Biology of Aging and Development

1. Front Matter

   Pages i-viii

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2. Introduction

   1. Introduction

      • G. J. Thorbecke

      Pages 1-1

3. Theoretical Concepts of Developmental and Age Changes

   1. Implications of aging research for society

      • Bernard L. Strehler

      Pages 3-9

   2. Current theories of biological aging

      • Leonard Hayflick

      Pages 11-19

   3. Towards a theory of development

      • L. Wolpert, J. H. Lewis

      Pages 21-34

4. Gene regulation in differentiation and development

   1. Introductory remarks

      • Michael Potter

      Pages 35-39

   2. Surface reorganization as an initial inductive event in the differentiation of prothymocytes to thymocytes

      • E. A. Boyse, J. Abbott

      Pages 41-48

   3. Germ line basis for antibody diversity

      • A. R. Williamson, E. Premkumar, M. Shoyab

      Pages 49-58

   4. Sequential expression of germ line genes in development of immunoglobulin class diversity

      • A. R. Lawton, P. W. Kincade, M. D. Cooper

      Pages 59-71

   5. Normal and altered phenotypic expression of immunoglobulin genes

      • Rose G. Mage

      Pages 73-85

   6. Expression of specific clones during B cell development

      • Norman R. Klinman, Joan L. Press

      Pages 87-95

5. Finite Versus Infinite Proliferative and Functional Capacities of Cells

   1. Growth and death of diploid and transformed human fibroblasts

      • Robin Holliday

      Pages 97-106

   2. Pathological implications of cell aging in vitro

      • S. Goldstein, S. Niewiarowski, D. P. Singal

      Pages 107-122

   3. Unlimited division potential of precancerous mouse mammary cells after spontaneous or carcinogen-induced transformation

      • C. W. Daniel, B. D. Aidells, D. Medina, L. J. Faulkin Jr.

      Pages 123-130

   4. Restricted replicative life-span of diabetic fibroblasts in vitro: its relation to microangiopathy

      • Rudolf Vracko, Earl P. Benditt

      Pages 131-135

   5. Hayflick’s hypothesis: an approach to in vivo testing

      • U. Reincke, H. Burlington, E. P. Cronkite, J. Laissue

      Pages 137-147

   6. Contributions of cytoplasmic factors to in vitro cellular senescence

      • Woodring E. Wright, Leonard Hayflick

      Pages 149-157

6. Aging of homeostatic control systems

   1. Introductory remarks

      • Paola S. Timiras

      Pages 159-160

   2. Age-related changes in thermoregulatory capacity of tryptophan-deficient rats

      • Paul E. Segall, Paola S. Timiras

      Pages 161-166

   3. Zinc deficiency and brain development in the rat

      • Harold H. Sandstead, Gary J. Fosmire, Joan M. McKenzie, Edward S. Halas

      Pages 167-172

"e of the reasons for all the F ASEB Societies to meet yearly is the possibility O to interrelate recent progress in diverse areas of research. The F ASEB Conferences have been organized to promote such interdisciplinary approaches. They center around a basic theme with the aim of discussing active research, in­ cluding widely divergent approaches, towards a better understanding of a general biological phenomenon. Because of the mounting interest in the subject of aging and development, this has been chosen as the theme for this year's symposia. We have necessarily been limited in the number of topics that could be covered. In our choice we have attempted to' select those facets of the main subject which at this time are gen­ erating active research interest among our membership. We have included invited speakers from abroad, such as Drs. Goldstein, Liew and Miller from Canada and Drs. Wolpert, Holliday and Williamson from England. I am sorry to say that the two speakers that we had invited from Russia, Dr. Frolkis, and from Czechoslovakia, Dr. Sterzl, were unable to attend.

• aging
• biology
• cancer
• development
• research
• senescence

• New York University School of Medicine, USA

  G. Jeanette Thorbecke

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