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Inheritance of Oligomycin Resistance in Tissue Culture Cells

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Techniques in Somatic Cell Genetics

Abstract

The mitochondrial ATPase complex has been resolved into the soluble F1, having the catalytic site for ATP synthesis, and the hydrophobic membrane-integrated F0, involved in proton translocation (Senior, 1973; Koslov and Skulacher, 1977). The F0 has been studied with the use of oligomycin and dicyclohexylcarbodiimide (DCCD), which inhibit enzyme activity of the complex by acting on a component of F0, (Bulos and Racker, 1968; Roberton et al., 1968; Sebald et al., 1976, 1979; Kiehl and Hatefi, 1980).

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© 1982 Plenum Press, New York

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Eisenstadt, J.M., Kuhns, M.C. (1982). Inheritance of Oligomycin Resistance in Tissue Culture Cells. In: Shay, J.W. (eds) Techniques in Somatic Cell Genetics. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4271-7_9

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  • DOI: https://doi.org/10.1007/978-1-4684-4271-7_9

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-4273-1

  • Online ISBN: 978-1-4684-4271-7

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