Abstract
Dietrich and Dukor (1) have shown that a regimen of 5 daily injections of cortisone-acetate may severely affect the antibody response against sheep erythrocytes in mice. Suppression was most pronounced when the cortisone treatment was given just prior to the antigen. Similarly Elliott and Sinclair (2), using a single, large dose of cortisone-acetate, found maximal suppression of both IgM- and IgG-response when the cortisone was given before antigen. Recovery from this cortisone-induced immunological depression was shown to be independent of the thymus but correlated with increase of blood lymphocyte numbers. Everett and Tyler (3) demonstrated that hydrocortisone preferentially affected the short-lived category of lymphocytes in blood and peripheral lymphoid tissue. According to Esteban (4) especially those in the thymus and bone marrow were highly susceptible to cortisone. Together these results suggest that cortisone might affect lymphoid cells — possibly including antibody-forming-cell-precursors — prior to their stimulation by antigen.
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References
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© 1971 Plenum Press, New York
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van den Broek, A.A. (1971). Immunological Effects of Cortisone Caused by Interference with Lymphoid Cell Traffic. In: Lindahl-Kiessling, K., Alm, G., Hanna, M.G. (eds) Morphological and Functional Aspects of Immunity. Advances in Experimental Medicine and Biology, vol 12. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9011-8_84
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DOI: https://doi.org/10.1007/978-1-4615-9011-8_84
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