Abstract
Murine sarcoma virus (MSV), injected in immunocompetent adult mice, has the peculiarity of inducing tumors which have a high incidence of complete regression. However, when this virus is injected in newborn mice or in adults, immunosuppressed by various treatments (1,2,3), the induced sarcomas grow progressively and ultimately cause the host’s death. Since neoplastic cells release infectious virus and possess a strong antigenicity, it is generally agreed that tumor regression is mediated by an immunological reaction against tumor-specific virus and/or cellular antigens. The operational factors responsible for this regression are controversial. Therefore, we have elected to study the relationship between morphological and biological data on tumor growth and regression in mice injected with MSV. Moreover, preliminary data obtained on the effects of adoptive immunization and pre-infection with murine leukemia virus (MLV) on the oncogenicity of MSV will also be reported.
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© 1971 Plenum Press, New York
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Chieco-Bianchi, L., Pennelli, N., Collavo, D., Tridente, G. (1971). Tumor Induction by Murine Leukemia/Sarcoma Viruses: Morphological and Immunological Studies. In: Lindahl-Kiessling, K., Alm, G., Hanna, M.G. (eds) Morphological and Functional Aspects of Immunity. Advances in Experimental Medicine and Biology, vol 12. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9011-8_68
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DOI: https://doi.org/10.1007/978-1-4615-9011-8_68
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