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Brain Peptides, Neuroleptic-Induced Tolerance, and Dopamine Receptor Supersensitivity

Implications in Tardive Dyskinesia

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Movement Disorders

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Abstract

The number of prescriptions written in an average community in the United States includes 20% for medication intended to affect mental processes (Baldessarini, 1980). Among these medications are several classes of drugs that are effective in the symptomatic treatment of psychoses. The phenothiazines as a class, and especially fluphenazine, the prototype, are the most widely used in the treatment of psychotic patients. Another drug used to treat psychosis is haloperidol, which is a butyrophenone derivative. Although structurally different from phenothiazines, haloperidol shares many of their pharmacological properties. These agents have been shown to be effective in the treatment of the manic phase of manic-depressive illnesss and in schizophrenia.

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  1. Department of Pharmacodynamics, College of Pharmacy, The University of Illinois at Chicago, Health Sciences Center, Chicago, Illinois, 60612, USA

    Hemendra N. Bhargava

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  1. Ensor Foundation Research Laboratory, William S. Hall Psychiatric Institute, Columbia, South Carolina, USA

    Nandkumar S. Shah Ph.D. (Director, Research Professor) (Director, Research Professor)

  2. Department of Neuropsychiatry and Behavioral Science, University of South Carolina School of Medicine, Columbia, South Carolina, USA

    Nandkumar S. Shah Ph.D. (Director, Research Professor) & Alexander G. Donald M.D. (Director, Professor and Chairman) (Director, Research Professor) &  (Director, Professor and Chairman)

  3. William S. Hall Psychiatric Institute, Columbia, South Carolina, USA

    Alexander G. Donald M.D. (Director, Professor and Chairman) (Director, Professor and Chairman)

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Bhargava, H.N. (1986). Brain Peptides, Neuroleptic-Induced Tolerance, and Dopamine Receptor Supersensitivity. In: Shah, N.S., Donald, A.G. (eds) Movement Disorders. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5038-5_8

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  • DOI: https://doi.org/10.1007/978-1-4684-5038-5_8

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