Abstract
Somatic variations in the amount of nuclear DNA due to somatic polyploidization and differential DNA replication are events, which occur much more frequently than thought by many biologists and biochemists. This might be, in part, because there is particular interest in the genetic information of the DNA rather than on its “nucleotypical” (1) or “nucleoskeletal” effects (2). Actually, it is widely believed that the genome is an extremely stable constant, and that the genetic information stored in the nucleus is identical in all cells of an individual (dogma of DNA constancy). Classical cytologists, however, discovered already in 1939 the process of endomitosis (3), and somewhat later that of DNA endoreduplication (4). Recently, it was shown in a review that some kind of somatic polyploidy can be found in nearly every taxon investigated (5), and that often up to 70% of the cells of an organism may be polyploid (6). Hence, we should no longer ignore this fact, but search for the biological significance of somatic DNA increase.
Keywords
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
M.D. Bennett, Brookhaven Symp. Biol., 25: 344–366 (1973).
T. Cavalier-Smith, J. Cell Sci., 34: 247–278 (1978).
L. Geitler, Chromosoma, 1: 1–22 (1939).
A. Levan and T.S. Hauschka, J. Natl. Cancer Inst. 14: 1–43 (1953).
W. Nagl, “Endopolyploidy and Polyteny in Differentiation and Evolution”, North-Holland, Amsterdam (1978).
B. Frisch and W. Nagl, Plant Syst. Evol., 131: 261–276 (1979).
B. Wright, Trends Biochem. Res., 4: N110–N111 (1979).
W. Nagl, in: “Genome and Chromatin: Organization, Evolution, Function”, W. Nagl, V. Hemleben and F. Ehrendorfer, editors, p. 3–25, Springer, Vienna-New York (1979).
F. D’Amato, Caryologia, 17: 41–52 (1964).
E. Tschermak-Woess, in: Handbuch der Allgemeinen Pathologie, H.W. Altmann, et al., editors, p. 569–625, Springer, Berlin-Heidelberg-New York (1971).
F. D’amato, “Nuclear Cytology in Relation to Development” Cambridge University Press, New York (1977).
W. Nagl, Ann. Rev. Plant Physiol., 27: 39–69 (1976).
V. Ya Brodsky, I.V. Uryvaeva, “Cell Polyploidy: Its Relation to Growth and Differentiation” Academic Press, New York (1977).
W. Nagl, in: “Encyclopedia of Plant Physiology”, Vol. 16, B. Parthier and D. Boulter, editors, Springer, Berlin- Heidelberg-New York (in press)
K. Carniel, Oesterr.Bot.Z., 110: 145–176 (1963).
V.Ya. Brodsky and I.V. Uryvaeva, Intern. Rev. Cytol. 50: 275–332 (1977).
W. Nagl, Zelkern und Zellzyklen. Ulmer, Stuttgart (1976).
E. Heitz, Ber. Deutsch. Bot. Ges., 47: 274–284 (1929).
L. Geitler, Ergebn. Biol., 18: 1–54 (1941).
P.W. Barlow, Protoplasma, 90: 381–391 (1976).
W. Nagl, Protoplasma, 91: 389–407 (1977).
M. Buiatti, in: “Plant Cell, Tissue, and Organ Culture”, J. Reinert and S. Bajaj, editors, p. 358–374, Springer, Berlin-Heidelberg-New York (1977).
W. Nagl, V. Hemleben and F. Ehrendorfer, editors “Genome and Chromatin: Organization, Evolution and Function” Springer, Vienna-New York (1979).
W. Nagl, Progr. Bot. 39: 132–152 (1977).
A. Lima-de-Faria, Cold Spring Harb. Symp. Quant. Biol., 38: 559–571 (1974).
W. Nagl, in: “Tissue Culture and Plant Science 1974”, H.E. Street, editor, p. 19–42, Academic Press, New York, (1974).
W. Nagl, Cytobios, 5: 145–154 (1972).
W. Nagl, J. Hendon and W. Rucker, Cell Diff., 1: 229–237 (1972).
D. Schweizer and W. Nagl, Exptl. Cell Res., 98: 411–423 (1976).
W. Nagl and W. Rucker, Nucleic Acids Res., 3: 2033–2039 (1976).
A. Brito-da-Cunha, C. Pavan, J.S. Morgante and M.C. Garrido, Genetics Suppl., 61: 335–349 (1969).
L. Walter, Chromosoma, 41: 327–360 (1973).
J. Balsamo, J.M. Hierro, and F.J.S. Lara, Cell Diff., 2: 119–130 (1973).
R.J. Britten, E.H. Davidson, Science, 165: 349–357 (1969).
M.F. Bonaldo, R.V. Santelli, and F.J.S. Lara, Cell, 17: 827–833 (1979).
C.M. Strom, and A. Dorfman, Proc. Natl. Acad. Sci. US, 73: 3428–3432 (1976).
C.M. Strom, M. Moscona, and A. Dorfman, Proc. Natl. Acad. Sci. US, 75: 4451–4454 (1978).
F.W. Alt, R.E. Kellems, J.R. Bertino and R.T. Schimke, J. Biol. Chem. 253: 1357–1370 (1978).
R.J. Kaufman, P.C.. Brown, and R.T. Schimke, Proc. Natl. Acad. Sci. US, 76: 5669–5673 (1979).
B.J. Dolnick, R.J. Berenson, J.R. Bertino, R.J. Kaufman, J.H. Nunberg and R.T. Schimke, J. Cell Biol., 83: 394–402 (1979).
A.C. Spradling, and A.P. Mahowald, Proc. Natl. Acad. Sci. US, 77: 1080–1100 (1980).
W. Nagl, The Nucleus, 20: 10–27 (1977).
W. Nagl, Chromosomes Today, 6: 151–152 (1977).
W. Nagl, Nature, 261: 614–615 (1976).
P.W. Barlow, Protoplasma, 90: 381–391 (1976).
L.S. Evans, J. Van’t Hof, Amer. J. Bot., 62: 1060–1064 (1975).
W. Nagl, Z. Pflanzenphysiol., 95: 283–314 (1979).
C.R. Partanen, Intern. Rev. Cytol., 15: 215–243 (1963).
Th. Butterfass, Mittlg. Max-Planck-Ges., 1: 47–58 (1966).
W.F. Doolittle, and C. Spaienza, Nature, 284: 601–603 (1980).
L.E. Orgel and F.C.H. Crick, Nature, 284: 604–607 (1980).
S.A. Endow, and J.G. Gall, Chromosoma, 50: 175–192 (1975).
W. Nagl, Z. Pflanzenphysiol., 85: 45–51 (1977).
P.J. Gartner, and W. Nagl, Planta xx,xx–xx (1980).
C.A. Nciolini, in: Chromatin Structure and Function, C.A. Nicolini, editor, p. 613–666, Plenum Press, New York (1979).
I. Prigogine, “Thermodynamics of Irreversible Processes” Wiley-Interscience, New York (1955).
M. Eigen, and P. Schuster, “The Hypercycle” Springer, Berlin-Heidelberg-New York (1978).
P.O.P. Ts’o, “The Molecular Biology of the Mammalian Genetic Apparatus” North-Holland, Amsterdam (1979).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1982 Plenum Press, New York
About this chapter
Cite this chapter
Nagl, W. (1982). Cell Growth and Nuclear DNA Increase by Endoreduplication and Differential DNA Replication. In: Nicolini, C. (eds) Cell Growth. NATO Advanced Study Institutes Series, vol 38. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4046-1_29
Download citation
DOI: https://doi.org/10.1007/978-1-4684-4046-1_29
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-4048-5
Online ISBN: 978-1-4684-4046-1
eBook Packages: Springer Book Archive