Correlation of Immunogenetic and Histological Changes in Imnunodeficient Mutant hr/hr Mice

Abstract

At least the majority of peripheral T lymphocytes of the mouse can be classified serologically into three sets of cells that express different Lyt surface phenotypes, denoted Lyt-1, Lyt-23 and Lyt-123 (1). Each of these three sets is programmed for different immune functions (2). In brief, cells of the Lyt-1 set have helper-amplifier effects, whereas the functions of the Lyt-23 set are concerned with cell-mediated cytotoxicity and with suppression; the present view of the Lyt-123 set is that it constitutes an intermediary pool from which the two other T-cell sets are derived; other possible functions of this set are less well defined.