Abstract
The purpose of this study is to describe regional metabolic changes following an episode of cerebral ischemia in the cat. Regional characterization of metabolic derangements is imperative because it is unlikely that cerebral blood flow is uniformly reduced in most hypoxic-ischemic episodes.1, 2, 3 Furthermore, neurons in discrete anatomic regions such as hippocampus or arterial border zones4 are selectively vulnerable to hypoxia-ischemia. Consequently, we have investigated regional alterations of cerebral metabolites in a model of incomplete ischemia (oligemia).
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
Siesjo BK, Johannsson H, Ljunggren B, Norberg K: Brain Dysfunction in Cerebral Hypoxia and Ischemia. Res. Publ. Assoc. Nerve Ment. Dis. 53:75–112, 1974.
Eklöf B, Siesjo BK: Cerebral Blood Flow in Ischemia Caused by Carotid Artery Ligation in the Rat. Acta Physiol. Scand. 87:69–77, 2973.
Welsh FA, Durity F, Langfitt TW: The Appearance of Regional Variation in Metabolism at a Critical Level of Diffuse Cerebral Oligemia. Submitted to J. Neurochem. 1976.
Lindenberg R: Patterns of CNS Vulnerability in Acute Hypoxaemia, including Anaesthesia Accidents. In Schade JP, McMenemey WH (Editors): Selective Vulnerability of the Brain in Hypoxaemia. Philadelphia, FA Davis Pulbishing Company, 1963, pp 189–209.
Lowry OH, Passonneau JV: A Flexible System of Enzymatic Analysis. New York, Academic Press, 1972.
Schuette WH, Whitehouse, WC, Lewis DV, O’Connor, M, van Buren JM: A Television Fluorometer for Monitoring Oxidative Metabolism in Intact Tissue. Med. Instrum. 8:331–333, 1974.
Ponten U, Ratcheson RA, Salford LG, Siesjö BK: Optimal Freezing Conditions for Cerebral Metabolites in Rats. J. Neurochem. 21: 1127–1138, 1973.
Lowry OH, Passonneau JV, Hasselberger FX, Schulz DW: Effect of Ischemia on Known Substrates and Cofactors of the Glycolytic Pathway in Brain. J. Biol. Chem. 239:18–30, 1964
Lierse W: Die Kapillarastände in verschiedenen Hirnregionen der Katze. Z. Zellforsch. 54:199–206, 1961.
McIlwain H: Biochemistry and the Central Nervous System. Boston; Little, Brown and Company, Third Edition, 1966, p 55.
Reivich M: Blood Flow Metabolism Couple in Brain. Res. Publ. Assoc. Nerve Ment. Dis. 53:125–139, 1974.
Silver IA: Changes in pO2 and Ion Fluxes in Cerebral Hypoxiaischemia. These Proceedings.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1977 Plenum Press, New York
About this chapter
Cite this chapter
Welsh, F.A., O’Connor, M.J., Rieder, W., Marcy, V.R. (1977). Regional Changes in Metabolism in Hypoxia-Ischemia. In: Reivich, M., Coburn, R., Lahiri, S., Chance, B. (eds) Tissue Hypoxia and Ischemia. Advances in Experimental Medicine and Biology, vol 78. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9035-4_23
Download citation
DOI: https://doi.org/10.1007/978-1-4615-9035-4_23
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4615-9037-8
Online ISBN: 978-1-4615-9035-4
eBook Packages: Springer Book Archive