Abstract
The effects of the adenosine and ATP on the nervous system have been extensively studied, but the effects of pyrimidine bases and their 5′-nucleotides, e.g., UTP, have received little attention. Sympathetic ganglia may possess distinct extracellular receptors for purines and pyrimidines based on the fact that UTP is far more potent than alpha, beta-methylene-ATP (α, β-Me-ATP)(a metabolically stable ATP analogue) or ATP itself (Connolly et al., 1993) in depolarising intact rat superior cervical ganglia (SCG). It is however, known that the potency of an agonist on a tissue is dependent on whether it is susceptible to metabolism by the tissue and the metabolism of purines and pyrimidines by intact rat SCG has yet to be reported. Here we report on studies to examine if and how intact rat SCG (sympathetic ganglia), nodose ganglia (parasympathetic ganglia) and its nerve trunk, the vagus, metabolise ATP and UTP.
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© 1998 Springer Science+Business Media New York
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Connolly, G.P., Demaine, C., Duley, J.A. (1998). Ecto-Nucleotidases in Isolated Intact Rat Vagi, Nodose Ganglia, and Superior Cervical Ganglia. In: Griesmacher, A., Müller, M.M., Chiba, P. (eds) Purine and Pyrimidine Metabolism in Man IX. Advances in Experimental Medicine and Biology, vol 431. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5381-6_147
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DOI: https://doi.org/10.1007/978-1-4615-5381-6_147
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