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Mathematical Models of Carcinogenesis and Tumor Growth in an Experimental Rat Colon Adenocarcinoma

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Gastrointestinal Tract Cancer

Part of the book series: Sloan-Kettering Institute Cancer Series ((SKICS))

Abstract

An accurate assessment of the growth behavior of cancers is of invaluable help in the understanding of their biological and clinical properties, as well as in the planning of appropriate therapies. Yet, in the important field of colorectal tumors, little such quantitative information is available, because of the inaccessibility of those lesions for direct serial measurements.

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References

  • Armitage, P., and Doll R., 1954, The age distribution of cancer and a multi-stage theory of carcinogenesis, Br. J. Cancer 8: 1–12.

    Article  PubMed  CAS  Google Scholar 

  • Armitage, P., and Doll R., 1957, A two-stage theory of carcinogenesis in relation to the age distribution of human cancer, Br. J. Cancer 11: 161–169.

    Article  Google Scholar 

  • Ashley, D. J. B., 1969, The two “hit” and multiple “hit” theories of carcinogenesis, Br. J. Cancer 23: 313.

    Article  PubMed  CAS  Google Scholar 

  • Berenblum, I., 1974, Chemical carcinogenesis as a biological problem, in: Frontiers in Biology, Vol. 27, North-Holland, Amsterdam.

    Google Scholar 

  • Berenblum, I., and Shubik, P., 1949, An experimental study of the initiating stage of carcinogenesis, and a re-examination of the somatic cell mutation theory of cancer, Br. J. Cancer 3: 109–118.

    Article  PubMed  CAS  Google Scholar 

  • Burch, P. R. J., 1962, A biological principle and its converse some implications for Carcinogenesis, Nature (London) 195: 241–243.

    Article  CAS  Google Scholar 

  • Burdette, W., 1974, Colorectal carcinogenesis, Cancer 34: 872–877.

    Article  PubMed  CAS  Google Scholar 

  • Chomcai, C., Bhadrachari, N., and Nigro, N. D., 1974, The effect of bile on the induction of experimental intestinal tumors in rats, Colon Rectum 17: 310–312.

    Article  Google Scholar 

  • Clifton, K. H., and Yatvin, M. B., 1970, Cell population growth and cell loss in the MTG-B mouse mammary carcinoma, Cancer Res. 30: 658–664.

    PubMed  CAS  Google Scholar 

  • Cohen, D., and Steel, G. G., 1972, Thymidine labelling studies in a transmissible veneral tumour of the dog, Br. J. Cancer 26: 413–419.

    Google Scholar 

  • Dethlefsen, L., Prewitt, J., and Mendelsohn, M., 1968, Analysis of tumor growth curves, J. Natl. Cancer Inst. 40: 389–405.

    Google Scholar 

  • Druckrey, H., 1970, Production of colonic carcinomas by 1, 2 dimethylhydrazines and azoxyalkanes, in: Carcinoma of the Colon and Antecedent Epithelium ( W. J. Burdette, ed.), pp. 267–279, Thomas, Springfield, Ill.

    Google Scholar 

  • Druckrey, H., 1971, Genotypes and phenotypes of ten inbred strains of BD-rats, Arzneim. -Forsch. (Drug Res.) 21: 1274–1278.

    CAS  Google Scholar 

  • Druckrey, H., 1973, Specific carcinogenic and teratogenic effects of “indirect” alkylating methyl and ethyl compounds, and their dependency on stages of ontogenic developments, Xenobiotica 3: 271–303.

    Article  CAS  Google Scholar 

  • Druckrey, H., and Lange, A., 1972, Carcinogenicity of azoxymethane dependent on age in BD rats, Fed. Proc. 31: 1482–1484.

    PubMed  CAS  Google Scholar 

  • Druckrey, H., Preussman, R., Matzkies, F., and Ivankovic, S., 1967, Selektive Erzeugung von Darmkrebs bei Ratten durch 1, 2-Dimethylhydrazin, Naturwissenchaften 58: 285–286.

    Google Scholar 

  • Fiala, E. G., 1975, Investigation into the metabolism and mode of action of the colon carcinogen 1,2-dimethylhydrazin, Cancer 36: 2407–2412.

    Article  PubMed  CAS  Google Scholar 

  • Fisher, J. C., 1958, Multiple-mutation theory of carcinogenesis, Nature (London) 181: 651–652.

    Article  CAS  Google Scholar 

  • Frindel, E., Malaise, E., Alpen, E., and Tubiana, M., 1967, Kinetics of cell proliferation of an experimental tumor, Cancer Res. 27: 1122–1131.

    PubMed  CAS  Google Scholar 

  • Gennaro, A. R., Villanueva, R., Sukonthaman, Y., Vathanophas, and Rosemond, G. P., 1973, Chemical carcinogenesis in transposed intestinal segments, Cancer Res. 33: 536–541.

    PubMed  CAS  Google Scholar 

  • Griswold, D. P., Jr., Simpson-Herren, L., and Schabel, F. M., Jr., 1970, Altered sensitivity of a ramster plasmacytoma to cytosine arabinoside (NSC-63878), Cancer Chemother. Rep. 54: 337–340.

    Google Scholar 

  • Haase, P., Cowen, D. M., Sr., Knowles, J. C., and Cooper, E. H., 1973, Evaluation of dimethylhydrazine induced tumors in mice as a model system for colorectal cancer, Br. J. Cancer 28: 530–543.

    Article  PubMed  CAS  Google Scholar 

  • Hawks, A., and Magee, P., 1974, The alkylation of nucleic acids of rat and mouse in vivo by the carcinogen 1,2-dimethylhydrazine, Br. J. Cancer 30: 440–447.

    Article  PubMed  CAS  Google Scholar 

  • Hawks, A., Hicks, R., Holsman, J., and Magee, P., 1974, Morphological and biochemical effects of 1,2-dimethylhydrazine and 1-methylhydrazine in rats and mice, Br. J. Cancer 30: 429–439.

    Article  PubMed  CAS  Google Scholar 

  • Heidelberg, C., 1973, Current trends in chemical carcinogenesis, Fed. Proc. 32: 2154–2161.

    Google Scholar 

  • Hermens, A. F., and Barendsen G. W., 1969, Changes of cell proliferation characteristics in a rat rhabdomyosarcoma before and after X-irradiation, Eur. J. Cancer 5: 173–189.

    PubMed  CAS  Google Scholar 

  • Huemer, R. P., and Bickert, C., 1971, Growth and differentiation of a transplantable plasmacytoma, Oncology 25: 439–445.

    Article  PubMed  CAS  Google Scholar 

  • Kanagalingam, K., and Balis, A. E., 1975, In vivo repair of rat intestinal DNA damage by alkylating agents, Cancer 36: 2364–2372.

    Article  PubMed  CAS  Google Scholar 

  • Killmann, S. A., Cronkite, E. P., Fliedner, T. M., and Bond, V. P., 1962, Cell proliferation in multiple myeloma studied with tritiated thymidine in vivo, Lab. Invest. 11: 845–851.

    PubMed  CAS  Google Scholar 

  • Knudson, A. G., 1971, Mutation and cancer: Statistical study of retinoblastoma, Proc. Natl. Acad. Sci. USA 68: 820–823.

    Article  PubMed  Google Scholar 

  • Knudson, A. G., 1973, Mutation and human cancer, in: Advances in Cancer Research, Vol. 17 ( G. Klein and S. Weinhouse, eds.), pp. 317–352, Academic Press, New York.

    Chapter  Google Scholar 

  • Laird, A., 1964, Dynamics of tumor growth, Br. J. Cancer 18: 490–502.

    Google Scholar 

  • Laird, A., 1969, Dynamics of growth in tumors and in normal organisms, Natl. Cancer Inst. Monogr. 30: 15–28.

    Google Scholar 

  • Magee, P. N., 1974, Molecular Mechanisms in chemical carcinogenesis, in: Special Topics in Carcinogenesis (E. Grundmann, ed.), pp. 2–8, Vol. 44 of Recent Results in Cancer Research, Springer-Verlag, New York.

    Google Scholar 

  • Martin, M. S., Martin, F., Michiels, R., Bastien, H., Justrabo, E., Bordes, M., and Viry, B., 1973, An experimental model for cancer of the colon and rectum, Digestion 8: 22–34.

    Article  PubMed  CAS  Google Scholar 

  • Martin, M. S., Martin, F., Justrabo, E., Knopf, J.-F., Bastien, H., and Knobel, S., 1974, Induction de cancers coliques chez le rat par injection unique de 1,2-dimethylhydrazine, Biol. Gastroenterol. 7: 37–42.

    CAS  Google Scholar 

  • Maskens, A., 1976, Histogenesis and growth pattern of 1,2-dimethylhydrazine induced rat colon adenocarcinoma, Cancer Res. 36: 1585–1592.

    PubMed  CAS  Google Scholar 

  • Maskens, A., Meersseman, F., and Rahier, J., 1975, Growth rate of 1,2-dimethylhydrazine induced colon adenocarcinoma in rat (abstr.), Proc. Am. Assoc. Cancer Res. 16: 17.

    Google Scholar 

  • Matsumoto, H., and Higa, H., 1966, Studies on methylazoxymethanol, the aglycone of cycasin: Methylation of nucleic acids in vitro, Biochem. J. 98: 20c - 22c.

    PubMed  CAS  Google Scholar 

  • McCredie, J., Inch, W., Kruuv, J., and Watson, T., 1965, Growth 29: 331–347.

    Google Scholar 

  • McCredie, J. A., Inch, W. R., and Sutherland, R. M., 1971, Differences in growth and morphology between the spontaneous C3H mammary carcinoma in the mouse and its syngeneic transplants, Cancer 27: 635–642.

    Article  PubMed  CAS  Google Scholar 

  • Mendelsohn, M., 1960, The growth fraction: A new concept applied to tumors, Science 132: 1496.

    Google Scholar 

  • Mendelsohn, M., 1962, Autoradiographic analysis of cell proliferation in spontaneous breast cancer of C3H mouse. III. The growth fraction, J. Natl. Cancer Inst. 28: 1015–1029.

    Google Scholar 

  • Mendelsohn, M., 1963, Cell proliferation and tumour growth, in: Cell Proliferation ( L. F. Lamerton and R. J. M. Fry, eds.), pp. 190–210, Blackwell, London.

    Google Scholar 

  • Miller, J. A., 1970, Carcinogenesis by chemicals: An overview, G. H. A. Clowes Memorial Lecture, Cancer Res. 30: 559–576.

    Google Scholar 

  • Nigro, N. D., Bhadrachari, N., and Chomcai, C., 1973, A rat model for studying colonic cancer, Dis. Colon Rectum 16: 438–443.

    Google Scholar 

  • Nordling, C. O., 1953, A new theory on the cancer inducing mechanism, Br. J. Cancer 7: 68–72.

    Google Scholar 

  • Pozharisski, K., and Klimashevski, V., 1974, Comparative morphological and histoautoradiographic study of multiple experimental intestinal tumours, Exp. Pathol. 9: 88–98.

    Google Scholar 

  • Pozharisski, K., Kapustin, Y., Likhachev, A., and Shaposhnikov, J., 1975, The mechanism of carcinogenic action of 1,2-dimethylhydrazine ( SDMH) in rats, Int. J. Cancer 15: 673–683.

    Google Scholar 

  • Preussmann, R., 1974, Formation of carcinogens from precursors occurring in the environment; new aspects of nitrosamine induced tumorigenesis, in: Special Topics in Carcinogenesis (E. Grundmann, ed.), pp. 9–15, Vol. 44 of Recent Results in Cancer Research, Springer-Verlag, New York.

    Google Scholar 

  • Reddy, B., Weisburger, J., Narisawa, T., and Wynder, E., 1974a, Colon carcinogenesis in germ free rats with 1,2-dimethylhydrazine and N-methyl-N’-nitro-N-nitrosoguanidine, Cancer Res. 34: 2368–2372.

    PubMed  CAS  Google Scholar 

  • Reddy, B., Weisburger, J., and Wynder, E., 1974b, Effects of dietary fat level and dimethylhydrazine on fecal acid and neutral sterol excretion and colon carcinogenesis in rats, J. Natl. Cancer Inst. 52: 507–511.

    Google Scholar 

  • Ryser, H. J. P., 1971, Chemical carcinogenesis, N. Eng. J. Med. 285: 721–734.

    Google Scholar 

  • Schauer, A., Vollnagel, T., and Wildanger, F. 1969, Cancerisierung des Rattendarmes durch 1, 2-Dimethylhydrazine, Ztschr. Ges. Exp. Med. 150: 87–93.

    Google Scholar 

  • Schauer, A., Kunze, E., and Boxler, K., 1971, Generationszeitzyklus 1,2- Dimethylhydrazin-induzierten Adenocarcinomen des Rattencolon, Naturwissenschaften 58: 221.

    Article  PubMed  CAS  Google Scholar 

  • Shank, R. C., and Magee, P. N., 1967, Similarities between the biochemical actions of cycasin and dimethylnitrosamine, Biochem. J. 105: 521–527.

    Google Scholar 

  • Simpson-Herren, L., and Lloyd, H., 1970, Kinetic parameters and growth curves for experimental tumor systems, Cancer Chemother. Rep. 54: 143–174.

    Google Scholar 

  • Simpson-Herren, L., Sanford, A., and Holmquist, J., 1974, Cell population kinetics of transplanted and metastatic Lewis lung carcinoma, Cell Tissue Kinet. 7: 349–361.

    Google Scholar 

  • Smith, D., 1966, Mutagenicity of cycasin aglycone (methylazoxymethanol), a naturally occurring carcinogen, Science 152: 1273–1274.

    Google Scholar 

  • Springer, P., Springer, J., and Oehlert, W. 1970, Die Vorstufen des 1,2Dimethylhydrazin-induzierten Dick-und Dundarmcarcinoms der Ratte, Ztschr. Krebsforsch. 74: 236–240.

    Google Scholar 

  • Steel, G., 1967, Cell loss as a factor in the growth rate of human tumours, Eur. J. Cancer 3: 381387.

    Google Scholar 

  • Stocks, P., 1953, A study of the age curve for cancer of the stomach in connection with a theory of the cancer producing mechanism, Br. J. Cancer 7: 407–417.

    Google Scholar 

  • Sullivan, P. W., and Salmon, S. E., 1972, Kinetics of tumor growth and regression in Ig G multiple myeloma. J. Clin. Invest. 51: 1697–1708.

    Google Scholar 

  • Teas, J., and Dyson, J. G., 1967, Mutation in Drosophila by methylazoxymethanol, the aglycone of cycasin, Proc. Soc. Exp. Biol. Med. 125: 988–990.

    Google Scholar 

  • Thurnherr, N., Deschner, E., Stonehill, E., and Lipkin, M., 1973, Introduction of adenocarcinomas of the colon in mice by weekly injections of 1,2-dimethylhydrazine, Cancer Res. 33:940–945

    Google Scholar 

  • Ward, J. M., Yamamoto, R. S., and Brown, C. A., 1973a, Pathology of intestinal neoplasms and other lesions in rats exposed to azoxymethane, J. Natl. Cancer Inst. 51: 1029–1035.

    Google Scholar 

  • Ward, J. M., Yamamoto, R S., and Weisburger, J. H., 1973b, Cellulose dietary bulk andazoxymethane induced intestinal cancer,J Natl. Cancer Inst. 51: 713–715.

    Google Scholar 

  • Weisburger, J., 1971, Colon carcinogens: Their metabolism and mode of action, Cancer 28: 60–70.

    Google Scholar 

  • Welin, S., Youker, J., and Spratt, J., 1963, The rates and patterns of growth of 375 tumors of the large intestine and rectum observed serially by double contrast enema study ( Malmö tech-nique ), Am. J. Roentgen Radium Ther. Nucl. Med. 90: 673–687.

    Google Scholar 

  • Wiebecke, B., Löhrs, U., Gimmy, J., and Eder, M., 1969, Erzeugung von Darmtumoren beim Mausen durch 1,2-Dimethylhydrazin, Ztschr. Ges. Exp. Med. 149: 277–278.

    Article  CAS  Google Scholar 

  • Wiebecke, B., Krey, U., Löhrs, U., and Eder, M., 1973, Morphological and autoradiographical investigations on experimental carcinogenesis and polyp development in the intestinal tract of rats and mice, Virchows Arch. Pathol. Anat. 360: 179–193.

    Article  CAS  Google Scholar 

  • Zedeck, M. S., Sternberg, S. S., Poynter, R. W., and McGowan, J., 1970, Biochemical and pathological effects of methylazoxymethanol acetate, a potent carcinogen, Cancer Res. 30: 801–812.

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Cancer Research Unit, Clinique Saint-Michel, B-1040, Brussels, Belgium

    Alain P. Maskens

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  1. Alain P. Maskens
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Editors and Affiliations

  1. Sloan-Kettering Institute for Cancer Research, New York, New York, USA

    Martin Lipkin M.D.  & Robert A. Good Ph.D., M.D.  & 

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Maskens, A.P. (1978). Mathematical Models of Carcinogenesis and Tumor Growth in an Experimental Rat Colon Adenocarcinoma. In: Lipkin, M., Good, R.A. (eds) Gastrointestinal Tract Cancer. Sloan-Kettering Institute Cancer Series. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-2442-3_15

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  • DOI: https://doi.org/10.1007/978-1-4684-2442-3_15

  • Publisher Name: Springer, Boston, MA

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