Abstract
The literature relating to the relationship between the renal kallikrein/kinin system and the excretion of salt and water is somewhat confused because different effects have been reported in different studies. The object of the present study was to demonstrate that though appropriate doses of angiotensin may produce natriuresis in both the dog and the rat, the effect on the kallikrein excretion in the urine is quite different. In the dog natriuresis was associated with increased kallikrein in the urine, whereas in the rat the kallikrein excretion was progressively decreased by angiotensin infusion. Although natriuresis produced by angiotensin in the rat caused depression of urinary kallikrein, the super-imposition of synthetic atrial natriuretic peptide was still able to increase kallikrein excretion as it does without angiotensin in rats.
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References
Beaven, V.H., Pierce, J.V. and Pisano, J.J., 1971, A sensitive isotopic procedure for the assay of esterase activity: measurements of human urinary kallikrein, Clinica him. Acta, 32: 67.
Brownlee, A.A., Lee, G., Mills, I.H., Spinelli, F. and Wakabayashi, Y., 1986, Stimulation of kallikrein excretion by infusion of atrial natriuretic peptide (ANP) in rats: correlation with urine flow, sodium and potassium excretion, J. Physiol., 377: 52P.
Brownlee, A.A., Lee, G., Mills, I.H., Spinelli, F. and Wakabayashi, Y., 1987, Stimulation of kallikrein excretion by atrial natriuretic peptide (ANP) after suppression by angiotensin or amiloride in rats, J. Physiol., 387: 49P.
Mills, I.H. and Newport, P.A., 1978, The dependence of the natriuretic and kallikrein responses to intra-arterial angiotensin on renal artery pressure, J. Physiol., 284: 153P.
Mills, I.H. and Newport, P.A., 1979, Decrease in kallikrein response to arterial angiotensin during simultaneous indomethacin infusion, J. Physiol., 300: 50P.
Mills, I.H. and Newport, P.A., 1982, The inter-relationship between decreased sodium and kallikrein excretion during arterial infusion of 10 ng per minute angiotensin II in the dog, J. Physiol., 334: 61P.
Pollock, D.M., Butterfield, M.I., Ader, J.L. and Arendshorst, W.J., 1986, Dissociation of urinary kallikrein activity and salt and water excretion, Amer J. Physiol., 250: F1082.
Tomita, K., Pisano, J.J. and Knepper, M.A., 1985, Control of sodium and potassium transport in the cortical collecting duct of the rat. Effects of bradykinin, vasopressin and deoxycorticosterone, J. Clin. Invest., 76: 132.
Tomita, K., Pisano, J.J., Burg, M.B. and Knepper, M.A., 1986, Effect of vasopressin and bradykinin on anion transport by the rat cortical collecting duct, J. Clin. Invest., 77, 136.
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© 1989 Plenum Press, New York
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Mills, I.H., Newport, P.A., Wakabayashi, Y., Spinelli, F. (1989). Opposite Effects on Kallikrein Excretion of Natriuretic Doses of Angiotensin Infused into the Dog and the Rat: Reversal of the Effect in the Rat by Atrial Natriuretic Peptide. In: Abe, K., Moriya, H., Fujii, S. (eds) Kinins V. Advances in Experimental Medicine and Biology, vol 247 A. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9543-4_101
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DOI: https://doi.org/10.1007/978-1-4615-9543-4_101
Publisher Name: Springer, Boston, MA
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