Abstract
Human milk is rich in secretory IgA (SIgA) antibodies, many of which are directed against food vroteins and antigens of microorganisms found in the intestine(1,2,3). The appearance of these milk antibodies against antigens from the intestinal content is explained by the enteromammaric link: antigenic exposure of the Peyer’s patches leads to homing of cells committed to IgA sunthesis to various exocrine glands, including the mammary gland (4,5). In addition there may be a selective transfer via serum or IgA dimer-J chain complexes that are taken up by secretory component (SC). The SC which is produced in epithelial cells in exocrine glands functions as a receptor on the cell membrane of these epithelial cells. SIgA is formed by the binding of IgA-J to the SC and is transferred into the exocrine secretion. At least in mice this serum transfer may provide a substantial portion of the milk SIgA(6 Halsey personal communication). Presumably the serum IgA dimers originate from the extensive production of IgA in the intestinal lamina propria.
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Hanson, L.Å., Carlsson, B., Jalil, F., Lindblad, B.S., Svennerholm, AM. (1981). Implications for Immunisation: The Milk IgA Antibody Response to Live and Inactivated Polio Virus Vaccines. In: Wilkinson, A.W. (eds) The Immunology of Infant Feeding. Ettore Majorana International Science Series, vol 8. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4049-2_13
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