Abstract
In this chapter I discuss the need for automated channel analysis, touch on various approaches to analyzing data, and discuss in some detail the experiences of our laboratory in automating data analysis. Colquhoun and Sigworth, in Chapter 11, have treated some of the aspects of channel analysis, and the reader is referred to that chapter for additional information.
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References
Auerbach, A., and Sachs, F., 1982, Flickering of a nicotinic ion channel to a subconductance state, Biophys. J. 42:1–10.
Bendat, J. S., and Piersol, A. G., 1971, Random Data Analysis and Measurement Procedures, Wiley-Interscience, New York.
Christensen, R., 1981, Entropy Minimax Sourcebook, Entropy Ltd., Lincoln, Massachusetts.
Dionne, V. E., and Leibowitz, M. D., 1982, Acetylcholine receptor kinetics: A description from single channel currents at snake neuromuscular junctions, Biophys. J. 39:253–261.
Dubes, R. C., 1974, Signal analysis, in: Electronic Designer’s Handbook (Giacoletto ed.), pp. 4–1–4–54, McGraw-Hill, New York.
FitzHugh, R., 1983, Statistical properties of the asymmetric random telegraph signal with applications to single channel analysis, Math. Biosci. 64:75–89.
Hamill, O. P., Marty, A., Neher, E., Sakmann, B., and Sigworth, F. J., 1981, Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches, Pfluegers Arch. 391(2):85–100.
Harris, F. J., 1978, On the use of windows for harmonic analysis with discrete Fourier transform, IEEE 661(l):51–83.
Horn, R., and Lange, K., 1983, Estimating kinetic constants from single channel data, Biophys. J. (in press).
Korn, H., Triller, A., Mallet, A., and Faber, D., 1981, Fluctuating responses at a central synapse: n of binomial fit predicts number of stained presynaptic boutons, Science 213:898–901.
IEEE, 1979, Programs for Digital Signal Processing, IEEE Press, New York.
Neher, E., and Sakmann, B., 1976, Single channel currents recorded from membrane of denervated frog muscle fibres, Nature 260:799–802.
Oppenheim, A. V., and Schafer, R. W., 1975, Digital Signal Processing, Prentice Hall, Englewood Cliffs, New Jersey.
Ostrem, J., and Falconer, D., 1981, A differential operator technique for restoring degraded signals and images, IEEE Trans. Pattern Anal. Mach. Intel. 3(3):278–284.
Palotta, B. S., Magleby, K. L., and Barrett, J. N., 1981, Single channel recordings of Ca++-activated K+ currents in rat muscle cell culture. Nature 293:471 – 474.
Patlak, J. B., Gration, K. B., and Usherwood, P. N. R., 1979, Single glutamate activated channels in locust muscle, Nature 278:643–645.
Patlak, J., and Horn, R., 1982, The effect of n-bromoacetamide on single sodium channel currents in excised membrane patches,J. Gen. Physiol. 79(3):333–351.
Patlak, J. B., Gration, K. B., and Usherwood, P. N. R., 1979, Single glutamate activated channels in locust muscle, Nature 278:643–645.
Peled, A., and Liu, B., 1976, Digital Signal Processing, pp. 67–70, John Wiley & Sons, New York.
Rice, S. O., 1954, Mathematical analysis of random noise, in: Selected Papers on Noise and Stochastic Processes (N. Wax, ed.), pp. 133–294, Dover, New York.
Sachs, F., and Barkakati, N., 1980, The amplitude distribution of single channel currents can yield dose response information, Biophys. Soc. Abstr. 2425:174.
Sachs, F., Neil, J., and Barkakati, N., 1982, The automated analysis of data from single ionic channels, Pfluegers Arch. 395:331–340.
Sigworth, F. J., 1982, Fluctuations in the current through open ACh-receptor channels, Biophys. J. 37:309a.
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© 1983 Plenum Press, New York
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Sachs, F. (1983). Automated Analysis of Single-Channel Records. In: Sakmann, B., Neher, E. (eds) Single-Channel Recording. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-7858-1_12
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DOI: https://doi.org/10.1007/978-1-4615-7858-1_12
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