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Pathophysiology of Perinatal Hypoxic-ischemic Brain Damage

  • Chapter
Biology of Brain Dysfunction

Abstract

Impaired learning, cerebral palsy, and other forms of limited or abnormal neurological development blight the lives of an estimated 10% of children in Western society. Although the mechanisms for a substantial percentage of these abnormalities in development are at least partly explained by alreadyknown anatomical or chemical disorders, the causes for many of the cases remain elusive (Fig. 1). Among the known causes of mental and physical retardation, perinatal anoxic-ischemic injury ranks high, and we review here the present understanding and some of the known problems of this important cause of human disability.

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  1. Robert C. Vannucci

    Present address: Departments of Pediatrics and Neurology, Hershey Medical Center, Hershey, Pa., USA

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  1. Department of Neurology, New York Hospital-Cornell Medical Center, New York, New York, USA

    Robert C. Vannucci & Fred Plum

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  1. New York State Institute for Basic Research in Mental Retardation, Staten Island, New York, USA

    Gerald E. Gaull

  2. Mount Sinai School of Medicine, City University of New York, New York, New York, USA

    Gerald E. Gaull

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Vannucci, R.C., Plum, F. (1975). Pathophysiology of Perinatal Hypoxic-ischemic Brain Damage. In: Gaull, G.E. (eds) Biology of Brain Dysfunction. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-2673-1_1

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