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Immunobiology of Proteins and Peptides—II pp 141–155Cite as

Immune Response Gene Control of T Dependent Reactivity to Collagen in Man

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 150))

Abstract

T dependent reactivity controlled by immune response (Ir) genes in rodents exhibits the following three characteristics. (1–3) First, it is dependent on interactions between T cells and antigen presenting accessory cells (conveniently referred to here as MØ). Second, the reactivity is directed against determinants inherent in either synthetic polypeptides or limited regions of globular proteins. Third, the reactivity is controlled by genes present in the immune response (Ir) locus of the major histocompatibility complex.

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Author information

Authors and Affiliations

  1. Section of Rheumatology/Clinical Immunology Dept. of Medicine and The Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, CA, 94143, USA

    Alan M. Solinger & John D. Stobo

Authors
  1. Alan M. Solinger
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  2. John D. Stobo
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Editor information

Editors and Affiliations

  1. Mayo Clinic, Rochester, Minnesota, USA

    M. Z. Atassi

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© 1982 Plenum Press, New York

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Solinger, A.M., Stobo, J.D. (1982). Immune Response Gene Control of T Dependent Reactivity to Collagen in Man. In: Atassi, M.Z. (eds) Immunobiology of Proteins and Peptides—II. Advances in Experimental Medicine and Biology, vol 150. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4331-8_8

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  • DOI: https://doi.org/10.1007/978-1-4684-4331-8_8

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-4333-2

  • Online ISBN: 978-1-4684-4331-8

  • eBook Packages: Springer Book Archive

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