Abstract
The susceptibility of Mongolian gerbils (Meriones unguiculatus) has provided a suitable model for the investigation of not only prolonged ischemia but also the recovery process after such ischemic insult. The characteristics of metabolite restoration during recirculation indicate that the recovery process is more than a simple reversal of the events which occurred during ischemia. Recirculation appeared to trigger its own series of e-vents including reported changes in certain metabolites and enzymes (15, 16, 22). Although glutamate remained unchanged during ischemia, it has been shown to decrease during postischemia (15). Also, cyclic AMP levels increased an additional 3- to 6-fold during subsequent recirculation (15). While the restoration of P-creatine was rapid and complete, recovery of ATP appeared to occur in stages. The initial increase of ATP was rapid, but complete restoration quite slow, apparently requiring the replenishment of the total adenylate pool.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Cox, R.H., Jr. and Perbach, J.L., Jr. (1973): A sensitive, rapid and simple method for the simultaneous spectrophotofluorimetric determination of norepinephrine, dopamine, 5-hydroxytryptamine and 5-hydroxy-indolacetic acid in discrete areas of brain. J. Neurochem. 20: 1777–1780.
Dahl, N.A. and Balfour, W.M. (1974): Prolonged anoxic survival due to anoxia pre-exposure: brain ATP, lactate, and pyruvate. Amer. J. Physiol. 207: 452–456.
Forsander, A.O., Raiha, N., Salaspuro, M. and Maenpaa, P. (1965): Influence of ethanol on the liver metabolism of fed and starved rats. Biochem. J. 94: 259–265.
Hohorst, H-J., Kreutz, F.H. and Bucher, T. (1959: über Metabolitgehklte und Metabolitkonzentrationen in der Leber der Ratte. Biochem. Z. 332: 18–49.
Ito, U., Spatz, M., Walker, J.T., Jr. and Klatzo, I. (1975): Experimental cerebral ischemia in Mongolian gerbils. I. Light microscopic observations. Acta Neuropathol. (Berlin) 32: 209–223.
Ito, U., Go, K.G., Walker, J.T., Jr., Spatz, M. and Klatzo, I. (1976): Experimental cerebral ischemia in Mongolian gerbils. III. Behavior of blood-brain barrier. Acta Neuropathol. (Berlin) 34, 1–6.
Ito, U., Mšsulja, B.B., Fujimoto, T., Klatzo, I. and Spatz, M. (1976): Effects of hypertension on the postischemic brain following temporary ischemia in gerbils, In: Pathophysiological, Biochemical and Morphological Aspects of Cerebral Ischemia and Arterial Hypertension. Ed. M. Mossakowski, Polish Academy of Sciences, Warsaw, 73–78.
Johansson, B., Li, C.-L., Olsson, Y. and Klatzo, I. (1970): The effect of acute arterial hypertension on the blood-brain barrier to protein tracer, Acta Neuropathol. (Berlin) 16: 117–124.
Kahn, K.M.D. (1972): The natural course of experimental cerebral infarction in the gerbil. Neurology (Minneapolis) 22: 510–515.
Klatzo, I. (1975): Pathophysiologic aspects of cerebral ischemia. In: The Nervous System. Vol. 1. The Basic Neurosciences. Ed. D.W. Tower, Raven Press, New York, 313–322.
Kleihues, P., Hossmann, K.A., Pegg, A.E., Kobayashi, K. and Zimmermann, V. (1975): Resuscitation of the monkey brain after one hour complete ischemia. III. Indications of methabolic recovery. Brain Res. 95: 61–73.
Lowry, O.H. and Passonneau, J.V. (1972): A Flexible System of Enzymatic Analysis, Academic Press, New York, 146–218.
Lust, W.D., Mršulja, B.B., Mršulja, B.J., Passonneau, J.V. and Klatzo, I. (1975): Putative neurotransmitters and cyclic nucleotides in prolonged ischemia of the cerebral cortex. Brain Res. 98: 394–399.
Mršulja, B.B., Mršulja, B.J., Ito, U., Walker, J.T. Jr., Spatz, M. and Klatzo, I. (1975): Experimental cerebral ischemia in Mongolian gerbils. II. Changes in carbohydrates. Acta Neuropathol. (Berlin) 33: 91–103.
Mršulja, B.B., Lust, W.D., Mršulja, B.J., Passonneau, J.V. and Klatzo, I. (1976): Post-ischemic changes in certain metabolites following prolonged ischemia in the gerbil cerebral cortex. J. Neurochem. 26: 1099–1103.
Mršulja, B.B., Lust, W.D., Mršulja, B.J., Passonneau, J.V. and Klatzo, I. (1976): Brain glycogen following experimental cerebral ischemia in gerbils (Meriones unguiculatus). Experientia 32: 732–734.
Mršulja, B.B., Mršulja, B.J., Spatz, M. and Klatzo, I. (1976): Catecholamines in brain ischemia — effects of alpha-methyl-p-tyrosine and paraglyne. Brain Res. 104: 373–378.
Mršulja, B.B., Lust, W.D., Mršulja, B.J. and Passoneau, J.V. (1977): Effect of repeated cerebral ischemia on metabolites and metabolic rate in gerbil cortex. Brain Res. 119: 480–486.
Mršulja, B.J., Spatz, M. and Klatzo, I. (1978): Cytochemistry of hippocampus following cerebral ischemia. In: Pathophysiology of Cerebral Energy Metabolism. Eds. B.B. Mršulja, Lj.M. Rakic and I. Klatzo, Plenum Press, New York (in press).
Passonneau, J.V. and Lauderdale, A.R. (1974): A comparison of three methods of glycogen measurement in tissues. Analyt. Biochem. 60: 405–412.
Rakic, L.M. (1965): Cortical inhibition and subcortical inhibitory influence. Israel J. Med. Sci. 1: 1376–1383.
Schwartz, J.P., Mršulja, B.B., Mršulja, B.J., Passonneau, J.V. and Klatzo, I. (1976): Alterations of cyclic nucleotide-related enzymes and of ATPase during unilateral ischemia and recirculation in gerbil cortex. J. Neurochem. 27: 101–107.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1979 Plenum Press, New York
About this chapter
Cite this chapter
Mršulja, B.B. (1979). Some New Aspects of the Pathochemistry of the Post-Ischemic Period. In: Mršulja, B.B., Rakić, L.M., Klatzo, I., Spatz, M. (eds) Pathophysiology of Cerebral Energy Metabolism. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3348-7_5
Download citation
DOI: https://doi.org/10.1007/978-1-4684-3348-7_5
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-3350-0
Online ISBN: 978-1-4684-3348-7
eBook Packages: Springer Book Archive