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Diffusion-Weighted Magnetic Resonance Imaging

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Magnetic Resonance Spectroscopy and Imaging in Neurochemistry

Part of the book series: Advances in Neurochemistry ((ANCH,volume 8))

Summary

Contrast in magnetic resonance imaging (MRI) is generated by exploiting a variety of physicochemical properties. Conventional clinical MRI techniques are largely based upon disease-induced changes in water relaxation, but these have been complemented by a number of other approaches, including a sensitization to the diffusion of water. It has been shown that diffusion-weighted (DW) imaging can be used to advantage in the diagnosis of a number of pathologies that are undetectable using standard imaging protocols. Moreover, DW imaging can provide information concerning the nature of the pathology, in addition to the spatial information that is obtained from the image per se. This chapter starts with a brief description of the diffusion phenomenon and nuclear magnetic resonance (NMR) methods for measuring diffusion coefficients. This is followed by sections devoted to some theoretical and instrumental aspects of DW imaging. The remainder of the chapter is concerned with some biomedical applications of DW imaging, with an emphasis on cerebral pathophysiology. No attempt has been made to provide an exhaustive review of the literature on DW imaging. On the contrary, we have identified a few studies that specifically serve to illustrate its potential application to neuroscience.

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Authors and Affiliations

  1. RCS Unit of Biophysics, Institute of Child Health, London, WC1N 1EH, UK

    Martin King, Albert Busza & Robert Turner

  2. Department of Neuroscience, Genentech Inc., South San Francisco, California, 94080, USA

    Nick van Bruggen

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  1. Martin King
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  1. University of Nottingham, Nottingham, England

    Herman Bachelard

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King, M., van Bruggen, N., Busza, A., Turner, R. (1997). Diffusion-Weighted Magnetic Resonance Imaging. In: Bachelard, H. (eds) Magnetic Resonance Spectroscopy and Imaging in Neurochemistry. Advances in Neurochemistry, vol 8. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5863-7_8

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