Abstract
Secondary changes in regional cerebral blood flow (rCBF) have been observed to occur within hours to days in acute focal cerebral ischemia. Following experimental occlusion of the middle cerebral artery (MCA) the secondary decline in rCBF during the first 4 hours of ischemia appeared to correlate with progressive brain swelling (Hossmann and Schuier, 1980). In subsequent studies the delayed rise in intracortical vascular resistance as the cause of the decrease in rCBF was noted (Shima et al, 1983). It is assumed that the continuing failure of cerebral hemodynamics associated with the delayed rise in regional cerebral vascular resistance (rCVR) can aggravate the ischemia and in this way can contribute to the extension of cerebral infarction.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
Ames, A.III., Wright, R.L., Kowada, M., Thurston, J.M., and Majno, G., 1968, Cerebral ischemia. II. The no-reflow phenomenon, Am. J. Phath., 52:437.
Astrup, J., Siesjo, B.K., and Symon, L., 1981, Thresholds in cerebral ischemia — the ischemic penumbra, Stroke, 12:723.
Aukland, K., Bower, B.F., and Berliner, R.W., 1964, Measurement of local blood flow with hydrogen gas, Circ. Res., 14:164.
Branston, N.M., Strong, A. J., and Symon, L., 1977, Extracellular potassium activity, evoked potential and tissue blood flow: relationship during progressive ischemia in baboon cerebral cortex, J. Neurol. Sci., 32:305.
Branston, N.M., Symon, L., Crockard, H.A., and Pasztor, E., 1974, Relationship between the cortical evoked potential and local cortical blood flow following acute middle cerebral artery occlusion in the baboon, Exp. Neurology, 45:195.
Fischer, E.G., 1973, Impaired perfusion following cerebrovascular stasis, Arch. Neurol., 29:361.
Fujishima, M., and Cmae, T., 1976, Lower limit of cerebral autoregulation in normotensive and spontaneously hypertensive rats, Experientia, 32:1021.
Furlow, T.W. Jr., 1982, Cerebral ischemia produced by four-vessel occlusion in the rat: A quantitative evaluation of cerebral blood flow, Stroke., 13:852.
Haining, J.L., Turner, D., and Pantall, R.M., 1968, Measurement of local cerebral blood flow in the unanesthetized rat using a hydrogen clearance method, Circ. Res., 23:313.
Halsey, J.H., Jr., and Clark, L.C., Jr., 1970, Sane regional circulatory abnormalities following experimental cerebral infarction, Neurology, 20:238.
Heiss, W.D., 1983, Flow thresholds of functional and morphological damage of brain tissue, Stroke, 14:329.
Hossmann, K.A., and Schuier, F.J., 1980, Experimental brain infarcts in cats, Stroke, 11:583.
König, J.F.R., and Klippel, R.A., 1963, “The Rat Brain,” Robert E. Krieger, Huntington.
Little, J.R., Kerr, F.W.L., and Sundt, T.M., 1976, Microcirculatory obstruction in focal cerebral ischemia: An electron microscopic investigation in monkeys, Stroke, 7:25.
Morawetz, R.B., DeGirolami, U., Ojemann, R.G., Marcoux, F.W., and Crowell, R.M., 1978, Cerebral blood flow determined by hydrogen clearance during middle cerebral artery occlusion in unanesthetized monkeys, Stroke, 9:143.
Pulsinelli, W.A., and Brierley, J.B., 1979, A new model of bilateral hemispheric ischemia in the anesthetized rat, Stroke, 10:267.
Shima, T., Hossman, K.A., and Date, H., 1983, Pial arterial pressure in cats following middle cerebral artery occlusion, Stroke, 14:713.
Symon, L., Branston, N.M., and Chikovani, O., 1979, Ischemic brain edema following middle cerebral artery occlusion in baboons: Relationship between regional cerebral water content and blood flow at 1 to 2 hours, Stroke, 10:184.
Yamakawa, T., Sugiayama, I., and Niimi, H., 1984, Behaviours of white blood cells in microcirculatory of the cat brain cortex during hemorrhagic shock: intravital microscopic study, Int. J. Microcirc., 3:588.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1985 Plenum Press, New York
About this chapter
Cite this chapter
Hudetz, A.G., Conger, K.A., Halsey, J.H., McCormick, J., Wilson, T.A., Roesel, J.F. (1985). Changes in Regional Cerebrovascular Resistance During Partial Cerebral Ischemia in Rats. In: Kreuzer, F., Cain, S.M., Turek, Z., Goldstick, T.K. (eds) Oxygen Transport to Tissue VII. Advances in Experimental Medicine and Biology, vol 191. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3291-6_11
Download citation
DOI: https://doi.org/10.1007/978-1-4684-3291-6_11
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-3293-0
Online ISBN: 978-1-4684-3291-6
eBook Packages: Springer Book Archive