Abstract
Kininogens are precursor proteins of bradykinin that are widely distributed in mammalian blood plasma1-3. Kininogens are comprised of two distinct proteins, designated low molecular weight (LMW) and high molecular weight (HMW) kininogens. Both kininogens are single-chain glycoproteins and carry a bradykinin moiety in the interior of the polypeptide chains bridged by a disulfide linkage. The kininogens thus consist of three domains: an amino-terminal heavy chain (H chain), bradykinin, and a carboxyl-terminal light chain (L chain). The key functions of kininogens, effected via kinin, are smooth muscle contraction, induction of hypotension, pain generation and increase of vascular permeability. Another well-established kininogen function is related to the initial step of blood coagulation and fibrinolysis, and this function is attributed to the L chain of HMW kininogen. Although the pharmacology, physiology and biochemistry of the kinin-kininogen system have been remarkably developed through studies conducted in a number of laboratories, the molecular and genetic aspects of this system remained to be clarified. Our laboratory is concerned with investigations on the structure, expression and regulation of the kininogen gene with the aid of molecular cloning and its related technology.
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© 1989 Plenum Press, New York
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Nakanishi, S. et al. (1989). Control of Kininogen Gene Expression. In: Abe, K., Moriya, H., Fujii, S. (eds) Kinins V. Advances in Experimental Medicine and Biology, vol 247 A. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9543-4_2
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DOI: https://doi.org/10.1007/978-1-4615-9543-4_2
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