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Role of Cysteine and Lysine Residues in Human Hypoxanthine-Guanine Phosphoribosyltransferase

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Purine and Pyrimidine Metabolism in Man IX

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 431))

Abstract

Hypoxanthine-guanine phosphoribosyltransferase (HPRT) is a purine salvage enzyme which is widely distributed in human tissues. It catalyses the synthesis of the purine mononucleotides, IMP and GMP. In humans, partial enzyme deficiency is associated with gout and hyperuricemia while complete enzyme deficiency results in the Lesch-Nyhan syndrome.

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Author information

Authors and Affiliations

  1. Department of Biochemistry, University of Queensland, Brisbane, Australia, 4072

    D. T. Keough, C. L. Gee & J. de Jersey

  2. Department of Medicine, University of Queensland, Brisbane, Australia, 4072

    D. T. Keough & B. T. Emmerson

Authors
  1. D. T. Keough
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  2. C. L. Gee
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  3. B. T. Emmerson
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  4. J. de Jersey
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Editor information

Editors and Affiliations

  1. Emperor Franz Joseph Hospital, Vienna, Austria

    Andrea Griesmacher  & Mathias M. Müller  & 

  2. University of Vienna, Vienna, Austria

    Peter Chiba

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© 1998 Springer Science+Business Media New York

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Keough, D.T., Gee, C.L., Emmerson, B.T., de Jersey, J. (1998). Role of Cysteine and Lysine Residues in Human Hypoxanthine-Guanine Phosphoribosyltransferase. In: Griesmacher, A., Müller, M.M., Chiba, P. (eds) Purine and Pyrimidine Metabolism in Man IX. Advances in Experimental Medicine and Biology, vol 431. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5381-6_66

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  • DOI: https://doi.org/10.1007/978-1-4615-5381-6_66

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-7456-5

  • Online ISBN: 978-1-4615-5381-6

  • eBook Packages: Springer Book Archive

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