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Uptake and Exchange of GABA and Glutamate in Isolated Nerve Endings

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Transport Phenomena in the Nervous System

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 69))

Abstract

In the last years an increasing number of reports have favoured the concept that GABA and glutamate act as inhibitory and excitatory neurotransmitters respectively in the mammalian CNS11, 12, 25. One of the essential biochemical steps of neurotransmission is the rapid inactivation of the active substance liberated in the synaptic cleft. With the only known exception of acetylcholine, which is rapidly hydrolyzed by a specific enzyme, reuptake into the presynaptic terminal is considered as the major means for terminating the action of most other putative neurotransmitters11, 12, 21, 24, 37.

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Author information

Authors and Affiliations

  1. Laboratory of Cell Biology, Via Romagnosi 18/A, Rome, Italy

    Giulio Levi & Ugo Poce

  2. Institute of Pharmacology, Catholic University, Rome, Italy

    Maurizio Raiteri

Authors
  1. Giulio Levi
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  2. Ugo Poce
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  3. Maurizio Raiteri
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Editors and Affiliations

  1. National Research Council, Rome, Italy

    Giulio Levi

  2. University of Padua Medical School, Padua, Italy

    Leontino Battistin

  3. Research Institute of Neurochemistry, New York, New York, USA

    Abel Lajtha

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© 1976 Plenum Press, New York

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Levi, G., Poce, U., Raiteri, M. (1976). Uptake and Exchange of GABA and Glutamate in Isolated Nerve Endings. In: Levi, G., Battistin, L., Lajtha, A. (eds) Transport Phenomena in the Nervous System. Advances in Experimental Medicine and Biology, vol 69. Springer, New York, NY. https://doi.org/10.1007/978-1-4684-3264-0_21

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  • DOI: https://doi.org/10.1007/978-1-4684-3264-0_21

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4684-3266-4

  • Online ISBN: 978-1-4684-3264-0

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