Abstract
It is not uncommon for abnormalities of the skin and malignant disease of an internal organ to coexist, although the relationship between the two is not always of straightforward cause and effect. There are four possibilities:
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1.
The internal malignancy can be the cause of the skin disorder.
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2.
The skin disorder can cause the internal malignancy.
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3.
Skin disease and internal malignancy can occur as part of the same pathological process or in response to a common stimulus.
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4.
Skin disease and internal malignancy may be related not by cause and effect as in 1 and 2, nor by a common pathology as in 3, but indirectly as in the genetic cutaneosystemic syndromes.
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Marks, J., Shuster, S. (1978). The Skin and Gastrointestinal Malignancy. In: Lipkin, M., Good, R.A. (eds) Gastrointestinal Tract Cancer. Sloan-Kettering Institute Cancer Series. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-2442-3_23
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