Abstract
Humans are blessed with at least five herpesviruses, i.e., herpes simplex 1 (human herpesvirus 1, HSV-1), herpes simplex 2 (human herpesvirus 2, HSV-2), herpes zoster virus (human herpesvirus 3, HZV), Epstein-Barr virus (human herpesvirus 4, EBV), cytomegalovirus (human herpesvirus 5, CMV). In recent years three of these viruses, EBV, HSV-1, HSV-2, have become prominently associated with human cancer. The purpose of this chapter is to describe briefly the biology of these three herpesviruses in human cells and tissues. The chapter is organized into four sections dealing respectively with the virion and its components, the replication of herpesviruses in permissive cells, the infection of restrictive and nonpermissive cells, with the acute diseases, latency, neoplastic diseases associated with these herpesviruses.
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References
Abodeely, R. A., Lawson, L. A., Randall, C. C., 1970, Morphology and entry of enveloped and de-enveloped equine abortion (herpes) virus, J. Virol. 5: 513–523.
Adam, E., Kaufman, R. H., Melnick, J. L., Levy, A. H., Rawls, W. E., 1972, Seroepidemiologic studies of herpesvirus type 2 and carcinoma of the cervix. III. Houston, Texas, AM. J. Epidemioi. 96: 427–442.
Adam, E., Kaufman, R. H., Melnick, J. L., Levy, A., Rawls, E., 1973, Seroepidemiologic studies of herpesvirus type 2 and carcinoma of the cervix. IV. Dysplasia and carcinoma in situ, Am. J. Epidemiol. 98: 77–87.
Adams, A., Lindahl, T., Klein, G., 1973, Linear association between cellular DNA and Epstein-Barr virus DNA in a human lymphoblastoid cell line, Proc. Natl. Acad. Sci. 70: 2888–2892.
Armstrong, D., Henle, G., Henle, W., 1966, Complement fixation tests with cell lines derived from Burkitt’s lymphoma and acute leukemias, J. Bacteriol. 91: 1257–1262.
Ashe, W. K., Notkins, A. L., 1966, Neutralization of an infectious herpes simplex virus-antibody complex by anti-gamma-globulin, Proc. Natl. Acad. Sci. 56: 447–451.
Aurelian, L., 1972, Possible role of herpesvirus hominis, type 2, in human cervical cancer, Fed. Proc. 21: 1651–1659.
Aurelian, L., 1973, Virions and antigens of herpes virus type 2 in cervical carcinoma, Cancer Res. 33: 1539–1547.
Aurelian, L., Roizman, B., 1964, The host range of herpes simplex virus: Interferon, viral DNA and antigen synthesis in abortive infection of dog kidney cells, Virology 22: 452–461.
Aurelian, L., Roizman, B., 1965, Abortive infection of canine cells by herpes simplex virus. II. The alternative suppression of synthesis of interferon and viral constituents, J. Mol. Biol. 11: 539–548.
Aurelian, L., Strandberg, J. D., 1974, Biologic and immunologic comparison of two HSV-2 variants, one an isolate from cervical tumor cells, Arch. Ges. Virusforsch.
Aurelian, L., Strandberg, J. D., Melendez, L. V., Johnson, L. A., 1971, Herpesvirus type 2 isolated from cervical tumor cells grown in tissue culture, Science 174: 704–707.
Aurelian, L., Schumann, B., Marcus, R. L., Davis, H. J., 1973a, Antibody to HSV-2 induced tumor specific antigens in serums from patients with cervical carcinoma, Science 181: 161–164.
Aurelian, L., Davis, H. G., Julian, C. G., 1973b, Herpesvirus type 2 induced, tumor-specific antigen in cervical carcinoma, Am. J. Epidemiol. 98: 1–9.
Bachenheimer, S. L., Roizman, B., 1972, Ribonucleic acid synthesis in cells infected with herpes simplex virus. VI. Polyadenylic acid sequences in viral messenger ribonucleic acid, J. Virol. 10: 875–879.
Bachenheimer, S. L., Kieff, E. D., Lee, L., Roizman, B., 1972, Comparative studies on DNAs of Marek’s disease and herpes simplex virus, in: Oncogenesis and Herpesviruses (P. M. Biggs, G. de The, and L. N. Payne, eds.), International Agency for Research on Cancer, Lyon, pp. 74–81.
Banatvala, J. E., Best, J. M., Walker, D. K., 1972, Epstein-Barr virus-specific IgM in infectious mononucleosis, Burkitt lymphoma, nasopharyngeal carcinoma, Lancet 1: 1205–1208.
Baringer, J. R., Swoveland, M. A., 1973, Recovery of herpes simplex virus from human trigeminal ganglia, New Engl. J. Med. 288: 648–650.
Bastian, F. O., Rabson, A. S., Lee, C. L., Tralka, T. S., 1972, Herpesvirus hominis: Isolation from human trigeminal ganglion, Science 178: 206–207.
Becker, Y., Weinberg, A., 1972, Molecular events in the biosynthesis of Epstein-Barr virus in Burkitt lymphoblasts, in: Oncogenesis and Herpesviruses ( P. M. Biggs, G. de Thé, L. N. Payne, eds.), pp. 326–335, International Agency for Research on Cancer, Lyon.
Bell, D., Wilkie, N. M., Subak-Sharpe, J. H., 1971, Studies on arginyl transfer ribonucleic acid in herpesvirus infected baby hamster kidney cells, J. Gen. Virol. 13: 463–475.
Bellanti, J. A., Catalano, L. W., Chambers, R. W., 1971, Herpes simplex encephalitis: Virologic and serologic study of a patient treated with an interferon inducer, J. Pediat. 78: 136–145.
Breidenbach, G. P., Skinner, M. S., Wallace, J. H., Mizell, M., 1971, In vitro induction of a herpes-type virus in “summer-phase” Lucké tumor explants, J. Virol. 7: 679–682.
Bremberg, S., Klein, G., Epstein, M., 1969, Direct membrane fluorescence reaction of EBV carrying human lymphoblastoid cells blocking tests with xenogenic antisera, Int. J. Cancer 4: 761–766.
Brier, A. M., Wohlenberg, C., Rosenthal, J., Mage, M., Notkius, A. L., 1971, Inhibition or enhancement of immunological injury of virus-infected cells, Proc. Natl. Acad. Sci. 68: 3073–3077.
Bronson, D. L., Graham, B. J., Ludwig, H., Benyesh-Melnick, M., Biswal, N., 1972, Studies on the relatedness of herpes viruses through DNA-RNA hybridization, Biochim. Biophys. Acta 259: 24–34.
Bronson, D. L., Dreesman, G. R., Biswal, N., Benyesh-Melnick, M. T., 1973, Defective virions of herpes simplex viruses, Intervirology 1: 141–153.
Brown, D. C., Kaufman, H. E., 1969, Chronic herpes simplex infection of the ocular adnexa, Arch. Ophthalmol. 81: 837–839.
Bubola, D., Olivetti, L., 1968, L’Intradermoreazione con virus erpetico inattivato. I. Analisi dei fattori the influenzano la reazione, G. Ital. Dermatol. 109: 363–376.
Burkitr, D. P., 1961, Observations on the geography of malignant lymphoma, E. Afr. Med. J. 38: 511–514.
Burkitt, D. P., 1962, A tumour safari in east and central Africa, Brit. J. Cancer 16: 379–386.
Burkitt, D. P., 1972, The trail to a virus, in: Oncogenesis and Herpesvirus ( P. M. Biggs, G. de Thé, L. N. Payne, eds.), pp. 345–348, International Agency for Research on Cancer, Lyon.
Burkitt, D. P., Davies, J., 1961, Lymphoma syndrome in Uganda and tropical Africa, Med. Press 245: 367–369.
Burkitt, D. P., Wright, D., eds., 1970, Burkitt Lymphoma, Livingstone, Edinburgh.
Burnet, F. M., Williams, S. W., 1939, Herpes simplex: A new point of view, Med. J. Austral. 1: 637–642.
Carton, C. A., 1953, Effect of previous sensory loss on the appearance of herpes simplex following trigeminal sensory root section, J. Neurosurg. 10: 463–468.
Carton, C. A., Kilbourne, E. D., 1952, Activation of latent herpes simplex by trigeminal sensory-root section, New Engl. J. Med. 246: 172–176.
Catalano, L. W., Baron, S., 1970, Protection against herpes virus and encephalomyocarditis virus encephalitis with a double-stranded RNA inducer of interferon, Proc. Soc. Exp. Biol. Med. 133: 684–687.
Catalano, L. W., Johnson, L. D., 1971, Herpesvirus antibody and carcinoma in situ of the cervix, J. Am. Med. Assoc. 217: 447–450.
Centifanto, Y. M., Little, J. M., Kaufman, H. E., 1970, The relationship between virus chemotherapy, secretory antibody formation and recurrent herpetic disease, Ann. N.Y. Acad. Sci. 173: 649–656.
Cesario, T. C., Poland, J. D., Wulf, H., Chin, Y., Wermer, H., 1969, Six years experience with herpes simplex virus in a children’s home, Am. J. Epidemiol. 90: 416–422.
Chang, R. S., 1971, Umbilical cord leukocytes transformed by lymphoid cell filtrates from healthy people, Nature New Biol. 233: 124.
Chang, R. S., Golden, H. D., 1971, Transformation of human leukocytes by throat washing from infectious mononucleosis patients, Nature (Lond.) 234: 359–360.
Cohen, G. H., 1972, Ribonucleotide reductase activity of synchronized KB cells infected with herpes simplex virus, J. Virol. 9: 408–418.
Cooper, E. H., Hughes, D. T., Topping, N. E., 1966, Kinetics and chromosome analyses of tissue culture lines derived from Burkitt lymphomata, Brit. J. Cancer 20: 102–113.
Courtney, R. J., Mccombs, R. M., Benyesh-Melnick, M., 1971, Antigens specified by herpesviruses. I,I. Effect of arginine deprivation on the synthesis of cytoplasmic and nuclear proteins, Virology 43: 356–365.
Couch, E. F., Nahmias, A. J., 1969, Filamentous structures of type 2 herpesvirus hominis infection of the chorioallantoic membrane, J. Virol. 3: 228–232.
Cushing, H., 1905. The surgical aspects of major neuralgia of trigeminal nerve; a report of twenty cases of operation on Gasserian ganglion with anatomic and physiologic notes on consequence of its removal, J. Am. Med. Assoc. 44: 773–779.
Cushing, H., 1905. The surgical aspects of major neuralgia of trigeminal nerve; a report of twenty cases of operation on Gasserian ganglion with anatomic and physiologic notes on consequence of its removal, J. Am. Med. Assoc. 44: 860–865.
Cushing, H., 1905. The surgical aspects of major neuralgia of trigeminal nerve; a report of twenty cases of operation on Gasserian ganglion with anatomic and physiologic notes on consequence of its removal, J. Am. Med. Assoc. 44: 920–929.
Cushing, H., 1905. The surgical aspects of major neuralgia of trigeminal nerve; a report of twenty cases of operation on Gasserian ganglion with anatomic and physiologic notes on consequence of its removal, J. Am. Med. Assoc. 44: 1002–1008.
Cushing, H., 1905. The surgical aspects of major neuralgia of trigeminal nerve; a report of twenty cases of operation on Gasserian ganglion with anatomic and physiologic notes on consequence of its removal, J. Am. Med. Assoc. 44: 1088–1093.
Dales, S., Silverberg, H., 1969, Viropexis of herpes simplex virus by HeLa cells, Virology 37: 475–480.
Darai, G., Munk, K., 1973, Human embryonic lung cells abortively infected with herpes virus hominis type 2 shows some properties of cell transformation, Nature New Biol. 241: 268–269.
Davidson, R. L., Adelstein, S. J., Oxman, M. N., 1973, Herpes simplex virus as a source of thymidine kinase for thymidine kinase deficient mouse cells: Suppression and reactivation of viral enzyme DNAs, Proc. Natl. Acad. Sci. 70: 1912–1916.
Deforest, A., Klein, M., 1968, The immunoglobulin response in recurrent herpes simplex infection in man, Fed. Proc. 27: 734.
Demissie, A., Svedmyr, A., 1969, Age distribution of antibodies to EB virus in Swedish females as studied by indirect immunofluorescence on Burkitt cells, Acta Pathol. Microbiol. Scand. 75: 457–465.
Schryver, A., Friberg, S., Jr., Klein, G., Henle, W., Henle, G., De The, G., Clifford, P., Ho, H. C., 1969, Epstein-Barr virus (EBV)-associated antibody patterns in carcinoma of the post-nasal space, Clin. Exp. Immunol. 5: 443–459.
Schryver, A., Klein, G., Henle, G., Henle, W., Cameron, H. M., Santesson, L., Clifford, P., 1972, EB-virus associated serology in malignant disease: Antibody levels to viral capsid antigens (VCA), membrane antigens (MA) and early antigens (EA) in patients with various neoplastic conditions, Int. J. Cancer 9: 353–364.
Thé, G., 1972, Virology and immunology of nasopharyngeal carcinoma: Present situation and outlook—A review, in: Oncogenesis and Herpesvirus (P. M. Biggs, G. de The, L. N. Payne, eds.), International Agency for Research on Cancer, Lyon, pp. 275–284.
Thé, G., Ambrosioni, J., Ho, H., Kwan, H., 1969, Lymphoblastoid transformation and presence of herpes type particles in Chinese nasopharyngeal tumor culture in vitro, Nature (Lond.) 221: 770.
Thé, G., Ho, H., Kwan, H., Desranges, C., Farre, M., 1970, Nasopharyngeal carcinoma. I. Types of cultures derived from tumor biopsies and non tumorous tissues of Chinese patients with special reference to lymphoblastoid transformation, Int. J. Cancer 6: 189–206.
Docherty, J. J., Mitchell, W. R., Thompson, C. J., 1973, Abortive herpes simplex virus replication in Rous sarcoma virus transformed cells, Proc. Soc. Exp. Biol. Med. 144: 697–704.
Douglas, R. G., JR., Couch, R. B., 1970, A prospective study of chronic herpes simplex virus infection and recurrent herpes labialis in humans, J. Immunol. 104: 289–295.
Duff, R., Rapp, F., 1971, Properties of hamster embryo fibróblasts transformed in vitro after exposure to ultraviolet-irradiated herpes simplex virus type 2, J. Virol. 8: 469–477.
Dunkel, V., Pry, T., Henle, G., Henle, W., 1972, Immunofluorescence tests for antibodies to Epstein-Barr virus with sera of lower primates, J. Natl. Cancer Inst. 49: 435–440.
Ejercito, P. M., Kieff, E. D., Roizman, B., 1968, Characterization of herpes simplex virus strains differing in their effect on social behavior of infected cells, J. Gen. Virol. 3: 357–364.
Ennis, F. A., 1973a, Host defense mechanisms against herpes simplex virus. I. Control of infection in vitro by sensitized spleen cells and antibody, Infect. Immunol. 7: 898–904.
Ennis, F. A., 1973b, Host defense mechanisms against herpes simplex virus. II. Protection conferred by sensitized spleen cells, J. Infect. Dis. 127: 632–638.
Epstein, M. A., 1962, Observations on the fine structure of mature herpes simplex virus and on the composition of its nucleoid, J. Exp. Med. 115: 1–11.
Epstein, M. A., Achong, B. G., Specific immunofluorescence test for the herpes type EB virus of Burkitt lymphoblasts, authenticated by electron microscopy, J. Natl. Cancer Inst. 40: 593–607.
Epstein, M. A., Achong, B. G., 1970, The EB virus, in: Burkitt’s Lymphoma ( D. P. Burkitt and D. H. Wright, eds.), pp. 231–248, Livingstone, Edinburgh.
Epstein, M. A., Achong, B. G., 1973, The EB virus, Ann. Rev. Microbiol. pp. 413–436.
Epstein, M. A., Barr, Y. M., 1964, Cultivation in vitro of human lymphoblasts from Burkitt’s malignant lymphoma, Lancet 1: 252–253.
Epstein, M. A., Achong, B. G., Barr, Y., 1964, Virus particles in cultured lymphoblasts from Burkitt’s lymphoma, Lancet 1: 702–703.
Epstein, M. A., Achong, B. G., Barr, Y., 1965, Morphological and biological studies on a virus in cultured lymphoblasts from Burkitt’s lymphoma, J. Exp. Med. 121: 761–770.
Epstein, M. A., Achong, B. G., Pope, J., 1967, Virus in cultured lymphoblasts from a New Guinea Burkitt lymphoma, Brit. Med. J. 21: 290–291.
Espmark, J. A., 1965, Rapid serological typing of herpes simplex virus and titration of herpes simplex antibody by the use of mixed hemadsorption, a mixed antiglobulin reaction applied to virus infected tissue cultures. Arch. Ges. Virusforsch. 17: 89–97.
Evans, A. S., Niederman, J. C., Mccollum, R. W., 1968, Seroepidemiologic studies of infectious mononucleosis with EB virus, New Engl. J. Med. 279: 1121–1127.
Evans, D. L., Barnett, J. W., Bowen, J. M., Dmochowski, L., 1972, Antigenic relationship between the herpesviruses of infectious bovine rhinotracheitis, Marek’s disease, Burkitt’s lymphoma, J. Virol. 10: 277–287.
Falke, D., 1961, Isolation of two variants with different cytopathic properties from a strain of herpes B virus, Virology 14: 492–495.
Fialkow, P. J., Klein, G., Gartler, S. M., Clifford, P., 1970, Clonal origin for individual Burkitt tumors, Lancet 1: 384–386.
Fialkow, P., Klein, E., Klein, G., Clifford, P., Singh, S., 1973, Immunoglobulin and glucose 6 phosphate dehydrogenase as markers of cellular origin in Burkitt lymphoma, J. Exp. Med. 138: 89–102.
Flanagan, J. F., 1967, Virus-specified ribonucleic acid synthesis in KB cells infected with herpes simplex virus, J. Virol. 1: 583–590.
Frenkel, N., Roizman, B., 1971, Herpes simplex virus: Studies of the genome size and redundancy by renaturation kinetics, J. Virol. 8: 591–593.
Frenkel, N., Roizman, B., 1972a, Separation of the herpesvirus deoxyribonucleic acid on sedimentation in alkaline gradients, J. Virol. 10: 565–572.
Frenkel, N., Roizman, B., 1972b, Ribonucleic acid synthesis in cells infected with herpes simplex virus: Control of transcription and of RNA abundance, Proc. Natl. Acad. Sci. 69: 2654–2658.
Frenkel, N., Roizman, B., Cassai, E., Nahmias, A., 1972, A herpes simplex 2 DNA fragment and its transcription in human cervical cancer tissue, Proc. Natl. Acad. Sci. 69: 3784–3789.
Frenkel, N., Silverstein, S., Cassai, E., Roizman, B., 1973, RNA synthesis in cells infected with herpes simplex virus. VII. Control of transcription and of transcript abundancies of unique and common sequences of herpes simplex 1 and 2, J. Virol. 11: 886–892.
Fritz, M. E., Nahmias, A. J., 1972, Reversed polarity in transmembrane potentials of cells infected with herpesviruses, Proc. Soc. Exp. Biol. Med. 139: 1159–1161.
Furlong, D., Swift, H., Roizman, B., 1972, Arrangement of herpesvirus deoxyribonucleic acid in the core, J. Virol. 10: 1071–1074.
Garfinkle, B., Mcauslan, B. R., 1974, Transformation of cultured mammalian cells by viable herpes simplex virus subtypes 1 and 2, Proc. Natl. Acad. Sci. 71: 220–224.
Gelb, L., Kohne, D., Martin, M., 1971, Quantitation of simian virus 40 sequences in African green monkey, mouse and virus transformed cell genomes, J. Mol. Biol. 57: 119.
Gerber, P., 1972, Activation of Epstein-Barr virus by 5’-bromodeoxyuridine in virus free human cells, Proc. Natl. Acad. Sci. 69: 83–85.
Gerber, P., Birch, S. M., 1967, Complement-fixing antibodies in sera of human and nonhuman primates to viral antigens derived from Burkitt’s lymphoma cells, Proc. Natl. Acad. Sci. 58: 478–484.
Gerber, P., Deal, D. R., 1970, Epstein-Barr virus-induced viral and soluble complement-fixing antigens in Burkitt lymphoma cell cultures, Proc. Soc. Exp. Biol. Med. 134: 748–751.
Gerber, P., Lorenz, D., 1974, Complement-fixing antibodies reactive with EBV in sera of marmosets and prosimians, Proc. Soc. Exp. Biol. Med. 145: 654–657.
Gerber, P., Monroe, J., 1968, Studies in leukocytes growing in continuous culture derived from normal human donors, J. Natl. Cancer Inst. 40: 855–866.
Gerber, P., Rosenblum, E. N., 1968, The incidence of complement-fixing antibodies to herpes simplex and herpes-like viruses in man and rhesus monkeys, Proc. Soc. Exp. Biol. Med. 128: 541–546.
Gerber, P., Whang-Peng, J., Monroe, J. H., 1969, Transformation and chromosome changes induced by Epstein-Barr virus in normal human leukocyte cultures, Proc. Natl. Acad. Sci. 63: 740–747.
Gerber, P., Nonoyama, M., Lucas, S., Perlin, E., Goldstein, L. I., 1972, Oral excretion of Epstein-Barr virus by healthy subjects and patients with infectious mononucleosis, Lancet 2: 988–989.
Gergely, L., Klein, G., Ernberg, I., 197la, The action of DNA antagonists on Epstein-Barr virus (EBV)-associated early antigen (EA) in Burkitt lymphoma lines, Int. J. Cancer 17: 293–302.
Gergely, L., Klein, G., Ernberg, I., 1971b, Appearance of Epstein-Barr virus-associated antigens in infected Raji cells, Virology 45: 10–21.
Gergely, L., Klein, G., Ernberg, I., 1971c, Host cell macromolecular synthesis in cells containing EBV-induced early antigens, studied by combined immunofluorescence and radioautography, Virology 45: 22–29.
Geser, A., De Thé, G., 1972, Does the Epstein-Barr virus play an aetiological role in Burkitt’s lymphoma? in: Oncogenesis and Herpesvirus ( P. M. Biggs, G. de Thé, L. N. Payne, eds.), International Agency for Research on Cancer, Lyon, pp. 372–375.
Gibson, W., Roizman, B., 1971, Compartmentalization of spermine and spermidine in herpes simplex virion, Proc. Natl. Acad. Sci. 68: 2818–2821.
Gibson, W., Roizman, B., 1972, Proteins specified by herpes simplex virus. VIII. Characterization and composition of multiple capsid forms of subtypes 1 and 2, J. Virol. 10: 1044–1052.
Gibson, W., Roizman, B., 1973, The structural and metabolic involvement of polyamines with herpes simplex virus, in: Polyamines in Normal and Neoplastic Growth ( D. H. Russell, ed.), Raven Press, New York, pp. 123–135.
Gibson, W., Roizman, B., 1974, Proteins specified by herpes simplex virus. X. Staining and radiolabeling properties of B-capsid and virion proteins in polyacrylamide gels, J. Virol. 13: 155–165.
Glade, P., Karel, J., Morse, H., Whang Peng, J., Hoffman, P., Kammermeyer, J., Chenin, L., 1968, Infectious mononucleosis continuous suspension cultures of peripheral leukocytes, Nature (Lond.) 217: 564–565.
Glaser, R., O’neill, F. J., 1972, Hybridization of Burkitt lymphoblastoid cells, Science 176: 1245–1247.
Glaser, R., Rapp, F., 1972, Rescue of Epstein-Barr virus from somatic cell hybrids of Burkitt lymphoblastoid cells, J. Virol. 10: 288–296.
Goldman, M., Reisker, J. I., Bushar, H. F., 1968a, Serum antibodies to Burkitt cell virus, Lancet 1: 1156.
Goldman, M., Landon, H. C., Reisher, J. I., 1968b, Fluorescent antibody and gel diffusion reactions of human and chimpanzee sera with cells cultured from Burkitt tumors and normal chimpanzee blood, Cancer Res. 28: 2489–2495.
Goodheart, C. R., Plummer, G., Waner, J. L., 1968, Density difference of DNA of human herpes simplex viruses types I and II, Virology 35: 473–475.
Goodpasture, E. W., 1929, Herpetic infection with especial reference to involvement of the nervous system, Medicine 8: 223–243.
Grafstrom, R. H., Alwine, J. C., Steinhart, W. L., Hill, C. W., 1974, Terminal redundancy of herpes simplex virus type 1 DNA, Cold Spring Harbor Symp. Quant. Biol. 36.
Graham, F., Van Der Eb, A., Heijneker, H., 1974, Size and location of the transforming region in human adenovirus type 5 DNA, Nature (Lond.) 251: 687–691.
Gray, A., Tokumaru, T., Scott, T. F. Mcn., 1958, Different cytopathogenic effects observed in HeLa cells infected with herpes simplex virus, Arch. Ges. Virusforsch. 8: 60–76.
Gripenberg, U., Levan, A., Clifford, P., 1969, Chromosomes in Burkitt lymphomas. I. Serial studies in a case with bilateral tumors showing different chromosomal stemlines, Int. 1. Cancer 4: 334–349.
Grose, C., Feorino, P. M., 1972, Epstein-Barr virus and Guillain-Barré syndrome, Lancet 2: 1285–1287.
Gunven, P., Klein, G., Henle, G., Henle, W., Clifford, P., 1970, Antibodies to EBV associated membrane and viral capsid antigens in Burkitt lymphoma patients, Nature (Lond.) 228: 1053–1056.
Gunven, P., Klein, G., Clifford, P., Singh, S., 1974, EBV associated membrane reactive antibodies during long term survival after Burkitt’s lymphoma, Proc. Natl. Acad. Sci. 71: 1422–1426.
Hampar, B., Ellison, S. A., 1961, Chromosomal aberrations induced by an animal virus, Nature (Land.) 192: 145–147.
Hampar, B., Ellison, S. A., 1963, Cellular alterations in the MCH line of Chinese hamster cells following infection with herpes simplex virus, Proc. Natl. Acad. Sci. 49: 474–480.
Hampar, B., Hsu, K. C., Martos, L. M., Walker, J. L., 1971, Serologic evidence that a herpes-type virus is the etiologic agent of heterophile-positive infectious mononucleosis, Proc. Natl. Acad. Sci. 68: 1407–1411.
Hampar, B., Derge, J. G., Martos, L. M., Walker, J. L., 1972, Synthesis of Epstein-Barr virus after activation of the viral genome in a “virus-negative” human lymphoblastoid cell (Raji) made resistant to 5-bromodeoxyuridine, Proc. Natl. Acad. Sci. 69: 78–82.
Hampar, B., Derge, J. G., Martos, L. M., Tagamets, M. A., Chang, S. Y., Chakrabarty, A., 1973, Identification of a critical period during the S phase for activation of the Epstein-Barr virus by 5-iododeoxyuridine, Nature New Biol. 244: 214–217.
Hampar, B., Derge, J. G., Showalter, S. D., 1974a, Enhanced activation of the repressed Epstein-Barr viral genome by inhibitors of DNA synthesis, Virology 58: 298–301.
Hampar, B., Tanaka, A., Nonoyama, M., Derge, J., 19746, Replication of the resident repressed EBV genome during early S phase (S-1 period) of nonproducer Raji cells, Proc. Natl. Acad. Sci. 71: 631–633.
Hay, J., Icoteles, G. J., Keir, H. M., Subak-Sharpe, H., 1966, Herpesvirus specified ribonucleic acids, Nature (Load.) 210: 387–390.
Hay, J., Perera, P. A. J., Morrison, J. M., Gentry, G. A., Subak-Sharpe, J. H., 1971, Herpes virus specified proteins, in: Ciba Symposium on Strategy of the Viral Genome ( G. E. W. Wolstenholme and M. O’Connor, eds.), Churchill Livingstone, London, pp. 355–372.
Heine, J. W., Roizman, B., 1973, Proteins specified by herpes simplex virus. IX. Contiguity of host and viral proteins in the plasma membrane of infected cells, J. Virol. 11: 810–813.
Heine, J. W., Spear, P. G., Roizman, B., 1972, The proteins specified by herpes simplex virus. VI. Viral protéin in the plasma membrane, J. Virol. 9: 431–437.
Heine, J. W., Honess, R. W., Cassai, E., Roizman, B., 1974, Proteins specified by herpes simplex virus. XII. The virion polypeptides of type 1 strains, J. Virol. 14: 640–651.
Heineman, H. S., 1967, Herpes simplex neutralizing antibody—Quantitation of the complement-dependent fraction in different phases of adult human infection, J. Immunol. 99: 214–222.
Henle, G., Henle, W, I966a, Immunofluorescence in cells derived from Burkitt’s lymphoma, J. Bacteriol. 91: 1248–1256.
Henle, G., Henle, W., 19666, Studies on cell lines derived from Burkitt’s lymphoma, Trans. N.Y. Acad. Sci. 29: 71.
Henle, G., Henle, W., 1967, Immunofluorescence, interference, complement fixation technics in the detection of herpes-type virus in Burkitt tumor cell lines, Cancer Res. 27: 2442–2446.
Henle, G., Henle, W., 1970, Observations on childhood infections with the Epstein-Barr virus, J. Infect. Dis. 121: 303–310.
Henle, G., Henle, W., Diehl, V., 1968, Relation of Burkitt tumor associated herpes-type virus to infectious mononucleosis, Proc. Natl. Acad. Sci. 59: 94–101.
Henle, G., Henle, W., Clifford, P., Diehl, V., Kafuko, G. W., Kirya, B. G., Klein, G., Morrow, R. H., Munube, G. M. R., Pike, M. C., Tukei, P. M., Ziegler, J. L., 1969, Antibodies to Epstein-Barr virus in Burkitt’s lymphoma and control groups, J. Natl. Cancer Inst. 43: 1147–1157.
Henle, G., Henle, W., Klein, G., Gunven, P., Clifford, P., Morrow, R. H., Ziegler, J. L., 1971a, Antibodies to early Epstein-Barr virus-induced antigens in Burkitt’s lymphoma, J. Natl. Cancer Inst. 46: 861–871.
Henle, G., Henle, W., Klein, G., 1971b, Demonstration of two distinct components in the early antigen complex of Epstein-Barr virus infected cells, Int. J. Cancer 8: 272–282.
Henle, W., Henle, G., 1968, Effect of arginine-deficient media on the herpes-type virus associated with cultured Burkitt tumor cells, J. Virol. 2: 182–191.
Henle, W., Henle, G., 1970, Comparative Leukemia Research (R. M. Dutcher, ed.), pp. 706–713, Karger, New York.
Henle, W., Hummeler, K., Henle, G., 1966, Antibody coating and agglutination of virus particles separated from EB3 line of Burkitt lymphoma cells, J. Bacteriol. 92: 269–271.
Henle, W., Diehl, V., Kohn, G., Zur Hausen, H., Henle, G., 1967, Herpes-type virus and chromosome marker in normal leukocytes after growth with irradiated Burkitt cells, Science 157: 1064–1065.
Henle, W., Henle, G., Ho, H. C., Burtin, P., Cachin, Y., Clifford, P., De Schryver, A., De Thé, G., Diehl, V., KLEIN, G., 1970a, Antibodies to Epstein-Barr virus in nasopharyngeal carcinoma, other head and neck neoplasms and control groups, J. Natl. Cancer Inst. 44: 225–231.
Henle, W., Henle, G., Scriba, J., Joyner, C. R., Harrison, S., Jr., Von Essen, R., Paloheimo, J., Klemola, E., 1970b, Antibody responses to the Epstein-Barr virus and cytomegaloviruses after open-heart and other surgery, New Engl. J. Med. 282: 1068–1074.
Henle, W., Henle, G., Zajac, B., Pearson, G., Waubke, R., Scriba, M., 1970c, Differential reactivity of human serums with early antigens induced by Epstein-Barr virus, Science 169: 188–190.
Henle, W., Henle, G., Niederman, J. C., Klemola, E., Haltia, K., 1971, Antibodies to early antigens induced by Epstein-Barr virus in infectious mononucleosis, J. Infect. Dis. 124: 58–67.
Henle, W., Henle, G., Gunven, P., Klein, G., Clifford, P., Singh, S., 1973a, Patterns of antibodies to Epstein-Barr virus-induced early antigens in Burkitt’s lymphoma: Comparison of dying patients with long-term survivors, J. Natl. Cancer Inst. 50: 1163–1173.
Henle, W., Ho, H.-C., Henle, G., Kwan, H., 1973b, Antibodies to Epstein-Barr virus-related antigens in nasopharyngeal carcinoma: Comparison of active cases with long-term survivors, J. Natl. Cancer Inst. 51: 361–369.
Hewetson, J. F., Rocchi, G., Henle, W., Henle, G., 1973, Neutralizing antibodies against Epstein-Barr virus in healthy populations and patients with infectious mononucleosis, J. Infect. Dis. 128: 283–289.
Hinuma, Y., Grace, J. T., 1967, Cloning of immunoglobulin-producing human leukemic and lymphoma cells in long-term cultures, Proc. Soc. Exp. Biol. 124: 107–111.
Hinuma, Y., Konn, M., Yamaguchi, J., Wudarski, D., Blakeslee, J., Grace, J., 1967, Immunofluorescence and herpes type virus particles in the P3HR-1 Burkitt lymphoma gene, J. Virol. 1: 1045–1051.
Hinze, H. C., Walker, D. L., 1961, Variation of herpes simplex virus in persistently infected tissde cultures, J. Bacteriol. 82: 498–504.
Hirsch, M. S., Zisman, B., Allison, A. C., 1970, Macrophages and age-dependent resistance to herpes simplex virus in mice, J. Immunol. 104: 1160–1165.
Hirshaut, Y., Glade, P., Moses, H., Manaher, B., Chessin, L., 1969, Association of herpes-like virus infection with infectious mononucleosis, Am. J. Med. 47: 520–527.
Ho, H., 1972, Current knowledge of the epidemiology of nasopharyngeal carcinoma, in: Oncogenesis and Herpesvirus (P. M. Biggs, G. de The, L. N. Payne, eds.), pp. 357–366, International Agency for Research on Cancer, Lyon.
Hoagland, R. J., 1967, Infectious Mononucleosis, Grune and Stratton, New York.
Hochberg, E., Becker, Y., 1968, Adsorption penetration and uncoating of herpes simplex virus, J. Gen. Virol. 2: 231–241.
Hoggan, M. D., Roizman, B., 1959a, The effect of the temperature of incubation on the formation and release of herpes simplex virus in infected FL cells, Virology 8: 508–524.
Hoggan, M. D., Roizman, B., 1959b, The isolation and properties of a variant of herpes simplex producing multinucleated giant cells in monolayer cultures in the presence of antibody, Am. J. Hyg. 70: 208–219.
Hoggan, M. D., Roizman, B., Turner, T. B., 1960, The effect of the temperature of incubation on the spread of herpes simplex virus in an immune environment in cell culture, J. Immunol. 84: 152–159.
Hollinshead, A., O’bong, L., Mckelway, W., Melnick, J. L., Rawls, W. E., 1972, Reactivity between herpesvirus type 2 related soluble cervical tumor cell membrane antigens and matched cancer and control sera, Proc. Soc. Exp. Biol. Med. 141: 688–693.
Hollinshead, A. C., O’bong, L., Chrétien, P. B., Tarpley, J. L., Rawls, W. E., Adam, E., 1973, Antibodies to herpesvirus nonvirion antigens in squamous carcinomas, Science 182: 713–715.
Honess, R. W., Roizman, B., 1973, Proteins specified by herpes simplex virus. XI. Identification and relative molar rates of synthesis of structural and nonstructural herpesvirus polypeptides in the infected cell, J. Virol. 12: 1347–1365.
Honess, R. W., Roizman, B., 1974, Regulation of herpesvirus macromolecular synthesis. I. Cascade regulation of the synthesis of three groups of viral proteins, J. Virol. 14: 8–19.
Honess, R. W., Watson, D. H., 1974, Herpes simplex virus-specific polypeptides studied by polyacrylamide gel electrophoresis of immune precipitates, J. Gen. Virol. 22: 171–185.
Hoover, R., Fraumeni, J., 1973, Risk of cancers in renal transplant patients, Lancet 2: 55–57.
Horosziewicz, J., Dunkel, V., Avela, L., Grace, J., 1970, Comparative Leukemia Research (R. M. Dutcher, ed.), Karger, New York, pp. 722–730.
Huang, C. C., 1967, Induction of a high incidence of damage to X chromosomes of Rattus (Mastomys) natalensis by base analogues, viruses and carcinogens, Chromosoma 23: 162–179.
Huang, C. C., Minowada, J., 1972, Differential effects of infection with herpes simplex virus on the chromosomes of human hematopoietic cell, Cancer Res. 32: 1218–1225.
Huang, E. S., Pagano, J. S., 1974, Human cytomegalovirus. II. Lack of relatedness to DNA of herpes simplex I and II, Epstein-Barr virus, nonhuman strains of cytomegalovirus, J. Virol. 13: 642–645.
Hull, R. N., Dwyer, A. C., Holmes, A. W., Nowakowski, E., Deinhardt, F., Lennette, E. H., Emmons, R. W., 1972, Recovery and characterization of a new simian herpesvirus from a fatally infected spider monkey, J. Natl. Cancer Inst. 49: 225–231.
Hummeler, K., Henle, G., Henle, W., 1966, Fine structure of a virus in cultured lymphoblasts from Burkitt lymphoma, J. Bacteriol. 91: 1366–1368.
Hummeler, K., Tomassian, N., Zajac, B., 1969, Early events in herpes simplex virus infection: A radioautographic study, J. Virol. 4: 67–74.
Ito, M., Barron, A. L., 1972, Surface antigen produced by herpes simplex virus (HSV), J. Immunol. 108: 711–718.
Ito, M., Barron, A. L., 1973, Surface antigens produced by herpesviruses: Varicella-zoster virus, Infect. Immun. 8: 48–52.
Iwasaki, Y., 1973, Ultrastructural study on the sequence of human cytomegalovirus infection in human diploid cells, Arch. Ges. Virusforsch. 40: 311–324.
Jehn, U., Lindahl, T., Klein, G., 1972, Fate of virus DNA in the abortive infection of human lymphoid cell lines by Epstein-Barr virus, J. Gen. Virol. 16: 409–412.
Jensen, E., De Sombre, E., 1972, Mechanism of action of sex hormones, Ann. Rev. Biochem. 41: 203–230.
Johansson, B., Klein, G., Henle, W., Henle, G., 1970, Epstein-Barr virus (EBV)-associated antibody patterns in malignant lymphoma and leukemia. I. Hodgkin’s disease, Int. J. Cancer 6: 450–462.
Johnson, R. T., 1964, The pathogenesis of herpes virus encephalitis. II. A cellular basis for the development of resistance with age, J. Exp. Med. 120: 359–374.
Jondal, M., Klein, G., 1973, Surface markers on human B and T lymphocytes. II. Presence of Epstein-Barr virus receptors on B lymphocytes, J. Exp. Med. 138: 1365–1378.
Junge, U., Hoekstra, J., Deinhardt, F., 1971, Stimulation of peripheral lymphocytes by allogeneic and antochthonous mononucleosis lymphocyte cell lines, J. Immunol. 106: 1306–1315.
Kafuko, G. W., Henderson, B. E., Kirya, B. G., Munube, G. M. R., Tukei, P. M., Day, N. E., Henle, G., Henle, W., Morrow, M. H., Pike, M. C., Smith, P. G., Williams, E. H., 1972, Epstein-Barr virus antibody levels in children from the West Nile District of Uganda: Report of a field study, Lancet 1: 706–709.
Kalter, S. S., Heberling, R. L., Ratner, J. J., 1972, Ebv antibody in sera of nonhuman primates, Nature (L(md.) 238: 353–354.
Kamiya, T., Ben-Porat, T., Kaplan, A. S., 1964, The role of progeny viral DNA in the regulation of enzyme and DNA synthesis, Biochem. Biophys. Res. Commun. 16: 410–415.
Kamiya, T., Ben-Porat, T., Kaplan, A. S., 1965, Control of certain aspects of the infective process by progeny viral DNA, Virology 26: 577–589.
Kaplan, A. S., 1973, A brief review of the biochemistry of herpesvirus host cell interaction, Cancer Res. 33: 1393–1398.
Kaplan, A. S., Ben-Porat, T., 1959, The effect of pseudorabies virus on the nucleic acid. metabolism and on the nuclei of rabbit kidney cells, Virology 8: 352–366.
Kaplan, A. S., Ben-Porat, T., Coto, C., 1967, Studies on the control of the infective process in cells infected with pseudorabies virus, in: Molecular Biology of Viruses ( J. Colter, ed.), pp. 527–545, Academic Press, New York.
Kaufman, H. E., 1968, Mechanisms of recurrent herpes simplex keratitis, Am. J. Ophthalmol. 66: 559.
Kaufman, H. E., Brown, D. C., Ellison, E. D., 1967, Recurrent herpes in the rabbit and man, Science 156: 1628–1629.
Kaufman, H. E., Brown, D. C., Ellison, E. D., 1968, Herpes virus in the lacrimal gland, conjunctiva and cornea of man—A chronic infection, Am. J. Ophthalmol. 65: 32–35.
Kawai, Y., Nonoyama, M., Pagano, J., 1973, Reassociation kinetics for EBV DNA: Non-homology to mammalian DNA and homology of viral DNA in various diseases, J. Virol. 12: 1006–1012.
Keir, H. M., 1968, Virus-induced enzymes in mammalian cells infected with DNA viruses, in: Molecular Biology of Viruses Vol. 18, pp. 67–99, Cambridge University Press, Cambridge.
Keller, J. M., Spear, P. G., Roizman, B., 1970, The proteins specified by herpes simplex virus. III. Viruses differing in their effects on the social behaviour of infected cells specify different membrane glycoproteins, Proc. Natl. Acad. Sci. 65: 865–871.
Kelly, R., Cozzarelli, N., Deutscher, M., Lehman, I., Kornberg, A., 1970, Enzymatic synthesis of DNA. XXXII. Replication of duplex DNA by polymeraseal a single strand break, J. Biol. Chem: 245: 39–45.
Kieff, E. D., Levine, J., 1974, Homology between Burkitt herpes viral DNA and DNA in continuous lymphoblastoid cells from patients with infectious mononucleosis, Proc. Natl. Acad. Sci. 71: 355–358.
Kieff, E. D., Bachenheimer, S. L., Roizman, B., 1971, Size, composition and structure of the DNA of subtypes 1 and 2 herpes simplex virus, J. Virol. 8: 125–132.
Kieff, E. D., Hoyer, B., Bachenheimer, S. L., Roizman, B., 1972. Genetic relatedness of type 1 and type 2 herpes simplex viruses, J. Virol. 9: 738–745.
Kirkwood, J., Geering, G., Old, L. J., 1972, Demonstration of group-and type-specific antigens of herpes viruses, in: Oncogenesis and Herpesvirus ( P. M. Biggs, G. de Thé, L. N. Payne, eds.), p. 479, International Agency for Research on Cancer, Lyon.
Klein, E., Vanfurth, R., Johannsen, B., Ernberg, I., Clifford, T., 1972, Immunoglobulin synthesis as cellular marker of malignant lymphoid cells, in: Oncogenesis and Herpesvirus ( P. M. Biggs, G. de Thé, L. N. Payne, eds.), International Agency for Research on Cancer, Lyon, pp. 253–260.
Klein, G., 1971, Immunologic aspects of Burkitt’s lymphoma, Advan. Immunol. 14: 187–250.
Klein, G., 1973, The Epstein-Barr virus, in: The Herpesviruses ( A. S. Kaplan, ed.), Academic Press, New York, pp. 521–555.
Klein, G., Dombos, L., 1973, Relationship between the sensitivity of EBV-carrying lymphoblastoid lines to superinfection and the inducibility of the resident viral genome, Int. J. Cancer 11: 327–337.
Klein, G., Clifford, P., Klein, E., Stjernswärd, J., 1966, Search for tumor specific immune reactions in Burkitt lymphoma patients by the membrane immunofluorescence reaction, Proc. Natl. Acad. Sci. 55: 1628–1635.
Klein, G., Clifford, P., Klein, E., Stjernswärd, J., 1966, Search for tumor specific immune reactions in Burkitt lymphoma patients by the membrane immunofluorescence reaction, in: Symposium on the Chemotherapy of Burkitt Lymphoma, Unio Int. Contra Cancrum Monogr. Ser. 8: 209–232.
Klein, G., Clifford, P., Henle, G., Henle, W., Old, L. J., Geering, L., 1969, EBV-associated serological patterns in a Burkitt lymphoma patient during regression and recurrence, Int. J. Cancer 4: 416–421.
Klein, G., Dombos, L., Gothoshar, B., 1972, Sensitivity of EBV producer and nonproducer human lymphoblastoid cell lines to superinfection with EBV, Int. J. Cancer 10: 44–57.
Klein, G., Klein, E., Clifford, P., 1967b, Search for host defenses in Burkitt lymphoma: Membrane immunofluorescence tests on biopsies and tissue culture lines, Cancer Res. 27: 2510–2520.
Klein, G., Pearson, G., Henle, G., Henle, W., Diehl, V., Niederman, J. C., 1968a, Relation between Epstein-Barr viral and cell membrane immunofluorescence in Burkitt tumor cells. II. Comparison of cells and sera from patients with Burkitt’s lymphoma and infectious mononucleosis, J. Exp. Med. 128: 1021–1030.
Klein, G., Pearson, G., Nadkarni, J. S., Nadkarni, J. J., Klein, E., Henle, G., Henle, W., Clifford, P., 1968b, Relation between Epstein-Barr viral and cell membrane immunofluorescence of Burkitt tumor cells. I. Dependence of cell membrane immunofluorescence on presence of EB virus, J. Exp. Med. 128: 1011–1020.
Klein, G., Wiener, F., Zech, L., Zur Hausen, H., Reedman, B., 1974a, Segregation of the EBV-determined nuclear antigen ( EBNA) in somatic cell hybrids derived from the fusion of a mouse fibroblast and a human Burkitt lymphoma line, Int. J. Cancer 14: 54–64.
Klein, G., Giovanella, B., Lindahl, T., Fialkow, P., Singh, S., Stehlin, J., 1974, Direct evidence for the presence of EBV DNA and nuclear antigen in malignant epithelial cells from patients with poorly differentiated carcinoma of the nasopharynx, Proc. Natl. Acad. Sci.
Kohlhage, H., 1964, Differentiation of plaque variants of the herpes simplex virus by gradient centrifugation and column chromatography, Arch. Ges. Virusforsch. 14: 348–365
Kohlhage, H., 1964, Differentiation of plaque variants of the herpes simplex virus by gradient centrifugation and column chromatography, Zbl. Bakteriol. 191: 252–256.
Kohlhage, H., Schieferstein, G., 1965, Untersuchungen über die genetische stabilität des plaquebildes beim Herpes-simplex-Virus in Zellkulturen (Investigations on the genetic stability of the plaque picture of herpes simplex virus in cell cultures), Arch. Ges. Virusforsch. 15: 640–650.
Kohlhage, H., Siegert, R., 1962, Zwei genetische determinierte Varianten eines Herpessimplex-Stammes, Arch. Ges. Virusforsch. 12: 273–286.
Kohn, G., Mellman, W. J., Moorhead, P. S., Loftus, J., Henle, G., 1967, Involvement of C group chromosomes in five Burkitt lymphoma cell lines, J. Natl. Cancer Inst. 38: 209–222.
Kufe, D., Magrath, I., Ziegler, J., Spiegelman, S., 1973, Burkitt’s tumors contain particles encapsulating RNA instructed DNA polymerase and high molecular weight virus related RNA, Proc. Natl. Acad. Sci. 70: 737–741.
Laibson, P. R., Kibrick, S., 1969, Recurrence of herpes simplex virus in rabbit eyes: Results of a three-year study, Invest. Ophthalmol. 8: 346–350.
Lando, D., Ryhiner, M.-L., 1969, Pouvoir infectieux du DNA d’herpesvirus hominis en culture cellulaire, Compt. Rend. Acad. Sci. Paris 269: 527–530.
Landon, J. C., Ellis, L. B., Zeve, V. H., Fabrigio, D. P. A., 1968, Herpes-type virus in cultured leukocytes from chimpanzees, J. Natl. Cancer Inst. 40: 181–192.
Larson, C. L., Ushijima, R. N., Karim, R., Baker, M. B., Baker, R. E., 1972, Herpesvirus hominis type 2 infections in rabbits: Effect of prior immunization with attenuated Mycobacterium bovis (BCG) cells, Infect. Immun. 6: 465–468.
Lee, L. F., Kieff, E. D., Bachenheimer, S. L., Roizman, B., Spear, P. G., Burmester, B. R., Nazerian, K., 1971, Size and composition of Marek’s disease virus DNA, J. Viral. 7: 289–294.
Leibold, W., Flanagan, T. D., Menezes, J., Klein, G., 1974, Induction of Epstein-Barr virus (EBV)-associated nuclear antigen (EBNA) during in vitro transformation of human lymphoid cells, J. Natl. Cancer Inst.
Lerner, A. M., Bailey, E. J., Nolan, D. C., 1970, Complement-requiring neutralizing antibodies in herpesvirus hominis encephalitis, J. Immunol. 104: 607–615.
Levin, A. G., Friberg, S., Jr., Klein, E., 1969, Xénotransplantation of a Burkitt lymphoma culture line with surface immunoglobulin specificity, Nature (Lond.) 222: 997–998.
Levine, P. H., Ablashi, D. V., Berard, C. W., Carbone, P. P., Waggoner, D. E., Malan, L., 1971, Elevated antibody titers to Epstein-Barr virus in Hodgkin’s disease, Cancer 27: 416–421.
Levine, P. H., O’conor, G. T., Berard, C. W., 1972, Antibodies to Epstein-Barr virus (EBV) inAmerican patients with Burkitt’s lymphoma, Cancer 30: 610–615.
Levy, J. A., Henle, L., Indirect immunofluorescence test with sera from African children and cultured Burkitt lymphoma cells, J. Bacteriol. 92: 275–276.
Lindahl, T., Klein, G., Reedman, B., Johansson, B., Singh, S., 1974, Relationship between EBV DNA and EBNA in Burkitt lymphoma biopsies and other lymphoproliferative malignancies, Int. J. Cancer 13: 764–772.
Lipman, M., Andrews, L., Miller, G., 1974, Direct visualization of enveloped herpes-like virus from throat washing with leukocyte transforming activity, in: Abstracts of the Annual Meeting of the American Society for Microbiology ( H. Godder, ed.), American Society for Microbiology, Washington, D.C.
Lodmell, D. L., Niwa, A., Hayashi, K., Notkins, A. L., 1973, Prevention of cell-to-cell spread of herpes simplex virus by leukocytes, J. Exp. Med. 137: 706–720.
Logan, W. S., Tindall, J. P., Elson, M. L., 1971, Chronic cutaneous herpes simplex, Arch. Dermatol. 103: 606–614.
London, W. T., Catalano, L. W., Nahmias, A. J., Fucillo, D. A., Sever, J. L., 1971, Genital herpesvirus type 2 infection of monkeys, Obstet. Gynecol. 37: 501–509.
Lowry, S. A., Melnick, J. L., Rawls, W. E., 1971, Investigation of plaque formation in chick embryo cells as a biological marker for distinguishing herpesvirus type 2 from type 1, J. Gen. Virol. 10: 1–19.
Ludwig, H. O., 1972, Untersuchungen am genetischen Material von Herpesviren. I. Biophysikalisch-chemische Charakterisierung von Herpesvirus-Desoxyribonucleinsauren, Med. Microbiol. Immunol. 157: 186–211.
Ludwig, H. O., Biswal, N., Benyesh-Melnick, M., 1971, Characterization of DNA isolated from metaphase chromosomes of cells containing Epstein-Barr virus, Biochim. Biophys. Acta 232: 261–270.
Ludwig, H. O., Biswal, N., Benyesh-Melnick, M., 1972, Studies on the relatedness of herpesviruses through DNA-DNA hybridization, Virology 49: 95–101.
Luse, S. A., Smith, M. G., 1959, Electron microscope studies of cells infected with the salivary gland viruses, Ann. N.Y. Acad. Sci. 81: 133–144.
Manolov, G., Manolova, Y., 1972, Marker band in one chromosome 14 from Burkitt lymphomas, Nature (Lond.) 237: 33–34.
Martin, E. M., 1967, Marital and cortal factors in cervical cancer, Am. J. Pub. Health 57: 803–814.
Maurer, B. A., Glick, J. L., Minowada, J., 1970, DNA synthesis in EB virus-containing Burkitt lymphoma cultures during a temperature cycling procedure, Proc. Soc. Exp. Biol. Med. 133: 1026–1030.
Mayyasi, S., Schidlovsky, G., Bulferre, L., Buschek, F., 1967, Coating reaction of herpes type virus isolated from malignant tissues with an antibody present in sera, Cancer Res. 27: 2020–2023.
Menezes, J., Leibold, W., Klein, G., 1974, Biological differences between different Epstein-Barrirus (EBV) strains with regard to lymphocyte transforming ability.
Miller, G., Lisa, H., Kohn, H. I., Stitt, D., 1971, Establishment of cell lines from normal adult human blood leukocytes by exposure to Epstein-Barr virus and neutralization by human sera with Epstein-Barr virus antibody, Proc. Soc. Exp. Biol. Med. 137: 1459–1465.
Miller, G., Niederman, J. C., Stitt, D. A., 1972a, Infectious mononucleosis: Appearance of neutralizing antibody to Epstein-Barr virus measured by inhibition of formation of lymphoblastoid cell lines, J. Infect. Dis. 125: 403–406.
Miller, G., Shope, T., Lisco, H., Stitt, D., Lipman, M., 1972b, Epstein-Barr virus: Transformation, cytopathic changes, viral antigens in squirrel monkey and marmoset leukocytes, Proc. Natl. Acad. Sci. 69: 383–387.
Miller, G., Niederman, J. C., Andrews, L., 1973, Prolonged oropharyngeal excretion of EB virus following infectious mononucleosis, New Engl. J. Med. 288: 229–232.
Miller, G., Robinson, J., Heston, L., Lipman, M., 1974, Differences between laboratory strains of Epstein-Barr virus based on immortalization, abortive infection and interference, Proc. Natl. Acad. Sci. 71: 4006–4010.
Miller, M. H., Stitt, D., Miller, G., 1970, Epstein-Barr viral antigen in single cell clones of two human leukocytic lines, J. Virol. 6: 699–701.
Moore, G. E., Minowada, J., 1973, B and T lymphoid cell lines, New Engl. J. Med. 288: 106.
Moore, G. E., Grace, J. T., Jr., Citron, P., Gerner, R., Burns, A., 1966, Leukocyte cultures of patients with leukemia and lymphomas, N.Y. State Med. J. 66: 2757–2764.
Morgan, C., Rose, H. M., Mednis, B., 1968, Electron microscopy of herpes simplex virus. I. Entry, J. Virol. 2: 507–516.
Mori, R., Tasaki, T., Kimura, G., 1967, Depression of acquired resistance against herpes simplex virus in neonatally thymectomized mice, Arch. Ges. Virusforsch. 21: 459–462.
Morris, V. L., Wagner, E. K., Roizman, B., 1970, RNA synthesis in cells infected with herpes simplex virus. III. Absence of virus-specified arginyl-and seryl-tRNA in infected HEP-2 cells, J. Mol. Biol. 52: 247–263.
Morse, D., Pope, J., 1972, Assay of the infectivity of EBV by transformation of human leukocytes in vitro, J. Gen. Virol. 17: 233–236.
Muir, C. S., 1972, Nasopharyngeal carcinoma in non-Chinese populations, in: Oncogenesis and Herpesviruss ( P. M. Biggs, G. de Thé, L. N. Payne, eds.), International Agency for Research on Cancer, Lyon, pp. 367–371.
Muller, S. A., Herrmann, E. C. Jr., Winkelmann, R. K., 1972, Herpes simplex infections in hematologic malignancies, Am. J. Med. 52: 102–114.
Munk, K., Darai, G., 1973, Human embryonic lung cells transformed by herpes simplex virus, Cancer Res. 33: 1535–1538.
Munk, K., Sauer, G., 1964, Relationship between cell DNA metabolism and nucleocytoplasmic alterations in herpes virus-infected cells, Virology 22: 153–154.
Munyon, W., Kraiselburd, E., Davis, D., Mann, J., 1971, Transfer of thymidine kinase to thymidine kinaseless L cells by infection with ultraviolet-irradiated herpes simplex virus, J. Virol. 7: 813–820.
Munyon, W., Kraiselburd, E., Davis, D., Zeigel, R., Buchsbaum, R., Paoletti, E., 1972a, Biochemical transformation of L-cells with ultraviolet irradiated herpes simplex virus, Fed. Proc. 31: 1669–1672.
Munyon, W., Buchsbaum, R., Paoletti, E., Mann, J., Kraiselburd, E., Davis, D., 1972b, Electrophoresis of thymidine kinase activity synthesized by cells transformed by herpes simplex virus, Virology 49: 683–689.
Nadkarni, J. S., Nadkarni, J. J., Clifford, P., Manolov, G., Fenjo, E. M., Klein, E., 1969, Characteristics of new cell lines derived from Burkitt lymphomas, Cancer 23: 64–79.
Nadkarni, J. S., Nadkarni, J. J., Klein, G., Henle, W., Henle, G., Clifford, P., 1970, EB viral antigens in Burkitt tumor biopsies and early cultures, Int. J. Cancer 6: 10–17.
Nahmias, A. J., 1970, Disseminated herpes-simplex-virus infections, New Engl. J. Med. 282: 684–685.
Nahmias, A. J., 1972, Herpesviruses from fish to man—A search for pathobiological unity, Pathobiol. Ann. 2: 153–182.
Nahmias, A. J., Roizman, B., 1973, Infection with herpes simplex virus 1 and 2, New Engl. J. Med. 289: 667–674.
Nahmias, A. J., Roizman, B., 1973, Infection with herpes simplex virus 1 and 2, New Engl. J. Med. 289: 719–725.
Nahmias, A. J., Roizman, B., 1973, Infection with herpes simplex virus 1 and 2, New Engl. J. Med. 289: 781–789.
Nahmias, A. J., Dowdle, W. R., Naib, Z. M., Josey, W. E., Luce, C. F., Genital infection with herpesvirus hominis types 1 and 2 in children, Pediatrics 42: 659–666.
Nahmias, A. J., Dowdle, W. R., Kramer, J. H., Luce, C. F., Mansour, S. C., 1969a, Antibodies to herpesvirus hominis types 1 and 2 in the rabbit, J. Immunol. 102: 956–962.
Nahmias, A. J., Hirsch, M. S., Kramer, J. H., Murphy, F. A., 1969b, Effect of antithymocyte serum on herpesvirus hominis (type 1) infection in adult mice, Proc. Soc. Exp. Biol. Med. 132: 696–698.
Nahmias, A. J., Josey, W. E., Nais, Z. M., Luce, C., Duffey, C., 1970a, Antibodies to herpesvirus hominis types 1 and 2 in humans. I. Patients with genital herpetic infections, Am. J. Epidemiol. 91: 539–546.
Nahmias, A. J., Josey, W. E., Naib, Z. M., Luce, C., Guest, B., 1970b, Antibodies to herpesvirus hominis types 1 and 2 in humans. II. Women with cervical cancer, Am. J. Epidemiol. 91: 547.
Nahmias, A. J., Del Buono, I., Pipkin, J., Hutton, R., Wickliffe, C., 1971, Rapid identification and typing of herpes simplex virus types 1 and 2 by a direct immunofluorescence technique, Appi. Microbiol. 22: 455–458.
Nahmias, A. J., Naib, Z. M., Josey, W. E., Franklin, E., Jenkins, R., 1973, Prospective studies of the association of genital herpes simplex infection and cervical anaplasia, Cancer Res. 33: 1491–1497.
Naib, Z. M., Nahmias, A. J., Josey, W. E., Kramer, J. H., 1969, Genital herpetic infection, Cancer 23: 940–946.
Niederman, J. C., Mccollum, R. W., Henle, G., Henle, W., 1968, Infectious mononucleosis—Clinical manifestations in relation to EB virus antibodies, J. Am. Med. Assoc. 203: 205–209.
Niederman, J. C., Evans, A. S., Subrahmanyan, L., Mccollum, R. W., 1970, Prevalence, incidence and persistence of EB virus antibody in young adults, New Engl. J. Med. 282: 361–365.
Nii, S., 1971a, Electron microscopic observations on FL cells infected with herpes simplex virus. I. Viral forms, Biken J. 14: 177–190.
Nit, S., 1971b, Electron microscopic observations on FL cells infected with herpes simplex virus. II. Envelopment, Biken J. 14: 325–348.
Nii, S., Kamahora, J., 1961, Cytopathic changes induced by herpes simplex virus, Biken J. 4: 255–270.
Nii, S., Kamahora, J., 1963, High frequency appearance of amitotic nuclear divisions in PS cells induced by herpes simplex virus, Biken J. 6: 33–36.
Nil, S., Morgan, C., Rose, H. M., 1968a, Electron microscopy of herpes simplex virus. II. Sequence of development, J. Virol. 2: 517–536.
Nh, S., Morgan, C., Rose, H. M., Hsu, K. C., 19686, Electron microscopy of herpes simplex virus. IV. Studies with ferritin-conjugated antibodies, J. Virol. 2: 1172–1184.
Nilsson, K., 1971, High frequency establishment of human immunoglobulin-producing lymphoblastoid lines from normal and malignant lymphoid tissue and peripheral blood, Int. J. Cancer 8: 432–442.
Nilsson, K., Klein, G., Henle, W., Henle, G., 1971, The establishment of lymphoblastoid lines from adult and fetal human lymphoid tissue and its dependence on EBV, Int. J. Cancer 8: 443–450.
Nilsson, K., Klein, G., Henle, G., Henle, W., 1972, The role of EBV in the establishment of lymphoblastoid cell line from adult and foetal lymphoid tissue, IARC Monogr. 2: 285–290.
Nonoyama, M., Pagano, J. S., 1971, Detection of Epstein-Barr viral genome in nonproductive cells, Nature New Biot 233: 103–106.
Nonoyama, M., Pagano, J. S., 1972a, Replication of viral deoxyribonucleic acid and breakdown of cellular deoxyribonucleic acid in Epstein-Barr virus infection, J. Virol. 9: 714–716.
Nonoyama, M., Pagano, J., 1972b, Separation of Epstein-Barr virus DNA from large chromosomal DNA in non-virus producing cells, Nature New Biol. 238: 169–171.
Nonoyama, M., Pagano, J. S., 1973, Homology between Epstein-Barr virus DNA and viral DNA from Burkitt’s lymphoma and nasopharyngeal carcinoma determined by DNA-DNA reassociation kinetics, Nature (Lond.) 242. 44–47.
Nonoyama, M., Huang, C. H., Pagano, J. S., Klein, G., Singh, S., 1973, DNA of Epstein-Barr virus detected in tissue of Burkitt’s lymphoma and nasopharyngeal carcinoma, Proc. Natl. Acad. Sci. 70: 3265–3268.
Notkins, A. K., 1971, Infectious virus-antibody complexes: Interaction with anti-immunoglobulins. complement and rheumatoid factor, J. Exp. Med. Suppl. 134: 41–51.
O’connor, G. T., Rabson, A. S., 1965, Herpes-like particles in an American lymphoma: Preliminary note, J. Natl. Cancer Inst. 35: 899–903.
Oettgen, H. F., Aoki, T., Geering, G., 1967, Definition of an antigenic system associated with Burkitt’s lymphoma, Cancer Res., 27: 2532–2534.
Old, L. J., Boyse, E. A., Oettgen, H. F., De Harven, E., Geering, G., Williamson, B., Clifford, P., 1966, Precipitating antibody in human serum to an antigen present in cultured Burkitt’s lymphoma cells, Proc. Natl. Acad. Sci. 56: 1699–1704.
O’neill, F. J., Rapp, F., 1971a, Synergistic effect of herpes simplex virus and cytosine arabinoside on human chromosomes, J. Virol. 7: 692–695.
O’neill, F. J., Rapp, F., 1971b, Early events required for induction of chromosome abnormalities in human cells by herpes simplex virus, Virology 44: 544–553.
Pagano, J. S., 1974, The EBV genome and its interactions with human lymphoblastoid cells and chromosomes, in: Viruses, Evolution, Cancer ( K. Marmarosch and E. Kurstak, eds.), Academic Press, New York.
Pagano, J. S., Huang, C. H., Levine, P., 1973, No EB viral DNA in American Burkitt’s lymphoma, New Engl. J. Med. 289: 1395–1399.
Paine, T. F., 1964, Latent herpes simplex infection in man. Bacteriol. Rev. 28: 472–479.
Park, J. H., Baron, S., 1968, Herpetic keratoconjunctivitis: Therapy with synthetic double-stranded RNA, science 162: 811–813.
Patrizi, G., Middelkamp, J. N., Reed, C. A., 1968, Fine structure of herpes simplex virus hepatoadrenal necrosis in newborn, Am. J. Clin. Pathol. 49: 325–341.
Pattengale, P. K., Smith, R. W., Gerber, P., 1973, Selective transformation of B lymphocytes by E.B. virus, Lancet 2: 93–94.
Pearson, G., Dewey, F., Klein, G., Henle, G., Henle, W., 1970a, Correlation between antibodies of Epstein-Barr virus (EBV)-induced membrane antigens and neutralization of EBV infectivity, J. Natl. Cancer Inst. 45: 989–995.
Pearson, G., Dewey, F., Klein, G., Henle, G., Henle, W., 19706, Relation between neutralization of Epstein-Barr virus and antibodies to cell membrane antigens induced by the virus, J. Natl. Cancer Inst. 45: 989–995.
Pereira, M. S., Blake, J. M., Macrae, A. D., 1969, EB virus antibody at different ages, Brit. Med. J. 4: 526–527.
Pereira, M. S., Field, A. M., Blake, J. M., Rodgers, F. G., Bailey, L. A., Davies, J. R., 1972, Evidence for oral excretion of EB virus in infectious mononucleosis, Lancet 1: 710–712.
Pettersson, U., Sambrook, J., 1973, Amount of viral DNA in the genome of cells transformed by adenovirus type 2, J. Mol. Biol. 73: 125–130.
Pfefferkorn, E. R., Burge, B., Coady, H. M., 1966, Characteristics of the photoreactivation of pseudorabies virus, J. Bacteriol. 92: 856–861.
Plummer, G., 1964, Serological comparison of the herpes viruses, Brit. J. Exp. Pathol. 45: 135–141.
Plummer, G., Masterson, J. G. C., 1970, Herpes simplex virus and cancer of the cervix, Am. J. Obstet. Gynecol. 3: 81–84.
Plummer, G., Hollingsworth, D. C., Phuangseb, A., 1970, Chronic infections by herpes simplex viruses and by the horse and cat herpesviruses, Infect. Immun. 1: 351–355.
Pope, J. H., 1967, Establishment of cell lines from peripheral leukocytes in infectious mononucleosis, Nature (Lond.) 216: 810–811.
Pope, J. H., Horne, M. K., Scott, W., 1968a, Transformation of foetal human leukocytes in vitro by filtrates of a human leukaemic cell tine containing herpes-like virus, Int. J. Cancer 3: 857–866.
Pope, J. H., Achong, B., Epstein, M., 1968b, Cultivation and pure structure of virus bearing lymphoblaste from 2nd N. G. Burkitt lymphoma establishment, Int. J. Cancer 3: 171–182.
Pope, J. H., Horne, M. K., Scott, W., 1969a, Identification of the filterable leukocytetransforming factor QIMRL-WIL cells as herpes-like virus, Int. J. Cancer 4: 255–260.
Pope, J. H., Horne, M. K., Wetters, E. J., 1969b, Significance of a complement-fixing antigen associated with herpes-like virus and detected in the Raji cell line, Nature (Lond.) 222: 186–187.
Porter, D. D., Wimberly, I., Benyesh-Melnick, M., 1969, Prevalence of antibodies to EB virus and other herpesviruses, J. Am. Med. Assoc. 208: 1675–1679.
Priden, M., Lilienfeld, A. M., 1971, Carcinoma of the cervix in Jewish women in Israel 1960–1969, an epidemiological study, Israel J. Med. Sci. 7: 1465–1470.
Pritchett, R., Hayward, D., Kieff, E., 1974, DNA of EBV. I. Comparative studies of the DNA of EBV from HR1 and B95–8 cells: Size, structure and relatedness, J. Virol., 15: (ín press, March 1975).
Pulvertaft, R. J. V., 1964, Cytology of Burkitt’s tumor (African lymphoma), Lancet 1: 238–240.
Rabson, A., O’connor, G., Baron, S., Whang, J., Legallais, F., 1966, Morphologic, cytogenetic and virologic studies in vitro of a malignant lymphoma from an African child, Int. J. Cancer 1: 89–106.
Rafferty, K. A., JR., 1964, Kidney tumors of the leopard frog: A review, Cancer Res. 24: 169–185.
Rakusanova, T., Ben-Porat, T., Himeno, M., Kaplan, A. S., 1971, Early functions of the genome of herpesvirus. I. Characterization of the RNA synthesized in cycloheximide-treated, infected cells, Virology 46: 877–889.
Rakusanova, T., Ben-Porat, T., Kaplan, A. S., 1972, Effect of herpesvirus infection on the synthesis of cell-specific RNA, Virology 49: 537–548.
Rapp, F., Duff, R., 1972a, Transformation of hamster cells after infection by inactivated herpes simplex virus type 2, in: Oncogenesis and Herpesviruses ( P. M. Biggs, G. de Thé, L. N. Payne, eds.), pp. 447–450, International Agency for Research on Cancer, Lyon.
Rapp, F., Duff, R., 1972b, In vitro cell transformation by herpesviruses, Fed. Proc. 21: 1660–1668.
Rapp, F., Duff, R., 1973, Transformation of hamster embryo fibroblasts by herpes simplex viruses type 1 and 2, Cancer Res. 33: 1527–1534.
Rapp, F., Conner, R., Glaser, R., Duff, R., 1972, Absence of leukosis virus markers in hamster cells transformed by herpes simplex virus type 2, J. Virol. 9: 1059–1063.
Rapp, F., LI, J., Jerkofsky, M., 1973, Transformation of mammalian cells by DNA-containing viruses following photodynamic inactivation, Virology 55: 339–346.
Rawls, W. E., 1973, Herpes Simplex Virus in Herpesviruses (A. S. Kaplan, ed.), Academic Press, New York, pp. 291–325.
Rawls, W. E., Tompkins, W. A. F., Melnick, J. L., 1969, The association of herpesvirus type 2 and carcinoma of the uterine cervix, Am. J. Epidemiol. 89: 547–554.
Rawls, W. E., Iwamoto, K., Adam, E., Melnick, J. L., Green, G. H., 1970, Herpes virus type 2 antibodies and carcinoma of the cervix, Lancet 2: 1142–1143.
Rawls, W. E., Adam, E., Melnick, J. L., 1973, An analysis of seroepidemiological studies of herpesvirus type L and carcinoma of the cervix, Cancer Res. 33: 1477–1482.
Reedman, B. M., Klein, G., 1973, Cellular localization of an Epstein-Barr virus (EBV)-associated complement-fixing antigen in producer and nonproducer lymphoblastoid cell lines, Int. J. Cancer 11: 499–520.
Reissig, M., Kaplan, A. S., 1960, The induction of amitotic nuclear division by pseudorabies virus multiplying in single rabbit kidney cells, Virology 11: 1–11.
Roane, P. R., Jr., Roizman, B., 1964a, Requirement for continuous protein synthesis for the development of resistance to UV light in HEp-2 cells infected with herpes simplex virus, Biochim. Biophys. Acta 91: 168–170.
Roane, P. R., Jr., Roizman, B., 1964b, Studies of the determinant antigens of viable cells. II. Demonstration of altered antigenic reactivity of HEp-2 cells infected with herpes simplex virus, Virology 22: 1–8.
Rocchi, G., Hewetson, J., Henle, W., 1973, Specific neutralizing antibodies in EBV associated diseases, Int. J. Cancer 11: 637–647.
Rogers, H. W., Scott, L. V., Patnode, R. A., 1972, Sensitization of guinea pigs to herpes simplex virus, J. Immunol. 109: 801–806.
Roizman, B., 1962a, Polykaryocytosis induced by viruses, Proc. Natl. Acad. Sci. 48: 228–234.
Roizman, B., 1962b, Polykaryocytosis, Cold Spring Harbor Symp. Quant. Biol. 27: 327–342.
Roizman, B., 1963, The programming of herpes virus multiplication in doubly-infected and in puromycin-treated cells, Proc. Natl. Acad. Sci. 49: 165–171.
Roizman, B., 1965, An inquiry into the mechanisms of recurrent herpes infections of man, in: Perspectives in Virology Vol. IV ( M. Pollard, ed.), Hoeber, New York, pp. 283–304.
Roizman, B., 1969, The herpesviruses—A biochemical definition of the group, in: Current Topics in Microbiology and Immunology, Vol. 49, Springer, Heidelberg, pp. 1–79.
Roizman, B., 1971a, Herpesvirus, man and cancer—Or the persistence of the viruses of love, in: Of Microbes and Life (J. Monod and E. Borek, eds.), Columbia University, New York, pp. 189–214.
Roizman, B., 1971b, Herpesviruses, membranes and the social behavior of infected cells, in: Proceedings of the Third International Symposium on Applied and Medical Virology, Fort Lauderdale, Fla., Warren Green Pub., St. Louis, pp. 37–72.
Roizman, B., 1972, Biochemical features of herpesvirus infected cells particularly as they relate to their potential oncogenicity, in: Oncogenesis and Herpesviruses ( P. M. Biggs, G. de Thé, L. N. Payne, eds.), International Agency for Research on Cancer, Lyon, pp. 1–17.
Roizman, B., Aurelian, L., 1965, Abortive infection of canine cells by herpes simplex virus. I. Characterization of viral progeny from cooperative infection with mutant differing in ability to multiply in canine cells, J. Mol. Biol. 11: 528–538.
Roizman, B., Furlong, D., 1974, The replication of herpesviruses, in: Comprehensive Virology, Vol. 3 ( H. Fraenkel Conrat and R. R. Wagner, eds.), Plenum Press, New York. pp. 229–403.
Roizman, B., Roane, P. R., Jr., 1961a, A physical difference between two strains of herpes simplex virus apparent on sedimentation in cesium chloride, Virology 15: 75–79.
Roizman, B., Roane, P. R., JR., 1961b, Studies of the determinant antigens of viable cells. I. A method, its application in tissue culture studies, for enumeration of killed cells, based on the failure of virus multiplication following injury by cytotoxic antibody and complement, J. Immunol. 87: 714–727.
Roizman, B., Roane, P. R„ Jr., 1963, Demonstration of a surface difference between virions of two strains of herpes simplex virus, Virology 19: 198–204.
Roizman, B., Roane, P. R., JR., 1964, The multiplication of herpes simplex virus. II. The relation between protein synthesis and the duplication of viral DNA in infected HEp-2 cells, Virology 22: 262–269.
Roizman, B., Spear, P. G., 1971, Herpesvirus antigens on cell membranes detected by centrifugation of membrane-antibody complexes, Science 171: 298–300.
Roizman, B., Spear, P. G., 1973, Herpesviruses, in: Ultrastructure of Animal Viruses and Bacteriophages: An Atlas ( A. J. Dalton and F. Haguenau, eds.), Academic Press, New York, pp. 83–107.
Roizman, B., Spring, S. B., 1967, Alteration in immunologic specificity of cells infected with cytolytic viruses, in: Proceedings of the Conference on Cross-Reacting Antigens and Neoantigens ( J. J. Trentin, ed.), Williams and Wilkins, Baltimore, pp. 85–96.
Roizman, B., Borman, G. S., Kamali-Rousta, M., 1965, Macromolecular synthesis in cells infected with herpes simplex virus, Nature (Lord.) 206: 1374–1375.
Roizman, B., Spring, S. B., Roane, P. R., Jr., 1967, Cellular compartmentalization of herpesvirus antigens during viral replication, J. Virol. 1: 181–192.
Roizman, B., Bachenheimer, L., Wagner, E. K., Savage, T., 1970, Synthesis and transport of RNA in herpesvirus-infected mammalian cells, Cold Spring Harbor Symp. Quant. Biol. 35: 753–771.
Roizman, B., Spear, P. G., Kieff, E. D., 1973, Herpes simplex viruses I and II: A biochemical definition, in: Perspectives in Virology, Vol. VIII ( M. Pollard, ed.), Academic Press, New York, pp. 129–169.
Roizman, B., Kozak, M., Honess, R. W., Hayward, G. 1974, Regulation of herpesvirus macromolecular synthesis: Evidence for multilevel regulation of herpes simplex 1 RNA and protein synthesis, Cold Spring Harbor Symp. Quant. Biol. 39: 1975.
Roizman, B., Hayward, G., Jacob, R., Wadsworth, S., Frenkel, N., Honess, R., Kozak, M., 1975, A model for molecular organization and regulation of herpesviruses, in: Proceedings of a Symposium on Oncogenesis and Herpesviruses ( H. zur Hausen, G. de Thé, M. Epstein, eds.), International Agency for Research on Cancer, Lyon.
Rosenberg, G. L., Wohlenberg, C., Nahmias, A. J., Notkins, A. L., 1972, Differentiation of type 1 and type 2 herpes simplex virus by in vitro stimulation of immune lymphocytes, J. Immunol. 109: 413–414.
Ross, L. J. N., Watson, D. H., Wildy, P., 1968, Development and localization of virus-specific antigens during the multiplication of herpes simplex virus in BHK 21 cells, J. Gen. Virol. 2: 115–122.
Ross, L. J. N., Cameron, K. R., Wildy, P., 1972a, Ultraviolet irradiation of herpes simplex virus: Reactivation processes and delay in virus multiplication, J. Gen. Virol. 16: 299–311.
Ross, L. J. N., Frazier, J. A., Biggs, P. M., 1972b, An antigen common to some avian and mammalian herpesviruses, in: Oncogenesis and Herpesvirus (P. M. Biggs, G. de Thé, L. N. Payne, eds.), International Agency for Research on Cancer, Lyon, pp. 480–484.
Rotkin, I. D., 1967, Sexual characteristics of a cervical cancer population, Am. J. Pub. Health 57: 815–829.
Rotkin, I. D., 1973, A comparison review of key epidemiologic studies in cervical cancer related to current searches for transmissible agents, Cancer Res. 33: 1353–1367.
Royston, I., Aurelian, L., 1970a, The association of genital herpesvirus with cervical atypia and carcinoma in situ, Am. J. Epidemiol. 91: 531–538.
Royston, I., Aurelian, L., 1970b, Immunofluorescent detection of herpesvirus antigens in exfoliated cells from human cervical carcinoma, Proc. Natl. Acad. Sci. 67: 204–212.
Rubenstein, D. S., Gravell, M., Darlington, R., 1972, Protein kinase in enveloped herpes simplex virions, Virology 50: 287–290.
Sabin, A. B., 1974, Herpes simplex-genitalis virus nonvirion antigens and their implication in certain human cancers: Unconfirmed, Proc. Natl. Acad. Sci. 71: 3248–3252.
Sabin, A. B., Tarro, G., 1973, Herpes simplex and herpes genitalis viruses in etiology of some human cancers, Proc. Natl. Acad. Sci. 70: 3225–3229.
Savage, T., Roizman, B., Heine, J. W., 1972, The proteins specified by herpes simplex virus. VII. Immunologic specificity of the glycoproteins of subtypes I and II, J. Gen. Virol. 17: 31–48.
Sawyer, R., Evans, A., Niederman, J., Mccollum, R., 1971, Prospective studies of a group of Yale University freshmen. I. Occurrence of infectious mononucleosis, J. Infect. Dis. 123: 263–270.
Schidlovsky, G., Toplin, I., 1966, Partial purification and electron microscopy of the virus in the EB-3 cell line derived from a Burkitt lymphoma, Science 152: 1084–1085.
Schiek, W., 1967, Die Massendichte des Herpes simplex-Virus im Casiumchlorid-WasserGradienten: Beziehungen zur Plaquemorphologie auf HeLa-Zellen und sum serologischen Typ, Z. Immunitat. 132: 207–217.
Schiek, W., Schneweiss, K. E., 1968, Beitrag zur Massendichte von Plaque Varianten des Herpesvirus hominis im Caesiumchlorid-Wasser-Gradienten (Density of plaque variants in type herpes simplex virus under cesium chloride-water gradients), Arch. Ges. Virusforsch. 23: 280–283.
Schneweiss, K. E., 1962, Der cytopatische Effekt des Herpes simplex Virus, Zbl. Bakteriol. 186: 467–485.
Schneweiss, K. E., Sommerhauser, H., Huber, D., 1972, Biologic and immunologic comparison of two plaque variants of herpes simplex virus type 1, Arch. Ges. Virusforsch. 38: 338–346.
Schulte-Holthausen, H., Zur Hausen, H., 1970, Partial purification of the Epstein-Barr virus and some properties of its DNA, Virology 40: 776–779.
Schwartz, J., Roizman, B., 1969a, Similarities and differences in the development of laboratory strains and freshly isolated strains of herpes simplex virus in HEp-2 cells: Electron microscopy, J. Virol. 4: 879–889.
Schwartz, J., Roizman, B., 1969b, Concerning the egress of herpes simplex virus from infected cells: Electron microscope observations, Virology 38: 42–49.
Scott, T. F. Mcn., Burgoon, C. F., Coriell, L. L., Blank, M., 1953, The growth curve of the virus of herpes simplex in rabbit corneal cells grown in tissue culture with parallel observations on the development of the intranuclear inclusion body, J. Immunol. 71: 385–396.
Shanmugaratnan, K., 1972, The pathology of nasopharyngeal carcinoma, in: Oncogenesis and Herpesvirus ( P. M. Biggs, G. de Thé, L. N. Payne, eds.), International Agency for Research on Cancer, Lyon, pp. 239–248.
Sharp, P., Pettersson, U., Sambrook, J., 1974, Viral DNA in transformed cells, J. Mol. Biol. 86: 709–725.
Sheldon, P. J., Papamichael, M., Hemsted, E. H., Holborow, E. J., 1973, Thymic origin of atypical lymphoid cells in infectious mononucleosis, Lancet 2: 1153–1155.
Sheldrick, P., Berthelot, N., 1974, Inverted repetitions in the chromosome of herpes simplex virus, Cold Spring Harbor Symp. Quant. Biol. 39.
Sheldrick, P., Laithier, M., Lando, D., Ryhiner, M. L., 1973, Infectious DNA from herpes simplex virus: Infectivity of double-stranded and single-stranded molecules, Proc. Natl. Acad. Sci. 70: 3621–3625.
Shope, T. C., Miller, G., 1973, Epstein-Barr virus: Heterophile responses in squirrel monkeys inoculated with virus-transformed autologous leukocytes, J. Exp. Med. 137: 140–147.
Siegert, R. S., Falke, D., 1966, Electron microscopic investigation of the development of herpes hominis virus in culture cells, Arch. Ges. Virusforsch. 19: 230–249.
Silverstein, S., Bachenheimer, S. L., Frenkel, N., Roizman, B., 1973, The relationship between post transcriptional adenylation of herpesvirus RNA and mRNA abundance (paper No. 8 in the series on RNA synthesis in cells infected with herpes simplex virus), Proc. Natl. Acad. Sci. 70: 2101–2104.
Silvestre, D., Kowilsky, F., Klein, G., Yath, Y., Neuport Sautes, C., Levy, J., 1971, Relationship between EBV associated membrane antigen on B L cells and the viral envelope demonstrated by immunofunction labelling, Int. J. Cancer 8: 222–233.
Skinner, G. R. B., Thouless, M. E., Jordan, J. A., 1971, Antibodies to type 1 and type 2 herpesvirus in women with abnormal cervical cytology, J. Obstet. Gynecol. Brit. Commonw. 78: 1031–1038.
Smith, J. D., De Harven, E., 1973, Herpes simplex virus and human cytomegalovirus replication in W1–38 cells. I. Sequence of viral replication, J. Virol. 12: 919–930.
Smith, J. W., Adam, E., Melnick, J. L., Rawls, W. E., 1972a, Use of the 51Cr release test to demonstrate patterns of antibody response in humans to herpesvirus types 1 and 2, J. Immunol. 109: 554–564.
Smith, J. W., Lowry, S. P., Melnick, J. L., Rawls, W. E., 1972b, Antibodies to surface antigens of herpesvirus type 1 and type 2 infected cells among women with cervical cancer and control women, Infect. Immun. 5: 305–310.
Smith, K. O., 1963, Physical and biological observations on herpes virus, J. Bacteriol. 86:999–1009
Smith, K. O., 1964, Relationship between the envelope and infectivity of herpes simplex virus, Proc. Soc. Exp. Biol. Med. 115: 814–816.
Spear, P. G., Roizman, B., 1967, The buoyant density of herpes simplex virus in CsCI solutions, Nature (Lond.) 214: 713–714.
Spear, P. G., Roizman, B., 1970, The proteins specified by herpes simplex virus. IV. The site of glycosylation and accumulation of viral membrane proteins, Proc. Natl. Acad. Sci. 66: 730–737.
Spear, P. G., Roizman, B., 1972, Proteins specified by herpes simplex virus. V. Purification and structural proteins of the herpesvirion, J. Virol. 9: 143–159.
Spear, P. G., Keller, J. M., Roizman, B., 1970, The proteins specified by herpes simplex virus. II. Viral glycoproteins associated with cellular membranes, J. Virol. 5: 123–131.
Spring, S. B., Roizman, B., 1968, Herpes simplex virus products in productive and abortive infection. III. Differentiation of infectious virus derived from nucleus and cytoplasm with respect to stability and size, J. Virol 2: 979–985.
Spring, S. B., Roizman, B., Schwartz, J., 1968, Herpes simplex virus products in productive and abortive infection. II. Electron microscopic and immunological evidence for failure of virus envelopment as a cause of abortive infection, J. Virol. 2: 384–392.
Springer, G. F., Seifert, M. H., Adye, J. C., Eyquem, A., 1974, Immunization of humans with infectious mononucleosis receptors from mammalian erythrocytes, Clin. Immunol. Immunopathol.
Steel, C., Mcbeath, S., O’riordan, M., 1971, Human lymphoblastoid cell lines. II. Cytogenetic studies, J. Natl. Cancer Inst. 47: 1203–1214.
Stein, S., Todd, P., Mahoney, J., 1970, The arginine requirement for nucleocapsid maturation in herpes simplex development, Canad. J. Micros. 16: 851–854.
Stern, H., 1972, Cytomegalovirus and EB virus infections of the liver, Brit. Med. Bull. 28: 180–185.
Stertz, H., Ludwig, H., Rott, R., 1974, Immunologic and genetic relationship between herpes simplex virus and bovine herpes mammillitis virus, Intervirology 2: 1–13.
Stevens, J. G., Cook, M. L., 1971a, Latent herpes simplex virus in spinal ganglia of mice, Science 173: 843–845.
Stevens, J. G., Cook, M. L., 19716, Restriction of herpes simplex virus by macrophages: An analysis of the cell-virus interaction, J. Exp. Med. 133: 19–38.
Stevens, J. G., Cook, M. L., 1972, Latent herpes simplex virus in sensory ganglia, in: Perspectives in Virology, Vol. VIII ( M. Pollard, ed.), Academic Press, New York, pp. 171–188.
Stevens, J. G., Cook, M. L., 1973, Latent infections induced by herpes simplex virus, Cancer Res. 33: 1399–1401.
Stewart, S., Lovelace, E., Whang, J., Ngu, V., 1965, Burkitt tumor, tissue culture, cytogenetic and viral studies, J. Natl. Can. Inst. 34: 319–328.
Stich, H. F., Hsu, T. C., Rapp, F., 1964, Viruses and mammalian chromosomes. I. Localization of chromosome aberrations after infection with herpes simplex virus, Virology 22: 439–445.
Stoker, M. G. P., 1959, Growth studies with herpes virus, in: Ninth Symposium of the Society for Microbiology, Cambridge University Press, Cambridge, pp. 142–170.
Stoker, M. G. P., Newton, A. A., 1959, Mitotic inhibitors in HeLa cell and caused by herpes virus, Ann. N.Y. Acad. Sci. 81: 129–132.
Subak-Sharpe, H., Hay, J., 1965, An animal virus with DNA of high guanine + cytosine content which codes for sRNA, J. Mol. Biol. 12: 924–928.
Subak-Sharpe, H., Shepherd, W. M., Hay, J., 1966, Studies on sRNA coded by herpes virus, Cold Spring Harbor Symp. Quant. Biol. 31: 583–594.
Sugawara, K., Mizuno, F., Osato, T., 1972, Epstein-Barr virus-associated antigens in nonproducing clones of human lymphoblastoid cell lines, Nature New Biol. 239: 242–243.
Svedmyr, A., Demissie, A., 1968, Age distribution of antibodies to Burkitt cells, Acta Pathol. Microbiol. Scand. 73: 653–654.
Svedmyr, A., Demissie, A., 1971, Complexity of antigen-antibody systems associated with Epstein-Barr virus, Ann. N.Y. Acad. Sci. 177: 241–249.
Swanson, J. L., Craighead, J. E., Reynolds, E. S., 1966, Electron microscopic observations on herpesvirus hominis (herpes simplex virus) encephalitis in man, Lab. Invest. 15: 1966–1981.
Sydiskis, R. J., Roizman, B., 1966, Polysomes and protein synthesis in cells infected with a DNA virus, Science 153: 76–78.
Sydiskis, R. J., Roizman, B., 1967, The disaggregation of host polyribosomes in productive and abortive infection with herpes simplex virus, Virology 32: 678–686.
Sydiskis, R. J., Roizman, B., 1968, The sedimentation profiles of cytoplasmic polyribosomes in mammalian cells productively and abortively infected with herpes simplex virus, Virology 34: 562–565.
Taniguchi, S., Yoshino, K., 1965, Studies on the neutralization of herpes simplex virus. II. Analysis of complement as the antibody-potentiating factor, Virology 26: 54–60.
Tarro, G., Sabin, A. B., 1970, Virus specific, labile, nonvirion antigen in herpesvirus-infected cells, Proc. Natl. Acad. Sci. 65: 753–760.
Tarro, G., Sabin, A. B., 1973, Nonvirion antigens produced by herpes simplex viruses 1 and 2, Proc. Natl. Acad. Sci. 70: 1032–1036.
Terni, M., 1971, Infection with the virus of herpes simplex, the recrudescence of the disease and the problem of latency, G. Mal. Infet. Parassit. 28: 433–468.
Tevethia, S. S., Lowry, S., Rawls, W. E., Melnick, J. L., Mcmillan, V., 1972, Detection of early cell surface changes in herpes simplex virus infected cells by agglutination with concanavalin A., J. Gen. Virol. 15: 93–97.
Thouless, M. E., 1972, Serological properties of thymidine kinase produced in cells infected with type 1 or type 2 herpesvirus, J. Gen. Virol. 17: 307–315.
Tokumaru, T., 1957, Pseudorabies virus in tissue culture: Differentiation of two distinct strains of virus by cytopathogenic pattern induced, Proc. Soc. Exp. Biol. Med. 96: 55–60.
Tokumaru, T., 1966, A possible role of yA-immunoglobulin in herpes simplex virus infection in man, J. Immunol. 97: 248–259.
Toplin, I., Schidlovsky, G., 1966, Partial purification and electron microscopy of virus in the EB-3 cell line derived from a Burkitt lymphoma, Science 152: 1084–1085.
University Health Physicians And Phls, 1971, Infectious mononucleosis and its relationship to EB virus antibody, Brit. Med. J. 4: 643–646.
Vahlne, A. G., Blomberg, J., 1974, Purification of herpes simplex virus, J. Gen. Virol. 22: 297–302.
Van Hoosier, G. L., Melnick, J. L., 1961, Neutralizing antibodies in human sera to herpes simiae (B virus), Texas Rep. Biol. Med. 19: 376–380.
Vantis, J. T., Wildy, P., 1962, Interaction of herpes virus and HeLa cells: Comparison of cell killing and infective center formation, Virology 17: 225–232.
Vonka, V., Benyesh-Melnick, M., Mccombs, R., 1970a, Antibodies in human sera to soluble and viral antigens found in Burkitt lymphoma and other lymphoblastoid cell lines, J. Natl. Cancer Inst. 44: 865–872.
Vonka, V., Benyesh-Melnick, M., Lewis, R. T., Wimberly, I., 1970b, Some properties of the soluble (S) antigen of cultured lymphoblastoid cell lines, Arch. Ges. Virusforsch. 31: 113–124.
Wagner, E. K., 1972, Evidence for transcriptional control of the herpes simplex genome in infected human cells, Virology 47: 502–506.
Wagner, E. K., Roizman, B., 1969a, RNA synthesis in cells infected with herpes simplex virus. I. The patterns of RNA synthesis in productively infected cells, J. Virol. 4: 36–46.
Wagner, E. K., Roizman, B., 1969b, RNA synthesis in cells infected with herpes simplex virus. II. Evidence that a class of viral mRNA is derived from a high molecular weight precursor synthesized in the nucleus, Proc. Natl. Acad. Sci. 64: 626–633.
Wagner, E. K., Roizman, B., Savage, T., Spear, P. G., Mizell, M., Dyjrr, F. E., Sypowicz, D., 1970, Characterization of the DNA of herpesviruses associated with Lucké adenocarcinoma of the frog and Burkitt lymphoma of man, Virology 42: 257–261.
Wagner, E. K., Tewari, K. K., Kolodnes, R., Warner, R. C., 1974, The molecular size of the herpes simplex virus type 1 genome, Virology 57: 436–447.
Wahren, B., Carlens, E., Espmark, A., Lundbeck, H., Löfgren, S., Madar, E., Henle, G., Henle, W., 1971, Antibodies to various herpes viruses in sera from patients with sarcoidosis, J. Natl. Cancer Inst. 47: 747–756.
Wallis, C., Melnick, J. L., 1971, Herpesvirus neutralization: The role of complement, J. Immunol. 107: 1235–1242.
Walters, M. K., Pope, J. H., 1971, Studies of the EB virus-related antigens of human leukocyte cell lines, Int. J. Cancer 8: 32–40.
Watkins, J. F., 1964, Adsorption of sensitized sheep erythrocytes to HeLa cells infected with herpes simplex virus, Nature (Lond.) 202: 1364–1365.
Watson, D. H., Wildy, P., Russell, W. C., 1964, Quantitative electron microscope studies on the growth of herpes virus using the techniques of negative staining and ultramicrotomy, Virology 24: 523–538.
Watson, D. H., Wildy, P., Harvey, B. A. M., Shedden, W. I. H., 1967, Serological relationship among viruses of the herpes group, J. Gen. Virol. 1: 139–141.
Weinberg, A., Becker, Y., 1969, Studies on EB virus of Burkitt’s lymphoblasts, Virology 39: 312–321.
Wetmur, J., Davidson, N., 1968, Kinetics of renaturation of DNA, J. Mol. Biol. 31: 349–370.
Wheeler, C. E., 1964, Biologic comparison of a syncytial and a small giant cell-forming strain of herpes simplex, J. Immunol. 93: 749–756.
Wilbanks, G. D., Campbell, J. A., 1972, Effect of herpesvirus hominis type 2 on human cervical epithelium: Scanning electron microscopic observations, Am. J. Obstet. Gynecol. 112: 924–929.
Wildy, P., 1973, Antigens of herpes simplex virus of oral and genital origin, Cancer Res. 33: 1465–1468.
Wildy, P., Russell, W. C., Horne, R. W., 1960, The morphology of herpes virus, Virology 12: 204–224.
Wilkie, N. M., 1973, The synthesis and substructure of herpesvirus dna: The distribution of alkali-labile single strand interruptions in HSV-1 DNA, J. Gen. Virol. 21: 453–467.
Wilton, J. M. A., Ivanyi, L., Lehner, T., 1972, Cell-mediated immunity in herpesvirus hominis infections, Brit. Med. J. 1: 723–726.
Wolf, H., Zur Hausen, H., Becker, V., 1973, EB viral genomes in epithelial nasopharyngeal carcinoma cells, Nature New Biol. 244: 245–247.
Wright, D. H., 1972, The pathology of Burkitt’s lymphoma, in: Oncogenesis and Herpesvirus ( P. M. Biggs, G., de Thé, L. N. Payne, eds.), International Agency for Research on Cancer, Lyon, pp. 217–229.
Yamaguchi, J., Hinuma, Y., Grace, J. T., Jr., 1967, Structure of virus particles extracted from a Burkitt lymphoma cell line, J. Virol. 1: 640–642.
Yamamoto, Y., 1966, A re-evaluation of the skin test of herpes simplex virus, Jap. J. Microbiol. 10: 67–77.
Yoshino, K., Taniguchi, S., 1965, Studies on the neutralization of herpes simplex virus. III. Mechanism of the antibody-potentiating action of complement, Virology 26: 61–72.
Yoshino, K., Taniguchi, S., 1966, Evaluation of the demonstration of complement-requiring neutralizing antibody as a means for early diagnosis of herpes virus infections, J. Immunol. 96: 196–203.
Zajac, B. A., Kohn, G., 1970, Epstein-Barr virus antigens, marker chromosome, interferon production in clones derived from cultured Burkitt tumor cells, J. Natl. Cancer Inst. 45: 399–406.
Zemla, J., Coto, C., Kaplan, A. S., 1967, Correlation between loss of enzymatic activity and of protein from cells infected with pseudorabies virus, Virology 31: 736–738.
Zimmerman, J. E., JR., Glaser, R., Rapp, F., 1973, Effect of dibutyryl cyclic AMP on the induction of Epstein-Barr virus in hybrid cells, J. Virol. 12: 1442–1445.
Zisman, B., Hirsch, M. S., Allison, A. C., 1970, Selective effects of antimacrophage serum, silica and anti-lymphocyte serum on pathogenesis of herpes virus infection of young adult mice, J. Immunol. 104: 1155–1159.
Zur Hausen, H., 1972, EBV in human tumor cells, in: International Review of Experimental Pathology, Vol. II ( G. Richter and M. Epstein, eds.), Academic Press, London, pp. 233–258.
Zur Hausen, H., Schulte-Holthausen, H., 1970, Presence of EB-virus nucleic acid homology in a “virus-free” line of Burkitt tumor cells, Nature (Lond.) 227: 245–248.
Zur Hausen, H., Schulte-Holthausen, H., 1972, Detection of Epstein-Barr viral genomes in human tumor cells by nucleic acid hybridization, in: Oncogenesis and Herpesvirus ( P. M. Biggs, G. de Thé, L. N. Payne, eds.), International Agency for Research on Cancer, Lyon, pp. 321–325.
Zur Hausen, H., Henle, W., Hummeler, K., Diehl, V., Henle, G., 1967, Comparative study of cultured Burkitt tumor cells by immunofluorescence autoradiography and electronmicroscopy, J. Virol. 1: 830–837.
Zur Hausen, H., Schulte-Holthausen, H., Klein, G., Henle, W., Henle, G., Clifford, P., Santesson, L., 1970, EBV DNA in biopsies of Burkitt tumors and anaplastic carcinomas of the nasopharynx, Nature (Lond.) 228: 1056–1058.
Zur Hausen, H., Diehl, V., Wolf, H., Schulte-Holthausen, H., Schneider, U., 1972, Occurrence of Epstein-Barr virus genomes in human lymphoblastoid cell lines, Nature New Biol. 237: 189–190.
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Roizman, B., Kieff, E.D. (1975). Herpes Simplex and Epstein-Barr Viruses in Human Cells and Tissues: A Study in Contrasts. In: Becker, F.F. (eds) Cancer a Comprehensive Treatise 2. Cancer, vol 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-2733-2_7
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