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Metabolism of Bradykinin in Isolated Perfused Rat Kidney Measurement of Kininase Activity in Perfusate and Urine

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Kinins IV

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 198A))

Summary

The effect of bradykinin and kininase on renal function and the metabolism of bradykinin in the kidney were examined in isolated perfused rat kidney. In this experimental system, exogenous bradykinin did not affect the water and electrolyte handling by the kidney. Most of bradykinin and kininase in urine were derived from kidney but not from circulating medium. Kininase II may not have a major role in bradykinin destruction by the kidney.

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References

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Authors and Affiliations

  1. Department of Internal Medicine, Hiratsuka City Hospital, Kanagawa, Japan

    Tohru Ogihara

  2. Department of Internal Medicine, Urawa City Hospital, Saitama, Japan

    Haruyuki Nakane & Yoko Nakane

  3. Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan

    Takao Saruta

  4. Inserm U36, Paris, France

    Therese Dupin, Jiro Misumi & Jöel Mènard

Authors
  1. Tohru Ogihara
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  2. Therese Dupin
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  3. Haruyuki Nakane
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  4. Yoko Nakane
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  5. Takao Saruta
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  6. Jiro Misumi
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  7. Jöel Mènard
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Editor information

Editors and Affiliations

  1. Medical College of Georgia, Augusta, Georgia, USA

    Lowell M. Greenbaum Ph.D (President, IKC) (President, IKC)

  2. Medical University of South Carolina, Charleston, South Carolina, USA

    Harry S. Margolius Ph.D, M.D. (Vice President, IKC) (Vice President, IKC)

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© 1986 Plenum Press, New York

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Ogihara, T. et al. (1986). Metabolism of Bradykinin in Isolated Perfused Rat Kidney Measurement of Kininase Activity in Perfusate and Urine. In: Greenbaum, L.M., Margolius, H.S. (eds) Kinins IV. Advances in Experimental Medicine and Biology, vol 198A. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5143-6_50

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  • DOI: https://doi.org/10.1007/978-1-4684-5143-6_50

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5145-0

  • Online ISBN: 978-1-4684-5143-6

  • eBook Packages: Springer Book Archive

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