Skip to main content
SpringerLink
Log in

RNA Oncogenic Virus-Associated Antigens

And Host Immune Response to Them

  • Chapter
Biology of Tumors: Surfaces, Immunology, and Comparative Pathology

Part of the book series: Cancer ((C,volume 4))

  • 75 Accesses

Abstract

The rapid development of analytical techniques has revealed the complexity of antigens associated with type B and type C RNA viruses. These antigens may be broadly categorized as either viral, cellular, or soluble (Aoki, 1973) (Table 1). Based on the morphological structure of viruses, which consists of an inner nucleoid and an outer shell surrounded by an envelope acquired during budding of the virus from the surface of infected cells (deHarven, 1968), viral antigens can additionally be divided into viral envelope antigens (VEAs) and intraviral antigens. Cell surface antigens (CSAs) induced by viruses and by malignant transformation (mutation of the cellular genome) possess several type specificities (Klein, 1969; Old and Boyse, 1965). To date, while viral antigens have been found intracellularly, no viral-genome-induced cellular antigens have been demonstrated there. Several groups of soluble antigens corresponding to the above specificities have been detected in the circulation and in the kidneys of virus-infected animals (see below).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Similar content being viewed by others

References

  • Aaronson, S. A., and Stephenson, J. R., 1974, Widespread natural occurrence of high titers of neutralizing antibodies to a specific class of endogenous mouse type-C virus, Proc. Natl. Acad. Sci. U.S.A. 71:1957.

    PubMed  CAS  Google Scholar 

  • Aaronson, S. A., Parks, W. P., Scolnick, E. M., and Todaro, G. J., 1971a, Antibody to the RNA-dependent DNA polymerase of mammalian C-type RNA tumor viruses, Proc. Natl. Acad. Sci. U.S.A. 68:920.

    PubMed  CAS  Google Scholar 

  • Aaronson, S. A., Todaro, G. J., and Scolnick, E. M., 1971b, Induction of murine C-type viruses from clonal lines of virus-free BALB/3T3 cells, Science 174:157.

    PubMed  CAS  Google Scholar 

  • Aoki, T., 1971, Surface antigens of murine leukemia cells and murine leukemia viruses, Transplant. Proc. 3:1195.

    Google Scholar 

  • Aoki, T., 1973, An analysis of antigens on the surface of murine leukemia viruses and cells, in: Unifying Concepts of Leukemia (R. M. Dutcher and L. Chieco-Bianchi, eds.), Bibl. Haematol. (Basel) 39:307.

    CAS  Google Scholar 

  • Aoki, T., 1974, Murine type-C RNA viruses: A proposed reclassification, other possible pathogenicities, and a new immunologic function, J. Natl. Cancer Inst. 52:1029.

    PubMed  CAS  Google Scholar 

  • Aoki, T., 1975, Surface antigens of normal and neoplastic lymphohematopoietic cells, in: Immunological Aspects of Neoplasia (E. Hersh, ed.), presented at the 26th Annual Symposium on Fundamental Cancer Research, Houston, Texas, pp. 149–167, Williams & Wilkinson, Baltimore, Md.

    Google Scholar 

  • Aoki, T., and Johnson, P. A., 1972, Suppression of Gross leukemia cell-surface antigens: A kind of antigenic modulation, J. Natl. Cancer Inst. 49:183.

    PubMed  CAS  Google Scholar 

  • Aoki, T., and Takahashi, T., 1972, Viral and cellular surface antigens of murine leukemias and myelomas: Serological analysis by immunoelectron microscopy, J. Exp. Med. 135:443.

    PubMed  CAS  Google Scholar 

  • Aoki, T., and Todaro, G. J., 1973, Antigenic properties of endogenous type-C viruses from spontaneously transformed clones of BALB/3T3, Proc. Natl. Acad. Sci. U.S.A. 70:1598.

    PubMed  CAS  Google Scholar 

  • Aoki, T., Boyse, E. A., and Old, L. J., 1966, Occurrence of natural antibody to the G (Gross) leukemia antigen in mice, Cancer Res. 26:1415.

    PubMed  CAS  Google Scholar 

  • Aoki, T., Boyse, E. A., and Old, L. J., 1968a, Wild-type Gross leukemia virus. I. Soluble antigen (GSA) in the plasma and tissues of infected mice, J. Natl. Cancer Inst. 41:89.

    PubMed  CAS  Google Scholar 

  • Aoki, T., Boyse, E. A., and Old, L. J., 1968b, Wild-type Gross leukemia virus. II. Influence of immunogenetic factors on natural transmission and on the consequences of infection, J. Natl. Cancer Inst. 41:97.

    PubMed  CAS  Google Scholar 

  • Aoki, T., Boyse, E. A., and Old, L. J., 1968c, Wild-type Gross leukemia virus. III. Serological tests as indicators of leukemia risk, J. Natl. Cancer Inst. 41:103.

    PubMed  CAS  Google Scholar 

  • Aoki, T., Boyse, E. A., Old, L. J., Deharven, E., Hämmerling, U., and Wood, H. A., 1970, G (Gross) and H-2 cell surface antigens: Location on Gross leukemia cells by electron microscopy with visually labeled antibody, Proc. Natl. Acad. Sci. U.S.A. 65:569.

    PubMed  CAS  Google Scholar 

  • Aoki, T., Herberman, R. B., Johnson, P. A., Liu, M., and Sturm, M. M., 1972, Wild-type Gross leukemia virus: Classification of soluble antigens (GSAs), J. Virol. 10:1208.

    PubMed  CAS  Google Scholar 

  • Aoki, T., Stephenson, J. R., and Aaronson, S. A., 1973a, Demonstration of a cell-surface antigen associated with murine sarcoma virus by immunoelectron microscopy, Pxoc. Natl. Acad. Sci. U.S.A. 70:742.

    CAS  Google Scholar 

  • Aoki, T., Potter, M., and Sturm, M. M., 1973b, Analysis of type C viruses associated with primary and short-term transplanted mouse plasma cell tumors by immunoelectron microscopy, J. Natl. Cancer Inst. 51:1609.

    PubMed  CAS  Google Scholar 

  • Aoki, T., Huebner, R. J., Chang, K. S. S., Sturm, M. M., and Liu, M., 1974a, Diversity of envelope antigens on murine type C RNA viruses, J. Natl. Cancer Inst. 52:1189.

    PubMed  CAS  Google Scholar 

  • Aoki, T., Kvedar, J. P., Kudo, T., Plata, E. J., Sendo, F., and Hollis, V. W., Jr., 1974b, Enhancement of host immune response to cell surface antigens by the extract of Streptococcus hemolyticus, in: Comparative Leukemia Research, 1973 (Y. Ito and R. M. Dutcher, eds.), pp. 237–240, University of Tokyo Press, Japan.

    Google Scholar 

  • Aoki, T., Stephenson, J. R., Aaronson, S. A., and Hsu, K. C., 1974c, Surface antigens of mammalian sarcoma virus-transformed nonproducer cells, Proc. Natl. Acad. Sci. U.S.A. (in press).

    Google Scholar 

  • August, J. T., Bolognesi, D. P., Fleissner, E., Gilden, R. V., and Nowinski, R. C., 1974, Letter to Editor: A proposed nomenclature for virion proteins of oncogenic RNA viruses, Virology 60:595.

    PubMed  CAS  Google Scholar 

  • Baldwin, R. W., Bowen, J. G., Embleton, M. J., Price, M. R., and Robins, R. A., 1974, Serum factors modifying lymphocyte cytotoxicity for tumor cells, Adv. Biosci. 12:539.

    Google Scholar 

  • Batzing, B. L., Yurconic, M., Jr., and Hanna, M. G., Jr., 1974, Autogenous immunity to endogenous RNA tumor virus: Chronic humoral immune response to virus envelope antigens in B6C3F, mice, J. Natl. Cancer Inst. 52:117.

    PubMed  CAS  Google Scholar 

  • Billingham, R. E., Brent, L., and Medawar, P. B., 1956, Quantitative studies on tissue transplantation immunity. III. Actively acquired tolerance, Philos. Trans. R. Soc. London 239:357.

    Google Scholar 

  • Borsos, T., and Rapp, H. J., eds., 1973, Conference on the use of BCG in therapy of cancer, Natl. Cancer Inst. Monogr. 39.

    Google Scholar 

  • Boyse, E. A., and Old, L. J., 1969, Some aspects of normal and abnormal cell surface genetics, Ann. Rev. Genet. 3:269.

    Google Scholar 

  • Boyse, E. A., Old, L. J., and Aoki, T., 1967, Immunogenetics of leukemia in the mouse, in: Treatment of Burkitt’s tumor (J. H. Burchenal and D. P. Burkitt, eds.), UICC Monograph Series, Vol. 8, pp. 248–257, Springer, New York.

    Google Scholar 

  • Chieco-Bianchi, L., Sendo, F., Aoki, T., and Barrera, O. L., 1974, Immunologic tolerance to antigens associated with murine leukemia viruses: T-cell unresponsiveness? J. Natl. Cancer Inst. 52:1345.

    PubMed  CAS  Google Scholar 

  • Deharven, E., 1968, Morphology of murine leukemia viruses, in: Experimental Leukemia (M. Rich, ed.), pp. 97–129, Appleton-Century-Crofts, New York.

    Google Scholar 

  • Dezfulian, M., Zee, T., DE Ome, K. B., Blair, P. B., and Weiss, D. W., 1968, Role of the mammary tumor virus in the immunogenicity of spontaneous mammary carcinomas of BALB/c mice and in the responsiveness of the hosts, Cancer Res. 28:1759.

    PubMed  CAS  Google Scholar 

  • Eckner, R. J., and Steeves, R. A., 1972, A classification of the murine leukemia viruses: Neutralization of pseudotype of Friend spleen focus-forming virus by type-specific murine antisera, J. Exp. Med. 136:832.

    PubMed  CAS  Google Scholar 

  • Gallagher, R. E., Todaro, G. J., Smith, R. G., Livingston, D. M., and Gallo, R. C., 1974, Relationship between RNA-directed DNA polymerase (reverse transcriptase) from human acute leukemic blood cells and primate type-C viruses, Proc. Natl. Acad. Sci. U.S.A. 71:1309.

    PubMed  CAS  Google Scholar 

  • Geering, G., Old, L. J., and Boyse, E. A., 1966, Antigens of leukemias induced by naturally occurring murine leukemia virus: Their relation to the antigens of Gross virus and other murine leukemia viruses, J. Exp. Med. 124:753.

    PubMed  CAS  Google Scholar 

  • Geering, G., Aoki, T., and Old, L. J., 1970, Shared viral antigen of mammalian leukemia viruses, Nature (London) 226:265.

    CAS  Google Scholar 

  • Gilden, R. V., and Oroszlan, S., 1972, Group-specific antigens of RNA tumor viruses as markers for subinfectious expression of the RNA virus genome, Proc. Natl. Acad. Sci. U.S.A. 69:1021.

    PubMed  CAS  Google Scholar 

  • Gilden, R. V., Toni, R., Hanson, M., Bova, D., Charman, H. P., and Oroszlan, S., 1974, Immunochemical studies of the major internal polypeptide of woolly monkey and gibbon ape type C viruses, J. Immunol. 112:1250.

    PubMed  CAS  Google Scholar 

  • Green, M., and Gerard, G. F., 1974, RNA-directed DNA polymerase—Properties and functions in oncogenic RNA viruses and cells, in: Progress in Nucleic Acid Research and Molecular Biology, Academic Press, New York.

    Google Scholar 

  • Greenberger, J. S., Stephenson, J. R., Aoki, T., and Aaronson, S. A., 1974, Cell surface antigens of murine sarcoma virus transformed nonproducer cells: Further evidence for lack of transplantation immunity, Int. J. Cancer 14:145.

    PubMed  CAS  Google Scholar 

  • Gregoriades, A., and Old, L. J., 1969, Isolation and some characteristics of a group-specific antigen of the murine leukemia viruses, Virology 37:189.

    PubMed  CAS  Google Scholar 

  • Gross, L., 1951, Pathogenic properties, and “vertical” transmission of the mouse leukemia agent, Proc. Soc. Exp. Bid. Med. 78:342.

    CAS  Google Scholar 

  • Hanafusa, H., Aoki, T., Kawai, S., Miyamoto, T., and Wilsnack, R. E., 1973, Presence of antigen common to avian tumor viral envelope antigen in normal chick embryo cells, Virology 56:22.

    PubMed  CAS  Google Scholar 

  • Hellström, I., Sjögren, H. O., Warner, G. A., and Hellström, K. E., 1971, Blocking of cell-mediated tumor immunity by sera from patients with growing neoplasms, Int. J. Cancer 7:226.

    PubMed  Google Scholar 

  • Herberman, R. B., 1972, Serological analysis of cell surface antigens of tumors induced by murine leukemia virus, J. Natl. Cancer Inst. 48:265.

    PubMed  CAS  Google Scholar 

  • Herberman, R. B., and Aoki, T., 1972, Immune and natural antibodies to syngeneic murine plasma cell tumors, J. Exp. Med. 136:94.

    PubMed  CAS  Google Scholar 

  • Herberman, R. B., Aoki, T., and Nunn, M. E., 1973, Solubilization of G (Gross) antigens on the surface of G leukemia cells, J. Natl. Cancer Inst. 50:481.

    PubMed  CAS  Google Scholar 

  • Herberman, R. B., Aoki, T., Nunn, M. E., Lavrin, D. H., Soares, N., Gazdar, A., Holden, H., and Chang, K. S. S., 1974, Specificity of 51Cr-release cytotoxicity by lymphocytes immune to murine sarcoma virus, J. Natl. Cancer Inst. 53:1103.

    PubMed  CAS  Google Scholar 

  • Hilgers, J., Nowinski, R. C., Geering, G., and Hardy, W., 1972, Detection of avian and mammalian oncogenic RNA viruses (oncornaviruses) by immunofluorescence, Cancer Res. 32:98.

    PubMed  CAS  Google Scholar 

  • Hollis, V. W., Jr., Aoki, T., Barrera, O. L., Oldstone, M. B. A., and Dixon, F. J., 1974, Detection of naturally occurring antibodies to RNA-dependent DNA polymerase of murine leukemia virus in kidney eluates of AKR mice, J. Virol. 13:448.

    PubMed  CAS  Google Scholar 

  • Ikeda, H., Stockert, E., Rowe, W. P., Boyse, E. A., Lilly, F., Sato, H., Jacobbs, S., and Old, L. J., 1973, Relation of chromosome 4 (linkage group VIII) to murine leukemia virus-associated antigens of AKR mice, J. Exp. Med. 137:1103.

    PubMed  CAS  Google Scholar 

  • Kassel, R. L., Old, L. J., Carswell, E. A., Fiore, N. C., and Hardy, W. D., Jr., 1973, Serum-mediated leukemia cell destruction in AKR mice: Role of complement in the phenomenon, J. Exp. Med. 138:925.

    PubMed  CAS  Google Scholar 

  • Kennel, S. J., DEL Villano, B. C., Levy, R. L., and Lerner, R. A., 1973, Properties of an oncornavirus glycoprotein: Evidence for its presence on the surface of virions and infected cells, Virology 55:464.

    PubMed  CAS  Google Scholar 

  • Klein, G., 1968, Tumor specific transplantation antigen, Cancer Res. 28:625.

    PubMed  CAS  Google Scholar 

  • Klein, G., 1969, Tumor antigens, Ann. Rev. Microbiol. 20:223.

    Google Scholar 

  • Kudo, T., Aoki, T., and Morrison, J. L., 1974, Stabilization of antigens on surfaces of malignant cells by formalin treatment, J. Natl. Cancer Inst. 52:1553.

    PubMed  CAS  Google Scholar 

  • Kurokawa, T., Hattori, T., and Furue, H., 1972, Clinical experiences with the streptococcal anticancer preparation, OK-432 (NSCB116209), Cancer Chemother. Rep. Part. 156:211.

    Google Scholar 

  • Levy, J. P., Varet, B., and Oppenheim, E., 1969, Neutralization of Graffi leukemia virus, Nature (London) 224:606.

    CAS  Google Scholar 

  • Lilly, F., and Nathanson, S. G., 1969, Studies on the FMR antigen, Transplant. Proc. 1:85.

    PubMed  CAS  Google Scholar 

  • Lowry, D. R., Rowe, W. P., Teich, N., and Hartley, J. A., 1971, High frequency activation in vitro by 5-iododeoxyuridine, Science 174:155.

    Google Scholar 

  • Mcallister, R. M., Nelson-Rees, W. A., Johnson, E. Y., Rongey, R. W., and Gardner, M. B., 1971, Disseminated rhabdomyosarcoma formed in kittens by cultured human rhabdomyosarcoma cells, J. Natl. Cancer Inst. 47:603.

    PubMed  CAS  Google Scholar 

  • Mellors, R. C., Shirai, T., Aoki, T., Huebner, R. J., and Krawczynski, K., 1971, Wild-type Gross leukemia viruses and the pathogenesis of the glomerulonephritis of New Zealand mice, J. Exp. Med. 133:113.

    PubMed  CAS  Google Scholar 

  • Morton, D. L., Miller, G. F., and Wood, D. A., 1965, Demonstration of tumor-specific immunity against antigens unrelated to the mammary tumor virus in spontaneous mammary adenocarcinomas, J. Natl. Cancer Inst. 42:303.

    Google Scholar 

  • Nowinski, R. C., and Peters, E. D., 1973, Cell surface antigens associated with murine leukemia virus: Definition of the GL and GT antigenic systems, H. Virol. 12:1104.

    CAS  Google Scholar 

  • Nowinski, R. C., Old, L. J., Boyse, E. A., Deharven, E., and Geering, G., 1968, Group-specific viral antigens in the milk and tissues of mice naturally infected with mammary tumor virus or Gross leukemia virus, Virology 34:617.

    PubMed  CAS  Google Scholar 

  • Nowinski, R. C., Sarkar, N. H., Old, L. J., Moore, D. H., Scheer, D. I., and Hilgers, J., 1971, Characteristics of the structural components of the mouse mammary tumor virus. II. Viral proteins and antigens, Virology 46:1.

    PubMed  Google Scholar 

  • Nowinski, R. C., Fleissner, E., Sarkar, N. H., and Aoki, T., 1972, Chromatographic separation and antigenic analysis of proteins of the oncornavirus. II. Mammalian leukemia—sarcoma viruses, J. Virol. 9:359.

    PubMed  CAS  Google Scholar 

  • Okabe, H., Gilden, R. V., and Hatanaka, M., 1973, Extensive homology of RD114 virus DNA with RNA of feline cell origin, Nature New Biol. 244:54.

    PubMed  CAS  Google Scholar 

  • Okamoto, H., Minami, M., Shoin, S., Koshimura, S., and Shimizu, R., 1966, Experimental anticancer studies. Part XXXI. On the streptococcal preparation having potent anticancer activity, Jpn. J. Exp. Med. 36:175.

    PubMed  CAS  Google Scholar 

  • Okamoto, H., Shoin, S., Koshimura, S., and Shimizu, R., 1972, ß-Hemolytic Streptococcus as a Cancer Controller, (H. Okamoto, ed.), Chugai Pharmaceutical Co., Japan.

    Google Scholar 

  • Old, L. J., and Boyse, E. A., 1965, Antigens of tumors and leukemias induced by viruses, Fed. Proc. 24:1009.

    PubMed  CAS  Google Scholar 

  • Old, L. J., Boyse, E. A., Clarke, D. A., and Carswell, E. A., 1962, Antigenic properties of chemically induced tumors, Ann. N.Y. Acad. Sci. 101:80.

    CAS  Google Scholar 

  • Old, L. J., Boyse, E. A., and Stockert, E., 1964, Typing of mouse leukemias by serological methods, Nature (London) 201:777.

    CAS  Google Scholar 

  • Old, L. J., Boyse, E. A., and Stockert, E., 1965, The G (Gross) leukemia antigen, Cancer Res. 25:813.

    PubMed  CAS  Google Scholar 

  • Old, L. J., Stockert, E., Boyse, E. A., and Kim, J. H., 1968, Antigenic modulation, loss of TL antigen from cells exposed to TL antibody: Study of the phenomenon in vitro, J. Exp. Med. 127:523.

    PubMed  CAS  Google Scholar 

  • Oldstone, M. B. A., Aoki, T., and Dixon, F. J., 1972a, The antibody response of mice to murine leukemia virus in spontaneous infection: Absence of classical immunologic tolerance, Proc. Natl. Acad. Sci. U.S.A. 69:134.

    PubMed  CAS  Google Scholar 

  • Oldstone, M. B. A., Tishon, A., Tonietti, G., and Dixon, F. J., 1972, Immune complex disease associated with spontaneous murine leukemia: Incidence and pathogenesis of glomerulonephritis, Clin. Immunol. Immunopathol. 1:6.

    Google Scholar 

  • Oroszlan, S., Fisher, C. L., Stanley, T. B., and Gilden, R. V., 1970, Proteins of the murine C-type RNA viruses. I. Isolation of a group-specific antigen by isoelectric focusing, J. Gen. Virol. 8:1.

    PubMed  CAS  Google Scholar 

  • Ortaldo, J. R., Ting, C. C., and Herberman, R. B., 1974, Modulation of fetal antigen(s) in mouse leukemia cells, Cancer Res. 34:1366.

    PubMed  CAS  Google Scholar 

  • Ortez de Landazuri, M., Kedar, E., and Fahey, J. L., 1974, Studies of antibody dependent cellular cytotoxicity (ADCC) to a syngeneic Gross virus-induced lymphoma, J. Natl. Cancer Inst. 52:147.

    Google Scholar 

  • Parks, W. P., and Scolnick, E. M., 1972, Radioimmunoassay of mammalian type C viral protein: Interspecies antigenic reactivities of the major internal polypeptide, Proc. Natl. Acad. Sci. U.S.A. 69:1766.

    PubMed  CAS  Google Scholar 

  • Parks, W. P., Scolnick, E. M., Ross, J., Todaro, G. J., and Aaronson, S. A., 1972, Immunological relationships of reverse transcriptases from ribonucleic acid tumor viruses, J. Virol. 9:110.

    PubMed  CAS  Google Scholar 

  • Parks, W. P., Howk, R. S., Scolnick, E. K., Oroszlan, S., and Gilden, R. V., 1974, Immunochemical characterization of two major polypeptides from murine mammary tumor virus, J. Virol. 13:1200.

    PubMed  CAS  Google Scholar 

  • Plata, E. J., Aoki, T., Collins, F., and Sibal, L. R., 1973, Mammary tumor virus (MTV): Soluble antigen (MSA) in the plasma of infected mice, Annual Meeting of the American Society of Microbiology, abst. 133, p. 216.

    Google Scholar 

  • Pourrean-Schneider, N., Stephens, R. J., and Gardner, W. U., 1968, Viral inclusions and other cytoplasmic components in a Leydig cell murine tumor: An electron microscopic study, Int. J. Cancer 3:155.

    Google Scholar 

  • Salaman, M. H., and Wedderburn, N., 1966, The immunodepressive effect of Friend virus, Immunology 10:445.

    Google Scholar 

  • Schäfer, W., Sźantó, J., Anderer, F. A., Frank, H., Gelderblom, H., Lange, J., and Pister, L., 1970, Tests for mouse leukemia viruses and isolation of some of their components, in: Comparative Leukemia Research (R. M. Dutcher, ed.), pp. 327–332, Karger, New York.

    Google Scholar 

  • Sherr, C. J., Lieber, M. M., Benveniste, R. E., and Todaro, G. J., 1974, Endogenous baboon type C virus (M7): Biochemical and immunologic characterization, Virology 58:492.

    PubMed  CAS  Google Scholar 

  • Silobreic, V., and Suit, H. D., 1967, Tumor specific antigen(s) in a spontaneous mammary carcinoma of C3H mice. I. Quantitative cell transplants into mammary-tumor-agent-positive and free mice, J. Natl. Cancer Inst. 39:1113.

    Google Scholar 

  • Sjögren, H. O., Hellström, I., Bansal, S. C., and Hellström, K. E., 1971, Suggestive evidence that the “blocking antibodies” of tumor bearing individuals may be antigen-antibody complexes, Proc. Natl. Acad. Sci. U.S.A. 68:1372.

    PubMed  Google Scholar 

  • Snell, G. D., and Stimpfling, J. H., 1966, Genetics of tissue transplantation, in: The Biology of the Laboratory Mouse (E. L. Green, ed.), pp. 457–492, McGraw-Hill, New York.

    Google Scholar 

  • Southam, C. M., 1960, Relationships of immunology to cancer, a review, Cancer Res. 20:271.

    PubMed  CAS  Google Scholar 

  • Stephenson, J. R., Tronick, S. R., Reynolds, R. K., and Aaronson, S. A., 1974, Isolation and characterization of C-type viral gene products of virus-negative mouse cells, J. Exp. Med. 139:427.

    PubMed  CAS  Google Scholar 

  • Stockert, E., Old, L. J., and Boyse, E. A., 1971, The GIX system: A cell surface alloantigen associated with murine leukemia virus; implications regarding chromosomal integration of the viral genome, J. Exp. Med. 133:1334.

    PubMed  CAS  Google Scholar 

  • Strand, M., and August, J. T., 1973, Structural proteins of oncogenic ribonucleic acid viruses: Interspec II, a new interspecies antigen, J. Biol. Chem. 248:5627.

    PubMed  CAS  Google Scholar 

  • Strand, M., and August, J. T., 1974, Structural proteins of mammalian oncogenic RNA viruses: Multiple antigenic determinants of the major internal protein and envelope glycoprotein, J. Virol. 13:171.

    PubMed  CAS  Google Scholar 

  • Stück, B., Old, L. J., and Boyse, E. A., 1964a, Occurrence of soluble antigen in the plasma of mice with virus-induced leukemia, Proc. Natl. Acad. Sci. U.S.A. 52:950.

    Google Scholar 

  • Stück, B., Old, L. J., and Boyse, E. A., 1964b, Antigenic conversion of established leukemias by an unrelated leukemogenic virus, Nature (London) 202:1016.

    Google Scholar 

  • Suit, H. D., and Silobreic, V., 1967, Tumor specific antigen(s) in a spontaneous mammary carcinoma of C3H mice. II. Active immunization of mammary-tumor-agent-free mice, J. Natl. Cancer Inst. 39:1121.

    PubMed  CAS  Google Scholar 

  • Teramoto, Y. A., Puentes, M. J., Young, L. J. T., and Cardiff, R. D., 1974, Structure of the mouse mammary tumor virus: Polypeptides and glycoproteins, J. Virol. 13:411.

    PubMed  CAS  Google Scholar 

  • Ting, C. C., and Herberman, R. B., 1974, Serological analysis of the immune response to Friend virus-induced leukemia, Cancer Res. 34:1676.

    PubMed  CAS  Google Scholar 

  • Ting, C. C., Shiu, G., Rodrigues, D., and Herberman, R. B., 1974, Cell-mediated immunity to Friend virus-induced leukemia, Cancer Res. 34:1684.

    PubMed  CAS  Google Scholar 

  • Todaro, G. J., 1972, “Spontaneous” release of type C viruses from clonal lines of “spontaneously” transformed BALB/3T3 cells, Nature (London) 240:157.

    CAS  Google Scholar 

  • Tronick, S. R., Stephenson, J. R., and Aaronson, S. A., 1973, Immunological characterization of a low molecular weight polypeptide of murine leukemia virus, Virology 54:199.

    PubMed  CAS  Google Scholar 

  • Tronick, S. R., Stephenson, J. R., and Aaronson, S. A., 1974, Comparative immunological studies of RNA C-type viruses: Radioimmunoassay for a low molecular Weight polypeptide of woolly monkey leukemia virus, Virology 57:347.

    PubMed  CAS  Google Scholar 

  • Vaage, J., 1968a, Non-virus-associated antigens in virus-induced mouse mammary tumors, Cancer Res. 28:2477.

    PubMed  CAS  Google Scholar 

  • Vaage, J., 1968b, Non-cross-reacting resistance to virus-induced mouse mammary tumors in virus-infected C3H mice, Nature (London) 218:101.

    CAS  Google Scholar 

  • Wedderburn, N., and Salaman, N. H., 1968, The immunodepressive effect of Friend virus. II. Reduction of splenic hemolysin-producing cells in primary and secondary responses, Immunology 15:439.

    PubMed  CAS  Google Scholar 

  • Yoshiki, T., Mellors, R. C., Hardy, W. D., Jr., and Fleissner, E., 1964, Common cell surface antigens associated with mammalian C-type RNA viruses: Cell membrane-bound gs antigen, J. Exp. Med. 139:925.

    Google Scholar 

  • Yoshiki, T., Mellors, R. C., and Hardy, W. D., Jr., 1973, Common cell-surface antigen associated with murine and feline C-type RNA leukemia viruses, Proc. Natl. Acad. Sci. U.S.A. 7:1878.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Viral Oncology Area, Division of Cancer Cause and Prevention, National Cancer Institute, NIH, Bethesda, Maryland, USA

    Tadao Aoki & Louis R. Sibal

Authors
  1. Tadao Aoki
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Louis R. Sibal
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. New York University School of Medicine, USA

    Frederick F. Becker

Rights and permissions

Reprints and permissions

Copyright information

© 1975 Plenum Press, New York

About this chapter

Cite this chapter

Aoki, T., Sibal, L.R. (1975). RNA Oncogenic Virus-Associated Antigens. In: Becker, F.F. (eds) Biology of Tumors: Surfaces, Immunology, and Comparative Pathology. Cancer, vol 4. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-2736-3_5

Download citation

  • DOI: https://doi.org/10.1007/978-1-4684-2736-3_5

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-2738-7

  • Online ISBN: 978-1-4684-2736-3

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation