Abstract
Taurine is an ubiquitous constituent of animal tissues (25); its highest levels are found in excitable organs like brain, heart and secretory glands, where it may reach concentrations as high as 20–100 mM (8,25,27). In spite of its wide distribution and of recent interest in studies on taurine, the elucidation of its functional role has been particularly difficult. Taurine is not associated to proteins and except for the formation of taurocholic acid it does not participate in metabolic reactions. Therefore, it could be thought that the presence of taurine in a tissue or organ should be related only to the specific function subserved by the amino acid. In this communication we will consider some possible roles of taurine in nervous tissue.
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References
Agrawal, H. C., Davies, S. M. and Himwich, W. A. Postnatal changes in free amino acid pool of rat brain. J. Neurochem. 13 (1966) 607–615.
Agrawal, H. C., Davies, J. M. and Himwich, W. A. Postnatal changes in free amino acid pool of rabbit brain. Brain Res. 3 (1966) 374–380.
Agrawal, H. C., Davison, A. N. and Kaczmarek, L. K. Subcellular distribution of taurine and cysteine sulfinate decarboxylase in developing rat brain. Biochem. J. 122 (1971) 759–763.
Barbeau, A. Zinc, taurine and epilepsy. Arch. Neurol. 30 (1974) 52–58.
Bergamíni, L., Mutani, R., Delsedime, M. and Durelli, L. First clinical experience on the antiepileptic action of taurine. Eur. Neurol, 11 (1974) 261–269.
Blaustein, M. P., Ratzlaff, R. W., Kendrick, N. C. and Schweitzer, E. S. Calcium buffering in presynaptic nerve terminals. I. Evidence for involvement of a nonmitochondrial ATP-dependent sequestration mechanism. J. Gen. Physiol., 72 (1977) 15–41.
Clark, R. M. and Collins, G. G. S. The release of endogenous amino acids from the mammalian visual cortex. J. Physiol. (Lond.) 246 (1975) 16 P.
Crabai, F., Sitzia, A. and Pepen, G. Taurine concentration in the neurohypophysis of different animal species. J. Neurochem. 23 (1974) 1091–1092.
Cutler, R. W. P. and Dudzinski, D. S. Regional changes in amino acid content in developing rat brain. J. Neurochem. 23 (1974) 1005–1009.
Curtis, D. R., Duggan, A. W., Felix, D., Johnston, G. A. R. and McLennan, H. Antagonism between bicuculline and GABA in the cat brain. Brain Res. 33 (1971) 57–73.
Curtis, D. R., Hosli, L. and Johnston, G. A. R. A pharmacological study of the depression of spinal neurons by glycine and related amino acids. Exp. Brain Res. 6 (1968) 1–18.
Curtis, D. R. and Johnston, G. A. R. Amino acid transmitters in mammalian nervous system. Ergebn. Physiol. 69 (1974) 97–188.
Curtis, D. R. and Tebgcis, A. K. Bicuculline and thalamic inhibition. Exp. Brain Res., 16 (1972) 210–218.
Curtis, D. R. and Watkins, J. C. The excitation and depression of spinal neurons by structurally related amino acids. J. Neurochem. 6 (1960) 117–141.
De Belleroche, J. J. and Bradford, H. F. Amino acids in synaptic vesicles from mammalian cerebral cortex: a reappraisal. J. Neurochem. 21 (1973) 441–451.
Dolara, P., Agresti, A., Giotti, A. and Pasquini, G. Effect of taurine on calcium kinetics of guinea-pig heart. Eur. J. Pharmacol. 24 (1973) 352–358.
Durelli, L., Mutani, R., Delsedime, M., Quattrocolo, G., Buffa, C., Mazzarion, M. and Fumero, S. Electroencephalographic and biochemical study of the antiepileptic action of taurine administered by cortical superfusion. Exp. Neurol. 52 (1976) 30–30.
Enna, S. J., Kuhar, M. and Snyder, S. H. Regional distribution of postsynaptic receptor binding for -aminobutyric acid (GABA) in monkey brain. Brain Res. 93 (1975) 168–175.
Hajós, F. An improved method for the preparation of synaptosomal fractions of high purity, Brain Res. 93 (1975) 485–489.
Hope, D. B. The persistence of taurine in the brains of pyridoxine-deficient rats. J. Neurochem. 1 (1957) 364–369.
Hruska, R., Huxtable, R., Bressler, J. and Yamamura, H. R. Sodium-dependent high affinity transport of taurine into rat brain synaptosomes. Proc. West. Pharmacol. Soc. 19 (1976) 152–156.
Izumi, K., Igisu, H. and Fukuda, T. Effects of edetate on seizure supressing actions of taurine and GABA, Brain Res. 88 (1975) 576–579.
Izumi, K., Igisu, H. and Fukuda, T. Supression of seizures by taurine -specific or nonspecific? Brain Res. 76 (1974) 171–173.
Jasper, H. H. and Koyama, I. Rate of release of amino acids from the cerebral cortex in the cat as affected by brain stem and thalamic stimulation. Can. J. Physiol. Pharmacol. 47 (1969) 889–905.
Jacobsen, J. G. and Smith, H. L. Biochemistry and physiology of taurine and taurine derivatives. Physiol. Rev. 48 (1968) 424–511.
Kaczmarek, L. K. and Davison, A. N. Uptake and release of taurine from rat brain slices. J. Neurochem. 19 (1972) 2355–2362.
Kocsis, J. J., Kostos, U. J. and Baskin, S. I. Taurine levels in the heart tissues of various species. In: R. Huxtable and A. Barbeau (Eds.), Taurine, Raven Press, New York, 1976, pp. 145–153.
Kontro, P., Marnela, K. M. and Oja, S. S. Free amino acids in the synaptosome and synaptic vesicle fractions of different bovine brain areas. Brain Res. 184 (1980) 129–141.
Kuriyama, K., Muramatsu, M., Nakagawa, K. and Kakita, K. Modulating role of taurine on release of neurotransmitters and calcium transport in excitable tissues. In: A. Barbeau and R. Huxtable (Eds.) Taurine and Neurological Disorders, Raven Press, New York, 1978, pp. 201–216.
Kuriyama, K., Yoneda, Y. and Kurihara, E. Microdistribution of taurine and cysteine sulfinate decarboxylase activity in rat spinal cord and thalamus: comparison with Y-aminobutyric acid and L-glutamic acid decarboxylase. In: A. Barbeau and R. Huxtable (Eds.) Taurine and Neurological Disorders, Raven Press, New York, (1978) pp. 35–48.
Landesmaki, P., Karppinen, A., Saarni, H. and Winter, R. Amino acids in the synaptic vesicle fraction from calf brain: content, uptake and metabolism. Brain Res. 138 (1977) 295–308.
LeFauconnier, J. M., Urban, P. F. and Mandel, P. Taurine transport into the brain in rat. Biochimie 60 (1978) 381–387.
Lipton, J. M. and Tickner, C. B. Central effect of taurine and its analogues on fever caused by intravenous leukocytic pyrogen in the rabbit. J. Physiol. (tond.) 287 (1979) 535–543.
López-Colomé, A. M. and Pasantes-Morales, H. Taurine interactions with chick retinal membranes. J. Neurochem 34 (1980) 1047–1053.
Mandel, P. and Pasantes-Morales, H. Taurine in the nervous tissue In: S. Ehrenpreis and I. Kopin (Eds.) Reviews in Neurosciences. Raven Press, New York. 1978, Vol. 3, pp. 157–194.
McBride, W. J. and Frederickson, R. C. A. Neurochemical and neurophysiological evidence for a role of taurine as an inhibitory neurotransmitter in the cerebellum of the rat. In: A. Barbeau and R. Huxtable (Eds.), Taurine and Neurological Disorders, Raven Press, New York, 1978, pp. 415–428.
Mutani, R., Bergamini, L., Fariello, R. and Delsedime, H. Effects of taurine on cortical acute epileptic foci, Brain Res., 70 (1974) 170–173.
Pasantes-Morales, H., Bonaventure, N., Wioland, N. and Mandel, P. Effect of intravitreal injections of taurine and GABA on chicken ERG. Int. J. Neurosci. 5 (1973) 235–241.
Pasantes-Morales, H., Klethi, J., Urban, P. F. and Mandel, P. The effect of electrical stimulation, light and amino acids on the efflux of 35S-taurine from the retina of the domestic fowl. Exp. Brain Res., 19 (1974) 131–142.
Schmid, R., Sieghart, W. and Karobath, M. Taurine uptake in synaptosomal fractions of rat cerebral cortex. J. Neurochem. 25 (1975) 5–9.
Sgaragli, G. P. and Pavan, F. Effects of neutral amino acids injected into cerebrospinal fluid space on glucose metabolism in the rat brain. Neuropharmacology 12 (1973) 653–661.
Sgaragli, G. P., Magnani, M., Carla, U. and Giotti, A. Muscle relaxation induced in the rabbit by intracerebroventricular taurine injection: a supraspinal effect. Naunyn Schmied. Arch. Pharmacol . 295 (1976) 95–97.
Sieghart, W. and Heckl, K. Potassium-evoked release of taurine from synaptosomal fractions of rat cerebral cortex. Brain Res. 116 (1976) 538–543.
Snyder, S. H. The glycine synaptic receptor in the mammalian central nervous system. Br. J. Pharmacol. 53 (1975) 475–484.
Sturman, J. A. Taurine pool sizes in the rat: effects of vitamin-B6 deficiency and high taurine diet. J. Nutr. 103 (1973) 1566–1580.
Van Gelder, N. M., Sherwin, A. L. and Rasmussen, T. Amino acid content of epileptogenic human brain: focal versus surrounding regions. Brain Res. 40 (1972) 385–393.
Van Gelder, N. M. Antagonism by taurine of cobalt induced epilepsy in cat and mouse. Brain Res. 47 (1972) 157–168.
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Pasantes-Morales, H., Morán, J. (1981). Taurine as a Neuromodulator: Its Action on Calcium Fluxes and Neurotransmitter Release. In: Tapia, R., Cotman, C.W. (eds) Regulatory Mechanisms of Synaptic Transmission. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3968-7_7
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DOI: https://doi.org/10.1007/978-1-4684-3968-7_7
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