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Membrane Toxicity pp 117–137Cite as

Liver Endoplasmic Reticulum: Target Site of Halocarbon Metabolites

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 84))

Abstract

Initial injury produced by exposure of rats to carbon tetrachloride, halothane, vinyl chloride or trichloroethylene appears to involve the endoplasmic reticulum. First, there is dispersion of the ergastoplasm, then vacuolization and degranulation of the rough endoplasmic reticulum with concomitant retraction of the smooth endoplasmic reticulum into tightly clumped tubular aggregates. In addition, membranes in these tubular aggregates seem to undergo supra-molecular disassembly. Along with this structural disorganization, functional capacity of the organelle diminishes. Activation of these halocarbons to toxic species by functional elements of the endoplasmic reticulum is indicated by the enhancement of their toxicity by pretreatment with chemicals which induce components of the mixed function oxidase system and by the formation of certain metabolites and/or covalently bound products. Insight into the molecular mechanisms of membrane injury brought about by these halocarbon hepatotoxins has been provided by the characterization of chemical changes produced, such as increased lipid diene conjugate content, and the patterns of enzyme deactivation.

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Author information

Authors and Affiliations

  1. Department of Pathology, Peter Bent Brigham Hospital and Harvard Medical School Boston, Massachusetts, 02115, USA

    Edward S. Reynolds

  2. Harvard Medical School Boston, Massachusetts, 02115, USA

    Edward S. Reynolds

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  1. Edward S. Reynolds
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Editor information

Editors and Affiliations

  1. The University of Rochester, Rochester, New York, USA

    Morton W. Miller  & Adil E. Shamoo  & 

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© 1977 Plenum Press, New York

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Reynolds, E.S. (1977). Liver Endoplasmic Reticulum: Target Site of Halocarbon Metabolites. In: Miller, M.W., Shamoo, A.E. (eds) Membrane Toxicity. Advances in Experimental Medicine and Biology, vol 84. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3279-4_6

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  • DOI: https://doi.org/10.1007/978-1-4684-3279-4_6

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-3281-7

  • Online ISBN: 978-1-4684-3279-4

  • eBook Packages: Springer Book Archive

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