Abstract
From the mid 1960s to the late 1970s, most immunologists espoused either the germline or somatic theory to explain antibody variability. There were, however, a number of investigators who steadfastly maintained that neither theory adequately explained the structural and/or genetic data. Each proposed different solutions that we refer to here as “maverick” because they do not depend on the germline position (for every immunoglobulin V region there resides in the DNA a faithful copy) or the somatic mutation theory (that in the DNA there exists only a very few genes that somatically mutate and give rise to the great variety of antibody molecules). Although each author of a maverick solution depended on different interpretations of much of the data that has been presented so far in this volume, there were six bodies of evidence that the maverick theorists focused on that were difficult to reconcile with either the germline or somatic theories. We will first review these data and then discuss the various alternative theories that were developed that attempted to explain not only these data but also data generally used to support germline or somatic theories.
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…there are many possible worlds; but the interesting one is the world that exists and has already shown itself to be at work for a long time. Science attempts to confront the possible with the actual. It is the means devised to build a representation of the world that comes ever closer to what we call reality.
—Francois Jacob
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References and Bibliography
Capra, J. D., 1976, The implications of phylogenetically associated residues and idiotypes on theories of antibody diversity, in: The Generation of Antibody Diversity: A New Look ( A. J. Cunningham, ed.), Academic Press, New York, p. 65.
Capra, J. D., and Kindt, T. J., 1975, Antibody diversity: Can more than one gene encode each variable region?, editorial, Immunogenetics 1: 417.
Capra, J. D., and Kehoe, J. M., 1974, Structure of antibodies with shared idiotypy: The complete sequence of the heavy chain variable regions of two IsM anti-gamma globulins, Proc. Natl. Acad. Sci. U.S.A. 71: 4032.
Capra, J. D., and Klapper, D. G., 1976, Complete amino acid sequence of the variable domains of two human IgM anti-gamma globulins with shared idiotypic specificities, Scand. J. Immunol. 5: 667.
Edelman, G. M., and Gaily, J. A., 1967, Somatic recombination of duplicated genes: An hypothesis on the origin of antibody diversity, Proc. Natl. Acad. Sci. U.S.A. 57: 353.
Fett, J. W., and Deutsch, H., 1975, A new lambda-chain gene, Immunochemistry 12: 643.
Gally, J. A., and Edelman, G. M., 1970, Somatic translocation of antibody genes, Nature (London) 227: 341.
Jacob, F., 1982, The Possible and the Actual, University of Washington Press/Pantheon, New York.
Kabat, E. A., Wu, T. T., and Bilofsky, H., 1979, Evidence supporting somatic assembly of the DNA segments (minigenes), coding for the framework, and complementarity- determining segments of immunoglobulin variable regions, J. Exp. Med. 149: 1299.
Kindt, T. J., and Capra, J. D., 1978, Gene-insertion theories of antibody diversity: A reevaluation, Immunogenetics 6: 309.
Kindt, T. J., Klapper, D. G., and Waterfield, M. D., 1973, An idiotypic crossreaction between allotype A3 and allotype a negative rabbit antibodies to streptococcal carbohydrate, J. Exp. Med. 137: 636.
Klinman, N. R., Sigal, N. H., Metcalf, E. S., Pierce, S. K., and Gearhart, P. J., 1976, The interplay of evolution and environment in B-cell diversification, Cold Spring Harbor Symp. Quant. Biol. 41: 285.
Smith, G. P., 1973, The Variation and Adaptive Expression of Antibodies, Harvard University Press, Cambridge, Massachusetts.
Smithies, O., 1970, Pathways through networks of branched DNA, Science 169: 822.
Smithies, O., 1978, Immunoglobulin genes: Arranged in tandem or in parallel?cold spring Harbor Symp. Quant. Bio., p. 725.
Wilkinson, J. M., 1969, Variation in the N-terminal sequence of heavy chains of immunoglobulin G from rabbits of different allotype, Biochem. J. 112: 173.
Wu, T. T., and Kabat, E. A., 1970, An analysis of the sequences of the variable regions of Bence Jones proteins and myeloma light chains and their implications for antibody complementarity, J. Exp. Med. 132: 211.
Wu, T. T., Kabat, E. A., and Bilofsky, H., 1975, Similarities among hypervariable segments of immunoglobulin chains, Proc. Natl. Acad. Sci. U.S.A. 72: 5107.
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© 1984 Plenum Press, New York
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Kindt, T.J., Capra, J.D. (1984). The Maverick Solutions. In: The Antibody Enigma. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4676-0_6
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DOI: https://doi.org/10.1007/978-1-4684-4676-0_6
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