Abstract
The biosynthetic conversion of the esterified arachidonate in membrane lipids to the various eicosanoids can be divided into three stages. First, arachidonate must be released from tissue esters as the free acid. It can then react with one of the fatty acid oxygenases (the various lipoxygenases and cyclooxygenase are in this category) to form a hydroperoxy acid. In the third stage, the intermediate hydro-peroxy acid is chemically modified to furnish the leukotrienes, classical prosta-glandins, thromboxanes, and prostacyclin.
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Kulmacz, R.J. (1985). Properties of Prostaglandin-Biosynthesizing Enzymes. In: Bailey, J.M. (eds) Prostaglandins, Leukotrienes, and Lipoxins. GWUMC Department of Biochemistry Annual Spring Symposia. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4946-4_3
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DOI: https://doi.org/10.1007/978-1-4684-4946-4_3
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