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Calcium (Ca) Mediated Phosphate (PO4) Transport in the Proximal Convoluted Tubule (PCT) of the Rabbit

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Phosphate and Mineral Metabolism

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 178))

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Abstract

Several clearance studies have suggested a direct effect of calcium (Ca) on phosphate (PO4) handling by the kidney. Micropuncture studies by Amiel and colleagues1 have shown enhancement of fractional phosphate reabsorption in the proximal convoluted tubule when plasma calcium was raised from low towards normal values in parathyroidectomized rats. Conversely, Goldfarb et al 2 have shown a decline in fractional phosphate reabsorption in this portion of the nephron with the induction of mild hypercalcemia in thyroparathyroidectomized dogs. The divergence of these results may be due to species differences, the level of plasma phosphate or ionized calcium before and after calcium chloride administration, or the other various indirect effects of calcium on phosphate handling by the nephron.

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References

  1. C. Amiel, H. Kuntziger, S. Couette, C. Coureau, and N. Bergounioux, Evidence for a parathyroid hormone-induced calcium modulation of phosphate transport along the nephron, J. Clin. Invest. 57: 256 (1976).

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  2. S. Goldfarb, P. Bosanac, M. Goldberg, and Z.S. Agus, Effects of calcium on renal tubular phosphate reabsorption, Am. J. Physiol. 234 (1): F22 (1978).

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  3. M. Burg, J. Grantham, M. Abramow, and J. Orloff, Preparation and study of fragments of single rabbit nephrons. Am. J. Physiol. 210: 1293 (1966).

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Authors and Affiliations

  1. Baylor College of Medicine and The Methodist Hospital, Houston, Texas, USA

    Diane Rouse & Wadi N. Suki

Authors
  1. Diane Rouse
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  2. Wadi N. Suki
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Editor information

Editors and Affiliations

  1. University of Southern California, Los Angeles, California, USA

    Shaul G. Massry

  2. University of Verona, Verona, Italy

    Giuseppe Maschio

  3. University of Heidelberg, Heidelberg, Federal Republic of Germany

    Eberhard Ritz

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© 1984 Plenum Press, New York

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Rouse, D., Suki, W.N. (1984). Calcium (Ca) Mediated Phosphate (PO4) Transport in the Proximal Convoluted Tubule (PCT) of the Rabbit. In: Massry, S.G., Maschio, G., Ritz, E. (eds) Phosphate and Mineral Metabolism. Advances in Experimental Medicine and Biology, vol 178. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4808-5_12

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  • DOI: https://doi.org/10.1007/978-1-4684-4808-5_12

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-4810-8

  • Online ISBN: 978-1-4684-4808-5

  • eBook Packages: Springer Book Archive

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