaver, J.E. (1984) DNA repair deficiencies and cellular senescence are unrelated in xeroderma pigmentosum cell lines. Mech. Aging Devel. 27:189.

    Article  CAS  Google Scholar 

  15. Cleaver, J.E. (1986) Xeroderma pigmentosum. In Photomedicine, E. Ben-Hur and I. Rosenthal, eds. CRC Press, Boca Raton, Florida (in press).

    Google Scholar 

  16. Cleaver, J.E., R.M. Arutyunyan, T. Sarkisian, W.K. Kaufmann, A.E. Greene, and L. Coriell (1980) Similar defects in DNA repair and replication in the pigmented xerodermoid and the xeroderma pigmentosum variants. Carcinogenesis 1:647.

    Article  Google Scholar 

  17. Cleaver, J.E., G.H. Thomas, and S.D. Park (1979) Xeroderma pigmentosum variants have a slow recovery of DNA synthesis after irradiation with ultraviolet light. Biochim. Biophys. Acta 564:122.

    CAS  Google Scholar 

  18. Cohn, S.M., and M.W. Lleberman (1984) The distribution of DNA exci- sion-repair sites in human diploid fibroblasts following ultraviolet irradiation. J. Biol. Chem. 259:12463.

    CAS  Google Scholar 

  19. Cornforth, M.N., and J.S. Bedford (1985) On the nature of the defect in cells from individuals with ataxia-telangiectasia. Science 227: 1589.

    Article  CAS  Google Scholar 

  20. Day, III, R.S, C.H.J. Ziolkowski, D.A. Scudiero, S.A. Meyer, and M.R. Mattern (1980) Human tumor cell strains defective in the repair of alky lation damage. Carcinogenesis 1:21.

    Article  CAS  Google Scholar 

  21. Deluca, J.G., D.A. Kaden, E.A. Komives, and W.G. Thilly (1984) Mutation of xeroderma pigmentosum lymphoblasts by far-ultraviolet light. Mutat. Res. 128:47.

    Article  CAS  Google Scholar 

  22. de Weerd-Kastelein, E.A., W. Keijzer, G. Rainaldi, and D. Bootsma (1977) Induction of sister chromatid exchanges in xeroderma pigmentosum cells after exposure to ultraviolet light. Mutat. Res. 45:253.

    Article  Google Scholar 

  23. Fornace, Jr., A.J., and D.S. Seres (1983) Detection of DNA single- strand breaks during the repair of UV damage in xeroderma pigmentosum cells. Radiat. Res. 93:107.

    Article  CAS  Google Scholar 

  24. Gautschi, J.R., B.R. Young, and J.E. Cleaver (1973) Repair of damaged DNA in the absence of protein synthesis in mammalian cells. Exp. Cell Res. 76:87.

    Article  CAS  Google Scholar 

  25. German, J. (1972) Genes which increase chromosomal instability in somatic cells and predispose to cancer. Prog. Med. Genet. 8:61.

    Google Scholar 

  26. Giannelli, F., and S.A. Pawsey (1974) DNA repair synthesis in human heterokaryons. II. A test for heterozygosity in xeroderma pigmentosum and some insight into the structure of the defective enzjmie. J. Cell Sei. 15:163.

    CAS  Google Scholar 

  27. Giannelli, F., and S.A. Pawsey (1976) DNA repair synthesis in human heterokaryons. III. The rapid and slow complementing varieties of xeroderma pigmentosum. J. Cell Sei. 20:207.

    CAS  Google Scholar 

  28. Giannelli, F., P.M. Croll, and S.A. Lewin (1973) DNA repair synthesis in human heterokaryons formed by normal and UV-sensitive fibroblasts. Exp. Cell Res. 78:175.

    Article  CAS  Google Scholar 

  29. Giannelli, F., S.A. Pawsey, and J.A. Avery (1982) Differences in patterns of complementation of the more common groups of xeroderma pigmentosum: Possible implications. Cell 29:451.

    Article  CAS  Google Scholar 

  30. Glover, T.W., C.-C. Chang, J.E. Trosko, and S.S.-L. Li (1979) Ultraviolet light induction of diphtheria toxin-resistant mutants in normal and xeroderma pigmentosum human fibroblasts. Proc. Natl. Acad. Sei., USA 76:3982.

    Article  CAS  Google Scholar 

  31. Grosovsky, A.J., and J.B. Little (1983) Mutagenesis and lethality fol lowing S phase irradiation of xeroderma pigmentosum and normal human diploid fibroblasts with ultraviolet light. Carcinogenesis 4:1389.

    Article  CAS  Google Scholar 

  32. Hori, T.-A., T. Shiomi, and K. Sato (1983) Human chromosome 13 compensates a DNA repair defect in UV-sensitive mouse cells by mouse-human cell hybridization. Proc. Natl. Acad. Sei., USA 80:5655.

    Article  CAS  Google Scholar 

  33. Imray, P., T. Mangan, A. Saul, and C. Kidson (1983) Effects of ultraviolet irradiation on the cell cycle in normal and UV-sensitive cell lines with reference to the nature of the defect in xeroderma pigmentosum variant. Mutat. Res. 112:301.

    CAS  Google Scholar 

  34. Ishizaki, K., T. Yagi, and H. Takebe (1980) Cytotoxic effects of protease Inhibitors on human cells. 1. High sensitivity of xeroderma pigmentosum cells to antipain. Cancer Lett. 10:199.

    Article  CAS  Google Scholar 

  35. Kano, Y., and Y. Fujiwara (1983) Defective thymine dimer excision from xeroderma pigmentosum chromatin and its characteristic catalysis by cell-free extracts. Carcinogenesis 4:1419.

    Article  CAS  Google Scholar 

  36. Karentz, D., and J.E. Cleaver (1986) Excision repair in xeroderma pigmentosum group C but not group D is clustered in a small fraction of the total genome. Mutat. Res, (in press).

    Google Scholar 

  37. Keijzer, W., M. Stefanini, A. Westerveld, and D. Bootsma (1984) Mapping of the XPAC gene involved in complementation of the defect in xeroderma pigmentosum group A cells (abstract). Cytogenet. Cell Genet. 37:508.

    Google Scholar 

  38. Keijzer, W., A. Verkerk, and D. Bootsma (1982) Phenotypic correction of the defect in xeroderma pigmentosum cells after fusion with isolated cytoplasts. Exp. Cell Res. 140:119.

    Article  CAS  Google Scholar 

  39. Klein, G., and E. Klein (1984) Oncogene activation and tumor progres- sion. Carcinogenesis 5:429.

    Article  CAS  Google Scholar 

  40. Konze-Thomas, B., R.M. Hazard, V.M. Maher, and J.J. McCormick (1982) Extent of excision repair before DNA synthesis determines the mutagenic but not the lethal effect of UV radiation. Mutat. Res. 94:421.

    Article  CAS  Google Scholar 

  41. Kraemer, K.H., M.M. Lee, and J. Scotto (1984) DNA repair protects against cutaneous and internal neoplasia: Evidence from xeroderma pigmentosum. Carcinogenesis 5:511.

    Article  CAS  Google Scholar 

  42. Lalley, P.A., J.A. Diaz, Ä.A. Francis, W.C. Dunn, and J.D. Regan (1984) The expression and chromosomal assignments of genes required for repair of UV-induced DNA damage (abstract). Cytogenet. Cell Genet. 37:516.

    Google Scholar 

  43. Legerski, R.J., D.B. Brown, C.A. Pederson, and D.L. Robberson (1984) Transient complementation of xeroderma pigmentosum cells by microinjection of poly(A) RNA. Proc. Natl. Acad. Sei., USA 81:5676–5689.

    Article  CAS  Google Scholar 

  44. Lehmann, A.R. (1979) The relationship between pyrimidine dimers and replicating DNA in UV-irradiated human fibroblasts. Nucl. Acids Res. 7:1901.

    Article  CAS  Google Scholar 

  45. Lehmann, A.R. (1982) Three complementation groups in Cockayne syndrome. Mutat. Res. 106:347.

    Article  CAS  Google Scholar 

  46. Lehmann, A.R., S. Kirk-Bell, C.F. Arlett, M.C. Paterson, P.H.M. Lohman, E.A. de Weerd-Kastelein, and D. Bootsma (1975) Xeroderma pigmentosum cells with normal levels of excision repair have a defect in DNA synthesis after UV-irradiation. Proc. Natl. Acad. Sei., USA 72:219.

    Article  CAS  Google Scholar 

  47. Lehmann, A.R., S. Kirk-Bell, and L. Mayne (1979) Abnormal kinetics of DNA synthesis in ultraviolet light-irradiated cells from patients with Cockaynesyndrome. Cancer Res. 39:4237.

    CAS  Google Scholar 

  48. Lin, P.-F., and F.H. Ruddle (1981) Murine DNA repair gene located on chromosome 4. Nature 289:191.

    Article  CAS  Google Scholar 

  49. Lo, L.W., and H.F. Stich (1975) DNA damage, DNA repair and chromosome aberrations of xeroderma pigmentosum cells and controls following exposure to nitrosation products of methylguanidine. Mutat. Res. 30: 397.

    Article  CAS  Google Scholar 

  50. Maher, V.W., D.J. Dorney, A.L. Mendrala, B. Konze-Thomas, and J.J. McCormick (1979) DNA excision-repair processes in human cells can eliminate the cytotoxic and mutagenic consequences of ultraviolet irradiation. Mutat. Res. 62:311.

    Article  CAS  Google Scholar 

  51. Maher, V.M., J.J. McCormick, P.L. Grover, and P. Sims (1977) Effect of DNA repair on the cytotoxicity and mutagenicity of polycyclic hydrocarbon derivatives in normal and xeroderma pigmentosum human fibroblasts. Mutat. Res. 43:117.

    Article  CAS  Google Scholar 

  52. Maher, V.M., L.M. Ouellette, R.D. Curren, and J.J. McCormick (1976) Frequency of ultraviolet light-induced mutations is higher in xeroderma pigmentosum variant cells than in normal human cells. Nature 261:593.

    Article  CAS  Google Scholar 

  53. Maher, V.M., L.A. Rowan, K.C. Silinskas, S.A. Kateley, and J.J. McCormick (1982) Frequency of UV-induced neoplastic transformation of diploid human fibroblasts is higher in xeroderma pigmentosum cells than in normal cells. Proc. Natl. Acad. Sei., USA 79:2613.

    Article  CAS  Google Scholar 

  54. Mansbridge, J.N., and P.C. Hanawalt (1983) Domain-limited repair of DNA in ultraviolet irradiated fibroblasts from xeroderma pigmentosum complementation group C. In Cellular Pesponses to DNA Damage, E.C. Friedberg and B.A. Bridges, eds. Alan R. Liss, Inc., New York, p. 195.

    Google Scholar 

  55. Marshall, R.R., C.F. Arlett, S.A. Harcourt, and B.A. Broughton (1980) Increased sensitivity of cell strains from Cockayne’s syndrome to sister-chromatid-exchange induction and cell killing by UV light. Mutat. Res. 69:107.

    Article  CAS  Google Scholar 

  56. Marshall, R.R., and D. Scott (1976) The relationship between chromosome damage and cell killing in UV-irradiated normal and xeroderma pigmentosum cells. Mutat. Res. 36:397.

    Article  CAS  Google Scholar 

  57. Matsukuma, S., B. Zelle, W. Keijzer, F. Berends, and D. Bootsma (1981) Different rates of restoration of the repair capacity in complementing xeroderma pigmentosum cells after fusion. Exp. Cell Res. 134:103.

    Article  CAS  Google Scholar 

  58. Mayne, L.V., and A.R. Lehmann (1982) Failure of RNA synthesis to recover after UV irradiation: An early defect in cells from individuals with Cockayne’s syndrome and xeroderma pigmentosum. Cancer Res. 42: 1473.

    CAS  Google Scholar 

  59. Morgan, W.F., J. Bodycote, M.L. Fero, P.J. Hahn, L.N. Kapp, G.E. Pantelias, and R.B. Painter (1985) A cytogenetic investigation of DNA rereplication after hydroxyurea treatment: Implications for gene amplification. Chromosoma (in press).

    Google Scholar 

  60. Morison, W.L., C. Bucana, N. Hashem, M.L. Kripke, J.E. Cleaver, and J.L. German (1985) Impaired immune function in patients with xeroderma pigmentosum. Cancer Res. 45:3929.

    CAS  Google Scholar 

  61. Mortelmans, K., E.C. Friedberg, H. Slor, G. Thomas, and J.E. Cleaver (1976) Defective thymine dimer excision by cell-free extracts of xeroderma pigmentosum cells. Proc. Natl. Acad. Sei., USA 73:2757.

    Article  CAS  Google Scholar 

  62. Mullenders, L.H.F., A.C. van Kesteren, C.J.M. Bussmann, A.A. van Zeeland, and A.T. Natarajan (1984) Preferential repair of nuclear matrix associated DNA in xeroderma pigmentosum complementation group C. Mutat. Res. 141:75.

    Article  CAS  Google Scholar 

  63. Myhr, B.C., D. Turnbull, and J.A. DiPaolo (1979) Ultraviolet mutagenesis of normal and xeroderma pigmentosum variant human fibroblasts. Mutat. Res. 62:341.

    Article  CAS  Google Scholar 

  64. Natarajan, A.T., E.A.M. Verdegaal-Immerzeel, M.J. Ashwood-Smith, and G.A. Poulton (1981) Chromosomal damage induced hy furocoumarins and UVA in hamster and human cells including cells from patients with ataxia telangiectasia and xeroderma pigmentosum. Mutat. Res. 84:113.

    Article  CAS  Google Scholar 

  65. Painter, R.B. (1981) Radioresistant DNA synthesis: An intrinsic fea ture of ataxia-telangiectasia. Mutat. Res. 84:183.

    Article  CAS  Google Scholar 

  66. Painter, R.B., and B.R. Young (1980) Radiosensitivity in ataxia-tel- angiectasia: A new explanation. Proc. Natl. Acad. Sei., USA 77:7315.

    Article  CAS  Google Scholar 

  67. Paterson, M.C., B.P. Smith, P.H.M. Lohman, A.K. Anderson, and L. Fishman (1976) Defective excision repair of y-ray-damaged DNA in human (ataxia-telangiectasia) fibroblasts. Nature 260:444.

    Article  CAS  Google Scholar 

  68. Regan, J.D., and R.B. Setlow (1974) Two forms of repair in the DNA of human cells damaged by chemical carcinogens and mutagens. Cancer Res. 34:3318.

    CAS  Google Scholar 

  69. Robbins, J.H., K.H. Kraemer, M.A. Lutzner, B.W. Festoff, and H.G. Coon (1974) Xeroderma pigmentosum: An inherited disease with sun sensitivity, multiple cutaneous neoplasms, and abnormal DNA repair. Ann. Intern. Med. 80:221.

    CAS  Google Scholar 

  70. Royer-Pokora, B., and W.A. Haseltine (1984) Isolation of UV-resistant revertants from a xeroderma pigmentosum complementation group A cell line. Nature 311:390.

    Article  CAS  Google Scholar 

  71. Rubin, J.S., A.L. Joyner, A. Bernstein, and G.F. Whitmore (1983) Molecular identification of a human DNA repair gene following DNA-mediated gene transfer. Nature 306:206.

    Article  CAS  Google Scholar 

  72. Rubin, J.S., V.R. Prideaux, H.F. Willard, A.M. Dulhanty, G.F. Whitmore, and A. Bernstein (1985) Molecular cloning and chromosome localization of DNA sequences associated with a human DNA repair gene. Mol. Cell Biol. 5:398–405.

    CAS  Google Scholar 

  73. Schwab, M., J. Ellison, M. Busch, W. Rosenau, and H.E. Varmus (1984) Enhanced expression of the human gene N-myc consequent to amplifica tion of DNA may contribute to malignant progression of neuroblastoma. Proc. Natl. Acad. Sei., USA 81:4940.

    Article  CAS  Google Scholar 

  74. Seeburg, P.H., W.W. Colby, D.J. Capon, D.V. Goeddel, and A.D. Levinson (1984) Biological properties of human c-Ha-ras 1 genes mutated at codon 12. Nature 312:71.

    Article  CAS  Google Scholar 

  75. Shiloh, Y., E. Tabor, and Y. Becker (1985) Cells from patients with ataxia-telangiectasia are abnormally sensitive to the cytotoxic effects of a tumor promoter, phorbol-12-myristate-13-acetate. Mutat. Res. 149:283–286.

    Article  CAS  Google Scholar 

  76. Sklar, R., and B. Strauss (1981) Removal of Omethylguanine from DNA of normal and xeroderma pigmentosum-derived lymphoblastoid lines. Nature 289:417.

    Article  CAS  Google Scholar 

  77. Stefanini, M., W. Keijzer, and D. Bootsma (1985) Interspecies complementation analysis of xeroderma pigmentosum and UV-sensitlve Chinese hamster cells. Exp. Cell Res. 161:373.

    Article  CAS  Google Scholar 

  78. Stich, H.F., W. Stich, and R.H.C. San (1973) Chromosome aberrations in xeroderma pigmentosum cells exposed to the carcinogens, 4-nitroquino- line-l-oxide and N-methyl-Nnitro-N-nitrosoguanidine. Proc. Soc. Exp. Biol. Med. 142:1141.

    CAS  Google Scholar 

  79. Suzuki, N., T. Kojima, T. Kuwata, J. Nishimaki, Y. Takakubo, and T. Miki (1984) Cross sensitivity between interferon and uv in human cell strains: IF, HEC-1, and CRL1200. Virology 135:20.

    Article  CAS  Google Scholar 

  80. Takano, T., M. Nöda, and T.-A. Tamura (1982) Transfection of cells from a xeroderma pigmentosum patient with normal human DNA confers UV resistance. Nature 296:269.

    Article  CAS  Google Scholar 

  81. Taylor, A.M.R., J.A. Metcalfe, J.M. Oxford, and D.G. Harnden (1976) Is chromatid-type damage in ataxia-telangiectasia after irradiation at Gaconsequence of defective repair? Nature 260:441.

    Article  CAS  Google Scholar 

  82. Thompson, L.H., D.B. Busch, K. Brookman, C.L. Mooney, and D.A. Glaser (1981) Genetic diversity of UV-sensitive DNA repair mutants of Chinese hamster ovary cells. Proc. Natl. Acad. Sei., USA 78:3734.

    Article  CAS  Google Scholar 

  83. Tohda, H., and A. Oikawa (1983) Differential features of sister-chromatid exchange responses to ultraviolet radiation and caffeine in xeroderma pigmentosum lymphoblastoid cell lines. Mutat. Res. 107:387.

    Article  CAS  Google Scholar 

  84. Waldstein, E.A., S. Peller, and R.B. Setlow (1979) UV-endonuclease from calf thjmius with specificity toward pyrimidine dimers in DNA. Proc. Natl. Acad. Sei., USA 76:3746.

    Article  CAS  Google Scholar 

  85. Westerveld, A., J.H.J. Hoeijmakers, M. van Duin, J. de Wit, H. Odijk, A. Pastink, R.D. Wood, and D. Bootsma (1984) Molecular cloning of a human DNA repair gene. Nature 310:425.

    Article  CAS  Google Scholar 

  86. Yang, L.L., R.E. Kouri, and R.D. Curren (1984) Xeroderma pigmentosum fibroblasts are more sensitive to asbestos fibers than are normal human fibroblasts. Carcinogenesis 5:291.

    Article  Google Scholar 

  87. Yarosh, D.B., D.A. Scudiero, T. Yagi, and R.S. Day III, (1985) Human tumor strains both unable to repair Omethylguanine and hypersensitive to killing by human a and 3 interferon. Carcinogenesis 6:883–886.

    Google Scholar 

  88. Yuasa, Y, S.K. Srivastava, C.Y. Dunn, J.S. Rhim, E.P. Reddy, and S.A. Aaronson (1983) Acquisition of transforming properties by alternative point mutations within c-bas/has human proto-oncogene. Nature 303: 775.

    Article  CAS  Google Scholar 

  89. Zelle, B., and D. Bootsma (1980) Repair of DNA damage after exposure to 4-nitroquinoline-l-oxide in heterokaryons derived from xeroderma pigmentosum cells. Mutat. Res. 70:373.

    Article  CAS  Google Scholar 

  90. Zelle, B., and P.H.M. Lohman (1979) Repair of UV-endonuclease susceptible sites in the 7 complementation groups of xeroderma pigmentosum A through G. Mutat. Res. 62:363.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Laboratory of Radiobiology and Environmental Health, University of California, San Francisco, California, 94143, USA

    James E. Cleaver

Authors
  1. James E. Cleaver
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. University of Kansas, Lawrence, Kansas, USA

    Delbert M. Shankel

  2. Johns Hopkins University, Baltimore, Maryland, USA

    Philip E. Hartman

  3. National Institute of Genetics, Mishima, Japan

    Tsuneo Kada

  4. Council for Research Planning in Biological Sciences, Inc., Washington, D.C., USA

    Alexander Hollaender , Claire M. Wilson  & Gregory Kuny ,  & 

Rights and permissions

Reprints and permissions

Copyright information

© 1986 Plenum Press, New York

About this chapter

Cite this chapter

Cleaver, J.E. (1986). DNA Repair and Replication in Xeroderma Pigmentosum and Related Disorders. In: Shankel, D.M., Hartman, P.E., Kada, T., Hollaender, A., Wilson, C.M., Kuny, G. (eds) Antimutagenesis and Anticarcinogenesis Mechanisms. Basic Life Sciences, vol 39. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5182-5_38

Download citation

  • DOI: https://doi.org/10.1007/978-1-4684-5182-5_38

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5184-9

  • Online ISBN: 978-1-4684-5182-5

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation