Abstract
The pneumococcus (Streptococcus pneumoniae) is a major cause of pneumonia and meningitis worldwide. In his classic book entitled The Biology of the Pneumococcus, published in 1938, Benjamin White(1) listed 19 different names applied to the pneumococcus between 1897 and 1930, the year the designation Diplococcus pneumoniae Weichselbaum was approved in 4th edition of Bergey’s Manual.(2) In a more recent (8th) edition of Bergey’s Manual,(3) it is listed as Streptococcus pneumoniae, the designation that is now generally accepted.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
White, B. (with the collaboration of Robinson, E. S., and Barnes, L. A.), The Biology of Pneumococcus: The Bacteriological, Biochemical and Immunological Characters and Activities of Diplococcus pneumoniae, Commonwealth Fund, New York, 1938; reprinted by Harvard University Press, 1979.
Bergey, D. H., A key to the identification of organisms of the class Schizomycetes, in: Bergey’s Manual of Determinative Bacteriology, 4th ed., p. 48, Williams & Wilkins, Baltimore, 1934.
Buchanan, R. E., and Gibbons, W. E., (eds.) Bergey’s Manual of Determinative Bacteriology, 8th ed., Williams & Wilkins, Baltimore, 1974.
Finland, M., Pneumonia and pneumococcal infections, with special reference to pneumococcal pneumonia: The 1979 J. Burns Amberson Lecture, Am. Rev. Respir. Dis. 120:481–502 (1979).
Finland, M., and Barnes, M. W., Acute bacterial meningitis at Boston City Hospital during 12 selected years, 1935–1972, J. Infect. Dis. 136:400–415 (1977).
Schuchat, A., Robinson, K., Wenger, J. D., Harrison, L. E., Farley, M., Reingold, A. L., Lefkowitz, L., Perkins, B. A., For the active surveillance team, Bacterial meningitis in the United States in 1995, N. Engl. J. Med. 337:970–976 (1997).
Finland, M., and Barnes, M. W., Changing ecology of acute bacterial empyema: Occurrence and mortality at Boston City Hospital during twelve selected years from 1935 to 1972, J. Infect. Dis. 157:274–291 (1978).
Klein, J. O., The epidemiology of pneumococcal disease in infants and children, Rev. Infect. Dis. 3:246–253 (1981).
Block, S. L., Causative pathogens, antibiotic resistance and therapeutic considerations in acute otitis media. Pediatr. Infect. Dis. J. 16:449–456 (1997).
McGowan, J. E., Jr., Bratton, L., Klein, J. O., and Finland, M., Bacteremia in febrile children in a “walk-in” pediatric clinic, N. Engl. J. Med. 288:1309–1312 (1973).
Teele, D. W., Pelton, S. I., Grant, M. J. A., Herskowitz, J., Rosen, D. J., Allen, C. E., Wimer, R. S., and Klein, J. O., Bacteremia in febrile children under 2 years of age: Results of cultures of blood in 600 consecutive febrile children in a “walk-in” clinic, J. Pediatr. 87:227–230 (1975).
Finland, M., Recent advances in the epidemiology of pneumococcal infections, Medicine 21:307–344 (1942).
Austrian, R., Pneumococcus, the first hundred years, Rev. Infect. Dis. 3:183–189 (1981).
Neufeld, F., Ueber eine specifische bakteriolytische Wirkung der Galle, Z. Hyg. Infektionskr. 34:454–464 (1900).
Neufeld, F., Ueber die Agglutination der Pneumokokken and Ueber die Theorien der Agglutination, Z. Hyg. Infektionskr. 40:54–72 (1902).
Lister, F. S., Specific serological reactions with pneumococci from different sources, Publ. S. Afr. Inst. Med. Res. 1:1–14 (1913).
Dochez, A. R., and Gillespie, L. J., A biological classification of pneumococci by means of immunity reactions, J. Am. Med. Assoc. 61:727–730 (1913).
Lister, F. S., An experimental study of prophylactic inoculation against pneumococcal infection in the rabbit and in man, Publ. S. Afr. Inst. Med. Res. 1:231–287 (1916).
Orenstein, A. J., Vaccine prophylaxis in pneumonia: A review of fourteen years’ experience with inoculation of native mine workers on the Witwatersrand against pneumonia, J. Med. Assoc. S. Afr. 5: 339–346 (1931).
Armstrong, R. R., A swift and simple method for deciding pneumococcal “type,” Br. Med. J. 1:214–215 (1931).
Cooper, G., Rosenstein, C., Walter, A., and Peizer, L., The further separation of types among the pneumococci hitherto included in group IV and the development of therapeutic antisera for these types, J. Exp. Med. 55:531–554 (1932).
Lund, E., Types of pneumococci found in blood, spinal fluid and pleural exudate during 15 years (1954–1969), Acta Pathol. Microbiol. Scand. Sect. B 78:333–336 (1970).
Henrichsen, J., Six newly recognized types of Streptococcus pneumoniae,J. Clin. Microbiol. 33:2759–2762 (1995).
Wright, A. E., Morgan, W., Colbrook, L., and Dodgson, R. W. Observations on prophylactic inoculations against pneumococcus infection, and on the results which have been achieved by it, Lancet 1:1–10, 87–95 (1914).
Kass, E. H. (ed.), Assessment of the pneumococcal polysaccharide vaccine: A workshop held at the Harvard Club of Boston, Boston, Massachusetts, October 6, 1980, Rev. Infect. Dis. 3: (Suppl.):Sl-S197 (1981).
Schiffman, G., Immune response to pneumococcal polysaccharide antigens: A comparison of the murine model and the response in humans, Rev. Infect. Dis. 3:224–231 (1981).
Heffron, R., Pneumonia with Special Reference to Pneumococcus Lobar Pneumonia, Commonwealth Fund, New York, 1939; reprinted by Harvard University Press, 1979.
Collins, S. D., and Gover, M., Age and seasonal incidence of minor respiratory attacks classified according to clinical symptoms, Am. J. Hyg. 20:533–554 (1934).
Centers for Disease Control, Surveillance summary: Bacterial meningitis and meningococcemia, Morbid. Mortal. Week. Rep. 28:277–279 (1979).
Wenger, J. D., Hightower, A. W., Facklam, R. R., Gaventa, S., Broome, C. V., and the Bacterial Meningitis Study Group, Bacterial meningitis in the United States, 1986: Report of a multistate surveillance study, J. Infect. Dis. 162:1316–1323 (1990).
Burman, A., Norrby, R., and Trollfors, B., Invasive pneumococcal infections: Incidence, predisposing factors and prognosis, Rev. Infect. Dis. 7:133–142 (1985).
Mufson, M. A., Pneumococcal infections, J. Am. Med. Assoc. 246:1942–1948 (1981).
Centers for Disease Control, Recommendations of the Immunization Practices Advisory Committee (ACIP): Pneumococcal polysaccharide vaccine, Morbid. Mortal. Week. Rep. 30:410–419 (1981).
Eskola, J., Takala, A., Kela, E., Pekkanen, E., Kalliokosk, R., and Leinonen, M., Epidemiology of invasive pneumococcal infections in children in Finland, J. Am. Med. Assoc. 268:3323–3327 (1992).
Dagon, R., Englehard, D., Piccard, E., and the Israeli Pediatric Bacteremia and Meningitis Group, Epidemiology of invasive childhood pneumococcal infections in Israel, J. Am. Med. Assoc. 268:3328–3332 (1992).
Hoge, C. W., Reichler, M. R., Dominguez, E. A., Bremer, J. C., Mastro, T. D., Hendrick, K. A., Musher, D. M., Elliott, J. A., Facklam, R. R., and Breiman, R. F., An epidemic of pneumococcal disease in an overcrowded, inadequately ventilated jail, N. Engl. J. Med. 331:643–648 (1994).
Davidson, M., Parkinson, A. J., Bulkow, L. R., Fitzgerald, M. A., Peters, H. V., and Parks, D. J., The epidemiology of invasive pneumococcal disease in Alaska, 1986–1990-Ethnic differences and opportunities for prevention, J. Infect. Dis. 170:368–376 (1994).
Cortese, M. M., Wolff, M., Almeido-Hill, J., Reed, R., Ketcham, J., and Santosham, M., High incidence rates of pneumococcal disease in the White Mountain Apache population, Arch. Intern. Med. 152:2277–2282 (1992).
Sabin, A. B., “Stained slide” microscopic agglutination test: Application to (1) rapid typing of pneumococci, (2) determination of antibody, Am. J. Public Health 19: 1148–1150 (1929).
Rytel, M. W., Pneumococcal pneumonia, in: Rapid Diagnosis in Infectious Disease (M. W. Rytel, ed.), pp. 91–103, CRC Press, Boca Raton, FL, 1979.
Schiffman, G., Douglas, R. M., Bonner, M. J., Robbins, M., and Austrian, R., A radioimmunoassay for immunologic phenomena in pneumococcal disease and for the antibody response to pneumococcal vaccines. 1. Methods for the radioimmunoassay of anticapsular antibodies and comparison of other techniques, J. Immunol. Methods 33:133–144 (1980).
Moore, H. F., and Chesney, A. M., A further study of ethylhydrocupreine (optochin) in the treatment of acute lobar pneumonia, Arch. Intern. Med. 21:659–681 (1918).
Lowell, F. C., Strauss, E., and Finland, M., Observations on the susceptibility of pneumococci to sulfapyridine, sulfathiazole and sulfamethoxazole, Ann. Intern. Med. 14:1001–1023 (1940).
Whitby, L., Chemotherapy of bacterial infections (Bradshaw Lecture), Lancet 2:1095–1103 (1938).
Applebaum, P. C., Antimicrobial resistance in Streptococcus pneumoniae: An overview, Clin. Infect. Dis. 15:77–83 (1992).
Austrian, R., Some observations on the pneumococcus and on the current status of pneumococcal disease and its prevention, Rev. Infect. Dis. 3:(Suppl.) S1–S17 (1981).
Mundy, L. M., Auwaerter, P. G., Oldach, D., Warner, M. L., Burton, A., Vance, E., Gaydos, C. A., Joseph, J. M., Gopalan, R., Moore, R. D., Quinn, T. C., Charache, P., and Bartlett, J. G., Community-acquired pneumonia: Impact of immune status, Am. J. Respir. Crit. Care Med. 152:1309–1315 (1995).
Hansman, D., and Bullen, M. M., A resistant pneumococcus, Lancet 2:264–265 (1967).
Applebaum, P. C., Bhamjee, A., Scragg, J. N., Hallett, A. F., Bowen, A. J., and Cooper, R. C., Streptococcus pneumoniae resistant to penicillin and chloramphenicol, Lancet 2:995–997 (1977).
Jacobs, M. R., Koornhof, H. J., Robins-Brown, R. M., Stevenson, C. M., Vermaak, Z. A., Freiman, I., Miller, G. B., Witcomb, M. A., Isaäcson, M., Ward, J. I., and Austrian, R., Emergence of multiply resistant pneumococci, N. Engl. J. Med. 299:735–740 (1978).
Zighelboim, S., and Tomasz, A., Multiple antibiotic resistance in South African strains of Streptococcus pneumoniae: Mechanism of resistance to 3-lactam antibiotics, Rev. Infect. Dis. 3:267–276 (1981).
Handwerger, S., and Tomasz, A., Alterations in penicillin-binding proteins of clinical and laboratory isolates of pathogenic Streptococcus pneumoniae with low levels of penicillin resistance, J. Infect. Dis. 153:83–89 (1986).
Tomasz, A., The pneumococcus at the gates, N. Engl. J. Med. 333:514–515 (1995).
Caputo, G. M., Applebaum, P. C., and Liu, H. H., Infections due to penicillin-resistant pneumococci. Clinical, epidemiologic, and microbiologic features, Arch. Intern. Med. 153:1301–1310 (1993).
Pallares, R., Liñares, J., Vadillo, M., Cabellos, C., Manresa, F., Viladrich, P. F., Martin, R., and Gudiol, F., Resistance to penicillin and cephalosporin and mortality from severe pneumococcal pneumonia in Barcelona, Spain, N. Engl. J. Med. 333:474–480 (1995).
Saah, A. J., Mallonee, J. R., Tarpay, M., Thornsberry, C. T., Roberts, M. A., and Rhoades, E. R., Relative resistance to penicillin in the pneumococcus, J. Am. Med. Assoc. 243:1824–1827 (1980).
Pallares, R., Gudiol, F., Linares, J., Ariza, J., Rufi, G., Murgui, L., Dorca, J., and Viladrich, P. F., Risk factors and response to antibiotic therapy in adults with bacteremic pneumonia caused by penicillin-resistant pneumococci, N. Engl. J. Med. 317:18–22 (1987).
Hofmann, J., Cetron, M. S., Farley, M. M., Baughman, W. S., Facklam, R. R., Elliott, J. A., Deaver, K. A., and Breiman, R. F., The prevalence of drug-resistant Streptococcus pneumoniae in Atlanta, N. Engl. J. Med. 333:481–486 (1995).
Friedland, I. R., and Kingman, K. P., Antibiotic-resistant pneumococcal disease in South African children, Am. J. Dis. Child. 146:920–923 (1992).
Mason, E. O., Kaplan, S. L., Lamberth, L. B., and Tillman, J., Increased rate of isolation of penicillin-resistant Streptococcus pneumoniae in a children’s hospital and in vitro susceptibilities to antibiotics of potential therapeutic use, Antimicrob. Agents Che-mother. 36:1703–1707 (1992).
Pikis, A., Akram, S., Donkersloot, J., Campos, J. M., and Rodriguez, W. J., Penicillin-resistant pneumococci from pediatric patients in the Washington, DC area, Arch. Pediatr. Adolesc. Med. 149:30–35 (1995).
Block, S., Harrison, C. J., Hedrick, J. A., Tyler, R. D., Smith, R. A., Keegan, E., and Chartrand, S. A., Penicillin-resistant Streptococcus pneumoniae in acute otitis media: Risk factors, susceptibility patterns and antimicrobial management, Pediatr. Infect. Dis. J. 14:751–759 (1995).
Duchin, J. S., Breiman, R. F., Diamond, A., Lipman, H. B., Block, S. L., Hedrick, J. A., Finger, R., and Elliott, J. A., High prevalence of multidrug-resistant Streptococcus pneumoniae among children in a rural Kuntucky community, Pediatr. Infect. Dis. J. 14:745–750 (1995).
Feldman, C., Kaltenbach, J. M., Miller, S. D., Thorburn, J. R., and Koornhof, H., Community-acquired pneumonia due to penicillin-resistant pneumococci, N. Engl. J. Med. 313:615–617 (1985).
Koornhof, H. J., Wasas, A., and Klugman, K., Antimicrobial resistance in Streptococcus pneumoniae: A South African perspective, Clin. Infect. Dis. 15:84–94 (1992).
. Finland, M., and Barnes, M. W. Changes ion occurrence of capsular serotypes of Streptococcus pneumoniae at Boston City Hospital during selected years between 1935 and 1974, J. Clin. Microbiol. 5:154–166 (1977).
Baltimore, R. S., New challenges in the development of a conjugate pneumococcal vaccine, J. Am. Med Assoc. 268:3366–3367 (1992).
Ordman, D., Pneumococcus typing: Its value in pneumonia, S. Afr. Med. J. 11:569–573 (1937).
Ordman, D., Pneumococcus types in South Africa: A study of their occurrence and the effect thereon of prophylactic inoculation, Publ. S. Afr. Inst. Med. Res. 9:1–27 (1938).
Finland, M., The present status of the higher types of antipneumococcus serums, J. Am. Med. Assoc. 120:1294–1307 (1942).
Lund, E., Pulverer, G., and Jeljaszewicz, J., Serological types of Diplococcus pneumoniae strains isolated in Germany, Med. Microbiol. Immunol. 159:171–178 (1974).
Parker, M. T., Type distribution of pneumococci isolated from serious diseases in Britain, in: Pathogenic Streptococci (M. T. Parker, ed.), pp. 191–192, Redbooks, Chertsey, England, 1979.
Echániz-Aviles, G., Carnalla-Barajas, N., Velázquez-Meza, M. E., Soto-Noguerón, A., Espitiosa-de los Monteros, L. E., and Solórozano-Santos, F., Capsular types of Streptococcus pneumoniae causing disease in children from Mexico City, Pediatr. Infect. Dis. J. 14:907–909 (1995).
Nemir, R. L., Andrews, E. T., and Vinograd, J., Pneumonia in infants and children: Bacteriologic study with special reference to clinical significance, Am. J. Dis. Child. 51:1277–1295 (1936).
Shapiro, E. D., and Austrian, R., Serotypes responsible for invasive Streptococcus pneumoniae infections among children in Connecticut, J. Infect. Dis. 169:212–214 (1994).
Finland, M., and Winkler, A. W., Recurrences in pneumococcus pneumonia, Am. J. Med. Sci. 188:309–320 (1934).
Strauss, E., and Finland, M., Further studies on recurrences in pneumococcic pneumonia with special reference to the effect of specific treatment, Ann. Intern. Med. 16:17–32 (1942).
Quie, P. G., Giebink, G. S., and Winkelstein, J. A. (guest eds.), The Pneumoncoccus: A symposium held at the Kroc Foundation Headquarters, Santa Ynez Valley, California, February 25–29, 1980, Rev. Infect. Dis. 3: 183–371 (1981).
Riley, I. D., and Douglas, R. M., An epidemiologic approach to pneumococcal disease, Rev. Infect. Dis. 3:233–245 (1981).
Cole, R., and MacCallum, W. G., Pneumonia at a base hospital, J. Am. Med. Assoc. 70:1146–1156 (1918).
Small, A. A., Pneumonia at a base hospital: Observations in one thousand and one hundred cases at Camp Pike, Ark., J. Am. Med. Assoc. 71:700–702 (1918).
Opie, E. L., Blake, F. G., Small, J. C., and Rivers, T. M., Epidemic Respiratory Disease: The Pneumonias and Other Infections of the Respiratory Tract Accompanying Influenza and Measles,Mosby, St. Louis, 1921.
Netter, Contagion de la pneumonie, Arch. Gen. Med. (Paris) 21: 530–544, 699–718; 22:42–59 (1888).
Cruickshank, R., Pneumococcal infections (Milroy Lectures), Lancet 1:563–568, 621–626, 680–685 (1933).
Johnston, H., Pneumonia as contagious disease, Can. Med. Assoc. J. 38:270–271 (1938).
Brown, J. W., and Finland, M., A family outbreak of type V pneumococcus infections: Clinical, bacteriological and immunological studies, Ann. Intern. Med. 13:394–401 (1939).
Finland, M., and Tilghman, R. C., Bacteriological and immunological studies in families with pneumococcic infections: The development of type-specific antibodies in healthy contact carriers, J. Clin. Invest. 15:501–508 (1936).
Smillie, W. E., Study of an outbreak of type II pneumococcus pneumonia in Veterans’ Administration Hospital at Bedford, Massachusetts, Am. J. Hyg. 24:522–535 (1936).
Smillie, W. E., Warnock, G. H., and White, H. J., Study of a type I pneumococcus epidemic at the State Hospital at Worcester, Mass., Am. J. Public Health 28:293–302 (1938).
Tomforde, Eine Endemic von croupöser Pneumonie im Dorfe Laumuhlen, Kreis Neuhaus an der Oste, Januar 1902, Dtsch. Med. Wochensche 28:577–579 (1902).
Gorgas, W. C., Sanitation on the Panama Canal, J. Am. Med. Assoc. 40:953–955 (1913).
Park, J. H., Jr., and Chickering, H. T., Type I pneumococcal lobar pneumonia among Puerto Rican laborers of Camp Jackson, South Carolina, J. Am. Med. Assoc. 73:183–186 (1919).
Tenny, C. F., and Rivenburgh, W. T., A group of 68 cases of type I pneumonia occurring in 30 days at Camp Upton, Arch. Intern. Med. 24:545–552 (1919).
Hirsch, E. F., and McKinney, M., An epidemic of pneumococcus bronchopneumonia, J. Infect. Dis. 24:594–617 (1919).
Holle, H. A., and Bullowa, J. G. M., Pneumococcal cross-infections in home and hospital, N. Engl. J. Med. 223:887–890 (1940).
Harris, A. H., and Ingraham, H. S., Study of carrier condition associated with type II pneumonia in camp of Civilian Conservation Corps, J. Clin. Invest. 16:41–48 (1937).
Greenberg, D., Relation of meteorological conditions to the prevalence of pneumonia, J. Am. Med. Assoc. 72:252–257 (1919).
Rogers, L., Relationship between pneumonia incidence and climate in India, Lancet 1:1173–1177 (1925).
McGowan, J. E., Jr., Barnes, M. W., and Finland, M., Bacteremia at Boston City Hospital: Occurrence and mortality during 12 selected years 1935–1972, with special reference to hospital-acquired cases, J. Infect. Dis. 132:316–335 (1975).
Tillotson, J. R., and Finland, M., Bacterial colonization and clinical superinfection of the respiratory tract complicating antibiotic treatment of pneumonia, J. Infect. Dis. 119:597–624 (1969).
Brundage, D. K., Russell, A. E., Jones, R. R., Bloomfield, J. J., and Thompson, R., Frequency of pneumonia among iron and steel workers, Public Health Bulletin,No. 202, US Government Printing Office, Washington, DC, 1932.
Gilman, B. B., and Anderson, G. W., Community outbreak of type I pneumococcus infection, Am. J. Hyg. 28:345–358 (1938).
Sydenstricker, V. P. W., and Sutton, A. C., An epidemiological study of lobar pneumonia, Bull. Johns Hopkins Hosp. 38:312–315 (1918).
Lister, S., and Ordman, D., Epidemiology of pneumonia on the Witwatersrand goldfields and prevention of pneumonia and other acute respiratory diseases in native laborers in South Africa by means of vaccine, Publ. S. Afr. Inst. Med. Res. 7:1–124 (1935).
Ordman, D., Pneumonia in the native mine workers of the Witwatersrand goldfields: A bacteriological and epidemiological study, J. Med. Assoc. S. Afe 5:108–116 (1931).
Ordman, D., Pneumonia in the native mine labourers of northern Rhodesia copperfields with an account of an experiment in pneumonia prophylaxis by means of a vaccine at the Roan Antelope Mine, Publ. S. Afr. Inst. Med. Res. 7:1–124 (1935).
Ebgert, J. H., Epidemic pneumonia in the tropics, NY Med. J. 103:1125 (1916).
Robertson, O. H., Instance of lobar pneumonia acquired in the laboratory, J. Prev. Med. 5:221–224 (1931).
Benjamin, J. E., Ruegsegger, J. M., and Senior, F. A., Cross-infection in pneumococcic pneumonia, J. Am. Med. Assoc. 112: 1127–1130 (1939).
Verhoef, J., Effects of nutrition on antibiotic action, in: Action of Antibiotics in Patients (L. D. Sabath and G. G. Grassi, eds.), Huber, Bern, 1982.
Perlino, C. A., and Rimland, D., Alcoholism leukopenia and pneumococcal sepsis, Am. Rev. Respir. Dis. 132:757–760 (1985).
Giebink, G. S., The pathogenesis of otitis media in chinchillas and the efficacy of vaccination on prophylaxis, Rev. Infect. Dis. 3: 342–352 (1981).
Giebink, G. S., Berzins, J. K., Marker, S. C., and Schiffman, G., Experimental otitis media after nasal inoculation of Streptococcus pneumoniae and influenza A in chinchillas, Infect. Immun. 30:445–450 (1980).
Kass, E. H., Green, G. M., and Goldstein, E., Mechanism of antibacterial action in the respiratory tract, Bacteriol. Rev. 30:488–496 (1966).
Coonrod, J. D., and Yoneda, K., Complement and opsonins in alveolar secretions and serum of rats with pneumonia due to Streptococcus pneumoniae, Rev. Infect. Dis. 3:310–322 (1981).
Drinker, C. K., and Field, M. E., Lymphatics,Lymph and Tissue Fluid, Williams & Wilkins, Baltimore, 1933.
Terrell, E. E., Robertson, O. H., and Coggeshall, L. T., Experimental pneumococcus lobar pneumonia in the dog. I. Method of production and course of disease, J. Clin. Invest. 12:393–432 (1933).
Stillman, E. G., and Branch, A., Experimental production of pneumococcus pneumonia in mice by inhalation method, J. Exp. Med. 40:733–742 (1924).
Stillman, E. G., Susceptibility of rabbits to infection by the inhalation of type II pneumococcus, J. Exp. Med. 52:215–224 (1930).
Goodner, K., Development and localization of dermal pneumococcic infection in the rabbit, J. Exp. Med. 54:847–858 (1931).
Tilghman, R. C., and Finland, M., Clinical significance of bacteremia in pneumococcal pneumonia, Arch. Intern. Med. 59:602–619 (1937).
Finland, M., and Sutliff, W. D., Specific cutaneous reactions and circulating antibodies in the course of lobar pneumonia. I. Cases receiving no serum therapy, J. Exp. Med. 54:637–652 (1931).
Tuomanen, E. I., Austrian, R., and Masure, H. R., Pathogenesis of pneumococcal infection, N. Engl. J. Med. 332:1280–1284 (1995).
Giebink, G. S., Grebner, J. V., Kim, Y., and Quie, P. G., Severe opsonic deficiency produced by Streptococcus pneumoniae and by capsular polysaccharide antigens, Yale J. Biol. Med. 51:527–538 (1978).
Rytel, M. W., Dee, T. H., Ferstenfeld, J. E., and Hensley, G. T., Possible pathogenic role of capsular antigens in fulminant pneumococcal disease with disseminated intravascular coagulation, Am. J. Med. 57:889–896 (1974).
Bernstein, L. J., Krieger, B. Z., Novick, B., Sicklick, M. J., and Rubinstein, A., Bacterial infection in the acquired immunodeficiency syndrome of children, Pediatr. Infect. Dis. 4:472–475 (1985).
Andiman, W. A., Mezger, J., and Shapiro, E., Invasive bacterial infections in children born to women infected with human immunodefiency virus type 1, J. Pediatr. 124:846–852 (1994).
Farley, J. J., King, J. C., Jr., Nair, P., Hines, S. E., Tressler, R. L., and Vink, P. E., Invasive pneumococcal disease among infected and uninfected children of mothers with human immunodeficiency virus infection, J. Pediatr. 124:853–858 (1994).
Hirschtick, R. E., Glassroth, J., Jordan, M. C., Bacterial pneumonia in persons infected with the human immunodeficiency virus, N. Engl. J. Med. 333:845–851 (1995).
Janoff, E., Breiman, R. F., Daley, C. L., Pneumococcal disease during HIV infection, Ann. Intern. Med. 117:314–324 (1992).
The National Institutes of Child Health and Human Development Intravenous Immunoglobulin Study Group, Intravenous immune globulin for the prevention of bacterial infections in children with symptomatic human immunodeficiency virus infection, N. Engl. J. Med. 325:73–80 (1991).
Ivemark, B., Implications of agenesis of the spleen on the pathogenesis of conotruncus anomalies in children, Acta Pediatr. Scand. (Suppl. 104) 44:590–592 (1955).
Waldman, J. D., Rosenthal, A., Smith, A. L., Shurin, S., and Nadas, A. S., Sepsis and congenital asplenia, J. Pediatr. 90:555–559 (1977).
Styrt, B., Infection associated with asplenia: Risks, mechanisms, and prevention, Am. J. Med. 88:33N–44N (1990).
Pearson, H. A., Splenectomy: Its risks and its roles, Hosp. Pract. 15(August):85–94 (1980).
Gaston, M. H., Verter, J. I., Woods, G., Prophylaxis with oral penicillin in children with sickle cell anemia. A randomized trial, N. Engl. J. Med. 314:1593–1599 (1986).
Brown, E. J., Hosea, S. W., and Frank, M. M., The role of antibody and complement in the reticuloendothelial clearance of pneumococci from the blood stream, Rev. Infect. Dis. 5:S797–S805 (1983).
Winkelstein, J. A., The role of complement in the hosts’ defense against Streptococcus pneumoniae, Rev. Infect. Dis. 3:289–298 (1981).
Davies, J. A. V., The response of infants to inoculation with type 1 pneumococcus carbohydrate, J. Immunol. 33:1–7 (1937).
Sell, S. H., Wright, P. F., Vaughan, W. K., Thompson, J., and Schiffman, G., Clinical studies of pneumococcal vaccine in infants. 1. Reactogenicity and immunogenicity of two polyvalent polysaccharide vaccines, Rev. Infect. Dis. 3:S97–S107 (1981).
Wara, D. W., Host defense against Streptococcus pneumoniae: The role of the spleen, Rev. Infect. Dis. 3:299–309 (1981).
Maynard, G. D., An enquiry into the etiology, manifestations and prevention of pneumonia amongst natives on the Rand from tropical areas, Publ. S. Afr. Inst. Med. Res. 1:1–101 (1913).
Ekwurzel, G. M., Simmons, J. S., Dublin, H., and Felton, L. D., Studies of immunizing substances in pneumococci. VIII. Report on field test to determine the prophylactic value of a pneumococcus antigen, Public Health Rep. 53:1877–1893 (1938).
Felton, L. D., Studies on immunizing substances in pneumococci. VII. Response in human beings to antigenic pneumococcus polysaccharides, type I and II, Public Health Rep. 53:2855–2877 (1938).
Lister, F. S., Prophylactic inoculation of man against pneumococcal infections, and more particularly against lobar pneumonia, Publ. S. Afr. Inst. Med. Res. 10:304–322 (1917).
Kaufman, P., Pneumonia in old age. Active immunization against pneumonia with pneumococcus polysaccharides: Results of a six year study, Arch. Intern. Med. 79:518–531 (1947).
MacLeod, C. M., Hodges, R. G., Heidelberger, M., and Bernhard, W. G., Prevention of pneumococcal pneumonia by immunization with specific capsular polysaccharides, J. Exp. Med. 82:445–465 (1945).
Austrian, R., and Gold, J., Pneumococcal bacteremia with especial reference to bacteremic pneumococcal pneumonia, Ann. Intern. Med. 60:759–776 (1964).
US Congress, Office of Technology Assessment, A Review of Selected Federal Vaccine and Immunization Policies, US Government Printing Office, Washington, DC, 1979.
Austrian, R., Douglas, R. M., Schiffman, G., Coetzee, A. M., Koornhof, H. J., Hayden-Smith, S., and Reid, R. D. W., Prevention of pneumococcal pneumonia by vaccination, Trans. Assoc. Am. Physicians 89:184–194 (1976).
Smit, P., Oberholzer, D., Hayden-Smith, S., Koornhof, H. J., and Hilleman, M. R., Protective efficacy of pneumococcal polysaccharide vaccines, J. Am. Med. Assoc. 238:2613–2616 (1977).
Austrian, R., Surveillance of Pneumococcal Infection for Field Trials of Polyvalent Pneumococcal Vaccine, Report DAB-VDP12–84, National Institutes of Health, Bethesda, 1980.
Schwartz, J. S., Pneumococcal vaccine: Clinical efficacy and effectiveness, Ann. Intern. Med. 96:208–220 (1982).
Ammann, A. J., Addiego, J., Wara, D. W., Lubin, B., Smith, W. B., and Mentzer, W. C., Polyvalent pneumococcal-polysaccharide immunization of patients with sickle-cell anemia and patients with splenectomy, N. Engl. J. Med. 297:897–900 (1977).
Centers for Disease Control, Recommendation of the Public Health Service Advisory Committee on Immunization Practices: Pneumococcal polysaccharide vaccine, Morbid. Mortal. Week. Rep. 27:25–31 (1978).
Centers for Disease Control, Recommendations of the Immunization Practices Advisory Committee (ACIP) update: Pneumococcal vaccine usage-United States, Morbid. Mortal. Week. Rep. 33:273–281 (1984).
Centers for Disease Control, Recommendations of the Immunization Practices Advisory Committee (ACIP): Prevention of Pneumococcal Disease, Morbid. Mortal. Week. Rep. 46(suppl. RR-8): 1–24 (1997).
Health and Public Policy Committee, American College of Physicians, Pneumococcal vaccine, Ann. Intern. Med. 104:118–120 (1986).
Broome, C. V., and Facklam, R. R., Epidemiology of clinically significant isolates of Streptococcus pneumoniae in the United States, Rev. Infect. Dis. 3:277–281 (1981).
Broome, C. V., Facklam, R. R., Allen, J. R., Fraser, D. W., and Austrian, R., Epidemiology of pneumococcal serotypes in the United States, 1978–1979, J. Infect. Dis. 141:119–123 (1980).
Ahonkhai, V. I., Landesman, S. H., Fikrig, S. M., Schmalzer, E. A., Brown, A. K., Cherubin, C. E., and Schiffman, G., Failure of pneumococcal vaccine in children with sickle-cell disease, N. Engl. J. Med. 301:26–27 (1979).
Giebink, G. S., Schiffman, G., Krivit, W., and Quie, P. G., Vaccine-type pneumococcal pneumonia after vaccination in an asplenic patient, J. Am. Med. Assoc. 241:2736–2737 (1979).
Ammann, A. J., Schiffman, G., Addiego, J. E., Wara, W. M., and Wara, D. W., Immunization of immunosuppressed patients with pneumococcal polysaccharide vaccine, Rev. Infect. Dis. 3 (Suppl.):5160–5167 (1981).
Giebink, G. S., Le, C. T., Cosio, F. G., Spika, J. S., and Schiffman, G., Serum antibody responses of high-risk children and adults to vaccination with capsular polysaccharides of Streptococcus pneumoniae, Rev. Infect. Dis. 3(Suppl.):S168–S178 (1981).
Lazarus, H. M., Lederman, M., Lubin, A., Herzig, R. H., Schiff-man, G., Jones, P., Wine, A., and Rodman, H. M., Pneumococcal vaccination: The response of patients with multiple myeloma, Am. J. Med. 69:419–423 (1980).
Broome, C. V., Efficacy of pneumococcal polysaccharide vaccines, Rev. Infect. Dis. 3(Suppl.):S82–S83 (1981).
Broome, C. V., Facklam, R. R., and Fraser, D. W., Pneumococcal disease after pneumococcal vaccination: An alternative method to estimate the efficacy of pneumococcal vaccine, N. Engl. J. Med. 303:549–552 (1980).
Clemens, J. D., and Shapiro, E. D., Resolving the pneumococcal vaccine controversy: Are there alternatives to randomized clinical trials? Rev. Infect. Dis. 6:589–600 (1984).
Shapiro, E. D., and Clemens, J. D., A controlled evaluation of the protective efficacy of pneumococcal vaccine for patients at high risk for serious pneumococcal infections, Ann. Intern. Med. 101: 325–330 (1984).
Bolan, G., Broome, C. V., Facklam, R. R., Pilkaytis, B. D., Fraser, D. W., and Schiech, W. F., III, Pneumococcal vaccine efficacy in selected populations in the United States, Ann. Intern. Med. 104: 1–6 (1986).
Austrian, R., A reassessment of pneumococcal vaccine [editorial], N. Engl. J. Med. 310:651–653 (1984).
LaForce, F. M., and Eickhoff, T. C., Pneumococcal vaccine: The evidence mounts, Ann. Intern. Med. 104:110–112 (1986).
Patrick, K. M., and Woolley, F. R., A cost-benefit analysis of immunization of pneumococcal pneumonia, J. Am. Med. Assoc. 245:473–477 (1981).
Sisk, J. E., and Riegelman, R. K., Cost effectiveness of vaccination against pneumococcal pneumonia: An update, Ann. Intern. Med. 104:79–86 (1986).
Simberkoff, M. S., Cross, A. P., Al-Ibrahim, M., Baltch, A. L., Geister, P. J., Nadler, J., Richmond, A. S., Smith, R. P., and Van Eeckhout, J. P., Efficacy of pneumococcal vaccine in high-risk patients: Results of a Veterans Administration cooperative study, N. Engl. J. Med. 315:1318–1327 (1986).
Shapiro, E. D., Pneumococcal vaccine failure [letter], N. Engl. J. Med. 316:1272–1273 (1987).
Robbins, J. B., Austrian, R., Lee, C.-J., Rastogi, S. C., Schiffman, G., Henrichsen, J., Makela, P. H., Broome, C. V., Facklam, R. R., Tiesjema, R. H., and Parke, J. C., Jr., Considerations for formulating the second-generation pneumococcal capsular lysaccharide vaccine with emphases on the cross-reactive types within groups, J. Infect. Dis. 148:1136–1159 (1983).
Fedson, D. S., Improving the use of pneumococcal vaccine through a strategy of hospital-based immunization: A review of its rationale and implications, J. Am. Geriatr. Soc. 33:142–150 (1985).
Shapiro, E. D., Berg, A. T., Austrian, R., et al., The protective efficacy of polyvalent pneumococcal polysaccharide vaccine, N. Engl. J. Med. 325:1453–1460 (1991).
Butler, J. C., Breiman, R. F., Campbell, J. F., Lipman, H. B., Broome, C. V., and Facklam, R. R., Pneumococcal polysaccharide vaccine efficacy: An evaluation of current recommendations, J. Am. Med. Assoc. 270:1826–1831 (1993).
Borgono, J. M., McLean, A. A., Vella, P. P., Woodhour, A. F., Canepa, I., Davidson, W. L., and Hilleman, M. R., Vaccination and revaccination with polyvalent pneumococcal polysaccharide vaccines in adults and infants, Proc. Soc. Exp. Biol. Med. 157:148–154 (1978).
Giebink, G. S., Preventing pneumococcal disease in children: Recommendations for using pneumococcal vaccine, Pediatr. Infect. Dis. 4:343–348 (1985).
Committee on Infectious Diseases, American Academy of Pediatrics, Recommendations for using pneumococcal vaccine in children, Pediatrics 75:1153–1158 (1985).
Käyhty, H., Ahman, H., Rönnberg, P.-R., Tillikainen, R., and Eskola, J., Pneumococcal polysaccharide-meningococcal outer membrane protein complex conjugate vaccine is immunogenic in infants and children, J. Infect. Dis. 172:1273–1278 (1995).
Wood, C. C., McNamara, J. G., Schwarz, D. F., Merrill, W. W., and Shapiro, E. D., Prevention of pneumococcal bacteremia in a child with AIDS-related complex, Pediatr. Infect. Dis. J. 6:564–566 (1987).
Calvelli, T. A., and Rubinstein, A., Intravenous gammaglobulin in infant acquired immunodeficiency syndrome, Pediatr. Infect. Dis. 5:S207–S210 (1986).
Siber, G. R., Thompson, C., Reid, G. R., Almeido-Hill, J., Zachet, B., Wolff, M., and Santosham, M., Evaluation of bacterial polysaccharide immune globulin for the treatment or prevention of Haemophilus influenzae type b and pneumococcal disease, J. Infect. Dis. 165(Suppl.):S129–S133 (1992).
Tomasz, A., Surface components of Streptococcus pneumoniae, Rev. Infect. Dis. 3:190–211 (1981).
Lee, C.-J., Fraser, B. A., Szu, S., and Lin, K.-T., Chemical structure of and immune response to polysaccharides of Streptococcus pneumoniae, Rev. Infect. Dis. 3:323–331 (1981).
Avery, O. T., MacLeod, C. M., and McCarty, M., Studies on the chemical nature of the substance inducing transformation of pneumococcal types: Induction of transformation by a desoxyribonucleic acid fraction isolated from pneumococcus type III, J. Exp. Med. 79:137–158 (1944).
Suggested Reading
Finland, M., and Sutliff, W. D., Specific antibody response of human subjects to intracutaneous injection of pneumococcus products, J. Exp. Med. 55:853–865 (1932).
Applebaum, P. C., Antimicrobial resistance in Streptococcus pneumoniae: An overview, Clin. Infect. Dis. 15:77–83 (1992).
Austrian, R., and Gold, J., Pneumococcal bacteremia with especial reference to bacteremic pneumococcal pneumonia, Ann. Intern. Med. 60:759–776 (1964).
Heffron, R., Pneumonia with Special Reference to Pneumococcal Lobar Pneumonia,Commonwealth Fund, New York, 1939; reprinted by Harvard University Press, 1979.
Mufson, M. A., Pneumococcal infections, J. Am. Med. Assoc. 246:1942–1948 (1981).
Tuomanen, E. I., Austrian, R., and Masure, H. R., Pathogenesis of pneumococcal infection, N. Engl. J. Med. 332:1280–1284 (1995).
White, B. (with the collaboration of Robinson, E. S., and Barnes, L. A.), The Biology of Pneumococcus: The Bacteriological,Biochemical and Immunological Characters and Activities of Diplococcus pneumoniae, Commonwealth Fund, New York, 1938; reprinted by Harvard University Press, 1979.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1998 Springer Science+Business Media New York
About this chapter
Cite this chapter
Baltimore, R.S., Shapiro, E.D. (1998). Pneumococcal Infections. In: Evans, A.S., Brachman, P.S. (eds) Bacterial Infections of Humans. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5327-4_29
Download citation
DOI: https://doi.org/10.1007/978-1-4615-5327-4_29
Publisher Name: Springer, Boston, MA
Print ISBN: 978-0-306-45323-6
Online ISBN: 978-1-4615-5327-4
eBook Packages: Springer Book Archive