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The Skin and Gastrointestinal Malignancy

  • Chapter
Gastrointestinal Tract Cancer

Part of the book series: Sloan-Kettering Institute Cancer Series ((SKICS))

Abstract

It is not uncommon for abnormalities of the skin and malignant disease of an internal organ to coexist, although the relationship between the two is not always of straightforward cause and effect. There are four possibilities:

  1. 1.

    The internal malignancy can be the cause of the skin disorder.

  2. 2.

    The skin disorder can cause the internal malignancy.

  3. 3.

    Skin disease and internal malignancy can occur as part of the same pathological process or in response to a common stimulus.

  4. 4.

    Skin disease and internal malignancy may be related not by cause and effect as in 1 and 2, nor by a common pathology as in 3, but indirectly as in the genetic cutaneosystemic syndromes.

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References

  • Achord, J. L., and Proctor, H. D., 1963, Malignant degeneration and metastasis in Peutz-Jeghers syndrome, Arch. Intern. Med. 111: 498–502.

    Google Scholar 

  • Albright, E. C., and Allday, R. W., 1967, Thyroid carcinoma after radiation therapy for adolescent acne, J. Am. Med. Assoc. 199: 280–281.

    Google Scholar 

  • Anderson, H., Dotevall, G., and Mabacken, H., 1971, Malignant mesenteric lymphoma in a patient with dermatitis herpetiformis, hypochlorhydria and small bowel abnormalities, Scand. J. Gastroenterol. 6: 397–399.

    Article  Google Scholar 

  • Austad, W. I., Cornes, J. S., Gough, K. R., McCarthy, C. F., and Read, A. E., 1967, Steatorrhoea and malignant lymphoma, Am. J. Digest. Dis. N.S. 12: 475–490.

    Article  CAS  Google Scholar 

  • Badenoch, J., 1960, Steatorrhoea in the adult, Br. Med. J. 2: 879–887.

    Article  PubMed  CAS  Google Scholar 

  • Berlin, C., 1955, Urticaria pigmentosa as a systemic disease, Arch. Dermatol. 71:703–712. Bluefarb, S. M., 1960, Leukemia Cutis, Thomas, Springfield, Ill.

    Google Scholar 

  • Brett, E. M., Ong, B. H., and Friedmann, T., 1967, Mast-cell disease in children, Br. J. Dermatol. 79: 197–209.

    Article  PubMed  CAS  Google Scholar 

  • Brow, J. R., Parker, F., Weinstein, W. M., and Rubin, C. E., 1971, The small intestinal mucosa in dermatitis herpetiformis, Gastroenterology. 60: 355–361.

    PubMed  CAS  Google Scholar 

  • Bussey, H. J. R., 1970, Gastrointestinal polyposis, Gut 11: 970–978.

    Article  PubMed  CAS  Google Scholar 

  • Cooke, W. J., Peeney, A. L. P., and Hawkins, C. F., 1953, Symptoms, signs and diagnostic features of idiopathic steatorrhoea, Q. J. Med. N.S. 22: 59–77.

    CAS  Google Scholar 

  • Cormane, R. H., 1967, Immunofluorescent studies of the skin in lupus erythematosus and other diseases, Pathol. Eur. 2: 170–180.

    Google Scholar 

  • Cunliffe, W. J., Hall, R., Newell, D. J., and Stevenson, C. J., 1968, Vitiligo, thyroid disease and autoimmunity, Br. J. Dermatol. 80: 135–139.

    Article  PubMed  CAS  Google Scholar 

  • Cunliffe, W. J., Hudgson, P., Fulthorpe, J. J., Black, M. M., Hall, R., Johnston, D.D.A., and Shuster, S., 1970, A calcitonin-secreting medullary thyroid carcinoma associated with mucosal neuromas Marfanoid features, myopathy and pigmentation, Am. J. Med. 48: 120–126.

    Article  PubMed  CAS  Google Scholar 

  • Edwards, F. C., and Truelove, S. C., 1964, The course and prognosis of ulcerative colitis, Gut 5: 1–15.

    Article  PubMed  CAS  Google Scholar 

  • Ferguson, R., Basu, M. J., Asquith, P., and Cooke, W. T., 1975, Recurrent aphthous ulceration and its association with coeliac disease, Gut 16: 393.

    PubMed  CAS  Google Scholar 

  • Flaxman, B. A., Zelazny, G., and Van Scott, E. J., 1971, Non-specificity of characteristic cells in mycosis fungoides, Arch. Dermatol. 104: 141–147.

    Article  PubMed  CAS  Google Scholar 

  • Fraser, N. G., 1970, Autoantibodies in dermatitis herpetiformis, Br. J. Dermatol. 83: 609–613.

    Article  PubMed  CAS  Google Scholar 

  • Fraser-Moodie, A., Hughes, R. G., Jones, S. M., Shorey, B. A., and Snape, L., 1976, Malignant melanoma metastases to the alimentary tract, Gut 17: 206–209.

    Article  PubMed  CAS  Google Scholar 

  • Fry, L., Kier, P., McMinn, R. M. H., Cowan, J. D., and Hoffbrand, A. V., 1967, Small-intestinal structure and function and haemotological changes in dermatitis herpetiformis, Lancet. 2: 729–734.

    Article  PubMed  CAS  Google Scholar 

  • Fry, L., Seah, P. P., McMinn, R. M. H., and Hoffbrand, A. V., 1972, Lymphocytic infiltration of epithelium in diagnosis of gluten-sensitive enteropathy, Br. Med. J. 3: 371–374.

    Article  PubMed  CAS  Google Scholar 

  • Fry. L., Seah, P. P., Riches, D. J., and Hoffbrand, A. V., 1973, Clearance of skin lesions in dermatitis herpetiformis after gluten withdrawal, Lancet 1: 288–291.

    Article  PubMed  CAS  Google Scholar 

  • Gardner, E. J., 1951, A genetic and clinical study of intestinal polyposis, a predisposing factor for carcinoma of the colon and rectum, Am. J. Hum. Genet. 3: 167–176.

    PubMed  CAS  Google Scholar 

  • Gebhard, R. L., Katz, S. I., Marks, J., Shuster, S., Trapani, R. J., Rogentine, G. N., and Strober, W., 1973, HL-A antigen type and small-intestinal disease in dermatitis herpetiformis, Lancet 2: 760–762.

    Article  PubMed  CAS  Google Scholar 

  • Gjone, E., and Nordöy, A., 1970, Dermatitis herpetiformis, steatorrhoea and malignancy, Br. Med. J. 1: 610.

    Article  PubMed  CAS  Google Scholar 

  • Goodwin, P., and Fry, L., 1973, Reticulum-cell sarcoma complicating dermatitis herpetiformis, Proc. R. Soc. Med. 66: 625–626.

    PubMed  CAS  Google Scholar 

  • Goolamali, S. G., Barnes, E. W., Irvine, W. J., and Shuster, S., 1974, Organ-specific antibodies in patients with lichen sclerosus, Br. Med. J. 4: 78–79.

    Article  PubMed  CAS  Google Scholar 

  • Gorlin, R. J., and Goltz, R. W., 1960, N. Eng. J. Med. 262: 908–912.

    Article  CAS  Google Scholar 

  • Graham-Smith, D. D., 1970, The carcinoid syndrome, Gut 11: 189–191.

    Article  Google Scholar 

  • Griffith, G. C., Nichols, G., Asher, J. D., and Flanagan, B., 1965, Heparin osteoporosis, J. Am. Med. Assoc. 193: 85–88.

    Article  Google Scholar 

  • Harris, O. D., Cooke, W. T., Thompson, H., and Waterhouse, J. A. H., 1967, Malignancy in adult coeliac disease and idiopathic steatorrhoea, Am. J. Med. 42: 899–912.

    Article  PubMed  CAS  Google Scholar 

  • Higgs, J. M., and Wells, R. S., 1973, Chronic inucocutaneous cannidiasis: New approach to treatment, Br. J. Dermatol. 89: 179–190.

    Article  PubMed  CAS  Google Scholar 

  • Howel-Evans, W., McConnell, R. B., Clarke, C. A., and Sheppar, P. M., 1958, Carcinoma of the oesophagus with keratosis palmaris et plantaris (tylosis), Q. J. Med. 27: 413–429.

    Google Scholar 

  • Howitz, J., and Schwartz, M., 1971, Vitiligo, achlorhydria and pernicious anaemia, Lancet 2: 1331–1335.

    Article  Google Scholar 

  • Jacobs, A., and Jenkins, D. J., 1960, Iron content of finger nails, Br. J. Dermatol. 72: 145–148.

    Article  PubMed  CAS  Google Scholar 

  • Jeghers, H., McKusick, V. A., and Katz, K. H., 1949, Generalized intestinal polyposis and melanin spots of the oral mucosa, lips and digits, N. Eng. J. Med. 241: 993–1005.

    Article  CAS  Google Scholar 

  • Kligman, A. M., 1961, Telogen effluvium: Pathologic dynamics of human hair loss, Arch. Dermatol. 83: 175–198.

    Article  PubMed  CAS  Google Scholar 

  • Kumar, P. J., and Dawson, A. M., 1973, Dermatitis herpetiformis with pernicious anaemia and thyrotoxicosis, Proc. R. Soc. Med. 66: 1128–1129.

    PubMed  CAS  Google Scholar 

  • Lancaster, Smith, M. J., and Kumar, P. J., 1974, Atrophic gastritis and dermatitis herpetiformis, Lancet. 3: 777.

    Article  Google Scholar 

  • Levy, D., and Khatib, R., 1960, Intestinal neurofibromatosis with malignant degeneration: Report of a case, Dis. Colon Rectum 3: 140–144.

    Article  PubMed  CAS  Google Scholar 

  • Mallinson, C. N., Bloom, S. R., Warin, A. P., Salmon, P. R., and Cox, B., 1974, A glucagonoma syndrome, Lancet 2: 1–5.

    Article  PubMed  CAS  Google Scholar 

  • Marks, J., 1977, Dogma and dermatitis hepatiformis, Clin. Exp. Dermatol. 2:189–207.

    Article  PubMed  CAS  Google Scholar 

  • Marks, J., Shuster, S., and Watson, A. J., 1966, Small bowel changes in dermatitis herpetiformis, Lancet 2: 1280–1282.

    Article  PubMed  CAS  Google Scholar 

  • Marks, J., Birkett, D., Shuster, S., and Roberts, D. F., 1970, Small intestinal mucosal abnormalities in relatives of patients with dermatitis herpetiformis, Gut 11: 493–497.

    Article  PubMed  CAS  Google Scholar 

  • Marks, R., and Whittle, M. W., 1969, Results of treatment of dermatitis herpetiformis with a gluten-free diet after one year, Br. Med. J. 4: 772–775.

    Article  PubMed  CAS  Google Scholar 

  • Pierard, J., and Whimster, I., 1961, The histological diagnosis of dermatitis herpetiformis, Br. J. Dermatol. 73: 253–266.

    Article  PubMed  CAS  Google Scholar 

  • Prottey, C., Hartop, P. J., and Press, M., 1975, Correction of the cutaneous manifestations of essential fatty acid deficiency in man by the application of sunflower seed oil to the skin, J. Invest. Dermatol. 64: 228–234.

    Article  PubMed  CAS  Google Scholar 

  • Reunala, T., Salo, O. P., Tülikainen, A., and Mattla, M. J., 1976, Histocompatability antigens and dermatitis herpetiformis with special reference to jejuna] abnormalities and acetylator phenotype, Br. J. Dermatol. 94: 139–143.

    Article  PubMed  CAS  Google Scholar 

  • Robson, A. O., and Jelliffe, A. M., 1963, Medicinal arsenic poisoning and lung cancer, Br. Med. J. 2: 207–209.

    Article  PubMed  CAS  Google Scholar 

  • Rowell, N. R.,1972,Lupus erythematosus, scleroderma and dermatomyositis, in: Textbook of Dermatology (A. Rook, D. S. Wilkinson, and F. J. G. Ebling, eds)., p. 1126, Blackwell, Oxford

    Google Scholar 

  • Sagher, F., and Even-Par, Z., 1967, Mastocytosis and the Mast Cell, Karger, Basel.

    Google Scholar 

  • Sagher, F., and Schorr, S., 1956, Bone lesions in urticaria pigmentosa, J. Invest. Dermatol. 26: 431–434.

    Article  PubMed  CAS  Google Scholar 

  • Scott, B. B., Young, S., Rajah, S. M., Marks, J., and Losowsky, M. S., 1975a, The incidence of coeliac disease and HL-A8 in dermatitis herpetiformis, Gut 16: 845.

    Article  PubMed  CAS  Google Scholar 

  • Scott, B. B., Hardy, G. J., and Losowsky, M. S., 1975b, Involvement of the small intestine in systemic mast cell disease, Gut 16: 918–924.

    Article  PubMed  CAS  Google Scholar 

  • Seah, P. P., Fry, L., Kearney, J. W., Campbell, E., Mawbray, J. F., Stewart, J. S., and Hoffbrand, A. V., 1976, A comparison of histocompatibility antigens in dermatitis herpetiformis and adult coeliac disease, Br. J. Dermatol. 94: 131–138.

    Article  PubMed  CAS  Google Scholar 

  • Shuster, S., 1963, High-output cardiac failure from skin disease, Lancet 1: 1338–1340.

    Article  PubMed  CAS  Google Scholar 

  • Shuster, S., 1967, The gut and the skin, in: Third Symposium on Advanced Medicine, pp. 349–361, Pitman Medical, London.

    Google Scholar 

  • Shuster, S., and Marks, J., 1965, Dermatogenic enteropathy—A new cause for steatorrhoea, Lancet 1: 1367–1368.

    Article  Google Scholar 

  • Shuster, S., and Marks, J., 1969, Dermatitis herpetiformis and the coeliac syndrome, Proc. R. Soc. Med. 62: 985–986.

    PubMed  CAS  Google Scholar 

  • Shuster, S., and Marks, J., 1970, Systemic Effects of Skin Disease, Heinemann, London. Shuster, S., and Scarborough, H., 1961, Senile purpura, Q. J. Med. 30: 33–40.

    Google Scholar 

  • Shuster, S., Watson, A. J., and Marks, J., 1968, Coeliac syndrome in dermatitis herpetiformis, Lancet 1: 1101–1106.

    Article  PubMed  CAS  Google Scholar 

  • Sneddon, I. B., 1963, The skin markers of malignancy, Br. Med. J. 2: 405–409.

    Article  PubMed  CAS  Google Scholar 

  • Solheim, B. G., Ek, J., Thune, P. 0., Baklien, K., Bratlie, A., Rankin, B., Thoresen, A. B., and Thorsby, E., 1976, HLA antigens in dermatitis herpetiformis and coeliac disease, Tissue Antigens 7: 57–59.

    Article  CAS  Google Scholar 

  • Stillman, M. A., and Baer, R. L., 1972, Pemphigus and thymoma, Acta Dermato-Venereol. 52: 393–397.

    CAS  Google Scholar 

  • Tan, R. S.-H., Butterworth, C. M., McLaughlin, H., Malka, S., and Samman, P. D., 1974, Mycosis fungoides—A disease of antigen persistence, Br. J. Dermatol. 91: 607–616.

    Article  PubMed  CAS  Google Scholar 

  • Thompson, R. P. H., Nicholson, D. C., Farnan, T., Whitmore, D. N., and Williams, R., 1970, Cutaneous porphyria due to a malignant primary hepatoma, Gastroenterology 59: 779–783.

    PubMed  CAS  Google Scholar 

  • Thomsen, M., Platz, P., Marks, J., Ryder, L. P., Shuster, S., Svejgaard, A., and Young, S. H., 1976, Association of LD-8a and LD-12a with dermatitis herpetiformis, Tissue Antigens 7: 60–62.

    Article  PubMed  CAS  Google Scholar 

  • Vickers, C. F. H., 1974, Nutrition and the skin, in: Tenth Symposium on Advanced Medicine ( J. G. G.Ledingham, ed.), Pitman Medical, London.

    Google Scholar 

  • Weinstein, W. M., 1974, Latent coeliac sprue, Gastroenterology 66: 489–493.

    PubMed  CAS  Google Scholar 

  • White, A. G., Barnetson, R. St. C., Da Costa, J. A. G., and McClelland, D. B. L., 1973, The incidence of HL-A antigens in dermatitis herpetiformis, Brit. J. Dermatol. 89: 133–136.

    Article  CAS  Google Scholar 

  • Winkelmann, R. K., and Linman, J. W., 1973, Erythroderma with atypical lymphocytes ( Sézarysyndrome ), Am. J. Med. 55: 192–198.

    Article  PubMed  CAS  Google Scholar 

  • Wormsley, K. G., 1964, The Skin and Gut in Disease, Pitman Medical, London.

    Google Scholar 

  • Wyatt, E. H., 1975, Lichen planus and ulcerative colitis, Br. J. Dermatol. 93: 465–468.

    Article  PubMed  CAS  Google Scholar 

  • Wyatt, E. H., Shuster, S., and Marks, J., 1971, A postal survey of patients with dermatitis herpetiformis, Br. J. Dermatol. 85: 511–518.

    Article  PubMed  CAS  Google Scholar 

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Marks, J., Shuster, S. (1978). The Skin and Gastrointestinal Malignancy. In: Lipkin, M., Good, R.A. (eds) Gastrointestinal Tract Cancer. Sloan-Kettering Institute Cancer Series. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-2442-3_23

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  • DOI: https://doi.org/10.1007/978-1-4684-2442-3_23

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