Abstract
Numerous brain injuries and brain tumors lead to edema in brain tissue which can have consequences for the oxygen supply to the damaged tissue as well as to adjacent tissue areas. In studies made of the blood flow and oxygen supply in perifocal edematous tissue of brain tumors and lesions in patients undergoing various brain operations a direct relationship between the regional blood flow and the water content could be demonstrated (3). As the water content of the tissue increased, the blood flow through it diminished. In many cases, the reduction of the blood flow in the brain tissue induced an insufficient oxygen supply. In the tissue samples under investigation, the CrP and ATP concentrations were diminished in comparison to normal brain tissue. At the same time a marked rise in the lactate concentration and the lactate-pyruvate ratio was determined. The studies in patients were the starting point for further animal experiments.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Bartko, D., H.J. Reulen, H. Koch and K. Schürmann: Effect of dexamethasone on the early edema following occlusion of the middle cerebral artery in cats. In: Steroids and Brain Edema, pp. 127 – 137. H.J. Reulen and K. Schürmann, eds. Berlin, Heidelberg, New York: Springer 1972
Frei, H.J., Th. Wallenfang, W. Poll, H.J. Reulen, R. Schubert and M. Brock: Regional cerebral blood flow and regional metabolism in cold induced oedema. Acta Neurochir. 29, 15–28 (1973)
Grote, J., H. Kreuscher, H.J. Reulen, P. Vaupel and H. Günther: Respiratory gas transport in brain under normal and pathological conditions. In: Advances in Chemistry Series, 118, Chemical Engineering in Medicine, pp. 35–46. Washington: American Chemical Society 1973
Grote, J., R. Schubert, W. Schaaf, H.J. Reulen and Th. Wallenfang: The influence of brain edema on regional cerebral blood flow and regional vascular reactivity. Pflügers Arch. 343, R 28 (1973)
Klatzo, J., A. Piraux and E. Laskowski: The relationship between edema, blood brain barrier and tissue elements in local brain injury.
Klatzo, J., H. Wisniewski, O. Steinwall and E. Streicher: Dynamics of cold injury edema. In: Brain Edema, pp. 554–563. J. Klatzo and F. Seitelberger, eds. Wien, New York: Springer 1967
Matsen, F.A. III and C.R. West: Supracortical fluid: a monitor of albumin exchange in normal and injured brain. Amer. J. Physiol. 222, 532–539 (1972)
Merlis, J.K.: The effect of changes in the calcium content of the cerebrospinal fluid on spinal reflex activity in the dog. Amer. J. Physiol. 131, 67–72 (1940)
Pannier, J.L., J. Weyne, G. Demeester and I. Leusen: Influence of changes in the acid-base composition of the ventricular system on cerebral blood flow in cats. Pflügers Arch. 333, 337–351 (1972)
Posner, J.B., F. Plum and D. Zee: Ventriculocasternal pH and cerebral blood flow. Arch. Neurol. (Chic.) 20, 664–667 (1969)
Reulen, H.J., F. Medzihradsky, R. Enzenbach, F. Marguth and W. Brendel: Electrolytes, fluids and energy metabolism in cerebral edema in man. Arch. Neurol. 21, 517–525 (1969)
Siesjö, B.K., A. Kjällquist, U. Ponten and N. Zwetnow: Extracellular pH in the brain and cerebral blood flow. In: Cerebral Circulation, pp. 93–98. W. Luyendijk, ed. Progress in Brain Research, vol. 30. Amsterdam, London, New York: Elsevier 1968
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1976 Plenum Press, New York
About this chapter
Cite this chapter
Grote, J., Schubert, R., Fenske, A., Brantzen, J. (1976). Cerebral Oxygen Supply in Brain Edema and During Ventriculo-Cisternal Perfusion. In: Grote, J., Reneau, D., Thews, G. (eds) Oxygen Transport to Tissue — II. Advances in Experimental Medicine and Biology, vol 75. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3273-2_38
Download citation
DOI: https://doi.org/10.1007/978-1-4684-3273-2_38
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-3275-6
Online ISBN: 978-1-4684-3273-2
eBook Packages: Springer Book Archive