Overview
- Editors:
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Chris H. M. M. Bruyn
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University of Nijmegen Faculty of Medicine, Nijmegen, The Netherlands
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H. Anne Simmonds
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Guy’s Hospital Medical School, London, UK
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Mathias M. Müller
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University of Vienna, Vienna, Austria
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Table of contents (105 chapters)
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Front Matter
Pages i-xvii
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Recent Advances in Diagnosis and Treatment of Purine and Pyrimidine Disorders
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Phosphoribosyltransferase Deficiencies
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- M. J. Dillon, H. A. Simmonds, T. M. Barratt, L. D. Fairbanks, P. C. Holland
Pages 1-6
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- J. S. Cameron, H. A. Simmonds, D. R. Webster, V. Wass, A. Sahota
Pages 7-12
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- N. Ogasawara, S. Kashiwamata, H. Oishi, K. Hara, K. Watanabe, S. Miyazaki et al.
Pages 13-18
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- H. E. Gruber, M. Vuchinich, T. A. Marlow, M. M. Plent, R. C. Willis, J. E. Seegmiller et al.
Pages 19-22
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- N. Lawrence Edwards, Walter Jeryc, Irving H. Fox
Pages 23-26
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- P. Banholzer, W. Gröbner, W. Löffler, S. Reiter, N. Zöllner
Pages 27-31
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Adenosine Deaminase Deficiency
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- R. J. Levinsky, E. G. Davies, H. A. Simmonds, D. R. Webster, M. Adinolfi
Pages 33-38
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- Morton J. Cowan, David W. Martin Jr., Diane W. Wara, Arthur J. Ammann
Pages 39-45
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- Charles Beauchamp, Peter E. Daddona, David P. Menapace
Pages 47-52
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Purine Nucleoside Phosphorylase Deficiency
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- A. R. Watson, H. A. Simmonds, D. R. Webster, L. Layward, D. I. K. Evans
Pages 53-59
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- J. W. Stoop, B. J. M. Zegers, L. J. M. Spaapen, W. Kuis, J. J. Roord, G. T. Rijkers et al.
Pages 61-66
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Ecto-5′-Nucleotidase Deficiency
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- A. D. B. Webster, T. Shah, T. J. Peters
Pages 67-72
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Xanthine Oxidase Deficiency
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- K. Nishioka, H. Yamanaka, T. Nishina, T. Hosoya, K. Mikanagi
Pages 73-76
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Myoadenylate Deaminase Deficiency
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- E. Joosten, C. van Bennekom, F. Oerlemans, C. De Bruyn, T. Oei, J. Trijbels
Pages 85-89
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Phosphoribosylpyrophosphate Synthetase Mutants
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- H. A. Simmonds, D. R. Webster, J. Wilson, C. F. Potter, L. D. Fairbanks
Pages 97-102
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Defects of Pyrimidine Metabolism
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- S. K. Wadman, F. A. Beemer, P. K. de Bree, M. Duran, A. H. van Gennip, D. Ketting et al.
Pages 109-114
About this book
These two volumes, entitled "Purine Metabolism in Man IV" con tain the paper presented at the "IV. International Symposium on Human Purine and Pyrimidine Metabolism," held in Maastricht (The Netherlands), June 1982. The proceedings of the three previous meet ings in Tel Aviv (Israel, 1973), Baden (Austria, 1976) and Madrid (Spain, 1979) were also published by Plenum Press. In the past few years interest in purine and pyrimidine metabo lism under normal and pathological conditions has been growing rapid ly. Apart from the more or less classical topics such as hyperuricae mia, clinical gout and urolithiasis, an increasing number of papers relating to other fields have been presented at successive meetings. Knowledge derived from the study of purine metabolism in relation to lymphocyte function, for instance, has opened up new possibilities for immunomodulation and leukaemia chemotherapy, with eventual conse quences for other types of cancer. At previous meetings there have been pointers implicating purine metabolism in relation to normal cardiac and skeletal muscle function. During the present meeting much new data on both issues have been re ported which indicate clear differences in the pathways of ATP metabo lism. The widening of the field of interest is also illustrated by the recent work on infectious disease: exploitation of the differences in purine metabolic pathways in certain parasites compared with those in human cells has resulted in new rationales for therapy being devel oped.
Editors and Affiliations
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University of Nijmegen Faculty of Medicine, Nijmegen, The Netherlands
Chris H. M. M. Bruyn
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Guy’s Hospital Medical School, London, UK
H. Anne Simmonds
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University of Vienna, Vienna, Austria
Mathias M. Müller