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Folate Status: Modulation of Colorectal Carcinogenesis

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Homocysteine Metabolism: From Basic Science to Clinical Medicine

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 196))

Abstract

A provocative array of observations from both laboratory and clinical investigations indicate that alterations in folate status may modulate the process of neoplastic transformation in selected epithelial tissues. Diminished folate status appears to promote carcinogenesis. Considerably more speculative is the concept that supraphysiologic folate status might afford some protective effect. Although observations to support such contentions exist for the uterine cervix, stomach, bronchopulmonary tree and esophagus, the evidence is most compelling for the colorectum. This chapter will focus on these issues as they pertain to the colorectum, and outline some of the possible mechanisms by which these effects may be exerted.

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Authors
  1. Joel B. Mason
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Editors and Affiliations

  1. The Adelaide Hospital, Trinity College, Dublin, Ireland

    Ian Graham MD

  2. Department of Clinical Biology, University of Bergen, Bergen, Norway

    Helga Refsum MD  & Per Magne Ueland MD  & 

  3. Jean Mayer Usda Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA

    Irwin H. Rosenberg MD

  4. Tufts University School of Nutrition Science and Policy, Medford, MA, USA

    Jill M. Shuman MS, RD, ELS

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Mason, J.B. (1997). Folate Status: Modulation of Colorectal Carcinogenesis. In: Graham, I., Refsum, H., Rosenberg, I.H., Ueland, P.M., Shuman, J.M. (eds) Homocysteine Metabolism: From Basic Science to Clinical Medicine. Developments in Cardiovascular Medicine, vol 196. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5771-5_23

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  • DOI: https://doi.org/10.1007/978-1-4615-5771-5_23

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