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Issues and Reviews in Teratology

Volume 2

  • Book
  • © 1984

Overview

Editors:
  1. Harold Kalter

    1. Children’s Hospital Research Foundation and Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, USA

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Table of contents (10 chapters)

  1. Front Matter

    Pages i-xvi
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  2. Birth Defects Monitoring Systems

    • Bengt KällĂ©n, Sylvia Hay, Marcus Klingberg
    Pages 1-22

  3. What Is a Teratogen?

    • Zena Stein, Jennie Kline, Martin Kharrazi
    Pages 23-66

  4. Congenital Hydrocephalus in Mice and Man

    • David G. McLone
    Pages 67-89

  5. Congenital Defects of Domestic and Feral Animals

    • Horst W. Leipold, Stanley M. Dennis
    Pages 91-156

  6. Transplacental Exposure to Diethylstilbestrol

    • Bruce E. Walker
    Pages 157-187

  7. Hormones, Growth Factors, and Their Receptors in Normal and Abnormal Prenatal Development

    • Robert M. Pratt
    Pages 189-217

  8. Vertebrate Limb Morphogenesis

    • Robert O. Kelley, John F. Fallon, Robert E. Kelly Jr.
    Pages 219-265

  9. Teratogenicity of Experimental and Occupational Exposure to Industrial Chemicals

    • J. A. John, D. J. Wroblewski, B. A. Schwetz
    Pages 267-324

  10. Critical Assessment of Genetic Effects of Ionizing Radiation on Pre- and Postnatal Development

    • William J. Schull, Julia K. Bailey
    Pages 325-398

  11. Adverse Effects in Humans and Animals of Prenatal Exposure to Selected Therapeutic Drugs and Estimation of Embryo-Fetal Sensitivity of Animals for Human Risk Assessment

    • K. S. Khera
    Pages 399-507

  12. Back Matter

    Pages 509-516
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Keywords

About this book

A growing sophistication of the American populace about the nature and realities of the impact of the environment on prenatal development was not much in evi­ dence in 1983. Continuing accusations against Agent Orange and Bendectin high­ light what must be a deep credulousness and need to blame others for one's bio­ logical misfortunes. We despair that ignorance and nonaccountability can be dissipated by objective means. But one can only learn and teach and hope. The need to know what causes congenital malformations becomes more imperative as they become the last major holdout, the most unyielding of all the reasons babies still die and are seriously ill. In the aggregate, congenital malfor­ mations are now the cause of about one-third of the deaths of infants less than one month old and one-fifth of the deaths of those under one year old, up 50% in the last two decades. In the instance of one suspected cause of congenital malformations, maternal insulin-dependent diabetes mellitus, while the perinatal mortality rate of children of such women has gone down greatly since World War II, the fraction of deaths due to congenital malformations has grown correspondingly and is now approach­ ing 50%. Present-day knowledge of the causes of congenital malformations is most imperfect. A recent authoritative review found that there is understanding to one extent or another of the causation of less than half of all congenital malformations.

Editors and Affiliations

  • Children’s Hospital Research Foundation and Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, USA

    Harold Kalter

Bibliographic Information

  • Book Title: Issues and Reviews in Teratology

  • Book Subtitle: Volume 2

  • Editors: Harold Kalter

  • DOI: https://doi.org/10.1007/978-1-4615-7314-2

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 1984

  • Softcover ISBN: 978-1-4615-7316-6Published: 22 June 2012

  • eBook ISBN: 978-1-4615-7314-2Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: XVI, 516

  • Number of Illustrations: 35 b/w illustrations

  • Topics: Human Genetics

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