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An Analysis of Ion Distribution in Brain Following Anoxia

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Oxygen Transport to Tissue — II

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 75))

Abstract

Experimental measurements of changes in the extracellular ion concentrations of rat brain cortex have been made with ultrami croelectrodes (1). During extended anoxia of several minutes duration, the changes in ionic concentrations may be characterized by the following statements:

  1. (1)

    Changes occurred in two phases: A preanoxic depolarization phase and an anoxic depolarization phase.

  2. (2)

    The preanoxic depolarization phase was characterized by small increases in extracellular Na+, K+, Cl- concentrations and usually a slight decrease in brain DC potential.

  3. (3)

    The anoxic depolarization phase was characterized by wery rapid increases in extracellular K+, simultaneous decreases in Na+ and Cl-, and rapid decreases in DC potential.

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References

  1. Zeuthen, T., and E. Dora: Brain Metabolism and Ion Movements in Brain Cortex of the Rat During Anoxia, Proceedings of the International Workshop on Ion Selective Electrodes, Ulm, Germany (In Press).

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  2. Brace, R. A., and D. K. Anderson: J. Applied Physiol., 35, 90–94, 1973.

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  3. Reneau, D. D.: A Mathematical Analysis of Simultaneous Transport Phenomena in the Microcirculation, Proceedings of the International Workshop on Ion Selective Electrodes, Ulm, Germany (In Press).

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Author information

Authors and Affiliations

  1. Department of Biomedical Engineering, Louisiana Tech University, Ruston, Louisiana, 71270, USA

    D. Reneau

  2. Department of Comparative Pathology, Bristol University, Bristol, England

    T. Zeuthen & E. Dóra

  3. Department of Physiology, Semmelweis University, Budapest, Hungary

    I. Silver

Authors
  1. D. Reneau
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  2. T. Zeuthen
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  3. E. Dóra
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  4. I. Silver
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Editor information

Editors and Affiliations

  1. University of Mainz, Mainz, West Germany

    Jürgen Grote  & Gerhard Thews  & 

  2. Louisiana Tech University, Ruston, Louisiana, USA

    Daniel Reneau

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© 1976 Plenum Press, New York

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Reneau, D., Zeuthen, T., Dóra, E., Silver, I. (1976). An Analysis of Ion Distribution in Brain Following Anoxia. In: Grote, J., Reneau, D., Thews, G. (eds) Oxygen Transport to Tissue — II. Advances in Experimental Medicine and Biology, vol 75. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3273-2_43

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  • DOI: https://doi.org/10.1007/978-1-4684-3273-2_43

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-3275-6

  • Online ISBN: 978-1-4684-3273-2

  • eBook Packages: Springer Book Archive

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