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Cholinergic and Catecholaminergic Modification of the Hippocampal Lesion Syndrome

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The Hippocampus

Abstract

The primary motivation for our study of the effects of brain damage in animals is the hope that, through such research, principles of the brain’s response to damage can be established that will lead, ultimately, to the discovery of ways in which such effects can be alleviated or even eliminated. The destruction of the hippocampus has been considered a useful model for the study of intervention processes in general because so many of the behavioral consequences of this damage have been extensively studied (see Isaacson, 1974, 1982; O’Keefe and Nadel, 1978; Pribram, this volume). This is not to say that the behavioral functions of the hippocampus are well understood. The interpretation of the behavioral alterations are, and will very likely continue to be, resistant to adequate theoretical analysis until the functions of other parts of the brain are also understood (see Isaacson, 1980a). Trying to develop a theory of hippocampal function without knowledge of how cortical and subcortical systems enact their own complicated roles in our mental and behavioral lives is like trying to place a piece in a jigsaw puzzle that has the majority of the pieces missing. Will our knowledge of how all the pieces work ever be adequate? This is both a philosophical and an empirical question. In a clinical sense, we believe that enough will be understood about the brain to be of practical assistance to those with brain damage, stroke, and congenital deformations.

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Authors and Affiliations

  1. Center for Neurobehavioral Sciences and Department of Psychology, University Center at Binghamton, Binghamton, New York, 13901, USA

    Robert L. Isaacson & Jeanne P. Ryan

  2. Department of Neurobiology and Anatomy, University of Rochester School of Medicine and Dentistry, Rochester, New York, 14642, USA

    Joe E. Springer

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  1. Robert L. Isaacson
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  2. Joe E. Springer
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Editors and Affiliations

  1. Center for Neurobehavioral Sciences and Department of Psychology, University Center at Binghamton, 13901, Binghamton, New York, USA

    Robert L. Isaacson

  2. Department of Psychology and Psychiatry and Behavioral Sciences, Stanford University, 94305, Stanford, California, USA

    Karl H. Pribram

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© 1986 Plenum Press, New York

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Isaacson, R.L., Springer, J.E., Ryan, J.P. (1986). Cholinergic and Catecholaminergic Modification of the Hippocampal Lesion Syndrome. In: Isaacson, R.L., Pribram, K.H. (eds) The Hippocampus. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-8024-9_5

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  • DOI: https://doi.org/10.1007/978-1-4615-8024-9_5

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