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The Structural Basis for the Biological Properties of Immunoglobulins

  • Chapter
Book cover Immunoglobulins

Part of the book series: Comprehensive Immunology ((COMIMUN,volume 5))

Abstract

Immunoglobulins (Ig’s) are polyfunctional molecules. The most thoroughly studied, and currently best understood, of the numerous functions of this protein family is antigen-binding, a subject that is discussed in detail in several other chapters of this volume. The various other functions are collectively referred to as the biological properties, or effector functions, of antibodies. These properties are mediated by the constant (C) regions of the heavy (H) chains of the various Ig molecules. In fact, most of the properties recognized at present have been associated with that carboxyterminal subcomponent of the H-chain C region referred to as the Fc (constant) segment, or fragment.

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  1. Department of Microbiology/Immunology, The Northeastern Ohio Universities College of Medicine, Rootstown, Ohio, 44272, USA

    J. Michael Kehoe

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  1. J. Michael Kehoe
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  1. Sloan-Kettering Institute for Cancer Research, Rye, New York, USA

    Gary W. Litman Ph. D.

  2. Sloan-Kettering Institute for Cancer Research, New York, New York, USA

    Robert A. Good Ph. D., M. D.

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Kehoe, J.M. (1978). The Structural Basis for the Biological Properties of Immunoglobulins. In: Litman, G.W., Good, R.A. (eds) Immunoglobulins. Comprehensive Immunology, vol 5. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-0805-8_6

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