Skip to main content

Cellular Mechanisms of Phosphate Transport

  • Chapter
Renal Handling of Phosphate

Abstract

Transepithelial phosphate transport in the kidney is one to two orders of magnitude more extensive than that in any other organ of the body. Large volumes of glomerular filtrate, 150 liters/day in a normal man, are presented to the renal tubule, from which 80% of the filtered phosphate is reclaimed by this transepithelial phosphate transport system.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Abou-Issa, H., Kratowich, N., and Mendicino, J., 1974, Properties of soluble and bound protein kinase isolated from swine kidney, Eur. J. Biochem. 42:464.

    Google Scholar 

  • Abou-Issa, H., Mendicino, J., Leibach, F., and Pillion, D., 1975, Phosphorylation and dephosphorylation of renal brush border membranes by protein kinase and phosphoprotein phosphatase, FEBS Lett. 50:121.

    PubMed  CAS  Google Scholar 

  • Adler, S., Roy, A., and Reiman, A. S., 1965, Intracellular acid-base regulation. I. The response of muscle cells to changes in CO2 tension or extracellular bicarbonate concentration, J. Clin. Invest. 44:8.

    PubMed  CAS  Google Scholar 

  • Adler, S., Anderson, B., and Zett, B., 1972a, The role of bicarbonate in determining pH heterogeneity in rat diaphragm, J. Lab. Clin. Med. 80:679.

    PubMed  CAS  Google Scholar 

  • Adler, S., Zett, B., and Anderson, B., 1972b, The effect of acute potassium depletion on muscle cell pH in vitro, Kidney Int. 2:159.

    PubMed  CAS  Google Scholar 

  • Adler, S., Zett, B., and Anderson, B., 1974, Renal citrate in the potassium deficient rat: Role of potassium and chloride ions, J. Lab. Clin. Med. 84:307.

    PubMed  CAS  Google Scholar 

  • Agus, Z. S., Puschett, B. J., Senesky, D., and Goldberg, M., 1971, Mode of action of parathyroid hormone and cyclic adenosine 3′,5′-monophosphate on renal tubular phosphate reabsorption in the dog, J. Clin. Invest. 50:617.

    PubMed  CAS  Google Scholar 

  • Angielski, S., and Szczepanska-Konkel, M., 1977, Restoration of PTH dependent phos-phaturia by metabolic (MA), respiratory acidosis (RA) and Diamox (D) in acutely par-athyroidectomized (PTX), lithium treated rats, in: Proceedings of 3rd International Workshop on Phosphate and Other Minerals, Madrid, Spain.

    Google Scholar 

  • Angielski, S., Pempkowiak, L., Gmaj, P., Hoppe, A., and Nowicka, C., 1976, The effect of maleate and lithium on renal fuction and metabolism, in: Renal Metabolism in Relation to Renal Function (U. Schmidt and U. C. Dubach, eds.), pp. 142–152, Hans Huber, Bern.

    Google Scholar 

  • Anner, B., Ferrero, J., Jirounek, P., and Straub, R. W., 1973, Na-dependent phosphate-influx into mammalian nerve fibers, Experientia 29:74.

    Google Scholar 

  • Arruda, J., Richardson, A. L., Wolfson, J. A., Nascimento, L., Rademacher, D. R., and Kurtzman, N. A., 1976, Lithium administration and phosphate excretion, Am. J. Physiol. 231:1140.

    PubMed  CAS  Google Scholar 

  • Aurbach, G. D., and Heath, D. A., 1974, Parathyroid hormone and calcitonin regulation of renal function, Kidney Int. 6:331.

    PubMed  CAS  Google Scholar 

  • Aurbach, G. D., Keutmann, H. T., Niall, H. D., Tregear, G. W., O’Riordan, J., Marcus, R., Marx, S. J., and Potts, J. T., Jr., 1972, Structure, synthesis, and mechanism of action of parathyroid hormone, Recent Prog. Horm. Res. 28:353.

    PubMed  CAS  Google Scholar 

  • Ausiello, D., Handler, J., and Orloff J., 1976. Effect of parathyroid hormone and cyclic AMP on protein phosphorylation in rabbit kidney cortex, Biochim. Biophys. Acta 451:372.

    PubMed  CAS  Google Scholar 

  • Banerjee, R. K., Shertzer H. G., Kanner, B. I., and Racker E. 1977. Purification and reconstitution of the phosphate transporter from bovine heart mitochondria. Biochem. Biophys. Res. Commun. 75:772.

    PubMed  CAS  Google Scholar 

  • Bank, N., Aynedjian, H. S., and Weinstein S. W. 1974, A microperfusion study of phosphate reabsorption by the rat proximal tubule. J. Clin. Invest. 54:1040.

    PubMed  CAS  Google Scholar 

  • Barker, E. S., Singer, R. B., Elkinton, J. R., and Clark, K. J., 1957, The renal response in man to acute experimental respiratory alkalosis and acidosis, J. Clin. Invest. 36:515.

    PubMed  CAS  Google Scholar 

  • Baumann, K., de Rouffignac, C., Roinel, N., Rumrich, G., and Ullrich, K. J., 1975a, Renal phosphate transport: Inhomogeneity of local-proximal transport rates and sodium dependence, Pflügers Arch. 356:287.

    PubMed  CAS  Google Scholar 

  • Baumann, K., Rumrich, G., Papavassiliou, F., and Klöss S., 1975b, pH dependence of phosphate reabsorption in the proximal tubule of rat kidney, Pflügers Arch. 360:183.

    PubMed  CAS  Google Scholar 

  • Baumann, K., Chan, Y.-L., Bode, F., and Papavassiliou, F., 1977, Effect of parathyroid hormone and cyclic adenosine 3′,5′-monophosphate on isotonic fluid reabsorption: Polarity of proximal tubular cells, Kidney Int. 11:77.

    PubMed  CAS  Google Scholar 

  • Beck, L. H., and Goldberg, M., 1974, Mechanism of the blunted phosphaturia in saline-loaded thyroparathyroidectomized dogs, Kidney Int. 6:18, 1974.

    Google Scholar 

  • Beck, N. P., DeRubertis, F. R., Michelis, M. F., Fusco, R. D., Field, J. B., and Davis, B. B., 1972, Effect of prostaglandin Ei on certain renal actions of parathyroid hormone, J. Clin. Invest. 51:2352.

    PubMed  CAS  Google Scholar 

  • Beck, W., and Davis, B. B., 1975, Impaired renal response to parathyroid hormone in potassium depletion, Am. J. Physiol. 228:179.

    PubMed  CAS  Google Scholar 

  • Bell, N. H., Avery, S., Sinha, T., Clark, C. M., Jr., Allen, D. O., and Johnston, C., Jr., 1972, Effects of dibutyryl cyclic adenosine 3′,5′-monophosphate and parathyroid extract on calcium and phosphorus metabolism in hypoparathyroidism and pseudohypoparathyroidism, J. Clin. Invest. 61:816.

    Google Scholar 

  • Berlin, R. D., Oliver, J. M., Ukena, T. E., and Yin, H. H., 1974, Control of cell surface topography, Nature 247:45.

    PubMed  CAS  Google Scholar 

  • Biddulph, D. M., and Wrean, R. W., 1977, Effects of parathyroid hormone on cyclic AMP, cyclic GMP, and efflux of calcium in isolated renal tubules, J. Cyclic Nucleotide Res. 3:129.

    PubMed  CAS  Google Scholar 

  • Bloch, R., 1974, Human erythrocyte sugar transport. Identification of the essential residues of the sugar carrier by specific modification, J. Biol. Chem. 249:1814.

    PubMed  CAS  Google Scholar 

  • Bonjour, J.-P., Trohler, U., Mühlbauer, R., and Fleisch, H., 1976, Tubular adaptation of inorganic phosphate (Pi) transport in response to variations in dietary Pi in rats, in: Renal Metabolism in Relation to Renal Function (U. Schmidt and U.C. Dubach, eds.), pp. 272–280, Hans Huber. Bern.

    Google Scholar 

  • Bonjour, J.-P., Preston, C., and Fleisch, H., 1977, Effect of 1,25-dihydroxyvitamin D3 on the renal handling of Pi in thyroparathyroidectomized rats, J. Clin. Invest. 60:1419.

    PubMed  CAS  Google Scholar 

  • Booth, A. G., and Kenny, A. J., 1976, A morphometric and biochemical investigation of the vesiculation of kidney microvilli, J. Cell Sci. 21:449.

    PubMed  CAS  Google Scholar 

  • Brassfield, C. R., and Behrman, V. G., 1941, A correlation of the pH of arterial blood and urine as affected by changes in pulmonary ventilation, Am. J. Physiol. 132:272.

    CAS  Google Scholar 

  • Bretscher, M. S., and Raff, M. C., 1975, Mammalian plasma membranes, Nature 258:43.

    PubMed  CAS  Google Scholar 

  • Brown, K. D., and Lamb, J. F., 1975, Na-dependent phosphate transport in cultured cells, J. Physiol. 251:58P.

    Google Scholar 

  • Butlen, D., and Jard, S., 1972, Renal handling of 3′,5′-cyclic AMP in the rat, Pflügers Arch. 331:172.

    PubMed  CAS  Google Scholar 

  • Caldwell, P. C., and Lowe, A. G., 1970, The influx of phosphate into squid giant axons, J. Physiol. 207:271.

    PubMed  CAS  Google Scholar 

  • Cassola, A. C., and Malnic, G., 1977, Phosphate transfer and tubular pH during renal stopped flow microperfusion experiments in the rat, Pflügers Arch. 367:249.

    PubMed  CAS  Google Scholar 

  • Chambers, E. L., 1963, Role of cations in phosphate transport by fertilized sea urchin eggs, Fed. Proc. Fed. Am. Soc. Exp. Biol. 22:331.

    Google Scholar 

  • Chasin, M., and Harris, D. N., 1976, Inhibitors and activators of cyclic nucleotide phosphodiesterase, Adv. Cyclic Nucleotide Res. 7:225.

    PubMed  CAS  Google Scholar 

  • Chen, S. T., 1976, Alkaline phosphatase, Front. Gastrointest. Res. 2:109.

    PubMed  CAS  Google Scholar 

  • Cohen, J. J., Berglund, E., and Lotspeich, W. D., 1956, Renal tubular reabsorption of acetoacetate, inorganic sulfate and inorganic phosphate in the dog as affected by glucose and phlorizin, Am. J. Physiol. 184:91.

    PubMed  CAS  Google Scholar 

  • Cohen, J. J., Berglund, E., and Lotspeich, W. D., 1957, Interrelations during renal tubular reabsorption in the dog among several anions showing a sensitivity to glucose and phlorizin, Am. J. Physiol. 189:331.

    PubMed  CAS  Google Scholar 

  • Cook, G. M. W., and Stoddart, R. W., 1973, Surface Carbohydrates of the Eukaryotic Cell Academic Press, New York.

    Google Scholar 

  • Coty, W. A., and Pederson, P. L., 1975, Phosphate transport in rat liver mitochondria. Membrane components labeled by N-ethylmaleimide during inhibition of transport, J. Biol. Chem. 250:3515.

    PubMed  CAS  Google Scholar 

  • Crawford, M. A., 1963, The effects of fluoroacetate, malonate and acid-base balance on renal disposal of citrate, Biochem. J. 88:115.

    PubMed  CAS  Google Scholar 

  • Cuche, J.-L., Marchand, G. R., Greger, R. F., Lang, F. C., and Knox, F. G., 1976, Phosphaturie effect of dopamine in dogs. Possible role of intrarenally produced dopamine in phosphate regulation, J. Clin. Invest. 58:71.

    PubMed  CAS  Google Scholar 

  • Cunningham, E. B., 1968, The enhancement of phosphoryl transfer by adenosine 3′,5′-monophosphate in the presence of a membranous fraction from canine kidney, Biochim. Biophys. Acta 165:574.

    CAS  Google Scholar 

  • Czaky, T. Z., Prachnamboli, K., Eiseman, B., and Ho, P. M., 1964, The effect of digitalis on the renal tubular transport of glucose in normal and heartless dogs, J. Pharmacol. Exp. Ther. 150:275.

    Google Scholar 

  • DeFronzo, R. A., Cooke, C. R., Anders, R., Fallona, G. R., and Davis, P. J., 1975, The effect of insulin on renal handling of sodium, potassium, calcium, and phosphate in man, J. Clin. Invest. 55:845.

    PubMed  CAS  Google Scholar 

  • DeFronzo, R. A., Goldberg, N., and Agus, Z. S., 1976, The effects of glucose and insulin on renal electrolyte transport, J. Clin. Invest. 58:83.

    PubMed  CAS  Google Scholar 

  • DeLuca, H. F., 1977, Vitamin D endocrine system, Adv. Clin. Chem. 19:125.

    PubMed  CAS  Google Scholar 

  • Dennis, V. W., Woodhall, P. B., and Robinson, R. R., 1976, Characteristics of phosphate transport in isolated proximal tubule, Am. J. Physiol. 231:979.

    PubMed  CAS  Google Scholar 

  • Denton, D. A., Maxwell, M., McDonald, I. R., Munro, J., and Williams, W., 1952, Renal regulation of the extracellular fluid in acute respiratory acidemia, Aust. J. Exp. Biol. Med. Sci. 80:489.

    Google Scholar 

  • DeRubertis, F. R., and Craven, P. A., 1976, Hormonal modulation of cyclic adenosine 3′,5′-monophosphate-dependent protein kinase activity in rat renal cortex, J. Clin. Invest. 57:1442.

    PubMed  CAS  Google Scholar 

  • DiBella, F. P., Dousa, T. P., Miller, S. S., and Arnaud, C. D., 1974, Parathyroid hormone receptors of renal cortex: Specific binding of biologically active, 125I-labeled hormone and relationship to adenylate cyclase activation, Proc. Natl. Acad. Sci. U.S.A. 71:723.

    CAS  Google Scholar 

  • Dousa, T. P., 1976, Drugs and other agents affecting the renal adenylate cyclase system, in: Methods in Pharmacology, Vol. 4A (M. Martinez-Maldonado, ed.), pp. 293–331, Plenum Press, New York.

    Google Scholar 

  • Dousa, T. P., and Barnes, L. D., 1977, Cyclic nucleotides in regulation of renal function, in: Cyclic 3′,5′-nucleotides: Mechanism of Action (H. Cramer and J. Schultz, eds.), pp. 251–262, John Wiley and Sons, London.

    Google Scholar 

  • Dousa, T. P., Duarte, C. G., and Knox, F. G., 1976, Effect of colchicine on urinary phosphate and regulation by parathyroid hormone, Am. J. Physiol. 231:61.

    PubMed  CAS  Google Scholar 

  • Dousa, T. P., Barnes, L. D., Ong, S.-H., and Steiner, A. L., 1977a, Immunohistochemical localization of 3′,5′-cyclic GMP in rat renal cortex: Effect of parathyroid hormone, Proc. Natl. Acad. Sci. U.S.A. 74:3569.

    PubMed  CAS  Google Scholar 

  • Dousa, T. P., Barnes, L. D., and Kim, J. K., 1977b, The role of the cyclic AMP-dependent protein phosphorylations and microtubules in the cellular action of vasopressin in mammalian kidney, in: Neurohypophysis (A. Moses and L. Share, eds.), pp. 220–235, Karger, New York.

    Google Scholar 

  • Earp, H. S., Smith, P., Ong, S.-H., and Steiner, A. L., 1977, Regulation of hepatic nuclear guanylate cyclase, Proc. Natl. Acad. Sci. U.S.A. 74:946.

    PubMed  CAS  Google Scholar 

  • Eisenberg, E., 1965, Effects of serum calcium level and parathyroid extracts on phosphate and calcium excretion in hypoparathyroid patients, J. Clin. Invest. 44:942.

    PubMed  CAS  Google Scholar 

  • Eknoyan, G., Suki, W. N., and Martinez-Maldonado, M., 1970, Effect of diuretics on urinary excretion of phosphate, calcium and magnesium in thyroparathyroidectomized dogs, J. Lab. Clin. Med. 76:257.

    PubMed  CAS  Google Scholar 

  • Fishman, W. H., 1974, Perspectives on alkaline phosphatase isoenzymes, Am. J. Med. 56:617.

    PubMed  CAS  Google Scholar 

  • Forte, L. R., Chao, W.-T. H., Walkenbach, R. J., and Byington, K. H., 1975, Studies of kidney plasma membrane adenosine 3′,5′-monophosphate-dependent protein kinase, Biochim. Biophys. Acta 389:84.

    PubMed  CAS  Google Scholar 

  • Forte, L. R., Nickols, G. A., and Anast, C. S., 1976, Renal adenylate cyclase and the interrelationship between parathyroid hormone and vitamin D in the regulation of urinary phosphate and adenosine cyclic 3′,5′-monophosphate excretion, J. Clin. Invest. 57:559.

    PubMed  CAS  Google Scholar 

  • Fox, M., Thier, S., Rosenberg, L., and Segal, S., 1964, Impaired renal tubular function induced by sugar infusion in man, J. Clin. Endocrinol. Metab. 24:1318.

    PubMed  CAS  Google Scholar 

  • Freeman, S., Jacobsen, A. B., and Williamson, B. J., 1957, acid-base balance and removal of injected calcium from the circulation, Am. J. Physiol. 191:377.

    CAS  Google Scholar 

  • Frick, A., 1969, Mechanism of inorganic phosphate diuresis secondary to saline infusions in the rat, Pflügers Arch. Gesamte Physiol. Menschen Tiere 313:106.

    CAS  Google Scholar 

  • Frick, A., 1972, Proximal tubule reabsorption of inorganic phosphate during saline infusion in the rat, Am. J. Physiol. 223:1034.

    PubMed  CAS  Google Scholar 

  • Fulop, M., and Brazeau, P., 1968, The Phosphaturic effect of sodium bicarbonate and ace-tazolamide in dog, J. Clin. Invest. 47:988.

    Google Scholar 

  • Gammeltoft, A., and Kjerulf-Jensen, K., 1943, The mechanism of renal excretion of fructose and galactose in the rabbit, cat, dog and man (with special reference to the phosphorylation theory), Acta Physiol. Scand. 6:368.

    CAS  Google Scholar 

  • George, E. R., Balakir, R. A., Filburn, C. R., and Sacktor, B., 1977, Cyclic adenosine monophosphate-dependent and -independent protein kinase activity of renal brush border membranes, Arch. Biochem. Biophys. 180:429.

    PubMed  CAS  Google Scholar 

  • George, S. G., and Kenny, A. J., 1973, Studies on the enzymology of purified preparations of brush border from rabbit kidney, Biochem. J. 134:43.

    PubMed  CAS  Google Scholar 

  • Ginsburg, J. N., 1972, Effect of glucose and free fatty acid on phosphate transport in dog kidney, Am. J. Physiol. 222:1153.

    PubMed  CAS  Google Scholar 

  • Ginsburg, J. N., and Lotspeich, N. D., 1963, Interrelations of arsenate and phosphate transport in the dog kidney, Am. J. Physiol. 205:707.

    PubMed  CAS  Google Scholar 

  • Glossmann, H., and Neville, D. M., 1971, Glycoproteins of cell surfaces. A comparative study of three different cell surfaces of the rat, J. Biol. Chem. 246:6339.

    PubMed  CAS  Google Scholar 

  • Gmaj P., Hoppe, A., Angielski, S., and Rogulski, J., 1973, Effects of maleate and arsenite on renal reabsorption of sodium and bicarbonate, Am. J. Physiol. 225:90.

    PubMed  CAS  Google Scholar 

  • Gold, L. W., Massry, S. G., and Friedler, R. M., 1977, Effect of phosphate depletion on renal tubular reabsorption of glucose, J. Lab. Clin. Med. 83:554.

    Google Scholar 

  • Goldberg, N. D., and Haddox, M. K., 1977, Cyclic GMP metabolism and involvement in biological regulation, Annu. Rev. Biochem. 46:823.

    PubMed  CAS  Google Scholar 

  • Gray, S. P., Morris, J. E. W., and Brooks, I., 1973, Renal handling of calcium, magnesium, inorganic phosphate and hydrogen ions during prolonged exposure to elevated carbon dioxide concentrations, Clin. Sci. Mol. Med. 45:751.

    PubMed  CAS  Google Scholar 

  • Greger, R. F., Lang, F. C., Knox, F. G., and Lechêne, C. P., 1977, Absence of significant secretory flux of phosphate in the proximal convoluted tubule, Am. J. Physiol. 232:F235.

    PubMed  CAS  Google Scholar 

  • Grollman, A. P., Harrison, H. C., and Harrison, H. E., 1961, The renal excretion of citrate, J. Clin. Invest. 40:1290.

    PubMed  CAS  Google Scholar 

  • Gruber, W., and Deuticke, B., 1973, Comparative aspects of phosphate transfer across mammalian erythrocyte membranes, J. Membr. Biol. 13:19.

    PubMed  CAS  Google Scholar 

  • Guest, G. M., 1942, Organic phosphates of the blood and mineral metabolism in diabetic acidosis, Am. J. Dis. Child. 64:401.

    CAS  Google Scholar 

  • Hadvarg, P., and Kadenbach, B., 1976, Identification of a membrane protein involved in mitochondrial phosphate transport, Eur. J. Biochem. 67:573.

    Google Scholar 

  • Haldane, J. B. S., Hill, R., and Luck, J. M., 1923, Calcium chloride acidosis, J. Physiol. (London) 57:301.

    CAS  Google Scholar 

  • Haldane, J. B. S., Wigglesworth, V. B., and Woochon, C. E., 1924, The effect of reaction changes on human inorganic metabolism, Proc. R. Soc. Med. 96:1.

    CAS  Google Scholar 

  • Hamburger, R. J., Lawson, N. L., and Dennis, V. W., 1974, Effect of cyclic adenosine nucleotides on fluid absorption by different segments of proximal tubule, Am. J. Physiol. 227:396.

    PubMed  CAS  Google Scholar 

  • Handler, J. S., and Orloff, J., 1963, Activation of Phosphorylase in toad bladder and mammalian kidney by antidiuretic hormone, Am. J. Physiol. 205:298.

    PubMed  CAS  Google Scholar 

  • Harkcom, T. M., Hui, Y. S. F., Palumbo, P. J., and Dousa, T. P., 1976, Phosphaturic effect of L-thyroxine (T4) in hypothyroid rats, Clin. Res. 24:272A.

    Google Scholar 

  • Harkcom, T. M., Kim, J. K., Palumbo P. J., Hui, Y. S. F. and Dousa T. P., 1978. Modulatory effect of thyroid fuction on enzymes of vasopressin-sensitive cyclic AMP system in renal medulla, Endocrinology 102:1475.

    PubMed  CAS  Google Scholar 

  • Harrison, H. E., and Harrison, H. C., 1954, Experimental production of renal glycosuria, phosphaturia and aminoaciduria by injection of maleic acid, Science 120:606.

    PubMed  CAS  Google Scholar 

  • Harrison, H. E., and Harrison, H. C., 1963, Sodium, potassium, and interstitial transport of glucose, L-tyrosine, phosphate, calcium, Am. J. Physiol. 205:107.

    PubMed  CAS  Google Scholar 

  • Ho, M. K., and Guidotti, G., 1975, A membrane protein from human erythrocytes involved in anion exchange, J. Biol. Chem. 250:675.

    PubMed  CAS  Google Scholar 

  • Hoffman, N., Thees, M., and Kinne, R., 1976, Phosphate transport by isolated renal brush border vesicles, Pflügers Arch. 362:147.

    Google Scholar 

  • Hoppe, A., and Knox, F. G., 1978, Effect of acute acid-base changes on fractional excretion in TPTX hamsters, Clin. Res. 26:542.

    Google Scholar 

  • Hosey, M. M., and Tao, M., 1977, Protein kinases and membrane phosphorylation, in: Current Topics in Membranes and Transport, Vol. 9 (F. Bronner and A. Kleinzeller, eds.), pp. 233–320, Academic Press, New York.

    Google Scholar 

  • Hui, Y. S. F., Torres, V. E., Northrup, T. E., and Dousa, T. P., 1978, Differential properties of cyclic nucleotide phosphodiesterases in glomeruli (GL) and tubuli (TB) of rat renal cortex, Clin. Res. 26:41A.

    Google Scholar 

  • Insel, P., Balakir, R., and Sacktor, B., 1975, The binding of cyclic AMP to renal brush border membranes, J. Cyclic Nucleotide Res. 1:107.

    PubMed  CAS  Google Scholar 

  • Israelachvili, J. N., 1977, Refinement of the fluid-mosaic model of membrane structure, Biochim. Biophys. Acta 469:221.

    PubMed  CAS  Google Scholar 

  • Kasahara, M., and Hinkle, P. C., 1976, Reconstitution of D-glucose transport catalysed by a protein fraction from human erythrocytes in sonicated liposomes, Proc. Natl. Acad. Sci. U.S.A. 73:396.

    PubMed  CAS  Google Scholar 

  • Kempson, S. A., Hui, Y. S. F., Kim, J. K., Knox, F. G., and Dousa, T. P., 1977, Cellular mechanism of renal phosphate handling in rats fed on low phosphate diet, Clin. Res. 25:595A.

    Google Scholar 

  • Kenny, A. J., and Booth, A. G., 1976, Organization of the kidney proximal-tubule plasma membrane, Biochem. Soc. Trans. 4:1011.

    PubMed  CAS  Google Scholar 

  • Kim, J. K., Frohnert, P. P., Hui, Y. S. F., Barnes, L. D., Farrow, G. M., and Dousa, T. P., 1977, Enzymes of cyclic 3′,5′-nucleotide metabolism in human renal cortex and renal adenocarcinoma, Kidney Int. 12:172.

    PubMed  CAS  Google Scholar 

  • Kinne, R., 1975, Polarity of the renal proximal tubular cell, Med. Clin. North Am. 59:615.

    PubMed  CAS  Google Scholar 

  • Kinne, R., 1976, Properties of the glucose transport system in the renal brush border membrane, Curr. Top. Membr. Transp. 8:209.

    CAS  Google Scholar 

  • Kinne, R., and Schwartz, I. L., 1976, Resolution of the epithelial cell envelope into luminal and contraluminal plasma membranes as a tool for the analysis of transport processes and hormone action, in: Membranes and Diseases (L. Bolis, J. F. Hoffman, and A. Leaf, eds.), pp. 331–343, Raven Press, New York.

    Google Scholar 

  • Kinne, R., and Schwartz, I. L., 1977, Asymmetric distribution of renal epithelial cell membrane function in the action of antidiuretic hormone and parathyroid hormone, in: Disturbances in Body Fluid Osmolality (T. E. Andreoli, J. J. Grantham, and F. C. Rector, eds.), pp. 37–55, American Physiological Society, Bethesda.

    Google Scholar 

  • Kinne, R., Shlatz, L. J., Kinne-Saffran, E., and Schwartz, I. L., 1975, Distribution of membrane-bound cyclic AMP dependent protein kinase in plasma membranes of cells of the kidney cortex, J. Membr. Biol. 24:145.

    PubMed  CAS  Google Scholar 

  • Kinne, R., Berner, W., Hoffman, N., and Murer, H., 1977, Phosphate transport by isolated renal and intestinal plasma membranes, in: Phosphate Metabolism (S. G. Massry and E. Ritz, eds.), pp. 265–277, Plenum Press, New York.

    Google Scholar 

  • Knox, F. G., 1977, The intrarenal metabolism of phosphate, Physiologist 20:25.

    PubMed  CAS  Google Scholar 

  • Knox, F. G., Schneider, E. G., Willis, L. R., Strandhoy, J. W., and Ott, C. E., 1973, Site and control of phosphate reabsorption by the kidney, Kidney Int. 3:347.

    PubMed  CAS  Google Scholar 

  • Knox, F. G., Haas, J. A., and Lechêne, C., 1976, Effect of parathyroid hormone on phosphate reabsorption in the presence of acetazolamide, Kidney Int. 10:216.

    PubMed  CAS  Google Scholar 

  • Knox, F. G., Preiss, J., Kim, J. K., and Dousa, T. P., 1977, Mechanism of resistance to the Phosphaturic effect of the parathyroid hormone in the hamster, J. Clin. Invest. 59:675.

    PubMed  CAS  Google Scholar 

  • Küntziger, H., Amiel, C., Roinel, N., and Morel, F., 1974, Effects of parathyroidectomy and cyclic AMP on renal transport of phosphate, calcium, and magnesium, Am. J. Physiol. 227:905.

    PubMed  Google Scholar 

  • Kupfer, S., and Kosovsky, J. D., 1965, Effect of cardiac glycosides on renal tubular transport of calcium, magnesium, inorganic phosphate and glucose in the dog, J. Clin. Invest. 44:1132.

    PubMed  CAS  Google Scholar 

  • Kupfer, S., and Kosovsky, J. D., 1970, Renal intracellular phosphate and phosphate excretion: The effect of digoxin and parathyroid hormone, Mt. Sinai J. Med. N. Y. 4:359.

    Google Scholar 

  • Kurokawa, K., Nagata, N., Sasaki, M., and Nakane, K., 1974, Effects of calcitonin on the concentration of cyclic adenosine 3′,5′-monophosphate in rat kidney in vivo and in vitro, Endocrinology 94:1514.

    PubMed  CAS  Google Scholar 

  • Lang, F., Greger, R. F., Marchand, G. R., and Knox, F. G., 1977a, Saturation kinetics of phosphate reabsorption in rats, in: Phosphate Metabolism (S. G. Massry and E. Ritz, eds.), pp. 153–155, Plenum Press, New York.

    Google Scholar 

  • Lang, F., Quehenberger, P., Greger, R., Oberleithner, H., and Deetjen, P., 1977b. Effect of luminal pH on renal phosphate reabsorption in intact and thyroparathyroidectomized rats, Proc. Int. Union Physiol. Sci. 13:427.

    Google Scholar 

  • Levitan, B. A., 1951, Effect in normal man of hyperglycemia and glycosuria on excretion and reabsorption of phosphate, J. Appl. Physiol. 4:225.

    Google Scholar 

  • Levitin, H., Branscome, W., and Epstein, F. H., 1958, The pathogenesis of hyperchloremia in respiratory acidosis, J. Clin. Invest. 37:1667.

    PubMed  CAS  Google Scholar 

  • Lo, H., Lehotary, D. C., Katz, D., and Levey, G. S., 1976, Parathyroid hormone-mediated incorporation of 32P-orthophosphate into phosphatidic acid and phosphatidylinositol in renal cortical slices, Endocr. Res. Commun. 3:377.

    PubMed  CAS  Google Scholar 

  • Maesaka, J. K., Levitt, M. F., and Abramson, R. G., 1973, Effect of saline infusion on phosphate transport in intact and thyroparathyroidectomized rats, Am. J. Physiol. 225:1421.

    PubMed  CAS  Google Scholar 

  • Malvin, R. L., and Lotspeich, W. D., 1956, Relation between tubular transport of inorganic phosphate and bicarbonate in the dog, Am. J. Physiol. 187:51.

    PubMed  CAS  Google Scholar 

  • Martin, H. E., and Jones, R., 1961, The effect of ammonium chloride and sodium bicarbonate on the urinary excretion of magnesium, calcium, and phosphate, Am. Heart J. 62:206.

    PubMed  CAS  Google Scholar 

  • Marx, S. J., Fedak, S. A., and Aurbach, G. D., 1972, Preparation and characterization of a hormone-responsive renal plasma membrane fraction, J. Biol. Chem. 247:6913.

    PubMed  CAS  Google Scholar 

  • Massry, S. G., Coburn, J. W., and Kleeman, C. R., 1969, The influence of extracellular volume expansion on renal phosphate reabsorption in the dog, J. Clin. Invest. 48:1237.

    PubMed  CAS  Google Scholar 

  • McCuaig, L. W., and Motzok, I., 1972, Regulation of intestinal alkaline phosphatase by dietary phosphate, Can. J. Physiol. Pharmacol. 50:1152.

    PubMed  CAS  Google Scholar 

  • Meister, A., and Tate, S. S., 1976, Glutathione and related γ-glutamyl compounds: Biosynthesis and utilization, Annu. Rev. Biochem. 45:559.

    PubMed  CAS  Google Scholar 

  • Melani, F., Ramponi, G., Farnararo, M., Cocucci, E., and Guerritore A., 1967, Regulation by phosphate of alkaline phosphatase in the rat kidney, Biochim. Biophys. Acta 138:411.

    PubMed  CAS  Google Scholar 

  • Mercado, A., Slatopolsky, E., and Klahr, S., 1975. On the mechanisms responsible for the phosphaturia of bicarbonate administration, J. Clin. Invest. 56:1386.

    PubMed  CAS  Google Scholar 

  • Moog, F., and Glazier, H. S., 1972, Phosphate absorption and alkaline phosphatase activity in the small intestine of the adult mouse and of the chick embryo and hatched chick. Comp. Biochem. Physiol. 42A:321.

    Google Scholar 

  • Mostellar, M. E., and Tuttle, E. P., 1964, Effect of alkalosis on plasma and urinary excretion of inorganic phosphate in man, J. Clin. Invest. 43:138.

    PubMed  CAS  Google Scholar 

  • Murer, H., Evers, C., Stoll, R., and Kinne, R., 1978. The effect of parathyroid hormone (PTH) and dietary phosphate on the sodium-dependent phosphate transport system located in the rat renal brush border membrane, in: Biochemical Nephrology (W. G. Guder and U. Schmidt, eds.), pp. 455–462, Hans Huber. Bern.

    Google Scholar 

  • Nagata, N., and Rasmussen, H., 1970, Parathyroid hormone, 3′,5′-AMP, Ca++, and renal gluconeogenesis, Proc. Natl. Acad. Sci. U.S.A. 65:368.

    PubMed  CAS  Google Scholar 

  • Neville, D. M., and Glossmann, H., 1971, Plasma membrane protein subunit composition. A comparative study by discontinuous electrophoresis in sodium dodecyl sulfate, J. Biol. Chem. 246:6335.

    PubMed  CAS  Google Scholar 

  • Nizet, A., Lefebore, P., Luyckx, A., and Crabbe, J., 1976, Hormonal and nonspecific humoral factors in the interference between sodium, glucose, and phosphate, in: Renal Metabolism in Relation to Renal Function (U. Schmidt and U. C. Dubach, eds.), pp. 262–280, Hans Huber, Bern.

    Google Scholar 

  • Northrup, T. E., Krezowski, P. A., Palumbo, P. J., Kim, J. K., Hui, Y., and Dousa, T. P., 1979, Insulin inhibition of hormone-stimulated protein kinase systems of rat adrenal cortex, Am. J. Physiol. 236:E649.

    PubMed  CAS  Google Scholar 

  • Oliver, J. M., Ukena, T. E., and Berlin, R. D., 1974, Effects of phagocytosis and colchicines on the distribution of lectin-binding sites on cell surfaces, Proc. Natl. Acad. Sci. U.S.A. 71:394.

    PubMed  CAS  Google Scholar 

  • Ostberg, O., 1931, Studien über die Zitronen Säureausscheidung der Menschennieren in normalen und pathologischen Zuständen, Skand. Arch. Physiol. 62:81.

    CAS  Google Scholar 

  • Oxender, D. L., and Quay, S. C., 1976, Isolation and characterization of membrane binding proteins, in: Methods in Membrane Biology, Vol. 6 (E. D. Korn, ed.), pp. 183–242, Plenum Press, New York.

    Google Scholar 

  • Pitts, R. F., 1933, The excretion of urine in the dog, Am. J. Physiol. 106:1.

    CAS  Google Scholar 

  • Pitts, R. F., and Alexander, R. S., 1944, The renal reabsorption mechanism for inorganic phosphate in normal and acidotic dogs, Am. J. Physiol. 142:648.

    CAS  Google Scholar 

  • Plante, G., Lehoux, J., and Petitclerc, C., 1977, Increased phosphaturia following inhibition of renal alkaline phosphatase, Clin. Res. 25:444.

    Google Scholar 

  • Polak, A., Hayie, G. D., Hays, R. M., and Schwartz, W. B., 1961, Effects of chronic hypercapnia on electrolyte and acid-base equilibration. I. Adaptation, J. Clin. Invest. 40:1223.

    PubMed  CAS  Google Scholar 

  • Popovtzer, M. M., Robinette, J. B., DeLuca, H. F., and Holick, M. F., 1974, The acute effect of 25-hydroxycholecalciferol on renal handling of phosphorus, J. Clin. Invest. 53:913.

    PubMed  CAS  Google Scholar 

  • Popovtzer, M. M., Robinette, J. B., McDonald, K. M., and Kuruvila, C. K., 1975, Effect of Ca++ on renal handling of PO4 =: Evidence for two reabsorptive mechanisms, Am. J. Physiol. 229:901.

    PubMed  CAS  Google Scholar 

  • Popovtzer, M. M., Flis, R. S., Mehandru, S. K., and Blum, M., 1977a, Effect of divalent cation ionophore (A23187) on renal handling of phosphorus. Kidney Int. 12:164.

    PubMed  CAS  Google Scholar 

  • Popovtzer, M. M., Blum, M. S., and Flis, R. S., 1977b, Evidence for interference of 25(OH)vitamin D3 with Phosphaturie action of calcitonin, Am. J. Physiol. 232:E515.

    PubMed  CAS  Google Scholar 

  • Poujeol, P., Chabardès, D., Roinel, N., and de Rouffignac, C., 1976, Influence of extracellular fluid volume expansion on magnesium, calcium and phosphate handling along the rat nephron, Pflügers Arch. 365:203.

    PubMed  CAS  Google Scholar 

  • Puschett, J. B., and Goldberg, M., 1969, The relationship between the renal handling of phosphate and bicarbonate in man, J. Lab. Clin. Med. 73:956.

    PubMed  CAS  Google Scholar 

  • Puschett, J. B., Moranz, J., and Kurnick, W. S., 1972a, Evidence for a direct action of cholecalciferol and 25-hydroxycholecalciferol on the renal transport of phosphate, sodium, and calcium, J. Clin. Invest. 51:373.

    PubMed  CAS  Google Scholar 

  • Puschett, J. B., Agus, Z. S., Senesky, D., and Goldberg, M., 1972b, Effects of saline loading and aortic obstruction on proximal phosphate transport, Am. J. Physiol. 223:851.

    PubMed  CAS  Google Scholar 

  • Rasmussen, H., 1972, Ionic and hormonal control of calcium homeostasis, Am. J. Med. 50:567.

    Google Scholar 

  • Rasmussen, H., and Tenenhouse, A.. 1970, Parathyroid hormone and calcitonin, in: Biochemical Actions of Hormones (F. Litwack, ed.), pp. 365–413, Academic Press, New York.

    Google Scholar 

  • Rasmussen, H., Pechet, M., and Fast, D., 1968, Effect of dibutyryl cyclic adenosine 3′,5′-monophosphate, theophylline, and other nucleotides upon calcium and phosphate metabolism, J. Clin. Invest. 47:1843.

    PubMed  CAS  Google Scholar 

  • Robison, G. A., Butcher, R. W., and Sutherland, E. W., 1971, Cyclic AMP, Academic Press, New York.

    Google Scholar 

  • Rosenberg, E. M., and Fogel, A. J., 1977, Role of cyclic 3′,5′-GMP in modulation of cellular uptake of phosphate, Am. J. Physiol. 233:E203.

    PubMed  CAS  Google Scholar 

  • Rostgaard, J., and Thuneberg, L., 1972, Electron microscopical observations on the brush border of proximal tubule cells of mammalian kidney, Z. Zellforsch. Mikrosk. Anat. 132:473.

    PubMed  CAS  Google Scholar 

  • Rostgaard, J., Kristensen, B. I., and Nielsen, L. E., 1972, Electron microscopy of filaments in the basal part of rat kidney tubule cells and their in situ interaction with heavy meromyosin, Z. Zeilforsch. Microsk. Anat. 132:497.

    CAS  Google Scholar 

  • Sacktor, B., 1968, Trehalase and the transport of glucose in the mammalian kidney and intestine, Proc. Natl. Acad. Sci. U.S.A. 60:1007.

    PubMed  CAS  Google Scholar 

  • Sakai, M., Matushita, S., Nakano, T., Kimura, N., Araki, N., and Nagata, N., 1976, Effects of parathyroid hormone in vivo on the protein kinase activity in rat kidney, Endocrinology 98:1443.

    PubMed  CAS  Google Scholar 

  • Sanslone, W. R., and Muntwyle, E., 1966, Muscle cell pH in relation to chronicity of potassium depletion, Proc. Soc. Exp. Biol. Med. 122:900.

    PubMed  CAS  Google Scholar 

  • Schneider, E. G., Strandhoy, J. W., Willis, L. R., and Knox, F. G., 1973, Relationship between proximal sodium reabsorption and excretion of calcium, magnesium and phosphate, Kidney Int. 4:369.

    PubMed  CAS  Google Scholar 

  • Schneider, E. G., Goldsmith, R. S., Arnaud, C. D., and Knox, F. G., 1975, Role of parathyroid hormone in the phosphaturia of extracellular fluid volume expansion, Kidney Int. 7:317.

    PubMed  CAS  Google Scholar 

  • Schussler, G. C., Verso, M. A., and Nemoto, T., 1972, Phosphaturia in hypercalcémie breast cancer patients, J. Clin. Endocrinol. Metab. 35:497.

    PubMed  CAS  Google Scholar 

  • Schwartz, W. B., Brackett, W. C., Jr., and Cohen, J. J., 1965, The response of extracellular hydrogen ion concentration to graded degrees of chronic hypercapnia: The physiologic limits of the defense of pH, J. Clin. Invest. 44:291.

    PubMed  CAS  Google Scholar 

  • Scott, D., 1972, Excretion of phosphorus and acid in the urine of sheep and calves fed either roughage or concentrate diets, Q. J. Exp. Physiol. Cogn. Med. Sci. 57:379.

    PubMed  CAS  Google Scholar 

  • Sellers, B. B., Hall, J. J., Both, C. W., and Mendoza, S. A., 1977, Active phosphate transport across the urinary bladder of the toad, Bufo marinus, J. Membr. Biol. 32:291.

    CAS  Google Scholar 

  • Shah, S. V., Kempson, S. A., Northrup, T. E., and Dousa, T. P., 1978a, Renal adaptation to low phosphate (P) diet and its blockade by actinomycin D (Act-D), Clin. Res. 26:42.

    Google Scholar 

  • Shah, S. V., Kempson, S. A., Northrup, T. E., and Dousa, T. P., 1978b, Renal adaptation of rats to low phosphate diet (LPD): Possible role of protein synthesis, Clin Res. 26:476.

    Google Scholar 

  • Shlatz, L. J., Schwartz, I. L., Kinne-Saffran, E., and Kinne, R., 1975, Distribution of parathyroid hormone-stimulated adenylate cyclase in plasma membranes of cells of the kidney cortex. J. Membr. Biol. 24:131.

    PubMed  CAS  Google Scholar 

  • Simoni, R. D., 1972, Macromolecular characterization of bacterial transport systems. in: Membrane Molecular Biology (C. F. Fox and A. D. Keith, eds.), pp. 289–322, Sinauer Associates, Inc., Stamford, Connecticut.

    Google Scholar 

  • Simpson, D. P., 1967, Regulation of renal citrate metabolism by bicarbonate ion and pH: Observations in tissue slices and mitochondria, J. Clin. Invest. 46:225.

    PubMed  CAS  Google Scholar 

  • Singer, S. J., 1974, The molecular organization of membranes, Annu. Rev. Biochem. 43:805.

    PubMed  CAS  Google Scholar 

  • Snyder, J. A., and Mcintosh, J. R., 1976, Biochemistry and physiology of microtubules, Annu. Rev. Biochem. 45:699.

    PubMed  CAS  Google Scholar 

  • Soderling, T. R., and Park, C. R., 1974, Recent advances in glycogen metabolism, in: Advances in Cyclic Nucleotide Research, Vol. 4 (P. Greengard and G. A. Robison, ed.), pp. 283–333, Raven Press, New York.

    Google Scholar 

  • Steele, T. H., 1970, Increased urinary phosphate excretion following volume expansion in normal man, Metabolism 19:129.

    PubMed  CAS  Google Scholar 

  • Steinberg, D., Mayer, S. E., Khoo, J. C., Miller, E. A., Miller, R. E., Fredholm, B., and Eichner, R., 1975, Hormone regulation of lipase, Phosphorylase, glycogen synthase in adipose tissue, in: Advances in Cyclic Nucleotide Research, Vol. 5 (G. I. Drummond, eds.), pp. 549–568, Raven Press, New York.

    Google Scholar 

  • Straub, R. W., Ferrero, J., Jirounek, P., Jones, G. J., and Salamin, A., 1975, Na-dependent transport of orthophosphate in vertebrate non-myelinated nerves at different pH, in: Proceedings of 6th International Congress of Pharmacology, Helsinki, Finland, p. 367 (Abstract).

    Google Scholar 

  • Straub, R. W., Ferrero, J., Jirounek, P., Rouiller, M., and Salamin A., 1976, Sodium-dependent transport of orthophosphate in nerve fibres, in: Phosphate Metabolism (S. G. Massry and E. Ritz, eds.), pp. 333–344, Plenum Press, New York.

    Google Scholar 

  • Suki, W. N., Martinez-Maldonado, M., Rouse, D., and Terry, A., 1969, Effect of expansion of extracellular fluid volume on renal phosphate handling, J. Clin. Invest. 48:1888.

    PubMed  CAS  Google Scholar 

  • Sutcliffe, H. S., Martin, T. J., Eisman, J. A., and Pilczyk, R., 1973, Binding of parathyroid hormone to bovine kidney-cortex plasma membranes, Biochem. J. 134:913.

    PubMed  CAS  Google Scholar 

  • Taylor, A. N., 1974, In vitro phosphate transport in chick ileum: Effect of cholecalciferol. calcium, sodium, and metabolic inhibitors. J. Nutr. 104:489.

    PubMed  CAS  Google Scholar 

  • Thomas, L., 1973, Isolation of N-ethylmaleimide-labelled phlorizin-sensitive D-glucose binding protein of brush border membrane from rat kidney cortex, Biochim. Biophys. Acta. 291:454.

    PubMed  CAS  Google Scholar 

  • Thomas, L., and Kinne, R., 1972, Studies on the arrangement of aminopeptidase and alkaline phosphatase in the microvilli of isolated brush border of rat kidney, Biochim. Biophys. Acta. 255:114.

    PubMed  CAS  Google Scholar 

  • Thuneberg, L., and Rostgaard, J., 1969, Motility of microvilli. A film demonstration, J. Ultrastruct. Res. 29:578.

    Google Scholar 

  • Trohler, U., Bonjour, J.-P., and Fleisch, H., 1976, Inorganic phosphate homeostasis: Renal adaptation to the dietary intake in intact and thyroparathyroidectomized rats, J. Clin. Invest. 57:264.

    PubMed  CAS  Google Scholar 

  • Tyson, G. E., and Bulger, R. E., 1973, Effect of vinblastine sulfate on the fine structure of proximal tubule cell of rat kidney, J. Cell Biol. 59:349.

    Google Scholar 

  • Ueland, P. M., and Doskeland, S. O., 1977, An adenosine 3′,5′-monophosphate-adenosine binding protein from mouse liver, J. Biol. Chem. 252:677.

    PubMed  CAS  Google Scholar 

  • Ullrich, K. J., 1977, Characterization of calcium, phosphate and para-aminohippurate transport in the proximal convolution of the mammalian kidney, Proc. Int. Union Physiol. Sci. 12:224.

    Google Scholar 

  • Ullrich, K. J., Capasso, G., Rumrich, G., Papavassiliou, F., and Klöss, S., 1977, Coupling between proximal tubular transport processes. Studies with ouabain, SITS and HCO3 - free solutions, Pflügers Arch. 368:245.

    PubMed  CAS  Google Scholar 

  • Vogel, B., Lauterbach, F., and Kroger, W., 1965, Die Bedeutung des Natriums für die renaler Transporte von Glucose und Para-aminihippursäure, Pflügers Arch. Gesamte Physiol. Menschen Tiere 283:151.

    PubMed  CAS  Google Scholar 

  • Webb, R. K., Woodhall, P. B., Tisher, C. C., Glaubiger, G., Neelon, F. A., and Robinson, R. R., 1977, Relationship between phosphaturia and acute hypercapnia in the rat, J. Clin. Invest. 60:829.

    PubMed  CAS  Google Scholar 

  • Wen, S. F., 1974, Micropuncture studies of phosphate transport in the proximal tubule of the dog, J. Clin. Invest. 53:143.

    PubMed  CAS  Google Scholar 

  • Wendel, A., Hahn, R., and Guder, W. G., 1976, On the role of γ-glutamyltransferase in renal tubular amino acid reabsorption, in: Renal Metabolism in Relation to Renal Function (U. Schmidt and U. C. Dubach, eds.), pp. 426–436, Hans Huber, Bern.

    Google Scholar 

  • Winzler, R. J., 1970, Carbohydrates in cell surfaces, Int. Rev. Cytol. 29:77.

    PubMed  CAS  Google Scholar 

  • Wolbach, R. A., 1970, Phlorizin and renal phosphate secretion in the spiny dog fish, Squalus acanthias, Am. J. Physiol. 219:886.

    CAS  Google Scholar 

  • Wolosin, J. M., Ginsburg, H., and Cabantchik, Z. I., 1977, Functional characterization of anion transport system isolated from human erythrocyte membranes, J. Biol. Chem. 252:2419.

    PubMed  CAS  Google Scholar 

  • Wombacher, H., Reuter-Smerdka, A., and Korber, F., 1973, Cyclic adenosine 3′,5′-mon-ophosphate dependent kinases in rat kidney, FEBS Lett. 30:313.

    PubMed  CAS  Google Scholar 

  • Zull, J. E., Malbon, C. C., and Chuang, J., 1977, Binding of tritiated bovine parathyroid hormone to plasma membranes from bovine kidney cortex, J. Biol. Chem. 252:1071.

    PubMed  CAS  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1980 Plenum Publishing Corporation

About this chapter

Cite this chapter

Knox, F.G., Hoppe, A., Kempson, S.A., Shah, S.V., Dousa, T.P. (1980). Cellular Mechanisms of Phosphate Transport. In: Massry, S.G., Fleisch, H. (eds) Renal Handling of Phosphate. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9152-8_4

Download citation

  • DOI: https://doi.org/10.1007/978-1-4615-9152-8_4

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4615-9154-2

  • Online ISBN: 978-1-4615-9152-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics