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Receptor-Mediated Gene Delivery with Synthetic Virus-Like Particles

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Targeting of Drugs 5

Part of the book series: NATO ASI Series ((NSSA,volume 290))

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Abstract

The development of successful somatic gene therapy is largely limited by technology. At present the deciding factors for progress are the development of efficient and safe delivery systems, rather than the characterization of therapeutic genes. Viral vectors (Jolly, 1994; Trapnell and Gorziglia, 1994; Kotin, 1994) have been the basis for the first gene therapies; their characteristics have strongly determined the design of the clinical studies. The high efficiency by which retroviral vectors transduce dividing cultured cells has resulted in ex vivo gene therapies where transduced cells are returned into the patient after expansion in culture. Recombinant adenoviruses are capable of being produced at higher titers, are stable to the bloodstream and transduce dividing and non-dividing cells with higher efficiency, also when directly administered into the body. For these reasons adenoviral vectors have been the first choice for direct in vivo gene therapy applications.

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Authors and Affiliations

  1. Institute of Biochemistry, Vienna University Biocenter, Dr. Bohr-Gasse 9/3, A-1030, Vienna, Austria

    Ernst Wagner

  2. Research Institute of Molecular Pathology, University of Graz, Austria

    Ernst Wagner & Matt Cotten

  3. Institute of Pathology, University of Graz, Austria

    Kurt Zatloukal

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  1. Ernst Wagner
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  2. Matt Cotten
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  1. School of Pharmacy, University of London, London, England

    Gregory Gregoriadis  & Brenda McCormack  & 

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Wagner, E., Cotten, M., Zatloukal, K. (1996). Receptor-Mediated Gene Delivery with Synthetic Virus-Like Particles. In: Gregoriadis, G., McCormack, B. (eds) Targeting of Drugs 5. NATO ASI Series, vol 290. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-6405-8_7

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  • DOI: https://doi.org/10.1007/978-1-4615-6405-8_7

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