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Survival in Alzheimer’s Disease

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Dementia
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Abstract

By definition survival time in illness is the interval between onset and termination, be that cure or death. Implicit in this statement is a confident diagnosis, knowledge of the natural history of the condition and understanding of the factors likely to influence the outcome.

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References

  • Bergmann, K., Foster, E.M., Justice, A.W. and Matthews, V. (1978) Management of the demented elderly patient in the community. Br. J. Psychiatry, 132, 441–9.

    Article  PubMed  CAS  Google Scholar 

  • Blessed, G. (1989) Clinico-pathological studies in mental disorder in old age: The Newcastle studies 1963–1967. In Contemporary Themes in Psychiatry — A Tribute to Sir Martin Roth (eds K. Davidson and A. Kerr ), Gaskell, London, pp. 314–21.

    Google Scholar 

  • Blessed, G. and Wilson, I.D. (1982) The contemporary natural history of mental disorder in old age. Br. J. Psychiatry, 141, 59–67.

    Article  PubMed  CAS  Google Scholar 

  • Blessed, G., Tomlinson, B.E. and Roth, M. (1968) The association between quantitative measures of dementia and of senile change in the cerebral grey matter of elderly subjects. Br. J. Psychiatry, 114, 797–811.

    Article  PubMed  CAS  Google Scholar 

  • Bondareff, W. (1983) Age and Alzheimer’s disease. Lancet, i, 1447.

    Article  Google Scholar 

  • Bondareff, W., Mountjoy, C.Q., Roth, M. et al. (1987) Age and histopathological heterogeneity in Alzheimer’s disease. Arch. Gen. Psychiatry, 44, 412–17.

    Article  PubMed  CAS  Google Scholar 

  • Brun, A. (1987) Frontal lobe degeneration of non-Alzheimer type. 1. Neurology. Arch. Gerontol. Geriatr., 6, 193–208.

    Article  PubMed  CAS  Google Scholar 

  • Brust, J.C.M. (1988) Vascular dementia is over-diagnosed. Arch. Neurol., 45, 799–801.

    Article  PubMed  CAS  Google Scholar 

  • Burns, A., Luthert, P., Levy, R. et al. (1990a) Accuracy of clinical diagnosis of Alzheimer’s disease. Br. Med. J., 301, 1026.

    Article  CAS  Google Scholar 

  • Burns, A., Jacoby, R., Luthert, P. and Levy, R. (1990b) Cause of death in Alzheimer’s disease. Age Ageing, 19, 341–4.

    Article  PubMed  CAS  Google Scholar 

  • Burns, A., Jacoby, R. and Levy, R. (1990c) Psychiatric phenomena in Alzheimer’s disease. IV: Disorders of behaviour. Br. J. Psychiatry, 157, 86–94.

    Article  PubMed  CAS  Google Scholar 

  • Burns, A., Jacoby, R. and Levy, R. (1991a) Neurological signs in Alzheimer’s disease. Age Ageing, 20, 45–51.

    Article  PubMed  CAS  Google Scholar 

  • Burns, A., Lewis, G., Jacoby, R. and Levy, R. (1991b) Factors affecting survival in Alzheimer’s disease. Psychol. Med., 21, 363–70.

    Article  PubMed  CAS  Google Scholar 

  • Burns, A., Jacoby, R. and Levy, R. (1991c) Progression of cognitive impairment in Alzheimer’s disease. J. Am. Geriatr. Soc., 39, 39–41.

    PubMed  CAS  Google Scholar 

  • Byrne, J.E., Lennox, G., Lowe, J. and Godwin-Austen, R.B. (1989) Diffuse Lewy body disease: clinical features in 15 cases. J. Neurol. Neurosurg. Psychiatry, 52, 709–17.

    Article  PubMed  CAS  Google Scholar 

  • Byrne, J.E., Smith, C.W. and Arie, T. (1991) The diagnosis of dementia — 1. Clinical and pathological criteria: A review of the literature. Int. J. Geriatr. Psychiatry, 6, 199–208.

    Article  Google Scholar 

  • Camargo, O. and Preston, G. (1945) What happens to patients who are hospitalized for the first time when over sixty-five years of age. Am. J. Psychiatry, 102, 168–73.

    Google Scholar 

  • Chandra, V., Bharucha, N.E. and Schoenberg, B.S. (1986) Conditions associated with Alzheimer’s disease at death. Neurology, 36, 209–11.

    Article  PubMed  CAS  Google Scholar 

  • Christie, A.B. (1982) Changing patterns in mental illness in the elderly. Br. J. Psychiatry, 140, 154–9.

    Article  PubMed  CAS  Google Scholar 

  • Christie, A.B. and Train, J.D. (1983) SHAPE, dementia and clinical experience. Health Bull., 41, 283–91.

    CAS  Google Scholar 

  • Christie, A.B. and Train, J.D. (1984) Change in the pattern of care for the demented. Br. J. Psychiatry, 144, 9–15.

    Article  PubMed  CAS  Google Scholar 

  • Christie, A.B. and Wood, E.R.M. (1987) Psycho-geriatrics 1974 to 1984. Expanding problems and fixed resources. Br. J. Psychiatry, 151, 813–17.

    Article  PubMed  CAS  Google Scholar 

  • Christie, A.B. and Wood, E.R.M. (1988) Age, clinical features and prognosis in SDAT. Int. J. Geriatr. Psychiatry, 3, 63–8.

    Article  Google Scholar 

  • Christie, A.B. and Wood, E.R.M. (1990) Further change in the pattern of mental illness in the elderly. Br. J. Psychiatry, 157, 228–31.

    Article  PubMed  CAS  Google Scholar 

  • Christie, A.B., Whitfield, E. and Wood, E.R.M. (1992) SHAPE, dementia and clinical experience — a reappraisal. Scott. Med. J., 37, 8–10.

    PubMed  CAS  Google Scholar 

  • Copeland, J.R.M. (1981) Mental illness amongst the elderly in London. In Epidemiology and Prevention of Mental Illness in Old Age (eds G. Magnussen, J. Neilson and J. Buch ), Nordisk Samrud for Eldreaktivitet, Denmark, pp. 63–6.

    Google Scholar 

  • Dastoor, D.P. and Cole, M.G. (1985) The course of Alzheimer’s disease: An uncontrolled longitudinal study. J. Clin. Exp. Gerontol., 7, 28999.

    Google Scholar 

  • Drevets, W.C. and Rubin, E.H. (1989) Psychotic symptoms and the longitudinal course of senile dementia of the Alzheimer type. Soc. Biol. Psychiatry, 25, 39–48.

    Article  CAS  Google Scholar 

  • Duckworth, G.S., Edworth, H.B. and Bailey, W.F. (1979) Prognosis in mental illness in old age. Can. J. Psychiatry, 24, 674–82.

    PubMed  CAS  Google Scholar 

  • Eagger, S.A., Levy, R. and Sahakian, B.J. (1991) Tacrine in Alzheimer’s disease. Lancet, 337, 989–92.

    Article  PubMed  CAS  Google Scholar 

  • Eagles, J.M. and Gilleard, C.J. (1984) The demented elderly admitted to a psychogeriatric assessment unit. Br. J. Psychiatry, 144, 31416.

    Article  Google Scholar 

  • Eagles, J.M., Beattie, J.A.G., Restall, D.B. et al. (1990) Relation between cognitive impairment and early death in the elderly. Br. Med. J., 300, 239–40.

    Article  CAS  Google Scholar 

  • Eisdorfer, C. and Cohen, D. (1980) Diagnostic criteria for primary neuronal degeneration of the Alzheimer type. J. Fam. Pract., 11, 553–7.

    PubMed  CAS  Google Scholar 

  • Erkinjuntti, T., Wilkstrom, J., Palo, J. and Autio, L. (1986) Dementia among medical inpatients: Evaluation of 2000 consecutive admissions. Arch. Intern. Med., 146, 1923–6.

    Google Scholar 

  • Filley, C.M., Kelly, J. and Heaton, R.K. (1986) Neuropsychologic features of early-and late-onset Alzheimer’s disease. Arch. Neurol., 43, 574–6.

    Article  PubMed  CAS  Google Scholar 

  • Folstein, M.F., Folstein, S.E. and McHugh, P.R. (1975) ‘Mini-Mental State’. A practical method for grading the cognitive state of patients for the clinician. J. Psychiatr. Res., 12, 189–98.

    Article  PubMed  CAS  Google Scholar 

  • Fries, J.F. (1980) Aging, natural death, and the compression of morbidity. N. Engl. J. Med., 303, 130–5.

    Article  PubMed  CAS  Google Scholar 

  • Goldfarb, A.I. (1969) Predicting mortality in the institutionalized aged. Arch. Gen. Psychiatry, 21, 172–6.

    Article  PubMed  CAS  Google Scholar 

  • Gruenberg, E.M. (1977) The failures of success. Millbank Memorial Fund Quarterly. Health and Society, Winter 1977, 3–24.

    Google Scholar 

  • Grundy, E. (1984) Mortality and morbidity among the old. Br. Med. J., 288, 663–4.

    Article  CAS  Google Scholar 

  • Grundy, E. and Arie, T. (1984) Institutionalization and the elderly: International comparisons. Age Ageing, 13, 129–37.

    Article  PubMed  CAS  Google Scholar 

  • Hagnell, O., Lanke, J. and Rorsman, B. (1981) Increasing prevalence and decreasing incidence of age psychosis. A longitudinal epidemiological investigation of a Swedish population. The Lundby Study. In Epidemiology and Prevention of Mental Illness in Old Age (eds G. Magnussen, J. Neilson and J. Buch ), Nordisk Samrud for Eldreaktivitet, Denmark, pp. 34–41.

    Google Scholar 

  • Henderson, A.S. (1988) The risk factors for Alzheimer’s disease: a review and a hypothesis. Acta Psychiatr. Scand., 78, 257–75.

    Article  PubMed  CAS  Google Scholar 

  • Henderson, A.S. and Huppert, F.A. (1984) The problem of mild dementia. Psychol. Med., 14, 5–11.

    Article  PubMed  CAS  Google Scholar 

  • Homer, A.C., Honavar, M., Lantos, P.L. et al. (1988) Diagnosing dementia: Do we get it right? Br. Med. J., 297, 894–6.

    Article  CAS  Google Scholar 

  • Horwitz, B. and Rapoport, S.I. (1990) Biological correlates of dementia. Curr. Opin. Psychiatry, 3, 497–500.

    Article  Google Scholar 

  • Huff, F.J., Growden, J.H., Corkin, S. and Rosen, T.J. (1987) Age at onset and rate of progression of Alzheimer’s disease. J. Am. Geriatr. Soc., 35, 27–30.

    PubMed  CAS  Google Scholar 

  • Jacoby, R.J. and Levy, R. (1980) Computed tomography in the elderly 2. Senile dementia: Diagnosis and functional impairment. Br. J. Psychiatry, 136, 256–69.

    Article  PubMed  CAS  Google Scholar 

  • Kahn, R.L., Goldfarb, A.I., Pollack, M. and Peck, A. (1960) Brief objective measures for the determination of mental status in the aged. Am. J. Psychiatry, 117, 326–8.

    PubMed  CAS  Google Scholar 

  • Katzman, R. (1976) The prevalence and malignancy of Alzheimer’s disease. Arch. Neurol., 33, 217–18.

    Article  PubMed  CAS  Google Scholar 

  • Katzman, R. (1985) Clinical presentation of the course of Alzheimer’s disease: The atypical patient. Interdiscipl. Topics Gerontol., 20, 12–18.

    Google Scholar 

  • Kay, D.W.K. (1962) Outcome and cause of death in mental disorders of old age: A long-term follow-up of functional and organic psychoses. Acta Psychiatr. Scand., 39, 249–76.

    Article  Google Scholar 

  • Kay, D.W.K., Norris, V. and Post, F. (1956) Prognosis in psychiatric disorders of the elderly. J. Ment. Sci., 102, 129–40.

    PubMed  CAS  Google Scholar 

  • Kohn, R.R. (1982) Cause of death in very old people. JAMA, 247, 2793–7.

    Article  PubMed  CAS  Google Scholar 

  • Koller, W., Glatt, S., Wilson, R. and Fox, J. (1982) Primitive reflexes and cognitive function in the elderly. Ann. Neurol., 12, 302–4.

    Article  PubMed  CAS  Google Scholar 

  • Lewis, A.J. (1946) Ageing and senility: A major problem of psychiatry. J. Ment. Sci., 92, 150–70.

    PubMed  CAS  Google Scholar 

  • Lishman, W.A. (1991) The evolution of research into the dementias. Dementia, 2, 177–85.

    Google Scholar 

  • Luxenberg, J.S., Haxby, J.V., Creasey, H. et al. (1987) Rate of ventricular enlargement in dementia of the Alzheimer type correlates with the rate of neuropsychological deterioration. Neurology, 37, 1135–40.

    Article  PubMed  CAS  Google Scholar 

  • Mayer-Gross, W., Slater, E. and Roth, M. (1954) Clinical Psychiatry, Cassel and Company Ltd, London, pp. 482–94.

    Google Scholar 

  • McDonald, C. (1969) Clinical heterogeneity in senile dementia. Br. J. Psychiatry, 115, 267–71.

    Article  PubMed  CAS  Google Scholar 

  • McKeith, I., Fairbairn, A., Perry, R. et al. (1992) Neuroleptic sensitivity in patients with senile dementia of Lewy Body Type. Br. Med. J., 305, 673–8.

    Article  CAS  Google Scholar 

  • McKhann, G., Drachman, D., Folstein, M. et al. (1984) Clinical diagnosis of Alzheimer’s disease: Report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer’s Disease. Neurology, 34, 939–44.

    Article  PubMed  CAS  Google Scholar 

  • Merriam, A.E., Aronson, M.K., Gaston, P. et al. (1988) The psychiatric symptoms of Alzheimer’s disease. J. Am. Geriatr. Soc., 36, 7–12.

    PubMed  CAS  Google Scholar 

  • Naguib, M. and Levy, R. (1982a) CT scanning in senile dementia, a follow-up of survivors. Br. J. Psychiatry, 141, 618–20.

    Article  PubMed  CAS  Google Scholar 

  • Naguib, M. and Levy, R. (1982b) Prediction of outcome in senile dementia — a computed tomography study. Br. J. Psychiatry, 140, 263–7.

    Article  PubMed  CAS  Google Scholar 

  • O’Brien, M.D. (1988) Vascular dementia is under-diagnosed. Arch. Neurol., 45, 797–8.

    Article  PubMed  Google Scholar 

  • O’Connor, D.W., Pollitt, P.A., Hyde, J.B. et al. (1988) Do general practitioners miss dementia in elderly patients. Br. Med. J., 297, 1107–10.

    Article  Google Scholar 

  • O’Connor, D.W., Pollitt, P.A., Brook, C.P.B. et al. (1991) Does early intervention reduce the number of elderly people with dementia admitted to institutions for long term care. Br. Med. J., 302, 871–4.

    Article  Google Scholar 

  • Odegard, O. (1967) Changes in the prognosis of functional psychoses since the days of Kraepelin. Br. J. Psychiatry, 113, 813–22.

    Article  PubMed  CAS  Google Scholar 

  • Peck, A., Wolloch, L. and Rodstein, M. (1978) Mortality of the aged with chronic brain syndrome. In Alzheimer’s Disease: Senile Dementia and Related Disorders (eds R. Katzman, R.D. Terry and K.L. Bick ), Raven Press, New York, pp. 299–307.

    Google Scholar 

  • Plum, F. (1979) Dementia: an approaching epidemic. Nature, 279, 372–3.

    Article  PubMed  CAS  Google Scholar 

  • Post, F. (1944) Some problems arising from a study of mental patients over the age of sixty years. J. Ment. Sci., 90, 554–65.

    Google Scholar 

  • Reisberg, B., Ferris, S.H., de Leon, M.J. and Crook, T. (1982) The global deterioration scale for assessment of primary dementia. Am. J. Psychiatry, 139, 1136–9.

    PubMed  CAS  Google Scholar 

  • Reisberg, B., Ferris, S.H., de Leon, M.J. et al. (1989) The stage specific temporal course of Alzheimer’s disease: Functional and behavioural concomitants based upon cross-sectional and longitudinal observation. Prog. Clin. Biol. Res., 317, 23–41.

    PubMed  CAS  Google Scholar 

  • Rosenman, S. (1991) The validity of the diagnosis of mild dementia. Psychol. Med., 21, 923–34.

    Article  PubMed  CAS  Google Scholar 

  • Rossor, M.N., Iversen, L.L., Reynolds, G.P. et al. (1984) Neurochemical characteristics of early and late onset types of Alzheimer’s disease. Br. Med. J., 288, 961–4.

    Article  CAS  Google Scholar 

  • Roth, M. (1955) The natural history of mental disorder in old age. J. Ment. Sci., 101, 281–301.

    PubMed  CAS  Google Scholar 

  • Roth, M., Tym, E., Mountjoy, C.Q. et al. (1986) CAMDEX. A standardised instrument for the diagnosis of mental disorder in the elderly with special reference to the early detection of dementia. Br. J. Psychiatry, 149, 698–709.

    Article  PubMed  CAS  Google Scholar 

  • Rubin, E.H., Drevets, W.C. and Burke, W.J. (1988) The nature of psychotic symptoms on senile dementia of the Alzheimer type. J. Geriatr. Psychiatry Neurol., 1, 16–20.

    Article  PubMed  CAS  Google Scholar 

  • Schneider, L.S., Pollock, V.E. and Lyness, S.A. (1990) A metaanalysis of controlled trials of neuroleptic treatment in dementia. J. Am. Geriatr. Soc., 38, 553–63.

    PubMed  CAS  Google Scholar 

  • Selkoe, D.J. (1991) Amyloid protein and Alzheimer’s disease. Sci. Am., 265, 40–7.

    Article  Google Scholar 

  • Seltzer, B. and Sherwin, I. (1983) A comparison of clinical features of early-and late-onset primary degenerative dementia. Arch. Neurol., 40, 143–6.

    Article  PubMed  CAS  Google Scholar 

  • Shah, K.V., Banks, G.D. and Merskey, H. (1969) Survival in atherosclerotic and senile dementia. Br. J. Psychiatry, 115, 1283–6.

    Article  PubMed  CAS  Google Scholar 

  • Shan Wang, H. (1978) Prognosis in dementia and related disorders in the aged. In Alzheimer’s Disease: Senile Dementia and Related Disorders (eds R. Katzman, R.D. Terry and K.L. Bick ), Raven Press, New York, pp. 309–13.

    Google Scholar 

  • Spagnoli, A. (1991) Editorial. Clinical relevance in drug trials for Alzheimer’s disease and related disorders. Int. J. Geriatr. Psychiatry, 6, 265–7.

    Article  Google Scholar 

  • Stern, Y., Mayeux, R., Sano, M. et al. (1987) Predictors of disease course in patients with probable Alzheimer’s disease. Neurology, 37, 1649–53.

    Article  PubMed  CAS  Google Scholar 

  • Sulkava, R. (1982) Alzheimer’s disease and senile dementia of Alzheimer type. Acta Neurol. Scand., 65, 636–50.

    Article  PubMed  CAS  Google Scholar 

  • Thomson, F.G. and Eastwood, M.R. (1981) Survivorship and senile dementia. Age Ageing, 10, 29–32.

    Article  Google Scholar 

  • Tierney, M., Fisher, R.H., Lewis, A.J. et al. (1988) The NINCDS-ADRDA Work Group criteria for the clinical diagnosis of probable Alzheimer’s disease. A clinicopathologic study of 57 cases. Neurology, 38, 359–64.

    Article  PubMed  CAS  Google Scholar 

  • Tweedy, J., Reding, M., Garcia, C. et al. (1982) Significance of cortical disinhibition signs. Neurology, 32, 169–73.

    Article  PubMed  CAS  Google Scholar 

  • Williamson, J., Stokoe, I.H., Gray, S. et al. (1964) Old people at home their unreported needs. Lancet, i, 1117–20.

    Article  Google Scholar 

  • Wood, E., Whitfield, E. and Christie, A.B. (1991) Changes in survival in demented hospital inpatients 1957–1987. Int. J. Geriatr. Psychiatry, 6, 523–8.

    Article  Google Scholar 

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Christie, A.B. (1994). Survival in Alzheimer’s Disease. In: Burns, A., Levy, R. (eds) Dementia. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-6805-6_6

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  • DOI: https://doi.org/10.1007/978-1-4615-6805-6_6

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