Abstract
Pre-implantation development in mammals begins with the one-cell zygote and continues through to the formation of the blastocyst which ultimately implants on the wall of the uterus. The maternal genome plays an important role in gene expression not only during oogenesis but also during early development. There are few genes which are specific to this period of embryogenesis (4–6, 19) and even fewer with known biological functions. However, the genes that code for proteins of the mouse zona pellucida are an exception. They are expressed during oogenesis in a coordinate manner and the production of their protein products is turned off as the oocyte matures even though biological roles of the zona proteins persist into pre-implantation development. By studying the genes coding for the zona proteins we hope to learn more about mechanisms that control gene expression during oogenesis and early embryogenesis.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Bleil, J.D. and P.M. Wassarman, Structure and function of the zona pellucida: Identification and characterization of the protein of the mouse oocyte’s zona pellucida, Dev. Biol., 76: 185 (1980).
Bleil, J.D. and P.M. Wassarman, Mammalian spermegg interaction: Identification of a glycoprotein in mouse egg zonae pellucidae possessing receptor activity for sperm, Cell, 20: 873 (1980).
Bleil, J.D., C.F. Beall and P.M. Wassarman, Mammalian sperm-egg interaction: Fertilization of mouse eggs triggers modification of the major zona pellucida glycoprotein, ZP-2, Dev. Biol., 86: 189 (1981).
Braude, P., H. Pelham, G. Flach and R. Lobatto, Post-transcriptional control in the early mouse embryo, Nature (Lond.), 282: 102 (1979).
Cascio, S.M. and P.M. Wassarman, Program of early development in the mammal: Post-transcriptional control of a class of proteins synthesized by mouse oocytes and early embryos. Dev. Biol., 89: 397 (1982).
Cullen, B., K. Emigholz and J. Monahan, The transient appearance of specific proteins in one-cell mouse embryos, Dev. Biol., 76: 215 (1980).
Dean, J. and I.J. East, Effects of anti-zona pellucida monoclonal antibodies on fertilization and early development, in: “The Molecular and Cellular Biology of Fertilization,” J.L. Hedrick, ed., Plenum Press, New York, in press.
East, I.J. and J. Dean, Monoclonal antibodies as probes of the distribution of ZP-2, the major sulfated glycoprotein of the murine zona pellucida. J. Cell Biol., 98: 795 (1984).
East, I.J., B.J. Gulyas and J. Dean, Monoclonal antibodies to the murine zona pellucida protein with sperm receptor activity: Effects on fertilization and early development, Devel. Biol., 109: 268 (1985).
East, I.J., D.R. Mattison and J. Dean, Monoclonal antibodies to the major protein of the murine zona pellucida: Effects on fertilization and early development. Devel. Biol., 104: 49 (1984).
East, I.J., A.M. Keenan, S.M. Larson and J. Dean, Scintigraphy of normal mouse ovaries with monoclonal antibodies to ZP-2, the major zona pellucida protein, Science, 225: 938 (1984).
Florman, H.M. and P.M. Wassarman, O-linked oligosaccharides of mouse egg ZP-3 account for its sperm receptor activity, Cell, 41:313 (1985)
Greve, J.M. and P.M. Wassarman, Mouse extracellular coat is a matrix of interconnected filaments possessing a structural repeat, J. Mol. Biol., 181: 253 (1985).
Johnson, M.H., The molecular and cellular basis of pre-implantation mouse development, Biol. Rev., 56: 463 (1981).
Jones, W.R., Immunization against the oocyte, in: “Immunological Fertility Regulation,” Blackwell, Oxford (1982), pp. 147–174.
Ringuette, M., D.A. Sobieski, S. Chamow and J. Dean, Molecular cloning of ZP-3: Sperm receptor of the mouse zona pellucida submitted for publication.
Salzmann, G.S., J.M. Greve, R.J. Roller and P.M. Wassarman, Biosynthesis of the sperm receptor during oogenesis in the mouse. EMBO J., 2: 1451 (1983).
Shimizu, S., M. Tsuji and J. Dean, In vitro biosynthesis of three sulfated glycoproteins of murine zonae pellucidae by oocytes grown in follicle culture. J. Biol. Chem., 258: 5858 (1983).
Van Blerkom, J., Structural relationship and posttranslational modification of stage specific proteins synthesized during preimplantation development in the mouse, Proc. Natl. Acad. Sci. U.S.A., 78: 7629 (1981).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1986 Plenum Press, New York
About this chapter
Cite this chapter
Dean, J., Ringuette, M., Sobieski, D.A., East, I.J., Chamow, S. (1986). Molecular Genetics of the Mouse Zona Pellucida: Implications for Fertilization and Early Development. In: Talwar, G.P. (eds) Immunological Approaches to Contraception and Promotion of Fertility. Reproductive Biology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5140-5_28
Download citation
DOI: https://doi.org/10.1007/978-1-4684-5140-5_28
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-5142-9
Online ISBN: 978-1-4684-5140-5
eBook Packages: Springer Book Archive